LOCUS       NP_036638               1013 aa            linear   ROD 04-JUN-2024
DEFINITION  sodium/potassium-transporting ATPase subunit alpha-3 [Rattus
            norvegicus].
ACCESSION   NP_036638
VERSION     NP_036638.1
DBSOURCE    REFSEQ: accession NM_012506.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1013)
  AUTHORS   Depierre,P., Ginet,V., Truttmann,A.C. and Puyal,J.
  TITLE     Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in
            hypoxic-ischemic neuronal death
  JOURNAL   Cell Death Dis 15 (5), 363 (2024)
   PUBMED   38796484
  REMARK    GeneRIF: Neuronal autosis is Na[+]/K[+]-ATPase alpha 3-dependent
            and involved in hypoxic-ischemic neuronal death.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1013)
  AUTHORS   Ohnishi,T., Yanazawa,M., Sasahara,T., Kitamura,Y., Hiroaki,H.,
            Fukazawa,Y., Kii,I., Nishiyama,T., Kakita,A., Takeda,H.,
            Takeuchi,A., Arai,Y., Ito,A., Komura,H., Hirao,H., Satomura,K.,
            Inoue,M., Muramatsu,S., Matsui,K., Tada,M., Sato,M., Saijo,E.,
            Shigemitsu,Y., Sakai,S., Umetsu,Y., Goda,N., Takino,N.,
            Takahashi,H., Hagiwara,M., Sawasaki,T., Iwasaki,G., Nakamura,Y.,
            Nabeshima,Y., Teplow,D.B. and Hoshi,M.
  TITLE     Na, K-ATPase alpha3 is a death target of Alzheimer patient
            amyloid-beta assembly
  JOURNAL   Proc Natl Acad Sci U S A 112 (32), E4465-E4474 (2015)
   PUBMED   26224839
  REMARK    GeneRIF: The amylospheroids target is neuron-specific
            Na(+)/K(+)-ATPase alpha3 subunit (NAKalpha3).
REFERENCE   3  (residues 1 to 1013)
  AUTHORS   Paciorkowski,A.R., McDaniel,S.S., Jansen,L.A., Tully,H., Tuttle,E.,
            Ghoneim,D.H., Tupal,S., Gunter,S.A., Vasta,V., Zhang,Q., Tran,T.,
            Liu,Y.B., Ozelius,L.J., Brashear,A., Sweadner,K.J., Dobyns,W.B. and
            Hahn,S.
  TITLE     Novel mutations in ATP1A3 associated with catastrophic early life
            epilepsy, episodic prolonged apnea, and postnatal microcephaly
  JOURNAL   Epilepsia 56 (3), 422-430 (2015)
   PUBMED   25656163
REFERENCE   4  (residues 1 to 1013)
  AUTHORS   Maturana-Teixeira,S., Braga,L.E., Carpi Santos,R., Calaza Kda,C.,
            Giestal-de-Araujo,E. and Leao-Ferreira,L.R.
  TITLE     The (Na(+)/K (+))-ATPase activity in the developing rat retina: the
            role of insulin-like growth factor-I (IGF-I)
  JOURNAL   Cell Mol Neurobiol 35 (2), 243-254 (2015)
   PUBMED   25274047
  REMARK    GeneRIF: the PI 3-kinase/PKB signaling pathway is involved in the
            IGF-I-sustained basal (Na(+)/K(+))-ATPase activity during the first
            7 days of the postnatal development of rat retina.
REFERENCE   5  (residues 1 to 1013)
  AUTHORS   Wilcox,R., Braenne,I., Bruggemann,N., Winkler,S., Wiegers,K.,
            Bertram,L., Anderson,T. and Lohmann,K.
  TITLE     Genome sequencing identifies a novel mutation in ATP1A3 in a family
            with dystonia in females only
  JOURNAL   J Neurol 262 (1), 187-193 (2015)
   PUBMED   25359261
REFERENCE   6  (residues 1 to 1013)
  AUTHORS   Mynett-Johnson,L., Murphy,V., McCormack,J., Shields,D.C.,
            Claffey,E., Manley,P. and McKeon,P.
  TITLE     Evidence for an allelic association between bipolar disorder and a
            Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3)
  JOURNAL   Biol Psychiatry 44 (1), 47-51 (1998)
   PUBMED   9646882
REFERENCE   7  (residues 1 to 1013)
  AUTHORS   He,H., Chin,S., Zhuang,K., Hartong,R., Apriletti,J. and Gick,G.
  TITLE     Negative regulation of the rat Na-K-ATPase alpha 3-subunit gene
            promoter by thyroid hormone
  JOURNAL   Am J Physiol 271 (5 Pt 1), C1750-C1756 (1996)
   PUBMED   8944660
REFERENCE   8  (residues 1 to 1013)
  AUTHORS   Herrera,V.L., Emanuel,J.R., Ruiz-Opazo,N., Levenson,R. and
            Nadal-Ginard,B.
