LOCUS       NM_012505               5149 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 2
            (Atp1a2), mRNA.
ACCESSION   NM_012505
VERSION     NM_012505.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5149)
  AUTHORS   Skogestad,J., Aronsen,J.M., Tovsrud,N., Wanichawan,P., Hougen,K.,
            Stokke,M.K., Carlson,C.R., Sjaastad,I., Sejersted,O.M. and Swift,F.
  TITLE     Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+
            exchanger activity in cardiomyocytes
  JOURNAL   Cardiovasc Res 116 (1), 78-90 (2020)
   PUBMED   30949686
  REMARK    GeneRIF: Coupling of the Na+/K+-ATPase to Ankyrin B controls
            Na+/Ca2+ exchanger activity in cardiomyocytes.
REFERENCE   2  (bases 1 to 5149)
  AUTHORS   Bouzinova,E.V., Hangaard,L., Staehr,C., Mazur,A., Ferreira,A.,
            Chibalin,A.V., Sandow,S.L., Xie,Z., Aalkjaer,C. and Matchkov,V.V.
  TITLE     The alpha2 isoform Na,K-ATPase modulates contraction of rat
            mesenteric small artery via cSrc-dependent Ca2+ sensitization
  JOURNAL   Acta Physiol (Oxf) 224 (1), e13059 (2018)
   PUBMED   29480968
  REMARK    GeneRIF: The alpha2 isoform Na,K-ATPase modulates contraction of
            rat mesenteric small artery via cSrc-dependent Ca(2+)
            sensitization.
            Erratum:[Acta Physiol (Oxf). 2019 Sep;227(1):e13343. doi:
            10.1111/apha.13343. PMID: 31402596]
REFERENCE   3  (bases 1 to 5149)
  AUTHORS   Hu,Y., Wang,Z., Ge,N., Huang,T., Zhang,M. and Wang,H.
  TITLE     Sodium pump alpha-2 subunit (ATP1A2) alleviates cardiomyocyte
            anoxia-reoxygenation injury via inhibition of endoplasmic reticulum
            stress-related apoptosis
  JOURNAL   Can J Physiol Pharmacol 96 (5), 515-520 (2018)
   PUBMED   29394489
  REMARK    GeneRIF: cardiomyocyte ATP1A2 is a target of A/R injury
REFERENCE   4  (bases 1 to 5149)
  AUTHORS   Yu,H., Cui,X., Zhang,J., Xie,J.X., Banerjee,M., Pierre,S.V. and
            Xie,Z.
  TITLE     Heterogeneity of signal transduction by Na-K-ATPase alpha-isoforms:
            role of Src interaction
  JOURNAL   Am J Physiol Cell Physiol 314 (2), C202-C210 (2018)
   PUBMED   29118027
  REMARK    GeneRIF: Report structural requirements for the Na-K-ATPase to
            function as a Src-dependent receptor and provide strong evidence of
            isoform-specific Src interaction involving the identified key amino
            acids.
REFERENCE   5  (bases 1 to 5149)
  AUTHORS   Stoica,A., Larsen,B.R., Assentoft,M., Holm,R., Holt,L.M.,
            Vilhardt,F., Vilsen,B., Lykke-Hartmann,K., Olsen,M.L. and
            MacAulay,N.
  TITLE     The alpha2beta2 isoform combination dominates the astrocytic Na+
            /K+ -ATPase activity and is rendered nonfunctional by the
            alpha2.G301R familial hemiplegic migraine type 2-associated
            mutation
  JOURNAL   Glia 65 (11), 1777-1793 (2017)
   PUBMED   28787093
REFERENCE   6  (bases 1 to 5149)
  AUTHORS   James,P.F., Grupp,I.L., Grupp,G., Woo,A.L., Askew,G.R.,
            Croyle,M.L., Walsh,R.A. and Lingrel,J.B.
  TITLE     Identification of a specific role for the Na,K-ATPase alpha 2
            isoform as a regulator of calcium in the heart
  JOURNAL   Mol Cell 3 (5), 555-563 (1999)
   PUBMED   10360172
REFERENCE   7  (bases 1 to 5149)
  AUTHORS   Blanco,G. and Mercer,R.W.
