LOCUS       NM_017228               4338 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus atrophin 1 (Atn1), mRNA.
ACCESSION   NM_017228 XM_003750658 XM_006244637
VERSION     NM_017228.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4338)
  AUTHORS   Zhang,F., Xu,D., Yuan,L., Sun,Y. and Xu,Z.
  TITLE     Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1
            is required for cortical progenitor maintenance
  JOURNAL   Nat Commun 5, 5815 (2014)
   PUBMED   25519973
  REMARK    GeneRIF: Epigenetic regulation of ATN1 by LSD1 is required for
            cortical progenitor maintenance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4338)
  AUTHORS   Yu,J., Ying,M., Zhuang,Y., Xu,T., Han,M., Wu,X. and Xu,R.
  TITLE     C-terminal deletion of the atrophin-1 protein results in growth
            retardation but not neurodegeneration in mice
  JOURNAL   Dev Dyn 238 (10), 2471-2478 (2009)
   PUBMED   19681162
REFERENCE   3  (bases 1 to 4338)
  AUTHORS   Hou,R. and Sibinga,N.E.
  TITLE     Atrophin proteins interact with the Fat1 cadherin and regulate
            migration and orientation in vascular smooth muscle cells
  JOURNAL   J Biol Chem 284 (11), 6955-6965 (2009)
   PUBMED   19131340
  REMARK    GeneRIF: Fat1 and Atrs 1,2 act in concert after vascular injury but
            show further that distinct Atr isoforms have disparate effects on
            VSMC directional migration.
REFERENCE   4  (bases 1 to 4338)
  AUTHORS   Redecker,P., Bockmann,J. and Bockers,T.M.
  TITLE     Secretory granules of hypophyseal and pancreatic endocrine cells
            contain proteins of the neuronal postsynaptic density
  JOURNAL   Cell Tissue Res 328 (1), 49-55 (2007)
   PUBMED   17120053
REFERENCE   5  (bases 1 to 4338)
  AUTHORS   Shen,Y., Lee,G., Choe,Y., Zoltewicz,J.S. and Peterson,A.S.
  TITLE     Functional architecture of atrophins
  JOURNAL   J Biol Chem 282 (7), 5037-5044 (2007)
   PUBMED   17150957
REFERENCE   6  (bases 1 to 4338)
  AUTHORS   Okamura-Oho,Y., Miyashita,T., Ohmi,K. and Yamada,M.
  TITLE     Dentatorubral-pallidoluysian atrophy protein interacts through a
            proline-rich region near polyglutamine with the SH3 domain of an
            insulin receptor tyrosine kinase substrate
  JOURNAL   Hum Mol Genet 8 (6), 947-957 (1999)
   PUBMED   10332026
REFERENCE   7  (bases 1 to 4338)
  AUTHORS   Ellerby,L.M., Andrusiak,R.L., Wellington,C.L., Hackam,A.S.,
            Propp,S.S., Wood,J.D., Sharp,A.H., Margolis,R.L., Ross,C.A.,
            Salvesen,G.S., Hayden,M.R. and Bredesen,D.E.
  TITLE     Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates
            cytotoxicity
  JOURNAL   J Biol Chem 274 (13), 8730-8736 (1999)
   PUBMED   10085113
REFERENCE   8  (bases 1 to 4338)
  AUTHORS   Morris-Rosendahl,D.J., Burgert,E., Uyanik,G., Mayerova,A.,
            Duval,F., Macher,J.P. and Crocq,M.A.
  TITLE     Analysis of the CAG repeats in the SCA1 and B37 genes in
            schizophrenic and bipolar I disorder patients: tentative
            association between B37 and schizophrenia
  JOURNAL   Am J Med Genet 74 (3), 324-330 (1997)
   PUBMED   9184318
REFERENCE   9  (bases 1 to 4338)
  AUTHORS   Schmitt,I., Epplen,J.T. and Riess,O.
