LOCUS       NM_012506               3559 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 3
            (Atp1a3), mRNA.
ACCESSION   NM_012506
VERSION     NM_012506.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3559)
  AUTHORS   Depierre,P., Ginet,V., Truttmann,A.C. and Puyal,J.
  TITLE     Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in
            hypoxic-ischemic neuronal death
  JOURNAL   Cell Death Dis 15 (5), 363 (2024)
   PUBMED   38796484
  REMARK    GeneRIF: Neuronal autosis is Na[+]/K[+]-ATPase alpha 3-dependent
            and involved in hypoxic-ischemic neuronal death.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3559)
  AUTHORS   Ohnishi,T., Yanazawa,M., Sasahara,T., Kitamura,Y., Hiroaki,H.,
            Fukazawa,Y., Kii,I., Nishiyama,T., Kakita,A., Takeda,H.,
            Takeuchi,A., Arai,Y., Ito,A., Komura,H., Hirao,H., Satomura,K.,
            Inoue,M., Muramatsu,S., Matsui,K., Tada,M., Sato,M., Saijo,E.,
            Shigemitsu,Y., Sakai,S., Umetsu,Y., Goda,N., Takino,N.,
            Takahashi,H., Hagiwara,M., Sawasaki,T., Iwasaki,G., Nakamura,Y.,
            Nabeshima,Y., Teplow,D.B. and Hoshi,M.
  TITLE     Na, K-ATPase alpha3 is a death target of Alzheimer patient
            amyloid-beta assembly
  JOURNAL   Proc Natl Acad Sci U S A 112 (32), E4465-E4474 (2015)
   PUBMED   26224839
  REMARK    GeneRIF: The amylospheroids target is neuron-specific
            Na(+)/K(+)-ATPase alpha3 subunit (NAKalpha3).
REFERENCE   3  (bases 1 to 3559)
  AUTHORS   Paciorkowski,A.R., McDaniel,S.S., Jansen,L.A., Tully,H., Tuttle,E.,
            Ghoneim,D.H., Tupal,S., Gunter,S.A., Vasta,V., Zhang,Q., Tran,T.,
            Liu,Y.B., Ozelius,L.J., Brashear,A., Sweadner,K.J., Dobyns,W.B. and
            Hahn,S.
  TITLE     Novel mutations in ATP1A3 associated with catastrophic early life
            epilepsy, episodic prolonged apnea, and postnatal microcephaly
  JOURNAL   Epilepsia 56 (3), 422-430 (2015)
   PUBMED   25656163
REFERENCE   4  (bases 1 to 3559)
  AUTHORS   Maturana-Teixeira,S., Braga,L.E., Carpi Santos,R., Calaza Kda,C.,
            Giestal-de-Araujo,E. and Leao-Ferreira,L.R.
  TITLE     The (Na(+)/K (+))-ATPase activity in the developing rat retina: the
            role of insulin-like growth factor-I (IGF-I)
  JOURNAL   Cell Mol Neurobiol 35 (2), 243-254 (2015)
   PUBMED   25274047
  REMARK    GeneRIF: the PI 3-kinase/PKB signaling pathway is involved in the
            IGF-I-sustained basal (Na(+)/K(+))-ATPase activity during the first
            7 days of the postnatal development of rat retina.
REFERENCE   5  (bases 1 to 3559)
  AUTHORS   Wilcox,R., Braenne,I., Bruggemann,N., Winkler,S., Wiegers,K.,
            Bertram,L., Anderson,T. and Lohmann,K.
  TITLE     Genome sequencing identifies a novel mutation in ATP1A3 in a family
            with dystonia in females only
  JOURNAL   J Neurol 262 (1), 187-193 (2015)
   PUBMED   25359261
REFERENCE   6  (bases 1 to 3559)
  AUTHORS   Mynett-Johnson,L., Murphy,V., McCormack,J., Shields,D.C.,
            Claffey,E., Manley,P. and McKeon,P.
  TITLE     Evidence for an allelic association between bipolar disorder and a
            Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3)
  JOURNAL   Biol Psychiatry 44 (1), 47-51 (1998)
   PUBMED   9646882
REFERENCE   7  (bases 1 to 3559)
  AUTHORS   He,H., Chin,S., Zhuang,K., Hartong,R., Apriletti,J. and Gick,G.
  TITLE     Negative regulation of the rat Na-K-ATPase alpha 3-subunit gene
            promoter by thyroid hormone
  JOURNAL   Am J Physiol 271 (5 Pt 1), C1750-C1756 (1996)
   PUBMED   8944660
REFERENCE   8  (bases 1 to 3559)
  AUTHORS   Herrera,V.L., Emanuel,J.R., Ruiz-Opazo,N., Levenson,R. and
            Nadal-Ginard,B.
