LOCUS       NM_001173432            3905 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ATPase cation transporting 13A2 (Atp13a2), mRNA.
ACCESSION   NM_001173432 XM_001072145 XM_342962
VERSION     NM_001173432.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3905)
  AUTHORS   van Veen,S., Martin,S., Van den Haute,C., Benoy,V., Lyons,J.,
            Vanhoutte,R., Kahler,J.P., Decuypere,J.P., Gelders,G., Lambie,E.,
            Zielich,J., Swinnen,J.V., Annaert,W., Agostinis,P., Ghesquiere,B.,
            Verhelst,S., Baekelandt,V., Eggermont,J. and Vangheluwe,P.
  TITLE     ATP13A2 deficiency disrupts lysosomal polyamine export
  JOURNAL   Nature 578 (7795), 419-424 (2020)
   PUBMED   31996848
REFERENCE   2  (bases 1 to 3905)
  AUTHORS   Marcos,A.L., Corradi,G.R., Mazzitelli,L.R., Casali,C.I., Fernandez
            Tome,M.D.C., Adamo,H.P. and de Tezanos Pinto,F.
  TITLE     The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid
            homeostasis
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182993 (2019)
   PUBMED   31132336
REFERENCE   3  (bases 1 to 3905)
  AUTHORS   Wang,R., Tan,J., Chen,T., Han,H., Tian,R., Tan,Y., Wu,Y., Cui,J.,
            Chen,F., Li,J., Lv,L., Guan,X., Shang,S., Lu,J. and Zhang,Z.
  TITLE     ATP13A2 facilitates HDAC6 recruitment to lysosome to promote
            autophagosome-lysosome fusion
  JOURNAL   J Cell Biol 218 (1), 267-284 (2019)
   PUBMED   30538141
REFERENCE   4  (bases 1 to 3905)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3905)
  AUTHORS   Kelm-Nelson,C.A., Stevenson,S.A. and Ciucci,M.R.
  TITLE     Atp13a2 expression in the periaqueductal gray is decreased in the
            Pink1 -/- rat model of Parkinson disease
  JOURNAL   Neurosci Lett 621, 75-82 (2016)
   PUBMED   27057733
  REMARK    GeneRIF: Pink1 -/- rats show significantly decreased levels of
            Atp13a2, a transmembrane lysosomal P5-type ATPase suggesting a
            potential mechanism for the observed abnormal aggregation.
REFERENCE   6  (bases 1 to 3905)
  AUTHORS   Ramonet,D., Podhajska,A., Stafa,K., Sonnay,S., Trancikova,A.,
            Tsika,E., Pletnikova,O., Troncoso,J.C., Glauser,L. and Moore,D.J.
  TITLE     PARK9-associated ATP13A2 localizes to intracellular acidic vesicles
            and regulates cation homeostasis and neuronal integrity
  JOURNAL   Hum Mol Genet 21 (8), 1725-1743 (2012)
   PUBMED   22186024
REFERENCE   7  (bases 1 to 3905)
  AUTHORS   Tan,J., Zhang,T., Jiang,L., Chi,J., Hu,D., Pan,Q., Wang,D. and
            Zhang,Z.
  TITLE     Regulation of intracellular manganese homeostasis by Kufor-Rakeb
            syndrome-associated ATP13A2 protein
  JOURNAL   J Biol Chem 286 (34), 29654-29662 (2011)
   PUBMED   21724849
  REMARK    GeneRIF: Regulation of intracellular manganese homeostasis by
            Kufor-Rakeb syndrome-associated ATP13A2 protein.
REFERENCE   8  (bases 1 to 3905)
  AUTHORS   Park,J.S., Mehta,P., Cooper,A.A., Veivers,D., Heimbach,A.,
            Stiller,B., Kubisch,C., Fung,V.S., Krainc,D., Mackay-Sim,A. and
            Sue,C.M.
  TITLE     Pathogenic effects of novel mutations in the P-type ATPase ATP13A2
            (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset
            parkinsonism
  JOURNAL   Hum Mutat 32 (8), 956-964 (2011)
   PUBMED   21542062
REFERENCE   9  (bases 1 to 3905)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   10 (bases 1 to 3905)
  AUTHORS   Ramirez,A., Heimbach,A., Grundemann,J., Stiller,B., Hampshire,D.,
            Cid,L.P., Goebel,I., Mubaidin,A.F., Wriekat,A.L., Roeper,J.,
            Al-Din,A., Hillmer,A.M., Karsak,M., Liss,B., Woods,C.G.,
            Behrens,M.I. and Kubisch,C.
