LOCUS       NM_053359                509 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus antioxidant 1 copper chaperone (Atox1), mRNA.
ACCESSION   NM_053359
VERSION     NM_053359.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Chen,X., Xiang,W., Li,L. and Xu,K.
  TITLE     Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by
            Regulating the Copper Transport Family and Cell Cycle
  JOURNAL   Int J Toxicol 43 (2), 134-145 (2024)
   PUBMED   37859596
  REMARK    GeneRIF: Copper Chaperone Atox1 Protected the Cochlea From
            Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Palm-Espling,M.E., Andersson,C.D., Bjorn,E., Linusson,A. and
            Wittung-Stafshede,P.
  TITLE     Determinants for simultaneous binding of copper and platinum to
            human chaperone Atox1: hitchhiking not hijacking
  JOURNAL   PLoS One 8 (7), e70473 (2013)
   PUBMED   23936210
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 509)
  AUTHORS   Kohno,T., Urao,N., Ashino,T., Sudhahar,V., McKinney,R.D.,
            Hamakubo,T., Iwanari,H., Ushio-Fukai,M. and Fukai,T.
  TITLE     Novel role of copper transport protein antioxidant-1 in neointimal
            formation after vascular injury
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (4), 805-813 (2013)
   PUBMED   23349186
REFERENCE   4  (bases 1 to 509)
  AUTHORS   Monnot,A.D., Zheng,G. and Zheng,W.
  TITLE     Mechanism of copper transport at the blood-cerebrospinal fluid
            barrier: influence of iron deficiency in an in vitro model
  JOURNAL   Exp Biol Med (Maywood) 237 (3), 327-333 (2012)
   PUBMED   22442359
  REMARK    GeneRIF: these results suggest that Ctr1, DMT1, ATOX1 and ATP7A
            contribute to Cu transport at the blood-CSF barrier
REFERENCE   5  (bases 1 to 509)
  AUTHORS   Tokuda,E., Okawa,E. and Ono,S.
  TITLE     Dysregulation of intracellular copper trafficking pathway in a
            mouse model of mutant copper/zinc superoxide dismutase-linked
            familial amyotrophic lateral sclerosis
  JOURNAL   J Neurochem 111 (1), 181-191 (2009)
   PUBMED   19656261
REFERENCE   6  (bases 1 to 509)
  AUTHORS   Hamza,I., Faisst,A., Prohaska,J., Chen,J., Gruss,P. and Gitlin,J.D.
  TITLE     The metallochaperone Atox1 plays a critical role in perinatal
            copper homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6848-6852 (2001)
   PUBMED   11391006
REFERENCE   7  (bases 1 to 509)
  AUTHORS   Kelner,G.S., Lee,M., Clark,M.E., Maciejewski,D., McGrath,D.,
            Rabizadeh,S., Lyons,T., Bredesen,D., Jenner,P. and Maki,R.A.
  TITLE     The copper transport protein Atox1 promotes neuronal survival
  JOURNAL   J Biol Chem 275 (1), 580-584 (2000)
   PUBMED   10617654
REFERENCE   8  (bases 1 to 509)
  AUTHORS   Hiromura,M. and Sakurai,H.
  TITLE     Molecular cloning of rat ATX1 homologue protein
  JOURNAL   Biochem Biophys Res Commun 265 (2), 509-512 (1999)
   PUBMED   10558899
REFERENCE   9  (bases 1 to 509)
  AUTHORS   Larin,D., Mekios,C., Das,K., Ross,B., Yang,A.S. and Gilliam,T.C.
  TITLE     Characterization of the interaction between the Wilson and Menkes
            disease proteins and the cytoplasmic copper chaperone, HAH1p
  JOURNAL   J Biol Chem 274 (40), 28497-28504 (1999)
   PUBMED   10497213
REFERENCE   10 (bases 1 to 509)
  AUTHORS   Naeve,G.S., Vana,A.M., Eggold,J.R., Kelner,G.S., Maki,R.,
            Desouza,E.B. and Foster,A.C.
  TITLE     Expression profile of the copper homeostasis gene, rAtox1, in the
            rat brain
  JOURNAL   Neuroscience 93 (3), 1179-1187 (1999)
   PUBMED   10473283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI281905.1, AF177671.1 and BM392393.1.
            
            On Dec 28, 2005 this sequence version replaced NM_053359.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058458.1, FQ220104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BI281905.1         491-505             c
            16-223              AF177671.1         31-238
            224-509             BM392393.1         1-286               c
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..509
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /note="antioxidant 1 copper chaperone"
                     /db_xref="GeneID:84355"
                     /db_xref="RGD:621684"
     exon            1..104
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..305
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /EC_number="6.2.1.2"
                     /note="ATX1 homolog protein Rah1; metal transport protein
                     ATX1; ATX1 (antioxidant protein 1) homolog 1; ATX1
                     antioxidant protein 1 homolog"
                     /codon_start=1
                     /product="copper transport protein ATOX1"
                     /protein_id="NP_445811.1"
                     /db_xref="GeneID:84355"
                     /db_xref="RGD:621684"
                     /translation="MPKHEFSVDMTCGGCAEAVSRVLNKLGGVEFNIDLPNKKVCIES
                     EHSSDILLATLNKTGKAVSYLGPK"
     exon            105..180
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..349
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..493
                     /gene="Atox1"
                     /gene_synonym="Atx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaaacgc cgctttggtg ttcgggagag gcgttctagt cctcgccgcc gcctgtgccg
       61 ccgcctgtgc cgcctgtgcc gcctgtgccg cgtcagtcat gccgaagcac gagttctctg
      121 tggacatgac ctgtggaggc tgtgcggaag ccgtctcccg agtcctcaac aagctgggag
      181 gagtggagtt caacattgac ttgcccaaca agaaggtctg cattgagtct gagcacagct
      241 cagacatcct gctggcaact ctcaacaaaa caggaaaagc ggtctcctac cttggcccca
      301 agtagccagg acctgggcga gtccttccgg atagaaactg aagaggcaga ctgttgatct
      361 ggtctccccc gctgatctgg aacaccaact gctcagtcca gctccgccat ggaattccag
      421 cccagacagg ccttccctgc tggctccctg ccagcttcct tgcaattaaa gtcaagctgc
      481 atttgttgat gaaaaaaaaa aaaaaaaaa
//
