LOCUS       NM_001109369            4793 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ATPase 13A3 (Atp13a3), mRNA.
ACCESSION   NM_001109369 XM_001052983
VERSION     NM_001109369.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4793)
  AUTHORS   Hamouda,N.N., Van den Haute,C., Vanhoutte,R., Sannerud,R.,
            Azfar,M., Mayer,R., Cortes Calabuig,A., Swinnen,J.V., Agostinis,P.,
            Baekelandt,V., Annaert,W., Impens,F., Verhelst,S.H.L.,
            Eggermont,J., Martin,S. and Vangheluwe,P.
  TITLE     ATP13A3 is a major component of the enigmatic mammalian polyamine
            transport system
  JOURNAL   J Biol Chem 296, 100182 (2021)
   PUBMED   33310703
REFERENCE   2  (bases 1 to 4793)
  AUTHORS   Lindhurst,M.J., Sapp,J.C., Teer,J.K., Johnston,J.J., Finn,E.M.,
            Peters,K., Turner,J., Cannons,J.L., Bick,D., Blakemore,L.,
            Blumhorst,C., Brockmann,K., Calder,P., Cherman,N., Deardorff,M.A.,
            Everman,D.B., Golas,G., Greenstein,R.M., Kato,B.M.,
            Keppler-Noreuil,K.M., Kuznetsov,S.A., Miyamoto,R.T., Newman,K.,
            Ng,D., O'Brien,K., Rothenberg,S., Schwartzentruber,D.J.,
            Singhal,V., Tirabosco,R., Upton,J., Wientroub,S., Zackai,E.H.,
            Hoag,K., Whitewood-Neal,T., Robey,P.G., Schwartzberg,P.L.,
            Darling,T.N., Tosi,L.L., Mullikin,J.C. and Biesecker,L.G.
  TITLE     A mosaic activating mutation in AKT1 associated with the Proteus
            syndrome
  JOURNAL   N Engl J Med 365 (7), 611-619 (2011)
   PUBMED   21793738
REFERENCE   3  (bases 1 to 4793)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Sep 11, 2019 this sequence version replaced NM_001109369.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The extent of this transcript is
            supported by orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000011.1  83870218-83870400
            184-227             JAXUCZ010000011.1  83871045-83871088
            228-328             JAXUCZ010000011.1  83891317-83891417
            329-502             JAXUCZ010000011.1  83896218-83896391
            503-673             JAXUCZ010000011.1  83897049-83897219
            674-744             JAXUCZ010000011.1  83897533-83897603
            745-825             JAXUCZ010000011.1  83899394-83899474
            826-895             JAXUCZ010000011.1  83901378-83901447
            896-1030            JAXUCZ010000011.1  83902661-83902795
            1031-1103           JAXUCZ010000011.1  83904006-83904078
            1104-1235           JAXUCZ010000011.1  83905705-83905836
            1236-1415           JAXUCZ010000011.1  83906817-83906996
            1416-1573           JAXUCZ010000011.1  83907109-83907266
            1574-1762           JAXUCZ010000011.1  83907996-83908184
            1763-1824           JAXUCZ010000011.1  83909720-83909781
            1825-1975           JAXUCZ010000011.1  83911206-83911356
            1976-2092           JAXUCZ010000011.1  83913708-83913824
            2093-2110           JAXUCZ010000011.1  83914357-83914374
            2111-2264           JAXUCZ010000011.1  83914468-83914621
            2265-2385           JAXUCZ010000011.1  83914706-83914826
            2386-2510           JAXUCZ010000011.1  83917589-83917713
            2511-2686           JAXUCZ010000011.1  83918322-83918497
            2687-2809           JAXUCZ010000011.1  83918838-83918960
            2810-2889           JAXUCZ010000011.1  83919041-83919120
            2890-2932           JAXUCZ010000011.1  83920091-83920133
            2933-3042           JAXUCZ010000011.1  83920231-83920340
            3043-3139           JAXUCZ010000011.1  83920993-83921089