  TITLE     Hereditary parkinsonism with dementia is caused by mutations in
            ATP13A2, encoding a lysosomal type 5 P-type ATPase
  JOURNAL   Nat Genet 38 (10), 1184-1191 (2006)
   PUBMED   16964263
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168672.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_342962.4, XM_001072145.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3905
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /note="ATPase cation transporting 13A2"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
     exon            1..121
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..3549
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /EC_number="7.2.2.10"
                     /note="probable cation-transporting ATPase 13A2; ATPase
                     type 13A2"
                     /codon_start=1
                     /product="polyamine-transporting ATPase 13A2"
                     /protein_id="NP_001166903.1"
                     /db_xref="GeneID:362645"
                     /db_xref="RGD:1307977"
                     /translation="MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP
                     WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQL
                     FTVQVQTEAVVDGSLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEAKQVLRY
                     YILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNVIGI
                     PVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQ
                     SMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECV
                     VNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTR
                     TGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVK
                     EIVIRALDLVTVVVPPALPAAMTVCTLYSQSRLRTQGIFCIHPLRINLGGKLRLVCFD
                     KTGTLTEDGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGD
                     PMDLKMVESTGWVLEEGSAAGSAPGTQVLVVMRPPPRGPQQQEESPEPVSVLRRFPFS
                     SALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVA
                     LAGKPLPTAPSLEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTV
                     MVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKD
                     PVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLV
                     CELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIR
                     EGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMS
                     RTGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVP
                     APDNLPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTNGLRNIADSSFKLLLLGL
                     VAFNFVGAFMLESVLDQCLPACLQWLRPKRASKKQFKQLQRELAERPWPTLPVGSMR"
     exon            122..216
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            217..399
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            400..458
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            459..573
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            574..653
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            654..731
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            732..801
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            802..936
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1003
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1135
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1291
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1402
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1449
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1638
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1845
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1935
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2095
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2216
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2341
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2502
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2619
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2699
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2852
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2949
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3173
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3325
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3411
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3790
                     /gene="Atp13a2"
                     /gene_synonym="RGD1307977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcccctcc gaagctcgcc tcagtcggtg tccccgaccg tgccccgggg cctcgcacgc
       61 cgagcccagg ccgcgggcca cagcggccgg cgatgagcgc gaggagtcga aatgagcgca
