LOCUS       NM_001394346            4352 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus atrophin 1 (Atn1), mRNA.
ACCESSION   NM_001394346 XM_017592505
VERSION     NM_001394346.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4352)
  AUTHORS   Zhang,F., Xu,D., Yuan,L., Sun,Y. and Xu,Z.
  TITLE     Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1
            is required for cortical progenitor maintenance
  JOURNAL   Nat Commun 5, 5815 (2014)
   PUBMED   25519973
  REMARK    GeneRIF: Epigenetic regulation of ATN1 by LSD1 is required for
            cortical progenitor maintenance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4352)
  AUTHORS   Yu,J., Ying,M., Zhuang,Y., Xu,T., Han,M., Wu,X. and Xu,R.
  TITLE     C-terminal deletion of the atrophin-1 protein results in growth
            retardation but not neurodegeneration in mice
  JOURNAL   Dev Dyn 238 (10), 2471-2478 (2009)
   PUBMED   19681162
REFERENCE   3  (bases 1 to 4352)
  AUTHORS   Hou,R. and Sibinga,N.E.
  TITLE     Atrophin proteins interact with the Fat1 cadherin and regulate
            migration and orientation in vascular smooth muscle cells
  JOURNAL   J Biol Chem 284 (11), 6955-6965 (2009)
   PUBMED   19131340
  REMARK    GeneRIF: Fat1 and Atrs 1,2 act in concert after vascular injury but
            show further that distinct Atr isoforms have disparate effects on
            VSMC directional migration.
REFERENCE   4  (bases 1 to 4352)
  AUTHORS   Redecker,P., Bockmann,J. and Bockers,T.M.
  TITLE     Secretory granules of hypophyseal and pancreatic endocrine cells
            contain proteins of the neuronal postsynaptic density
  JOURNAL   Cell Tissue Res 328 (1), 49-55 (2007)
   PUBMED   17120053
REFERENCE   5  (bases 1 to 4352)
  AUTHORS   Shen,Y., Lee,G., Choe,Y., Zoltewicz,J.S. and Peterson,A.S.
  TITLE     Functional architecture of atrophins
  JOURNAL   J Biol Chem 282 (7), 5037-5044 (2007)
   PUBMED   17150957
REFERENCE   6  (bases 1 to 4352)
  AUTHORS   Okamura-Oho,Y., Miyashita,T., Ohmi,K. and Yamada,M.
  TITLE     Dentatorubral-pallidoluysian atrophy protein interacts through a
            proline-rich region near polyglutamine with the SH3 domain of an
            insulin receptor tyrosine kinase substrate
  JOURNAL   Hum Mol Genet 8 (6), 947-957 (1999)
   PUBMED   10332026
REFERENCE   7  (bases 1 to 4352)
  AUTHORS   Ellerby,L.M., Andrusiak,R.L., Wellington,C.L., Hackam,A.S.,
            Propp,S.S., Wood,J.D., Sharp,A.H., Margolis,R.L., Ross,C.A.,
            Salvesen,G.S., Hayden,M.R. and Bredesen,D.E.
  TITLE     Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates
            cytotoxicity
  JOURNAL   J Biol Chem 274 (13), 8730-8736 (1999)
   PUBMED   10085113
REFERENCE   8  (bases 1 to 4352)
  AUTHORS   Morris-Rosendahl,D.J., Burgert,E., Uyanik,G., Mayerova,A.,
            Duval,F., Macher,J.P. and Crocq,M.A.
  TITLE     Analysis of the CAG repeats in the SCA1 and B37 genes in
            schizophrenic and bipolar I disorder patients: tentative
            association between B37 and schizophrenia
  JOURNAL   Am J Med Genet 74 (3), 324-330 (1997)
   PUBMED   9184318
REFERENCE   9  (bases 1 to 4352)
  AUTHORS   Schmitt,I., Epplen,J.T. and Riess,O.
  TITLE     Predominant neuronal expression of the gene responsible for
            dentatorubral-pallidoluysian atrophy (DRPLA) in rat
  JOURNAL   Hum Mol Genet 4 (9), 1619-1624 (1995)
   PUBMED   8541849
REFERENCE   10 (bases 1 to 4352)
  AUTHORS   Loev,S.J., Margolis,R.L., Young,W.S., Li,S.H., Schilling,G.,
            Ashworth,R.G. and Ross,C.A.
