LOCUS       NM_012504               3636 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 1
            (Atp1a1), mRNA.
ACCESSION   NM_012504
VERSION     NM_012504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3636)
  AUTHORS   Kemp,B.A., Howell,N.L., Gildea,J.J., Hinkle,J.D., Shabanowitz,J.,
            Hunt,D.F., Conaway,M.R., Keller,S.R. and Carey,R.M.
  TITLE     Evidence That Binding of Cyclic GMP to the Extracellular Domain of
            NKA (Sodium-Potassium ATPase) Mediates Natriuresis
  JOURNAL   Circ Res 132 (9), 1127-1140 (2023)
   PUBMED   36919600
  REMARK    GeneRIF: Evidence That Binding of Cyclic GMP to the Extracellular
            Domain of NKA (Sodium-Potassium ATPase) Mediates Natriuresis.
REFERENCE   2  (bases 1 to 3636)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3636)
  AUTHORS   Zhang,S., Malmersjo,S., Li,J., Ando,H., Aizman,O., Uhlen,P.,
            Mikoshiba,K. and Aperia,A.
  TITLE     Distinct role of the N-terminal tail of the Na,K-ATPase catalytic
            subunit as a signal transducer
  JOURNAL   J Biol Chem 281 (31), 21954-21962 (2006)
   PUBMED   16723354
  REMARK    GeneRIF: identified a well conserved Na,K-ATPase catalytic
            alpha-subunit motif that binds to the inositol 1,4,5-trisphosphate
            receptor and can trigger an anti-apoptotic calcium signal.
REFERENCE   4  (bases 1 to 3636)
  AUTHORS   Li,C., Crambert,G., Thuillard,D., Roy,S., Schaer,D. and Geering,K.
  TITLE     Role of the transmembrane domain of FXYD7 in structural and
            functional interactions with Na,K-ATPase
  JOURNAL   J Biol Chem 280 (52), 42738-42743 (2005)
   PUBMED   16269407
  REMARK    GeneRIF: the the TM domain of FXYD7 has a role in mediating the
            complex interactions of FXYD7 with Na,K-ATPase
REFERENCE   5  (bases 1 to 3636)
  AUTHORS   Hundal,H.S., Maxwell,D.L., Ahmed,A., Darakhshan,F., Mitsumoto,Y.
            and Klip,A.
  TITLE     Subcellular distribution and immunocytochemical localization of
            Na,K-ATPase subunit isoforms in human skeletal muscle
  JOURNAL   Mol Membr Biol 11 (4), 255-262 (1994)
   PUBMED   7711835
REFERENCE   6  (bases 1 to 3636)
  AUTHORS   Yagawa,Y., Kawakami,K. and Nagano,K.
  TITLE     Cloning and analysis of the 5'-flanking region of rat
            Na+/K(+)-ATPase alpha 1 subunit gene
  JOURNAL   Biochim Biophys Acta 1049 (3), 286-292 (1990)
   PUBMED   2166579
REFERENCE   7  (bases 1 to 3636)
  AUTHORS   Herrera,V.L., Emanuel,J.R., Ruiz-Opazo,N., Levenson,R. and
            Nadal-Ginard,B.
  TITLE     Three differentially expressed Na,K-ATPase alpha subunit isoforms:
            structural and functional implications
  JOURNAL   J Cell Biol 105 (4), 1855-1865 (1987)
   PUBMED   2822726
REFERENCE   8  (bases 1 to 3636)
  AUTHORS   Hara,Y., Urayama,O., Kawakami,K., Nojima,H., Nagamune,H.,
            Kojima,T., Ohta,T., Nagano,K. and Nakao,M.
  TITLE     Primary structures of two types of alpha-subunit of rat brain
            Na+,K+,-ATPase deduced from cDNA sequences
  JOURNAL   J Biochem 102 (1), 43-58 (1987)
   PUBMED   2822682
REFERENCE   9  (bases 1 to 3636)
  AUTHORS   Shull,G.E., Greeb,J. and Lingrel,J.B.