            3140-3212           JAXUCZ010000011.1  83922258-83922330
            3213-3381           JAXUCZ010000011.1  83924980-83925148
            3382-3569           JAXUCZ010000011.1  83926358-83926545
            3570-3658           JAXUCZ010000011.1  83931389-83931477
            3659-3739           JAXUCZ010000011.1  83935907-83935987
            3740-4793           JAXUCZ010000011.1  83943464-83944517
FEATURES             Location/Qualifiers
     source          1..4793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4793
                     /gene="Atp13a3"
                     /note="ATPase 13A3"
                     /db_xref="GeneID:678704"
                     /db_xref="RGD:1590881"
     exon            1..183
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            184..227
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            228..328
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..3937
                     /gene="Atp13a3"
                     /EC_number="7.6.2.16"
                     /note="probable cation-transporting ATPase 13A3; ATPase
                     type 13A3"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A3"
                     /protein_id="NP_001102839.2"
                     /db_xref="GeneID:678704"
                     /db_xref="RGD:1590881"
                     /translation="MDKEERTIINKGQEDEMEIHGYNLCRWKLAMVCVGVICTGGFLL
                     LLLYWMPEWRVKATCVRAAVKDCEVVLLRTTDEFRIWFCAKIHFLSLENQPNLNAKSL
                     VNKVSNGHAVRLTEENRCEMNKYSQSQSQQMRYFTHHSIRYFWNDAIHNFDFLKGLDE
                     GVSCASMYEKHSAGLTKGMHAYRKLLYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFS
                     VILWSIDEYYYYALAIVVMSIVSIISSLYSIRKQYVMLHDMVATHSTVRVSVCRVNEE
                     IEEIFSTDLVPGDVMIIPLNGTVMPCDAVLINGTCIVNESMLTGESVPVTKTNLPNPS
                     VDVKGMGEEQYSPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGFSTSKGQLVRSI
                     LYPKPTDFKLYRDAYLFLLCLVVVAGIGFIYTIVNSILNEKEVQEIIIKSLDIITITV
                     PPALPAAMTAGIVYAQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWG
                     IQRVENTRFLLPEDNVCNEMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGW
                     VLEEATEEETALHNRIMPTVVRPSKQLLPESTTAGDQEMELFELPAIYEIGIVRQFPF
                     SSALQRMSVVARTLGDKRMDAYMKGAPEVIASLCKPETVPVDFEKVLEDYTKQGFRVI
                     ALAHRKLESKLTWHKVQHVSRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRT
                     VMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYTDSLTQCSESS
                     AIDSEAIPIKLAHDSLEDLQVTRYHFAMNGKSFSVILEHFQDLVPKLMLHGTVFARMA
                     PDQKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISLSEFEASVASPFTSKTPSI
                     SCVPNLIREGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAII
                     LVVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIVISVGFQSLGFFWVKQYKEC
                     DPYSEVCNTTRSACWNSSHLYNGTELDSCKIQNYENTTVFFISSFQYLTVAVAFSKGK
                     PFRQPCYKNYFFVISVIILYVFILFIMLHPVASVDQLLEIMCVPYQWRIYMLIIVLTN
                     AFVSITVEESVDRWGKCCLSWALSCRKKTPKAKYMYLAQELQFDPEWPPKPQTTTEAK
                     AIVKENGSCQIITIA"
     exon            329..502
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            503..673
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..744
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..825
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            826..895
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1030
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1103
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1235
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1415