  TITLE     Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity
            in function
  JOURNAL   Am J Physiol 275 (5), F633-F650 (1998)
   PUBMED   9815123
  REMARK    Review article
REFERENCE   8  (bases 1 to 5149)
  AUTHORS   Seidel,B., Keilhoff,G., Reinheckel,T. and Wolf,G.
  TITLE     Differentially expressed genes in hippocampal cell cultures in
            response to an excitotoxic insult by quinolinic acid
  JOURNAL   Brain Res Mol Brain Res 60 (2), 296-300 (1998)
   PUBMED   9757068
REFERENCE   9  (bases 1 to 5149)
  AUTHORS   Kawakami,K., Yagawa,Y. and Nagano,K.
  TITLE     Regulation of Na+,K(+)-ATPases. I. Cloning and analysis of the
            5'-flanking region of the rat NKAA2 gene encoding the alpha 2
            subunit
  JOURNAL   Gene 91 (2), 267-270 (1990)
   PUBMED   2170235
REFERENCE   10 (bases 1 to 5149)
  AUTHORS   Shull,G.E., Greeb,J. and Lingrel,J.B.
  TITLE     Molecular cloning of three distinct forms of the Na+,K+-ATPase
            alpha-subunit from rat brain
  JOURNAL   Biochemistry 25 (25), 8125-8132 (1986)
   PUBMED   3028470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085764.1, JAXUCZ010000013.1 and CV795782.1.
            
            On Mar 30, 2010 this sequence version replaced NM_012505.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085764.1, M14512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3332              BC085764.1         1-3332
            3333-5065           JAXUCZ010000013.1  87262031-87263763   c
            5066-5149           CV795782.1         1-84                c
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..5149
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /note="ATPase Na+/K+ transporting subunit alpha 2"
                     /db_xref="GeneID:24212"
                     /db_xref="RGD:2168"
     exon            1..125
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            126..230
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..290
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..494
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..608
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..743
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..861
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1130
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1329
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1439
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1574
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1764
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1940
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2077
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2228
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2397
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2552
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2676
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2822
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2953
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3055
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3147
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..5132
                     /gene="Atp1a2"