  TITLE     Predominant neuronal expression of the gene responsible for
            dentatorubral-pallidoluysian atrophy (DRPLA) in rat
  JOURNAL   Hum Mol Genet 4 (9), 1619-1624 (1995)
   PUBMED   8541849
REFERENCE   10 (bases 1 to 4338)
  AUTHORS   Loev,S.J., Margolis,R.L., Young,W.S., Li,S.H., Schilling,G.,
            Ashworth,R.G. and Ross,C.A.
  TITLE     Cloning and expression of the rat atrophin-I (DRPLA disease gene)
            homologue
  JOURNAL   Neurobiol Dis 2 (3), 129-138 (1995)
   PUBMED   9173996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Apr 15, 2021 this sequence version replaced
            XM_003750658.4, XM_006244637.3, NM_017228.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U31777.1, SRR26643290.17925.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000004.1  159254244-159254378 c
            136-303             JAXUCZ010000004.1  159247908-159248075 c
            304-441             JAXUCZ010000004.1  159247622-159247759 c
            442-555             JAXUCZ010000004.1  159247393-159247506 c
            556-2552            JAXUCZ010000004.1  159244175-159246171 c
            2553-2775           JAXUCZ010000004.1  159243808-159244030 c
            2776-3472           JAXUCZ010000004.1  159242872-159243568 c
            3473-3616           JAXUCZ010000004.1  159241727-159241870 c
            3617-3797           JAXUCZ010000004.1  159241246-159241426 c
            3798-4338           JAXUCZ010000004.1  159240573-159241113 c
FEATURES             Location/Qualifiers
     source          1..4338
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4338
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /note="atrophin 1"
                     /db_xref="GeneID:29515"
                     /db_xref="RGD:61832"
     exon            1..135
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            136..303
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..3831
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /note="dentatorubral pallidoluysian atrophy;
                     dentatorubral-pallidoluysian atrophy protein homolog;
                     atrophin-1-like"
                     /codon_start=1
                     /product="atrophin-1"
                     /protein_id="NP_058924.2"
                     /db_xref="GeneID:29515"
                     /db_xref="RGD:61832"
                     /translation="MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSD
                     GKAEKSRQTAKKARVEETSTPKANKQGRSEEISESESEETSAPKKTKTEELPRPQSPS
                     DLDSLDGRSINDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHP
                     PPLFPPSPPPPDSIPRQPESGFEPHPSVPPTGYHAPMEPPTSRLFQGPPPGAPPPHPQ
                     LYPGSAGGGVLSGPPMGPKGGAAASSVGPPSGGKQHPPPTTPIPISSSGASGAPPAKP
                     PNTPVGAGNLPSAPPPATFPHVTPNLPPPPALRPLNNASASPPGMGAQPIPGHLPSPH
                     AMGQGMSGLPPGPEKGPTLAPSPHPLPPASSSAPGPPMRYPYSSCSSSSVAASSSSSA
                     ATSQYPASQTLPSYPHSFPPPTSMSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLL
                     PNNNTHPGPFPPTGGQSTAHPPAPAHHHHQQQQQPQPQPQPQPQQHHHGNSGPPPPGA
                     YPHPLESSNSHHAHPYNMSPSLGSLRPYPPGPAHLPPSHGQVSYSQAGPNGPPVSSSS
                     NSSGSSSQAAYSCSHPSSSQGPQGASYPFPPVPPITTSSATLSTVIATVASSPAGYKT
                     ASPPGPPQYSKRAPSPGSYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPG
                     SPTVGPGPLPPAGPSSLSSLPPPPAAPTTGPPLTATQIKQEPAEEYETPESPVPPARS
                     PSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVR
                     REAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPP
                     FEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNV
                     PALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLA
                     LQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGN
                     DPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPY
                     PAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQR
                     LALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL"
     exon            304..441
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            442..555
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            556..2552
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2775
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..3472
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3616
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3797
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..4338
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgccg ccgccgccgc ggcagcgact gaagccgcgc aacaaggagg ggcggggagt
       61 ggtcgccgcc gtccccggga ggcgccggag ctcgactgca ctcgctgcca gccagccgtc
      121 ccgagccgct cgcagattcc ctgagaacac ccggcaagta ccacgtgcct acaactgctt
      181 ccccggtcac agctgtgggg agcttggggt gcggcagaca agtttctgta ttcagctgcc
      241 caggcagagg agaatggggg ctccacagct tgaagaatga agacacgaca gaataaagac
      301 tcgatgtcaa tgaggagtgg acggaagaaa gaggcccccg ggccccggga agagctgaga
      361 tcgaggggcc gggcctcccc tggaggggtc agcacgtcca gcagtgatgg caaagccgag
      421 aaatccaggc agacagccaa gaaggcccga gtagaggaga cctctacccc aaaagccaac
      481 aagcagggcc ggagcgagga gatctcagag agtgaaagcg aagagaccag tgcgcccaaa
      541 aagaccaaga ccgaggagct tccgcgccca cagtctccct cggatctgga cagcttagat
      601 ggccgcagca tcaacgatga cggcagcagt gaccctagag atatagacca ggacaaccga
      661 agcacatccc ccagcatcta cagccctggc agtgtggaaa atgactcgga ttcatcctct
      721 ggcctgtccc agggcccggc tcgcccctac cacccacctc cactctttcc tccttcccct
      781 ccaccaccag acagcattcc ccgacagcca gagtctggct ttgaaccgca cccttctgtg
      841 ccgcctactg gatatcatgc tccaatggag ccccccacat ctcggttatt ccagggccca
      901 cctcctggag ctcctccccc acacccacag ctctaccctg ggagtgctgg tggaggtgtt
      961 ttatctggac cccccatggg tcccaaaggg ggagcagccg cctcctcagt gggtccccct
     1021 agtgggggca agcagcaccc cccacccact accccaattc caatatcaag ctctggggcc
     1081 agtggcgctc ctccagcaaa gccccccaat actccagtgg gtgctgggaa cttaccttct
     1141 gctccaccac cagctacttt cccccacgtg acaccaaacc tgcctcctcc acctgccctg
     1201 agacccctca acaatgcctc agcctctcct cctggcatgg gggctcagcc aatccctggg
     1261 catctgccct ctccccatgc catggggcag ggtatgagtg gacttcctcc tggcccagag
     1321 aagggcccaa ccctggcccc ctctccccac cctttacccc cggcttcttc ctccgctcct
     1381 gggcccccaa tgcggtaccc gtattcatcc tgctccagta gctctgttgc agcgtcttct
     1441 agttcctccg ccgccacctc ccagtaccca gcttcccaga ccctgcccag ttaccctcac
     1501 tccttccccc caccaacaag tatgtctgtc tctaatcagc cacccaagta cacccagcct
     1561 tctctcccat cccaggctgt gtggagccag ggcccacctc ctcctcctcc ttatggccgc
     1621 ctcttgccca acaacaacac tcatccgggc cctttccctc ctaccggggg tcaatccaca
