LOCUS       NM_001109238            2096 bp    mRNA    linear   ROD 12-JUN-2023
DEFINITION  Rattus norvegicus atonal bHLH transcription factor 1 (Atoh1), mRNA.
ACCESSION   NM_001109238 XM_001066177 XM_575508
VERSION     NM_001109238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Zheng Y, Luo W, Ma R, Cong N, Ren D, Chi F and Yang J.
  TITLE     The Atoh1 expression levels are correlated with the arrangement,
            ciliary morphology, and electrophysiological characteristics of
            ectopic hair cell-like cells
  JOURNAL   Neurosci Lett 720, 134758 (2020)
   PUBMED   31945449
  REMARK    GeneRIF: The Atoh1 expression levels are correlated with the
            arrangement, ciliary morphology, and electrophysiological
            characteristics of ectopic hair cell-like cells.
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Luo WW, Ma R, Cheng X, Yang XY, Han Z, Ren DD, Chen P, Chi FL and
            Yang JM.
  TITLE     Afferent synaptogenesis between ectopic hair-cell-like cells and
            neurites of spiral ganglion induced by Atoh1 in mammals in vitro
  JOURNAL   Neuroscience 357, 185-196 (2017)
   PUBMED   28576729
  REMARK    GeneRIF: Cochlear explants of auditory epithelia with native spiral
            ganglion neurons (SGNs) retained were cultured in vitro, and
            genetic vectors encoding Atoh1 were used to overexpress Atoh1 and
            induce ectopic hair-cell-like cells (EHCLCs). The neurites of the
            original SGNs extended toward the lesser epithelial ridge and
            innervated the EHCLCs.
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Li W, Wu J, Yang J, Sun S, Chai R, Chen ZY and Li H.
  TITLE     Notch inhibition induces mitotically generated hair cells in
            mammalian cochleae via activating the Wnt pathway
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 166-171 (2015)
   PUBMED   25535395
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Yang J, Cong N, Han Z, Huang Y and Chi F.
  TITLE     Ectopic hair cell-like cell induction by Math1 mainly involves
            direct transdifferentiation in neonatal mammalian cochlea
  JOURNAL   Neurosci Lett 549, 7-11 (2013)
   PUBMED   23669638
  REMARK    GeneRIF: Math1 induced hair cell-like cells from lateral epithelial
            ridge cells mainly underwent direct trans-differentiation instead
            of mitosis of LER cells or newly hair cell-like cells.
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Yang J, Bouvron S, Lv P, Chi F and Yamoah EN.
  TITLE     Functional features of trans-differentiated hair cells mediated by
            Atoh1 reveals a primordial mechanism
  JOURNAL   J Neurosci 32 (11), 3712-3725 (2012)
   PUBMED   22423092
  REMARK    GeneRIF: Atoh1 mediates trans-differentiation of morphological and
            functional 'ancestral' hair cells that are likely to undergo
            diversification in an endorgan-specific manner.
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Zine A and de Ribaupierre F.
  TITLE     Notch/Notch ligands and Math1 expression patterns in the organ of
            Corti of wild-type and Hes1 and Hes5 mutant mice
  JOURNAL   Hear Res 170 (1-2), 22-31 (2002)
   PUBMED   12208538
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Chen P, Johnson JE, Zoghbi HY and Segil N.
  TITLE     The role of Math1 in inner ear development: Uncoupling the
            establishment of the sensory primordium from hair cell fate
            determination
  JOURNAL   Development 129 (10), 2495-2505 (2002)
   PUBMED   11973280
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Zheng JL, Shou J, Guillemot F, Kageyama R and Gao WQ.
  TITLE     Hes1 is a negative regulator of inner ear hair cell differentiation
  JOURNAL   Development 127 (21), 4551-4560 (2000)
   PUBMED   11023859
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Farah MH, Olson JM, Sucic HB, Hume RI, Tapscott SJ and Turner DL.
  TITLE     Generation of neurons by transient expression of neural bHLH
            proteins in mammalian cells
  JOURNAL   Development 127 (4), 693-702 (2000)
   PUBMED   10648228
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Bermingham NA, Hassan BA, Price SD, Vollrath MA, Ben-Arie N, Eatock
            RA, Bellen HJ, Lysakowski A and Zoghbi HY.
