LOCUS       NP_058924               1184 aa            linear   ROD 31-MAR-2024
DEFINITION  atrophin-1 [Rattus norvegicus].
ACCESSION   NP_058924 XP_003750706 XP_006244699
VERSION     NP_058924.2
DBSOURCE    REFSEQ: accession NM_017228.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1184)
  AUTHORS   Zhang,F., Xu,D., Yuan,L., Sun,Y. and Xu,Z.
  TITLE     Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1
            is required for cortical progenitor maintenance
  JOURNAL   Nat Commun 5, 5815 (2014)
   PUBMED   25519973
  REMARK    GeneRIF: Epigenetic regulation of ATN1 by LSD1 is required for
            cortical progenitor maintenance.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1184)
  AUTHORS   Yu,J., Ying,M., Zhuang,Y., Xu,T., Han,M., Wu,X. and Xu,R.
  TITLE     C-terminal deletion of the atrophin-1 protein results in growth
            retardation but not neurodegeneration in mice
  JOURNAL   Dev Dyn 238 (10), 2471-2478 (2009)
   PUBMED   19681162
REFERENCE   3  (residues 1 to 1184)
  AUTHORS   Hou,R. and Sibinga,N.E.
  TITLE     Atrophin proteins interact with the Fat1 cadherin and regulate
            migration and orientation in vascular smooth muscle cells
  JOURNAL   J Biol Chem 284 (11), 6955-6965 (2009)
   PUBMED   19131340
  REMARK    GeneRIF: Fat1 and Atrs 1,2 act in concert after vascular injury but
            show further that distinct Atr isoforms have disparate effects on
            VSMC directional migration.
REFERENCE   4  (residues 1 to 1184)
  AUTHORS   Redecker,P., Bockmann,J. and Bockers,T.M.
  TITLE     Secretory granules of hypophyseal and pancreatic endocrine cells
            contain proteins of the neuronal postsynaptic density
  JOURNAL   Cell Tissue Res 328 (1), 49-55 (2007)
   PUBMED   17120053
REFERENCE   5  (residues 1 to 1184)
  AUTHORS   Shen,Y., Lee,G., Choe,Y., Zoltewicz,J.S. and Peterson,A.S.
  TITLE     Functional architecture of atrophins
  JOURNAL   J Biol Chem 282 (7), 5037-5044 (2007)
   PUBMED   17150957
REFERENCE   6  (residues 1 to 1184)
  AUTHORS   Okamura-Oho,Y., Miyashita,T., Ohmi,K. and Yamada,M.
  TITLE     Dentatorubral-pallidoluysian atrophy protein interacts through a
            proline-rich region near polyglutamine with the SH3 domain of an
            insulin receptor tyrosine kinase substrate
  JOURNAL   Hum Mol Genet 8 (6), 947-957 (1999)
   PUBMED   10332026
REFERENCE   7  (residues 1 to 1184)
  AUTHORS   Ellerby,L.M., Andrusiak,R.L., Wellington,C.L., Hackam,A.S.,
            Propp,S.S., Wood,J.D., Sharp,A.H., Margolis,R.L., Ross,C.A.,
            Salvesen,G.S., Hayden,M.R. and Bredesen,D.E.
  TITLE     Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates
            cytotoxicity
  JOURNAL   J Biol Chem 274 (13), 8730-8736 (1999)
   PUBMED   10085113
REFERENCE   8  (residues 1 to 1184)
  AUTHORS   Morris-Rosendahl,D.J., Burgert,E., Uyanik,G., Mayerova,A.,
            Duval,F., Macher,J.P. and Crocq,M.A.
  TITLE     Analysis of the CAG repeats in the SCA1 and B37 genes in
            schizophrenic and bipolar I disorder patients: tentative
            association between B37 and schizophrenia
  JOURNAL   Am J Med Genet 74 (3), 324-330 (1997)
   PUBMED   9184318
REFERENCE   9  (residues 1 to 1184)
  AUTHORS   Schmitt,I., Epplen,J.T. and Riess,O.