     1681 gcccacccgc cagcccctgc acatcaccat caccagcagc agcagcagcc acagccacag
     1741 ccacagccac agccgcaaca acatcatcat ggaaactctg ggccccctcc acctggggca
     1801 tatcctcacc ccctagagag cagtaactcc caccatgcac acccttacaa catgtcaccc
     1861 tccctggggt ctttgaggcc ctacccacca gggccagcac acctgcctcc gtctcatggc
     1921 caggtgtctt atagccaagc aggtcccaat ggtcccccgg tttcttcttc ttccaactct
     1981 tccgggtctt cgtctcaagc cgcctattca tgctcacacc cttcttcatc ccagggcccc
     2041 caaggggcat cctacccctt cccaccagtt cctccaatca ccacctcctc agctactctt
     2101 tccactgtca tcgccaccgt ggcttcctcg ccagcaggtt ataagacagc ctcaccacct
     2161 ggcccccctc agtacagcaa gagagcccca tccccagggt cctacaagac agccaccccg
     2221 cctggataca agccagggtc accaccgtcc ttcagaacag ggaccccacc tggctatcga
     2281 ggcacctctc cgccagcagg cccagggacc ttcaagccag gttcacccac cgtggggccg
     2341 gggcccctac cacccgcggg gccttcaagt ttgtcatctc tgcctccacc acccgcggcc
     2401 ccgactacag ggccgcccct gactgccacg cagatcaaac aggaaccagc tgaagagtat
     2461 gaaacccccg agagtccggt gcctccggct cgcagcccct cgccccctcc taaggtggtg
     2521 gacgtgccta gccatgccag ccagtcagcc aggttcaata agcacctgga ccgtggcttc
     2581 aactcgtgcg cgcgcagcga cctgtacttt gtgccgctgg agggatccaa gctggccaag
     2641 aagcgcgcgg acctggtgga gaaagtgcgg cgcgaggccg agcagcgcgc gcgcgaagaa
     2701 aaagagcgcg agcgcgagcg ggaacgtgag aaggagcgcg agcgcgagaa agagcgcgag
     2761 ctggagcgca gtgtgaaatt ggcccaggag ggccgtgctc cagtggagtg cccgtccctg
     2821 ggtccagtgc cccatcggcc tccctttgaa cctggcagcg ctgtggctac cgtgccccct
     2881 tacctgggtc ctgatactcc agccctgcgc actctcagtg aatacgcccg acctcatgtc
     2941 atgtctcctg gcaatcgcaa ccacccattc tatgtgccct tgggggcagt ggacccgggg
     3001 cttctgggtt acaatgtccc agccctgtac agcagcgacc cagctgcccg agaacgggag
     3061 cgggaagccc gtgaacgtga cctccgtgac cggctcaagc ctggctttga ggtgaaacct
     3121 agtgagctgg aacccctaca tggggtcccc gggccaggcc tggatccctt cccccgacac
     3181 gggggcctgg ctctacaacc tgggccacct ggcctgcatc ctttcccttt tcatccgagc
     3241 ctggggcccc tggaacgaga acggctagcg ctggcagctg ggccagccct gcgtcctgac
     3301 atgtcttatg ctgagcggtt ggcagctgaa aggcagcatg cagaaagggt ggcagccctg
     3361 ggcaatgacc cactagcccg gctgcagatg ctcaacgtga ctccccatca tcaccagcac
     3421 tcccacatcc actctcacct acacctgcac cagcaggatg ccatccatgc ggcctccgcc
     3481 tcggtgcacc ctctcattga ccccctggcc tcagggtctc accttacccg gatcccctac
     3541 ccagctggga ccctccctaa tccccttctt cctcaccctc tgcacgagaa cgaagttctt
     3601 cgtcaccagc tctttgctgc cccttaccgg gacctaccgg cctctctatc tgcgccaatg
     3661 tcagccgccc atcagctgca ggccatgcac gcacagtcag ccgagctgca gcgcttggca
     3721 ctggaacagc aacagtggct gcacgctcat cacccattgc acagcgtgcc gctgcctgcc
     3781 caggaggact actacagtca cctgaagaag gagagtgaca agccgctgta gaacctgcca
     3841 tccagacagc acccactgct ccttcatcca gaccttggag gaccaccccc gaccttttga
     3901 ccccatccca cccccaagcc gaggacaggg tgctgcccac ttgcagagct tctgcagccg
     3961 ggcagaggga gggagggaag aagggacaga caaggtcagg gcccggggaa gtggcaaggg
     4021 tggggacaga aagtggacag tatcttggac caggtccctc ctcccatccc ctgcttttct
     4081 tctgtatgcc caatccttgg tggccactgc tcctccccta acccgttggt gtgatttttt
     4141 tcatctgtta gatgtggctg ttttgcgtag cattgtgtgc tgcccctgcc ccatccctgt
     4201 gtgtgcaccc cctcggcgat atgtgcccct tgcccgtccc acattaataa tttatatata
     4261 taaatatcta tatgatgctc tttaaaaaca tcctgaccaa aacatcccaa caaaaacatc
     4321 ctcacggtgc cccaggaa
//