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1573
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1762
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1824
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1975
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2092
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2110
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2264
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2385
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2510
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2686
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2809
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2889
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2932
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3042
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3139
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3212
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3381
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3569
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3658
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3739
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..4793
                     /gene="Atp13a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgacgcg cggcggcgga ccctcgagcc cgagcgaccc gcggccgccg gctccggccg
       61 agggcgatgg ggctgggctg aggagaggcg gcggcggtgg cgaaagcggc cccccggccc
      121 cctgcggcct tttggctgcc cgggccggga ggccgcggag aagtcggccg ggcggcgcgg
      181 ctggtctgac agaatcatcc tgggatcttg gtgtctggac ataagagttc tcttcacctg
      241 ttgagtgaag caccgtacct ttcaagccac tgtagagatg gacaaagaag agaggacgat
      301 tatcaacaag ggacaagaag atgaaatgga gatacatggc tataacttat gccgctggaa
      361 gcttgccatg gtttgtgtag gggtgatttg tactggtggt tttctcctcc tcctcctcta
      421 ctggatgcct gagtggcgag tgaaggccac gtgtgttaga gctgcagtta aagactgtga
      481 agtggtgctt ctcaggacga ctgatgaatt tagaatatgg ttttgtgcaa aaattcactt
      541 tctttctctg gagaatcaac caaatttgaa tgcaaagtct ttagttaata aggtttctaa
      601 tggccatgct gttcgtctga ctgaagaaaa tagatgtgaa atgaataaat actcacaaag
      661 tcagtcacaa cagatgcgtt attttaccca ccatagcata agatatttct ggaatgatgc
      721 cattcacaat tttgatttct taaagggact ggatgaaggt gtgtcttgtg cgtcaatgta
      781 tgaaaagcat agtgcaggcc tgacaaaggg gatgcatgcc tacagaaagt tgctttatgg
      841 agtaaatgaa atagctgtga aagtgccttc tgtttttaag cttctgatta aagaggttct
      901 caacccattc tacattttcc aactgttcag tgttatcctg tggagcatcg atgagtacta
      961 ttactatgct ctagccattg tggtcatgtc catagtgtcc attataagtt cactgtattc
     1021 cattagaaag caatatgtta tgttacatga catggtggca actcacagta ctgtgagagt
     1081 ttcagtttgt agagtaaatg aagaaataga agagatcttt tctacagacc ttgtgccggg
     1141 agatgtcatg atcattccat taaatgggac agtcatgcct tgtgatgcag tacttattaa
     1201 tggtacttgc attgtaaatg aaagcatgtt aacaggagaa agtgttccag tgacaaagac
     1261 taatttgcca aatccttcag tggatgtgaa aggaatgggg gaggagcaat acagcccaga
     1321 gactcataag cggcacactt tgttctgtgg gacgactgtt attcagaccc gtttctacac
     1381 tggggaactt gtgaaagcca tagtagttag aacaggattt agtacttcca aaggacagct
     1441 tgttcgctct atactgtatc ccaagccaac tgattttaag ctctacagag acgcctactt
     1501 gtttctgcta tgtcttgtgg tcgtggccgg aattgggttt atctacacaa tcgtcaatag
     1561 catcctaaat gagaaagaag ttcaggaaat aattattaag tctcttgata tcattacaat
     1621 tactgtgcca cctgctcttc ctgctgcaat gactgctggg attgtgtatg ctcagagaag
     1681 actgaaaaaa gttgggattt tctgtattag tccccagagg ataaacatct gtggacagct
     1741 gaaccttgtg tgttttgaca agactggaac tcttactgaa gatggtttag atctgtgggg
     1801 aattcagcga gtagaaaata cccgattcct tttacctgaa gacaatgttt gcaatgagat