                     /gene_synonym="RATATPA2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctctct gcctgtctgc cagggtctcc agctgcccca gacaggcggt gtggtcttgg
       61 gatcctcctg gtgacctttc cagcctaggt cccctcagcc actctgcccc aagatgggtc
      121 gtggggcagg gcgtgagtac tcgcctgccg ccaccactgc ggagaatggg ggtggcaaga
      181 agaaacagaa agagaaggag ctcgatgagc tgaagaagga ggttgccatg gatgaccaca
      241 agctgtcctt ggatgagctg ggccgaaaat accaagtgga tctgtccaag ggcctcacca
      301 accagcgagc tcaggatatt ctggctagag acggacccaa cgccctcact ccacccccta
      361 caactcctga gtgggtcaag ttctgccgtc agctttttgg gggcttctct atcctgctgt
      421 ggattggggc gcttctctgc ttcttagcct atggtatcct ggccgccatg gaggacgaac
      481 catccaatga caatttatat ctaggtatcg tgctagcagc tgtagttatc gtcactggct
      541 gcttctccta ctaccaggaa gccaaaagct ccaagattat ggactccttc aagaacatgg
      601 tgcctcagca agctctggtc atccgagagg gagagaagat gcagatcaat gcagaggagg
      661 tggtcgtggg agacctggtg gaagtgaagg gtggagaccg tgtccccgct gacctccgga
      721 tcatctcctc ccacggttgc aaggtggata actcatccct gacaggggag tcggagcccc
      781 agacccggtc ccctgagttc acccatgaga atcccttgga gacccgcaat atctgtttct
      841 tctctaccaa ctgtgtggaa ggcactgcca ggggcattgt gatcgccaca ggtgaccgga
      901 cggtgatggg ccgcatagcc actcttgcct ctggcctaga ggtgggacag acgccgatag
      961 ccatggagat cgagcatttc atccagctga tcacgggggt ggccgtgttc ctgggggtct
     1021 ccttctttgt tctgtcgctc atcctgggct acagctggct ggaggctgtc atcttcctca
     1081 tcggcatcat cgtagccaac gtccccgaag ggctcttggc cactgttact gtgtgcctga
     1141 cgctgacagc caagcgcatg gctcgcaaga actgcctggt gaagaacctg gaggcggtgg
     1201 agacgctggg ctccacgtcc accatctgct cggacaagac aggcaccctc acccagaacc
     1261 gcatgacggt ggctcacatg tggtttgaca accagatcca tgaggctgac accactgaag
     1321 atcagtctgg ggccactttt gacaagcggt ccccgacgtg gacagccctg tctcggatcg
     1381 ctggtctctg caatcgtgcc gtcttcaagg ctgggcagga gaacatctcc gtgtctaagc
     1441 gggacacagc tggtgacgcc tctgagtcag ctctgctcaa gtgcatcgag ttgtcctgtg
     1501 gctcagtgag gaagatgagg gacaggaatc ccaaggtggc agaaattccc ttcaactcta
     1561 ccaacaaata tcagctttcc atccatgaga gggaagacag cccccagagc catgtgctgg
     1621 tgatgaaagg tgccccggag cgcatcctgg accgatgctc taccatcctg gtacagggca
     1681 aggagatccc tcttgacaag gagatgcaag atgcctttca aaacgcctac atggagctgg
     1741 gaggactcgg ggagcgagtg ctgggcttct gtcagctgaa cctgccttct ggaaagtttc
     1801 ctcggggctt caaatttgac acggatgagc tgaactttcc cacagagaag ctctgctttg
     1861 tggggctcat gtctatgatt gatcccccca gagcagctgt gccagatgct gtgggcaagt
     1921 gcagaagtgc aggcatcaag gtgatcatgg tgactgggga tcaccctatc acagccaagg
     1981 ccattgccaa aggtgtgggc atcatatcag agggtaacga gactgtggaa gacattgcag
     2041 ccaggctcaa cattcctgtg agtcaagtca atcccagaga agccaaggca tgtgtagtgc
     2101 acggctcaga cctgaaggac atgacttcag agcagctgga tgagatcctc agggaccaca
     2161 cggagatcgt gtttgcccgg acctcccctc agcagaagct catcattgtg gagggctgtc
     2221 agaggcaggg agccatcgtg gcagtgactg gtgacggggt gaacgactcc cccgcgctga
     2281 agaaggctga cattggcatt gccatgggca tctctggctc tgatgtctct aagcaggcag
     2341 ctgacatgat ccttctcgac gacaactttg cctccattgt gacgggcgtg gaggaggggc
     2401 gcctgatctt tgacaacctg aagaagtcca tcgcgtacac cctgaccagc aacatccctg
     2461 agatcacccc cttcctgctg ttcatcattg ccaacatccc ccttcccctg ggcaccgtga
     2521 ccatcctgtg catcgacctg ggcacagaca tggttcctgc catctcatta gcatacgaag