  TITLE     Predominant neuronal expression of the gene responsible for
            dentatorubral-pallidoluysian atrophy (DRPLA) in rat
  JOURNAL   Hum Mol Genet 4 (9), 1619-1624 (1995)
   PUBMED   8541849
REFERENCE   10 (residues 1 to 1184)
  AUTHORS   Loev,S.J., Margolis,R.L., Young,W.S., Li,S.H., Schilling,G.,
            Ashworth,R.G. and Ross,C.A.
  TITLE     Cloning and expression of the rat atrophin-I (DRPLA disease gene)
            homologue
  JOURNAL   Neurobiol Dis 2 (3), 129-138 (1995)
   PUBMED   9173996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Apr 15, 2021 this sequence version replaced
            XP_003750706.1, XP_006244699.1, NP_058924.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U31777.1, SRR26643290.17925.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     Protein         1..1184
                     /product="atrophin-1"
                     /note="dentatorubral pallidoluysian atrophy;
                     dentatorubral-pallidoluysian atrophy protein homolog;
                     atrophin-1-like"
                     /calculated_mol_wt=124776
     Region          1..1182
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          16..32
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P54258.1)"
     Site            34
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            100
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            102
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Region          511..561
                     /region_name="Involved in binding BAIAP2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P54258.1)"
     Region          618..761
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54258.1)"
     Site            626
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            635
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            647
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            663
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            733
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK8.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            740
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Region          781..856
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54258.1)"
     Region          873..888
                     /region_name="Required for interaction with FAT1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P54258.1)"
     Site            890
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P54259; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     Region          922..941
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54258.1)"
     Region          1027..1035
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P54258.1)"
     Site            1109
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:O35126; propagated from
                     UniProtKB/Swiss-Prot (P54258.1)"
     CDS             1..1184
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /coded_by="NM_017228.3:277..3831"
                     /db_xref="GeneID:29515"
                     /db_xref="RGD:61832"
ORIGIN      
        1 mktrqnkdsm smrsgrkkea pgpreelrsr graspggvst sssdgkaeks rqtakkarve
       61 etstpkankq grseeisese seetsapkkt kteelprpqs psdldsldgr sinddgssdp
      121 rdidqdnrst spsiyspgsv endsdsssgl sqgparpyhp pplfppsppp pdsiprqpes
      181 gfephpsvpp tgyhapmepp tsrlfqgppp gappphpqly pgsagggvls gppmgpkgga
      241 aassvgppsg gkqhpppttp ipisssgasg appakppntp vgagnlpsap ppatfphvtp
      301 nlppppalrp lnnasasppg mgaqpipghl psphamgqgm sglppgpekg ptlapsphpl
      361 ppasssapgp pmrypysscs sssvaassss saatsqypas qtlpsyphsf ppptsmsvsn
      421 qppkytqpsl psqavwsqgp pppppygrll pnnnthpgpf pptggqstah ppapahhhhq
      481 qqqqpqpqpq pqpqqhhhgn sgppppgayp hplessnshh ahpynmspsl gslrpyppgp
      541 ahlppshgqv sysqagpngp pvssssnssg sssqaayscs hpsssqgpqg asypfppvpp
      601 ittssatlst viatvasspa gyktasppgp pqyskrapsp gsyktatppg ykpgsppsfr
      661 tgtppgyrgt sppagpgtfk pgsptvgpgp lppagpssls slppppaapt tgppltatqi
      721 kqepaeeyet pespvppars pspppkvvdv pshasqsarf nkhldrgfns carsdlyfvp
      781 legsklakkr adlvekvrre aeqrareeke rererereke rerekerele rsvklaqegr
      841 apvecpslgp vphrppfepg savatvppyl gpdtpalrtl seyarphvms pgnrnhpfyv
      901 plgavdpgll gynvpalyss dpaarerere arerdlrdrl kpgfevkpse leplhgvpgp
      961 gldpfprhgg lalqpgppgl hpfpfhpslg plererlala agpalrpdms yaerlaaerq
     1021 haervaalgn dplarlqmln vtphhhqhsh ihshlhlhqq daihaasasv hplidplasg
     1081 shltripypa gtlpnpllph plhenevlrh qlfaapyrdl paslsapmsa ahqlqamhaq
     1141 saelqrlale qqqwlhahhp lhsvplpaqe dyyshlkkes dkpl
//