  TITLE     Three differentially expressed Na,K-ATPase alpha subunit isoforms:
            structural and functional implications
  JOURNAL   J Cell Biol 105 (4), 1855-1865 (1987)
   PUBMED   2822726
REFERENCE   9  (bases 1 to 3559)
  AUTHORS   Hara,Y., Urayama,O., Kawakami,K., Nojima,H., Nagamune,H.,
            Kojima,T., Ohta,T., Nagano,K. and Nakao,M.
  TITLE     Primary structures of two types of alpha-subunit of rat brain
            Na+,K+,-ATPase deduced from cDNA sequences
  JOURNAL   J Biochem 102 (1), 43-58 (1987)
   PUBMED   2822682
REFERENCE   10 (bases 1 to 3559)
  AUTHORS   Shull,G.E., Greeb,J. and Lingrel,J.B.
  TITLE     Molecular cloning of three distinct forms of the Na+,K+-ATPase
            alpha-subunit from rat brain
  JOURNAL   Biochemistry 25 (25), 8125-8132 (1986)
   PUBMED   3028470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M14513.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M14513.1, X05883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3559
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /note="ATPase Na+/K+ transporting subunit alpha 3"
                     /db_xref="GeneID:24213"
                     /db_xref="RGD:2169"
     exon            1..149
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3185
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /EC_number="7.2.2.13"
                     /note="Na+/K+ -ATPase alpha 3 subunit; sodium pump subunit
                     alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; ATPase, Na+/K+
                     transporting, alpha 3 polypeptide; Na(+)/K(+) ATPase
                     alpha(III) subunit; ATPase, Na+K+ transporting, alpha 3
                     subunit; NA,K-ATPase alpha subunit 3"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-3"
                     /protein_id="NP_036638.1"
                     /db_xref="GeneID:24213"
                     /db_xref="RGD:2169"
                     /translation="MGDKKDDKSSPKKSKAKERRDLDDLKKEVAMTEHKMSVEEVCRK
                     YNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCF
                     LAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQAL
                     VIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRS
                     PDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAI
                     EIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCL
                     TLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADT
                     TEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCI
                     ELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRC
                     ATILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDV
                     NFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGII
                     SEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFAR
                     TSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMIL
                     LDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITIL
                     CIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGF
                     FSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTFHTAFFV
                     SIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYP
                     LKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY"
     exon            150..236
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            237..296
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..500
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..614
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..749
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..867
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1136
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1335
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1445
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1580
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1773
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1949
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2086
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2237
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2406
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2561
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2685
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2831
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2962
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3064
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3156