     1861 gttggtaaaa tctcagtttg ttgcttgtat ggctacttgt cattcactta caaaaatcga
     1921 aggagttctt tctggtgatc cacttgattt gaaaatgttt gaagccattg ggtgggttct
     1981 ggaagaagca actgaggaag aaacagcgct tcacaaccgg atcatgccta ctgtggttcg
     2041 tccttccaag cagctgctgc ctgagtctac aactgcagga gaccaagaaa tggagctgtt
     2101 cgaacttcca gctatttatg agataggaat tgttcgacag tttccatttt cttcggcttt
     2161 gcaacggatg agtgtggttg caaggacact aggcgataag agaatggatg cctacatgaa
     2221 aggagccccc gaggtgattg ccagtctctg taaacctgaa acagttccag ttgactttga
     2281 gaaagtatta gaagattata ccaaacaagg cttccgtgta attgctcttg cacacagaaa
     2341 attggagtca aagctgacct ggcataaagt acagcatgtt agcagagatg ccattgaaaa
     2401 caacatggat tttatgggac tgattataat gcagaacaaa ttgaagcagg aaacccctgc
     2461 agtacttgaa gatttgcata aagccaacat tcgaactgtc atggtcacag gagacaacat
     2521 gttgacggct gtgtctgtgg ccagagactg cgggatgatt ctacctcagg acaaagttat
     2581 cattgctgaa gcactacctc caaaggatgg gaaagtggcc aagatcaatt ggcattacac
     2641 agactccctg acacagtgta gtgaatcgtc agccattgac tcagaggcta ttccaatcaa
     2701 acttgcccat gatagcttag aggatcttca ggtgactcgc taccattttg cgatgaatgg
     2761 aaagtcattt tcagtgatac tggaacattt tcaagatctc gttcctaagt tgatgttgca
     2821 tggcactgtg tttgcccgga tggcacccga tcagaagaca cagttggtgg aagcattgca
     2881 gaacgtagac tactttgttg ggatgtgcgg tgatggtgca aatgattgtg gtgctctgaa
     2941 gagggcacat ggtggcattt ccttatctga gtttgaagct tctgtggcgt ctccttttac
     3001 ttctaaaaca cccagtatct cttgtgtgcc aaaccttatc agggaaggcc gagctgcttt
     3061 aatgacatcc ttctgtgtgt ttaaatttat ggcgttatac agcatcatac aatatttcag
     3121 tgttactctc ctgtattcta tcttgagtaa cctgggagac tttcagtttc tcttcattga
     3181 tctggcaatc attttggtag tagtatttac aatgagttta aaccctgcct ggaaagagct
     3241 tgtggcacag agaccacctt caggccttat atccggggcg ctcctcttct ctgtcttgtc
     3301 tcagattgtg atctccgttg gatttcagtc gctgggcttc ttctgggtca agcagtataa
     3361 agagtgtgat ccgtattcag aggtttgcaa tacaacaaga agcgcatgtt ggaactcgtc
     3421 acacttatac aacgggactg aacttgattc ctgtaaaata caaaattatg agaataccac
     3481 agtgtttttt atctccagtt ttcagtacct cacagtggca gttgcctttt caaaaggaaa
     3541 accattcagg cagccttgct acaagaatta tttttttgtt atatctgtga ttattttgta
     3601 tgttttcata ttattcatca tgttgcatcc agttgcctct gttgaccagc ttctggagat
     3661 tatgtgtgtg ccataccagt ggcgcatata tatgcttatc attgtcctca ccaatgcctt
     3721 cgtgtctatc acggtggagg agtcagtgga tcgatggggg aaatgctgct tgtcctgggc
     3781 cctgagctgt agaaagaaga caccaaaagc aaagtacatg tatctagccc aggagctcca
     3841 gtttgatccc gagtggccgc cgaagcctca gacgacgacg gaagccaaag ctatagtgaa
     3901 ggagaacgga tcatgtcaga tcatcaccat agcatagcaa agactgctct gctgtccagt
     3961 agcagtgacg accctgtcag aacagcactc tttcagttta tatagccctc tcataatacg
     4021 gcagttaaaa acacagaaca gtgaagtgtc atttctgcac agttagcttt taactataaa
     4081 tctggctata tcttcatgca gtaacctaaa tacgatgcac actttgtatt gggtatgaga
     4141 aactgtttgt gttttacaga ttgtaggttt tgacactagt ttgcctctat aattttcaca
     4201 aatcccctta ttagaaagtt cttttacatg taggccccaa aattgtgata gttaaaaata
     4261 atagttaatt gtgattagcc tttagtgaaa ataggttgaa aacctgcttt gatccagtgt
     4321 tttctcccaa agaagactac attaaacgta caccagtttt cttttatgac ctgtagtgtt
     4381 attgttgata gagcaactca ggtgatttcc atttctggtt ttatattttc tgtgtagcct
     4441 gccttggtgt actttctaga cagctaggtg ctccactgct gtcttgagat gtccttcata
     4501 gtattccatg ggtcccatgt agtatctgac atcagcagtc tacttaagca aagaagtctc
     4561 tcactagaaa ggtctatttc tgagccaggt atgacagtaa aggcccctag tcctgcacag
     4621 gcaggaggct aaggcaggaa gattgttcct atagggtcca aggatagcct agaatagatg
     4681 gtagaagcct gtctcagaat acagttgcag ggagagagat tgagggtatt gtatttctct
     4741 tggcagtgga cttcattcat atgtcttcaa cctgtttgtt ttttcttttg gga
//