  TITLE     Three differentially expressed Na,K-ATPase alpha subunit isoforms:
            structural and functional implications
  JOURNAL   J Cell Biol 105 (4), 1855-1865 (1987)
   PUBMED   2822726
REFERENCE   9  (residues 1 to 1013)
  AUTHORS   Hara,Y., Urayama,O., Kawakami,K., Nojima,H., Nagamune,H.,
            Kojima,T., Ohta,T., Nagano,K. and Nakao,M.
  TITLE     Primary structures of two types of alpha-subunit of rat brain
            Na+,K+,-ATPase deduced from cDNA sequences
  JOURNAL   J Biochem 102 (1), 43-58 (1987)
   PUBMED   2822682
REFERENCE   10 (residues 1 to 1013)
  AUTHORS   Shull,G.E., Greeb,J. and Lingrel,J.B.
  TITLE     Molecular cloning of three distinct forms of the Na+,K+-ATPase
            alpha-subunit from rat brain
  JOURNAL   Biochemistry 25 (25), 8125-8132 (1986)
   PUBMED   3028470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M14513.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M14513.1, X05883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..1013
                     /product="sodium/potassium-transporting ATPase subunit
                     alpha-3"
                     /EC_number="7.2.2.13"
                     /note="Na+/K+ -ATPase alpha 3 subunit; sodium pump subunit
                     alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; ATPase, Na+/K+
                     transporting, alpha 3 polypeptide; Na(+)/K(+) ATPase
                     alpha(III) subunit; ATPase, Na+K+ transporting, alpha 3
                     subunit; NA,K-ATPase alpha subunit 3"
                     /calculated_mol_wt=111605
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Region          18..1013
                     /region_name="ATPase-IIC_X-K"
                     /note="sodium or proton efflux -- potassium uptake
                     antiporter, P-type ATPase, alpha subunit; TIGR01106"
                     /db_xref="CDD:273445"
     Site            37
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P06687.2)"
     Site            56
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6PIC6; propagated from
                     UniProtKB/Swiss-Prot (P06687.2)"
     Region          72..74
                     /region_name="Interaction with phosphoinositide-3 kinase.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            78..98
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            122..142
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            218
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P06687.2)"
     Site            265
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6PIC6; propagated from
                     UniProtKB/Swiss-Prot (P06687.2)"
     Site            279..298
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            311..328
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            442
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P06687.2)"
     Site            548
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q6PIC6; propagated from
                     UniProtKB/Swiss-Prot (P06687.2)"
     Site            763..782
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            793..813
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            834..856
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            909..928
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            933
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            942..960
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     Site            976..996
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P06687.2)"
     CDS             1..1013
                     /gene="Atp1a3"
                     /gene_synonym="Atpa1a3"
                     /coded_by="NM_012506.1:144..3185"
                     /db_xref="GeneID:24213"
                     /db_xref="RGD:2169"
ORIGIN      
        1 mgdkkddkss pkkskakerr dlddlkkeva mtehkmsvee vcrkyntdcv qglthskaqe
       61 ilardgpnal tpppttpewv kfcrqlfggf sillwigail cflaygiqag teddpsgdnl
      121 ylgivlaavv iitgcfsyyq eaksskimes fknmvpqqal viregekmqv naeevvvgdl
      181 veikggdrvp adlriisahg ckvdnssltg esepqtrspd cthdnpletr nitffstncv
      241 egtargvvva tgdrtvmgri atlasglevg ktpiaieieh fiqlitgvav flgvsffils
      301 lilgytwlea vifligiiva nvpegllatv tvcltltakr marknclvkn leavetlgst
      361 sticsdktgt ltqnrmtvah mwfdnqihea dttedqsgts fdksshtwva lshiaglcnr
      421 avfkggqdni pvlkrdvagd asesallkci elssgsvklm rernkkvaei pfnstnkyql
      481 sihetedpnd nryllvmkga perildrcat illqgkeqpl deemkeafqn aylelgglge
      541 rvlgfchyyl peeqfpkgfa fdcddvnftt dnlcfvglms midppraavp davgkcrsag
      601 ikvimvtgdh pitakaiakg vgiisegnet vediaarlni pvsqvnprda kacvihgtdl
      661 kdftseqide ilqnhteivf artspqqkli ivegcqrqga ivavtgdgvn dspalkkadi
      721 gvamgiagsd vskqaadmil lddnfasivt gveegrlifd nlkksiaytl tsnipeitpf
      781 llfimanipl plgtitilci dlgtdmvpai slayeaaesd imkrqprnpr tdklvnerli
      841 smaygqigmi qalggffsyf vilaengflp gnlvgirlnw ddrtvndled sygqqwtyeq
      901 rkvveftfht affvsivvvq wadliicktr rnsvfqqgmk nkilifglfe etalaaflsy
      961 cpgmdvalrm yplkpswwfc afpysflifv ydeirklilr rnpggwveke tyy
//