  TITLE     Molecular cloning of three distinct forms of the Na+,K+-ATPase
            alpha-subunit from rat brain
  JOURNAL   Biochemistry 25 (25), 8125-8132 (1986)
   PUBMED   3028470
REFERENCE   10 (bases 1 to 3636)
  AUTHORS   Schneider,J.W., Mercer,R.W., Caplan,M., Emanuel,J.R.,
            Sweadner,K.J., Benz,E.J. Jr. and Levenson,R.
  TITLE     Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA
  JOURNAL   Proc Natl Acad Sci U S A 82 (18), 6357-6361 (1985)
   PUBMED   2994074
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M14511.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M14511.1, BC061968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3636
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /note="ATPase Na+/K+ transporting subunit alpha 1"
                     /db_xref="GeneID:24211"
                     /db_xref="RGD:2167"
     exon            1..249
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            250..360
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            361..420
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            421..624
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            625..738
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            739..873
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            874..991
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1260
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1459
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1569
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1704
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1897
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2073
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2210
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2361
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2530
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2685
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2809
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2955
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3086
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3188
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3280
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3636
                     /gene="Atp1a1"
                     /gene_synonym="Nkaa1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcctcgg cgggaggagg cggacacgtg gcagcggcgg cggcagcggc agcagcagcg
       61 gcggcagcag cggcggcctc ggtccggggc gccggccgtc ctccctcttt cctccggcgg
      121 cagccctagt tcccgcctct cggctccccc ggctccactc tcccagccgg gagctgctct
      181 ctcctctttc tagtctccag ccacaggacc cggcgcgggg cccgcagcgc cgccaccatg
      241 gggaaggggg ttggacgaga caagtatgag cccgcagctg tatcagaaca tggggacaag
      301 aagagcaaga aggcgaagaa ggaaagggac atggacgaac tcaagaagga agtgtctatg
      361 gacgaccata aactcagcct ggatgaactc catcgtaaat acggaacaga tttgagccga
      421 ggcctaacac ccgcaagggc cgctgagatc ctggctcggg atggccccaa cgccctcacg
      481 ccccctccca ctactcccga gtgggtcaaa ttctgtcggc agctgttcgg tggcttctcc
      541 atgttactgt ggattggagc cattctttgt ttcttggctt atggcatccg aagtgctaca
      601 gaagaggaac caccaaatga tgatctgtac ctcggggtcg tgctgtctgc tgtcgtcatc
      661 ataactggct gtttctccta ttatcaagaa gcaaaaagct ccaagatcat ggaatccttc
      721 aagaacatgg tccctcagca agccctcgtg attcgaaatg gagagaagat gagcatcaac
      781 gcagaggatg tcgtcgttgg tgatctggtg gaggtgaagg gcggagaccg aatccctgct
      841 gatctcagaa tcatatctgc aaatggctgc aaggtggata actcctcact cactggtgaa