  TITLE     Math1: an essential gene for the generation of inner ear hair cells
  JOURNAL   Science 284 (5421), 1837-1841 (1999)
   PUBMED   10364557
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474042.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066177.1, XM_575508.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..2096
                     /gene="Atoh1"
                     /gene_synonym="RGD1565171"
                     /note="atonal bHLH transcription factor 1"
                     /db_xref="GeneID:500156"
                     /db_xref="RGD:1565171"
     exon            1..2096
                     /gene="Atoh1"
                     /gene_synonym="RGD1565171"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1252
                     /gene="Atoh1"
                     /gene_synonym="RGD1565171"
                     /note="protein atonal homolog 1"
                     /codon_start=1
                     /product="transcription factor ATOH1"
                     /protein_id="NP_001102708.1"
                     /db_xref="GeneID:500156"
                     /db_xref="RGD:1565171"
                     /translation="MSRLLHAEEWAEVKELGDHHRHPQPHHIPQLTPQPPATLQARDH
                     PVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSPELGASEAAAPGDEADGQGE
                     LVRRSGCGGLSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLA
                     ANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSVG
                     EQPPPPAASCKNDHHHLRAAASYEGGAGASAVAGAQPAPGGGPRPTPPGACRTRFSTP
                     ASSGGYSVQLDALHFPAFEDRALTAMMAQKDLSPSLPGGILQPVPEDSSKTSPRSHRS
                     DGEFSPHSHYSDSDEAS"
ORIGIN      
        1 cggagaagct tcgttgcacg cgacctggtg tgcgatctcc gagtgagagg gggagggtga
       61 gaggagaaaa aaaaaatcag accttgcaga agagactagg aaggtttttg ttgttgttgt
      121 tcggggcttt cccccttcgt tgaactgggt tgccagcacc tcctctaaca aggcacctcc
      181 gagccagtgc attgcgatgt cccgcctgct gcatgcagaa gagtgggctg aggtaaaaga
      241 gttgggggac caccatcgcc atccccagcc gcaccacatc cctcagctga cgccacagcc
      301 acctgctacc ctacaggcga gagaccatcc ggtctacccg gcagaactgt ccctcctgga
      361 tagcaccgac ccacgcgcct ggctgactcc cactttgcag ggcctctgca cggcacgcgc
      421 cgcccagtat ctgctgcatt ctcccgagct gggtgcctcc gaggccgcgg cgcccgggga
      481 cgaggctgac ggccagggtg agctggtaag gagaagcggc tgcggcggcc tcagcaagag
      541 ccccgggccg gtgaaagtgc gggaacaact gtgcaagctg aagggcgggg ttgtagtaga
      601 cgagctgggc tgcagccgcc agcgagcccc ttccagcaaa caggtgaatg gggtacagaa
      661 gcaaaggcga ctggcagcaa acgcaaggga gcggcgcagg atgcacgggc tgaaccacgc
      721 cttcgaccag ctgcgcaacg ttatcccgtc cttcaacaac gacaagaagc tgtccaaata
      781 tgagaccctg cagatggccc agatctacat caacgccctg tcggagttgc tgcagactcc
      841 cagtgtcgga gagcagccac cgccgccagc agcctcctgc aaaaatgacc accatcacct
      901 tcgcgcagcc gcctcttatg aaggaggagc aggcgcctct gcggtagctg gggctcagcc
      961 agccccggga gggggcccga gacccacccc gcctggagct tgccggactc gcttctccac
     1021 cccagcttcc tccgggggtt attcagtgca gctggacgct ttgcactttc cagctttcga
     1081 ggaccgggcc ctaacagcga tgatggcaca gaaggacctg tcgccttcgc tgcccggggg
     1141 catcctgcag ccagtaccgg aggacagcag caaaacatct cccaggtccc acagaagtga
     1201 cggagagttt tccccccact ctcattacag tgactctgac gaggccagtt aggaagacaa
     1261 cagcaccctg aaaactgaga caaccaaaag cccttcccag cgcgcgggga agtcccgcga
     1321 caaatatccc ttccaccacc ctttaatttt tgctctacgt gatctttgtt agcaacgatg
     1381 tgacttcgga gggctgcggc tcttccaaac cccttcctcc taccttctgc ttcctctgta
     1441 tatagattca gtgtcattat atgtaccttt acatgtcatc gtcccatagt ccgtgctgcc
     1501 aatatgctgc taaaatgtcg tatctctgtc tctggtctgg gtttcactta attttatacc
     1561 ttgggcgttc atcctggtgt gttgcgctca ctcactcgta agggagttag tcttcgaagt
     1621 tgtttcccca agcgcattcg gtgcttaact gaacacgaac tattgagttg ttaaaatgca
     1681 tgggacagat aagagaatct gtagagctta aacaccgagt gtgtctagcg gacccagaac
     1741 acgcacttca tcactggctg ctgtgccgcc ttgaagaaac tcaactgcca attgcagacc
     1801 aacttttgat tttaaaaata gccactcgta atccttaaac tctttgcaaa tgtttgtttt
     1861 tgcaaatgaa aattaaaaaa acatgtagtg tcaaaggcat ttggtcaatt ttattttgct
     1921 ttgttaacat tagaaaagtt atttattatc gcgtatttgg acccatttct acttatttgc
     1981 tttttttttt tacattttct actcgagatc attttatttt gatttagcaa atccagttgc
     2041 cattgattta tgtatgtatg ctctttacaa atgataaaat aaacttgaaa aaacca
//