     2581 cggctgagag cgacatcatg aagaggcagc cacggaactc ccagacggac aagctggtga
     2641 acgagaggct tatcagcatg gcttacggac agatcggcat gatccaggct ctgggcggct
     2701 tcttcaccta ctttgtaata ctggcagaga acggcttcct gccatcgagg ctgcttggga
     2761 tccgccttga ctgggatgat cggactacca acgacctgga ggacagctat ggacaagagt
     2821 ggacctatga gcagcggaag gtggtggagt tcacatgcca cacggccttc tttgccagca
     2881 tcgtggttgt gcagtgggct gacctcatca tttgcaagac ccggcgcaac tcggtgttcc
     2941 agcagggcat gaagaacaag atcctgattt ttgggctgct agaagagacg gctctggctg
     3001 ccttcctgtc ttactgcccg ggtatggggg tggccctccg aatgtaccca ctcaaggtca
     3061 cgtggtggtt ctgtgccttt ccctacagtc tcctcatctt catctatgat gaagtccgaa
     3121 agctcatcct gcggcggtac cctgggggct gggtggagaa ggagacgtac tactgagctc
     3181 accgacaaaa ggaagaacag gggagatggg gtgctccaga ggggctggtg ggtgttgtgg
     3241 tgaagggaag ggctggggag acacaaggaa gcgatggtgg cgtgaactca gtgggtaggc
     3301 ttgggtaaat aaacttgagg agactgctcc aactgctcca taggtcccgc tgtgaaccct
     3361 aagacagtgc atgttggggt cgcctcctca gatccttccc gtcccactct cccacattgt
     3421 ctacattttc tgaagaaccg ggggtcgccc tagccctccc tgtgtcccag tccttcaccc
     3481 tcacctgcat tattccatta ttcaaacaga tcaacaccca aaggttaatc ctgtctaacc
     3541 ctggaggaaa gcctgtcaga ccaccagtac ccaccactac caccaccacc accaccacca
     3601 ccaccaccac caccaccacc accaccaccc cctgttcact cctcttccca ttcttgcctt
     3661 cctcaccttc ctgcctgagt cttcccttgc tcctcccctt acaccttgaa aacacaaaat
     3721 tctgcttctg tgagtgcaag agcctagggc cagaaaagga agccagttgg agagatgggg
     3781 cctgtctccc agccaagacc agtcaggaac cagaggggag ctgggctggc aagtggaggt
     3841 tggggtgcac tggctgagaa agaaagaaag gaaggaagga aggaaggaag gaaggaagga
     3901 agaaaggaag gaaggaagtg accacaggtg tgtcatctcc agccttcagg tatatgggac
     3961 aggctctgga tctgtgagag acttaagaga ctagcacacc agcagaccaa attcccatct
     4021 catcagacta gcagtaagtg ccacccagtg cccctctgac ccttgggtag tggtcctctc
     4081 tgtccacaag gctcagattt cacagaaggt tcagctatct caaccacata ctcttgggaa
     4141 cacccccctt ctttagaata attagttctc tggggcctcg tgctgttctg agagccccat
     4201 tagctgccac ttctcctcgt gctctctcac tgccttctgc ttcctaccca cctgctgaac
     4261 ccacgttatg tccagtatcg ccttgcttgt cctgaaaaag gatctcttgg ccattggcag
     4321 gaatcagtgt agaaatgttt ccaggacatc cctgactttc gggaacatgc agaatcagtg
     4381 tagctcatga cacagtcaga aactttagac acaagagaaa ttcttaagag acctatgcac
     4441 ctttgacctc tcagattgag acaggaagct ggcttcaggt tcctatggca tagagttatc
     4501 tttccttact ctcttctcaa cctaacgtat tcgctcttca gacagctgcc tgttctctaa
     4561 tcctggccta gaaagcatag catagatgca cctggatgaa tgagggaagc aagagagaat
     4621 cagcaaggaa actggaaggc ttgaggtggg aatatgaaag tcaagacaag catcaagcca
     4681 ggcccaaggg cctcccaaag gctactgtct catcgtggtg gatggagttt tgccttaccc
     4741 taaatacctt gaaatttgtc agtcatgcat agccttcagt cggaagtcta aatgggacac
     4801 cgtatttatt tgggcctgac taatttgaga tcactgactt tgaacaaaag tttacctttg
     4861 cacaatcaat aaaatcatct gctaggtaat tcaagagcat aaacgatact gctaggagca
     4921 gcatagttag tttcaaagta tgctttccga gcactttagc aatctccctt tagaatcagg
     4981 aagtgcatag gctaattact atcagtcccg atatatttgt taaaggaaca cctacaagat
     5041 ccttactggt gaccttctgt gagacactag tttgaggcac tacatgtgta cttgaaaata
     5101 ataaagttgc atttctttat gaataattaa gaaaaaaaaa aaaaaaaaa
//