      121 gacagcagcc cgctcctggg cagcacgccc cccagctatg ggaccctgat gacagggaca
      181 tcaatcgatc ccctcagctc ctcagtttca tccgtgaggc tcagcggcta ctgtggcagt
      241 ccatggaggg ccatcggcta tcacgccgcg gtctggatgc tggccgggat cccttggctg
      301 ctattccgct ggaagccctt gtggggcgtg cgcctgcgcc tgaggccatg cagcctggcc
      361 cgcgccgaaa cactcgttat agaaataaga gacaaagagg gtagctccag acagctcttc
      421 actgtccagg tgcagactga ggctgttgtc gacggcagcc tggagctgcc ctcacaggcc
      481 aaggcagagg atggccggag cctggcggcc gtgggagtgg caccggagag catgtggcag
      541 gacactacgc agctccacag gcagaaagag gcaaagcagg tactgcgcta ttacatcctc
      601 cagggccaac gctatgtctg gatggagacc cagcaagcct tctgccaagt cagcctgctg
      661 gaccacggtc gtgcctgcga tgacatccat tgctccagtt ctggcctcag cctccaggac
      721 caggctgtga ggaagaccat ttacggcccc aacgtgattg gtattcccgt caagtcctac
      781 ctgcagctac tggtggatga ggcactgaac ccctactacg gattccaggc cttcagcatc
      841 gccctgtggc tggctgacca ctactactgg tatgctgtct gcatcttcct catctcggcc
      901 atctccatct gcctgtctct ctacaagacc aggaagcaaa gcatgactct gagggacatg
      961 gtcaagttgt ccgtgcgggt gcaggtgtgc cgacccggag gagaggaaga gtgggtggac
     1021 tccagtgagc tggtgcccgg agactgcctg gtgctgcccc aggagggcgg aatgatgccg
     1081 tgtgatgctg ctctggtggc cggggagtgt gtggtcaatg agagctccct gacaggagaa
     1141 agcatcccag tgttgaagac agccctgcca gaggggcccc agccctactg cccagagacc
     1201 caccggcggc acactctctt ctgtggcacc ctcgttctgc aggcccgggc ctacctggga
     1261 ccccgtgtcc tagccgtggt aactcggaca gggttctgca cagccaaagg gggcctggtg
     1321 agctccatcc tacacccacg gcccatcagc ttcaagttct acagacacag catgaagttt
     1381 gtggcagcgc tgtccgtcct ggctctgctc ggtaccatct acagcatcat cattctctac
     1441 cgaaaccggg tgcccgtgaa ggagatcgtg atccgagctc tggacctggt gacggtggtg
     1501 gtaccacccg ccctgccggc cgccatgacc gtgtgcacac tctactccca gagccggctg
     1561 cgtacacagg gcatcttctg tatccacccg ctgcgcatca acttgggggg caagctgcgc
     1621 ctcgtgtgct tcgacaagac aggcaccctc acggaggacg gattggacat aatgggggtg
     1681 gtgcccctaa aggggcagat gttgctgcca ctggtcccag agccctgcca cctgccccca
     1741 gggcccctcc tccgagcact ggtcacctgt catgccctca gccagctaca tgataccttg
     1801 gtgggcgacc ccatggatct caagatggtg gagtctacag gctgggtctt agaggagggt
     1861 tcggctgcag gctcagcacc tgggacccag gtcttggtgg taatgcgacc cccacccagg
     1921 gggcctcagc aacaggaaga gtcaccagag ccagtcagtg tcctccgccg cttccccttc
     1981 tcctctgccc tgcagcggat ggacgtggtg gtgacatggc caggggccac ccagcctgag
     2041 gcctacgtca aaggctcccc agagcttgtg gccagcctct gcagccccga gacagtgccc
     2101 agagactttc ctcaggtact gcagagctac acagctgctg gctaccgagt tgtggccctg
     2161 gctggcaagc cactgcccac tgcgcccagc cttgaggccg ctcagcagct gacaagggac
     2221 actgtggagc aggagctgag cctcctgggg ctgctggtca tgcggaacct gctgaagcca
     2281 cagacgaccc cagttataca gaccctgagg aagacgggca tccgtactgt tatggtgaca
     2341 ggggacaacc tgcagacagc agtcacggtg gccaaagcgt gtggcatggt gggcacccag
     2401 gagcacctgg ctatcatcca tgccacccac cctgagcagg gccagcctgc tgcccttgag
     2461 ttcctgccaa ctgagccctc tgcggccatg aatggggcaa aggatcctgt gcaggccacg
     2521 gactaccccg tggagccgga gtcccagtcc cgtcacctgg ccctcagtgg gtccacgttt
     2581 gctgtccttc agaagcactt ccccaagctg ctgcccaagg tcctggtgca ggccaccgtc
     2641 tttgcccgca tggccccgga gcagaagaca cagctagtgt gtgaacttca gagacttcag
     2701 tactgcgtgg gcatgtgcgg ggatggagcc aatgactgtg gggccctgaa ggcggctgac
     2761 gtgggcatct cactgtccca ggcagaggcc tcagtggtct ctccgttcac ctccagcatg
     2821 gccagtattg aatgtgtgcc cactgtcatc agggaaggcc gctgctctct ggacacttca
     2881 ttcagcgtct tcaagtatat ggccctatac agcctgaccc agttcatctc tgtcctcatt
     2941 ctctacacaa tcaacaccaa cctgggagac ctacagttct tggccatcga cctgttcatc
     3001 accaccacgg ttgccgtgct catgagccgc accggccctg cactgacctt ggtgcgagca
     3061 cggccaccag gggcgctgct gagcgtgcct gtacttggca gtttgctgct gcaggtggcc
     3121 ttggtggccg gcatccagct tgggggctac tttttggtca tagctcagcc ctggtttgtg
     3181 cctctgaaca gaactgtacc cgcacctgac aacctgccca actacgagaa cacagtgatc
     3241 ttctctctgt ctggcttcca gtacctcatc ctggccgcag cggtgtctaa gggggcaccc
     3301 ttccgccagc cgctctacac caacggactg aggaacattg cggacagctc tttcaagttg
     3361 ctgctgctgg gtctggtcgc cttcaacttt gtgggcgcct tcatgctgga gagcgtgctg
     3421 gaccagtgtc tcccagcctg cctgcagtgg ctgcggccta aacgggcctc caagaagcaa
     3481 ttcaagcagc tacaacggga gcttgctgaa cgtccatggc ccactctgcc cgttggctcc
     3541 atgaggtagt gcaggccttg gagggcatgc tggacactgg atctccctgc ccctgagcca
     3601 tgaccggaac tctccctaga gacagtacca gtcacctccc acagccctga ggttggctgt
     3661 cacactcctg gggacacact cgcctgggga ggcgttgatt gttgcctcac tgtgtagaga
     3721 cagcagctac caactccatc cggagcagct gtcatggagc aaataaagtg ccggctttcc
     3781 tgtcttggca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3841 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3901 aaaaa
//
