LOCUS       NM_001109241            2375 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus atonal bHLH transcription factor 8 (Atoh8), mRNA.
ACCESSION   NM_001109241 XM_001063489 XM_575552
VERSION     NM_001109241.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K,
            Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L,
            Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J,
            Bauersachs J, Batkai S and Thum T.
  TITLE     MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease
  JOURNAL   Circulation 134 (24), 1973-1990 (2016)
   PUBMED   27780851
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Fang F, Wasserman SM, Torres-Vazquez J, Weinstein B, Cao F, Li Z,
            Wilson KD, Yue W, Wu JC, Xie X and Pei X.
  TITLE     The role of Hath6, a newly identified shear-stress-responsive
            transcription factor, in endothelial cell differentiation and
            function
  JOURNAL   J Cell Sci 127 (Pt 7), 1428-1440 (2014)
   PUBMED   24463812
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Balakrishnan-Renuka A, Morosan-Puopolo G, Yusuf F, Abduelmula A,
            Chen J, Zoidl G, Philippi S, Dai F and Brand-Saberi B.
  TITLE     ATOH8, a regulator of skeletal myogenesis in the hypaxial myotome
            of the trunk
  JOURNAL   Histochem Cell Biol 141 (3), 289-300 (2014)
   PUBMED   24186058
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M,
            Simpson RJ and McKie AT.
  TITLE     The transcription factor ATOH8 is regulated by erythropoietic
            activity and regulates HAMP transcription and cellular pSMAD1,5,8
            levels
  JOURNAL   Br J Haematol 164 (4), 586-596 (2014)
   PUBMED   24236640
REFERENCE   5  (bases 1 to 2375)
  AUTHORS   Ejarque M, Altirriba J, Gomis R and Gasa R.
  TITLE     Characterization of the transcriptional activity of the basic
            helix-loop-helix (bHLH) transcription factor Atoh8
  JOURNAL   Biochim Biophys Acta 1829 (11), 1175-1183 (2013)
   PUBMED   23938248
REFERENCE   6  (bases 1 to 2375)
  AUTHORS   Rawnsley DR, Xiao J, Lee JS, Liu X, Mericko-Ishizuka P, Kumar V, He
            J, Basu A, Lu M, Lynn FC, Pack M, Gasa R and Kahn ML.
  TITLE     The transcription factor Atonal homolog 8 regulates Gata4 and
            Friend of Gata-2 during vertebrate development
  JOURNAL   J Biol Chem 288 (34), 24429-24440 (2013)
   PUBMED   23836893
REFERENCE   7  (bases 1 to 2375)
  AUTHORS   Lynn FC, Sanchez L, Gomis R, German MS and Gasa R.
  TITLE     Identification of the bHLH factor Math6 as a novel component of the
            embryonic pancreas transcriptional network
  JOURNAL   PLoS One 3 (6), e2430 (2008)
   PUBMED   18560595
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063489.1, XM_575552.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV768182.1, SRR8487226.217872.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..2375
                     /gene="Atoh8"
                     /gene_synonym="RGD1561512"
                     /note="atonal bHLH transcription factor 8"
                     /db_xref="GeneID:500200"
                     /db_xref="RGD:1561512"
     exon            1..1189
                     /gene="Atoh8"
                     /gene_synonym="RGD1561512"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1387
                     /gene="Atoh8"
                     /gene_synonym="RGD1561512"
                     /note="protein atonal homolog 8"
                     /codon_start=1
                     /product="transcription factor ATOH8"
                     /protein_id="NP_001102711.1"
                     /db_xref="GeneID:500200"
                     /db_xref="RGD:1561512"
                     /translation="MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPVRRANGYKTFR
                     LDLEAPEFGATASATAATNGLRDRTQPFPIATPVPASVAPAVPPGGGTDTAREFRGIR
                     APEVSDARKRGFALGTVGPGLPTPPPPPASQSLAPGDPEVQPLREQALRPRILLCAPP
                     ARPTPSAPLAPPAVPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEA
                     TAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIA
                     CNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE"
     exon            1190..1381
                     /gene="Atoh8"
                     /gene_synonym="RGD1561512"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..2375
                     /gene="Atoh8"
                     /gene_synonym="RGD1561512"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcgggag gcggcagtgg cggcggcggc ggcgggagct gcctcctctc cgggcgggcg
       61 gcgctgagtg atcttgcgaa ctgggcttct gtgtaaactg aggctaaaca aacacagatg
      121 gagcgcagcg ggcgttctgc agaaatgctg gcagggcggc agcgacttca gatgacactt
      181 tgagctctcc cggggaacgg gcagctccga ggcttcacgg agccggaggc gcagctgccc
      241 cgggagtggg ggtgcgaggg agggacccgg ggagggaggg taggaggaga gagcgcggcg
      301 acaaggcggc gctgagcgcg gcggccaccg ggcacaggca ggcgcgcggc gtgcagagca
      361 atcgttgtgg gcgcgtgtcc cgggcagtcc cacgctcctg cctcgcgccg tccgcgccat
      421 gaagcacatc ccggtcctcg aggatgggcc gtggaagacc gtgtgcgtga aagagctgaa
      481 cggcctcaag aagctcaagc ggaaaggcaa ggagccggtg cggcgcgcga atggctataa
      541 aactttccga ttggacttgg aagctcccga gttcggcgcc acggccagcg ccaccgccgc
      601 caccaacggt ctccgggaca ggacacaacc gttcccgatc gcgaccccag taccagcctc
      661 tgtggcgccg gcggttcctc caggtggagg cacagacaca gccagggaat tccggggcat
      721 cagagcgcct gaggtctcag acgcgcgcaa acgcggtttc gctctgggca cagtgggacc
      781 gggactaccc acgccaccgc cacctcccgc gtcccagagc ttggcacccg gggatcccga
      841 ggtgcagccc ttacgcgagc aggctctgcg tccccgcatc ttgctgtgcg cccctcccgc
      901 gcgtcccacg ccgtccgcgc ctctcgcacc cccagcggtg ccacaagagt cccccgtgcg
      961 ccctgcgccc cccacgcgcc cgggggaaag ttcctactcg tcaatttcac acgtaattta
     1021 caataaccac ccggattctt ccgcgtcgcc taggaaacgg ccaggcgaag cgaccgccgc
     1081 ctccaccgag atcaaagccc tgcagcagac ccggaggctc ctggccaacg ccagggagcg
     1141 gacgcgggtg cacaccatca gcgcagcctt tgaggcgctg aggaagcagg tgccctgcta
     1201 ctcctatggg cagaagctgt ccaaactggc catcctgagg attgcctgta actacatcct
     1261 gtccctggcg cggctggctg acctggacta cagtgccgac cacagcaacc tcagcttctc
     1321 cgagtgtgtg cagcgctgca cccgcaccct gcaggcagaa ggacgtgcca agaagcgtaa
     1381 ggagtgacct gtcacaggct agaccacgga caccactgtg agtctctccc cagtcaggcc
     1441 tgaggagaaa gctgggacca ccaggagaca gacagcctca ttccttgtct tcttcaagat
     1501 gctccatata ctcagcccat gcaccacctc tcagggtcac cgaggaccag gacaagggcc
     1561 accagcctcc ctcttagtct cctgatgtcc tccagccatc cagggttact tcagattttg
     1621 ccttctgcct gatggggtgg gctattgcca aagattctac agagatcgat cgtccaagga
     1681 aaccatggga tgaagttcca acagcacaaa accacaccat tgctgcccaa ccaagtccac
     1741 ctcaagccaa agatggatta gcacttctgc cagaactcac gcaaggtgtg ggcctttggt
     1801 gaccttcaga agcacttaac cctccaagcc agtgctctgt ctgtgccggg ctctgagcag
     1861 ctggtcatct tggagacagt cttcctagag ccatgacaag caggctggcc gtggaagatg
     1921 gggcctgaga tccttgactc ttcccattag ctacccaggc ctctgactcc tgttcctgat
     1981 accctttggg tcctggctcc ttgcaaccca agcctcctga gagaggaaga aagggggaga
     2041 ctgaagaagc aatattgccc cacgccccac ccaggacgtg ccccaaggaa atctttctga
     2101 gggtccttgc tcccagatgt gccccaccag gtgctcctca ccagtggcca ggttcaggct
     2161 atcacatggg gtagtactct gctggagggc agtagctgcc tgtgggcagg tcaggcacga
     2221 gcgtttaggg aggaagggac caggggaagg ggccagcatg tgggggaacg ggtacgttca
     2281 aagccaaggc ctgctccttg tgctccaggg gccaaagctg ttcacatctg tgtgcaacca
     2341 tctgcttcaa attgaagtaa aagctgcaac gtata
//