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3559
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtgggacc cacggaccga cagacgcacg ctcccaacgc ggcgcgggcg ctgcagaggc
       61 ccccagcccg agcccgcgcc tgagcccgtc ctgcggccac cgctcaccag cctgtccgcc
      121 gctcttcccg cggagccgcc aagatggggg acaaaaaaga tgacaagagc tcgcccaaga
      181 agagcaaggc caaagagcgc cgggacctgg atgacctcaa gaaggaagtg gctatgacag
      241 agcacaagat gtcagtagaa gaggtctgcc ggaaatacaa taccgactgc gtgcagggtc
      301 tgacacacag taaagcccag gagatcctag cccgggatgg gcctaacgcc ctcacaccac
      361 cgcccaccac cccagaatgg gtcaagttct gccgacagct atttggtggc ttctccatcc
      421 tgctgtggat cggggcgatc ctttgcttcc tggcctatgg catccaggca gggactgagg
      481 atgacccttc cggtgacaat ctgtacctgg gcatagtgct ggccgctgtg gtgatcatca
      541 ccggctgctt ctcctactac caagaagcca agagctctaa gattatggag tccttcaaga
      601 acatggttcc ccagcaagcc cttgtgatcc gggaaggtga aaagatgcag gtgaatgcgg
      661 aggaggtggt ggtcggggac ctggtggaga tcaagggtgg cgaccgggtg cccgctgacc
      721 tgcgcatcat ctcggcccat ggctgcaagg tggacaactc ttccctgact ggcgaatctg
      781 agcctcagac ccgctccccg gactgcacac acgacaaccc actggagacc cggaacatca
      841 ccttcttttc caccaactgt gtggaaggca ccgctcgtgg tgtggtggta gccacaggtg
      901 accgcaccgt catgggccgc attgccaccc tggcctcagg cctggaggtg ggcaagacgc
      961 ccatcgccat tgagatcgag cacttcatcc agctcatcac tggcgtggcc gtgttcctgg
     1021 gcgtctcctt cttcatcctc tccctcattc tgggctacac ctggctggag gctgtcatct
     1081 tcctcatcgg tatcattgtg gccaatgtcc cagaggggct gctggctact gtcacggtgt
     1141 gtctgacgct gaccgccaag cgcatggctc ggaagaactg tctggtaaag aacctggagg
     1201 cggtggagac gctaggctcc acatccacca tctgctccga caagaccggc accctcaccc
     1261 agaaccgcat gaccgtcgcc cacatgtggt ttgacaacca gatccacgag gccgacacta
     1321 ctgaggatca gtcagggacc tctttcgaca agagctcaca cacctgggtg gccctgtccc
     1381 acatcgccgg tctctgcaac cgggctgtct tcaagggcgg gcaggataac atccctgtac
     1441 tcaagaggga cgtggcgggt gatgcctcag agtccgccct gcttaagtgc atcgagctgt
     1501 cctcgggttc cgtaaagctg atgcgcgaac gaaacaagaa agtggccgag attcccttca
     1561 actccactaa caaataccag ctatccatcc atgagactga ggaccccaat gacaaccgat
     1621 acctgttagt gatgaagggc gcccctgaac gcattctgga ccgctgtgcg accatcctcc
     1681 tgcagggcaa ggagcagcct ctggatgagg agatgaagga ggccttccag aacgcctacc
     1741 tggagcttgg tggcctgggc gagcgtgtgc tgggtttctg ccattactac ctgccggagg
     1801 aacagttccc caagggcttt gcctttgact gtgatgacgt gaacttcacc acagacaacc
     1861 tttgcttcgt gggtctcatg tccatgatcg accctccccg ggcagctgtc cctgatgctg
     1921 tgggcaaatg ccgcagtgca ggcatcaagg tcatcatggt caccggcgat caccccatca
     1981 ctgcgaaggc catcgccaaa ggtgtaggca tcatctccga gggtaacgag actgtggagg
     2041 acatcgctgc ccggctcaac atccctgtca gccaggtcaa ccccagggat gccaaagcct
     2101 gtgtgattca tggcaccgac ctcaaggact tcacctctga gcagattgac gagatcctac
     2161 agaaccacac tgagatcgtc tttgcccgaa cctcccctca gcagaagctc atcatcgtgg
     2221 agggctgtca gagacaggga gcaattgtgg ctgtgactgg cgatggtgtg aatgactccc
     2281 ctgctctgaa gaaggctgat attggggtgg ccatgggcat tgctggctct gatgtctcta
     2341 agcaggctgc cgacatgatt ctgctggatg acaattttgc ttccattgtc actggtgtgg
     2401 aggaaggccg cctgatcttt gacaacctga agaaatccat cgcctacact ctgaccagca
     2461 acatccctga gatcacaccc ttccttctct tcatcatggc caacatccca ctgccccttg
     2521 gcaccatcac catcctctgc attgacctgg gcaccgacat ggtccctgca atctccttgg
     2581 cctacgaggc tgcagagagt gacatcatga agaggcagcc caggaaccca cgcacagaca
     2641 aactggtcaa cgaaaggctc atcagcatgg cctatgggca gatcgggatg atccaggccc
     2701 tcggtggttt cttctcctac tttgtcatcc tggcagaaaa tggtttcttg cccggtaacc
     2761 tggtgggcat ccggctcaac tgggatgacc gcactgtcaa cgacctggaa gacagctacg
     2821 ggcagcagtg gacttatgag cagaggaagg tggttgagtt cacgttccac acagccttct
     2881 tcgtgagcat agtggtggtc cagtgggctg acctgatcat ttgcaagacc aggaggaatt
     2941 ccgtcttcca gcagggcatg aagaataaga tcttgatctt cggactgttt gaggaaacgg
     3001 ccctcgctgc cttcctgtcc tactgcccag gcatggatgt ggcccttcgc atgtacccgc
     3061 tcaagcccag ctggtggttc tgtgccttcc cctacagttt cctcatcttc gtctatgatg
     3121 agattcgcaa actcatcctg cgcaggaacc ccgggggttg ggtggagaaa gagacctact
     3181 attgacctca gccaccacgt cgcccatgtc ttccctgccc cccagcccag gacagccctc
     3241 tccggtcccc cattttgtac tctgggggga ggggccttct ctccccatgg cccccctctc
     3301 tccttgtggc ccagtctcct ctcccacacc tcggttacct ctcactttcc ctcatttctc
     3361 cctctggctg gcttctctcc ccccacagcc cctgcctctc ttctccttcc cttttctgtg
     3421 tctctccccc tctctccctt gcagccctgc ccctcatttt ctccctgggc tcttttttac
     3481 acccctgggc cctgtctcct ggctaatgcc atctccggtt ctaaatctga acaattatca
     3541 aatatatcag tggggagag
//