      901 tcagaacccc agactcggtc cccggatttc acaaacgaga accccttgga gacaaggaac
      961 attgccttct tctcaaccaa ctgtgttgaa ggaactgcac gtggcatcgt tgtgtacact
     1021 ggggatcgca ccgtgatggg caggatcgcc acccttgctt ctgggctgga aggcggccag
     1081 acccccattg ctgaagaaat cgagcacttc atccacctca tcacgggtgt ggccgtgttc
     1141 ctgggggtgt ctttcttcat tctctctctg atccttgagt acacctggct cgaggctgtc
     1201 atcttcctca ttggtatcat cgtagccaac gtgccggaag gtttgctggc caccgtcacg
     1261 gtatgtctga cgctcactgc caagcgcatg gcgaggaaga actgcctggt gaagaacctg
     1321 gaagctgtgg agaccttggg gtccacatcc accatctgct ccgacaagac tggaactctg
     1381 actcagaacc ggatgacagt ggctcacatg tggtttgaca atcaaatcca tgaagctgac
     1441 accacagaga atcagagtgg ggtctccttt gacaagacgt cagccacctg gttcgctctg
     1501 tccagaattg ctggtctctg taacagggca gtgtttcagg ctaaccaaga aaacctgcct
     1561 atccttaagc gtgcagtagc gggagatgct tccgagtcgg cgctcttaaa gtgcatcgag
     1621 gtctgctgtg gctccgtgat ggagatgagg gagaagtaca ccaagatagt ggagattcct
     1681 ttcaactcca ccaacaagta ccagctctcc attcacaaga acccaaacgc atcggagcct
     1741 aagcacctgc tagtgatgaa gggcgcccca gaaaggatcc tggaccgatg cagttctatc
     1801 ctcctccacg gcaaggagca gcccctggac gaagagctga aggacgcctt tcagaatgcc
     1861 tacctagagc tggggggcct tggagagcgt gtgctaggtt tctgccacct ccttctgcct
     1921 gacgaacagt ttcccgaagg cttccagttt gacactgatg aagtcaattt ccccgtggat
     1981 aacctctgct tcgtgggtct tatctccatg attgaccctc ctcgagctgc tgtccccgat
     2041 gctgtgggca aatgccgcag cgctgggatt aaggtcatca tggtcacagg agaccatcca
     2101 atcacagcca aagccattgc taagggggtg ggcattatct cagaaggtaa cgagaccgtg
     2161 gaagacattg ctgcccgcct caacattcca gtgaaccagg tgaaccccag agatgccaag
     2221 gcctgtgtag tacatggcag tgacttgaag gacatgacct ctgaggagct ggatgacatt
     2281 ttgcggtacc acacggagat tgtctttgct aggacctctc ctcaacagaa gctcatcatt
     2341 gtggagggct gccagcggca gggtgccatc gtggctgtca caggggatgg tgtcaatgac
     2401 tctccagctt tgaaaaaggc agatattggg gttgccatgg ggattgttgg ctcggatgtg
     2461 tccaagcaag ctgctgacat gattcttctg gatgacaact ttgcctccat cgtgactgga
     2521 gtagaagaag gtcgtctgat atttgataac ttgaagaaat ccattgctta caccctaaca
     2581 agtaacattc cggaaatcac ccccttcttg atatttatta ttgcaaacat tccactgccc
     2641 ctgggcaccg tgaccatcct ctgcattgac ttgggcactg acatggttcc cgccatctct
     2701 ctggcctatg aacaggctga aagtgacatc atgaagaggc agcccagaaa tcccaaaacg
     2761 gacaaacttg tgaacgagcg tctgatcagc atggcctatg gacagatcgg tatgatccag
     2821 gccctgggag gcttcttcac ttattttgtg attctggctg agaacggttt cctgcccttt
     2881 cacctgttgg gcatccgaga gacctgggat gaccgctgga tcaatgatgt ggaggacagc
     2941 tacgggcagc agtggaccta cgagcagagg aagattgtgg agttcacctg ccacacggcc
     3001 ttctttgtca gtatcgtggt agtgcagtgg gctgacttgg tcatctgcaa gaccagaagg
     3061 aattctgtct tccagcaggg aatgaagaac aagatcttaa tatttggcct ctttgaagag
     3121 acagctcttg ctgctttcct gtcctactgc cctgggatgg gtgcagccct taggatgtat
     3181 cccctcaaac ctacttggtg gttctgtgcc ttcccctact cccttctcat cttcgtgtat
     3241 gacgaggtgc ggaagctcat catcaggcga cgccctggcg gctgggtgga gaaggaaacc
     3301 tactactagc ccactgccct gcacgccgtg gaacattgtg ccacacactg cacctacccc
     3361 taccccccct ttgtgtactt caagtcttgg agctcggaac tctaccctgg taggaaagca
     3421 ccaaagcatg tggggatcca gacgtcctgg aatgaagcat gtagctgtaa tggggggcgg
     3481 ggggagggct gcccgaaaaa caccgtggac ggggacgaca gcggggaagg tttatatgtg
     3541 cctttttgtt tttgtaaaaa aggaaaacct ggaaagactg aaagattacg ttttatatct
     3601 ggatttttac aaataaagat ggctattata acggaa
//