  TITLE     Cloning and expression of the rat atrophin-I (DRPLA disease gene)
            homologue
  JOURNAL   Neurobiol Dis 2 (3), 129-138 (1995)
   PUBMED   9173996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Apr 15, 2021 this sequence version replaced XM_017592505.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.17413.1,
                                           SRR26360190.3330379.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000004.1  159253932-159254080 c
            150-317             JAXUCZ010000004.1  159247908-159248075 c
            318-455             JAXUCZ010000004.1  159247622-159247759 c
            456-569             JAXUCZ010000004.1  159247393-159247506 c
            570-2566            JAXUCZ010000004.1  159244175-159246171 c
            2567-2789           JAXUCZ010000004.1  159243808-159244030 c
            2790-3486           JAXUCZ010000004.1  159242872-159243568 c
            3487-3630           JAXUCZ010000004.1  159241727-159241870 c
            3631-3811           JAXUCZ010000004.1  159241246-159241426 c
            3812-4352           JAXUCZ010000004.1  159240573-159241113 c
FEATURES             Location/Qualifiers
     source          1..4352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4352
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /note="atrophin 1"
                     /db_xref="GeneID:29515"
                     /db_xref="RGD:61832"
     exon            1..149
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            150..317
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..3845
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /note="dentatorubral pallidoluysian atrophy;
                     dentatorubral-pallidoluysian atrophy protein homolog;
                     atrophin-1-like"
                     /codon_start=1
                     /product="atrophin-1"
                     /protein_id="NP_001381275.1"
                     /db_xref="GeneID:29515"
                     /db_xref="RGD:61832"
                     /translation="MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSD
                     GKAEKSRQTAKKARVEETSTPKANKQGRSEEISESESEETSAPKKTKTEELPRPQSPS
                     DLDSLDGRSINDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHP
                     PPLFPPSPPPPDSIPRQPESGFEPHPSVPPTGYHAPMEPPTSRLFQGPPPGAPPPHPQ
                     LYPGSAGGGVLSGPPMGPKGGAAASSVGPPSGGKQHPPPTTPIPISSSGASGAPPAKP
                     PNTPVGAGNLPSAPPPATFPHVTPNLPPPPALRPLNNASASPPGMGAQPIPGHLPSPH
                     AMGQGMSGLPPGPEKGPTLAPSPHPLPPASSSAPGPPMRYPYSSCSSSSVAASSSSSA
                     ATSQYPASQTLPSYPHSFPPPTSMSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLL
                     PNNNTHPGPFPPTGGQSTAHPPAPAHHHHQQQQQPQPQPQPQPQQHHHGNSGPPPPGA
                     YPHPLESSNSHHAHPYNMSPSLGSLRPYPPGPAHLPPSHGQVSYSQAGPNGPPVSSSS
                     NSSGSSSQAAYSCSHPSSSQGPQGASYPFPPVPPITTSSATLSTVIATVASSPAGYKT
                     ASPPGPPQYSKRAPSPGSYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPG
                     SPTVGPGPLPPAGPSSLSSLPPPPAAPTTGPPLTATQIKQEPAEEYETPESPVPPARS
                     PSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVR
                     REAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPP
                     FEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNV
                     PALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLA
                     LQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGN
                     DPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPY
                     PAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQR
                     LALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL"
     exon            318..455
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            456..569
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            570..2566
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2789
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..3486
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3630
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3811
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..4352
                     /gene="Atn1"
                     /gene_synonym="Drpla"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggccgccc ggaggaggga cgcgggcccg ggagtcgcga gctcgggagg tgggggggag
       61 gagggtcttg gtaggagggc tgacggggca gagcgtcgcc aggaccagag cctaaagggg
      121 aggaacgccg aggtggagac ttggcggaga ttccctgaga acacccggca agtaccacgt
      181 gcctacaact gcttccccgg tcacagctgt ggggagcttg gggtgcggca gacaagtttc
      241 tgtattcagc tgcccaggca gaggagaatg ggggctccac agcttgaaga atgaagacac
      301 gacagaataa agactcgatg tcaatgagga gtggacggaa gaaagaggcc cccgggcccc
      361 gggaagagct gagatcgagg ggccgggcct cccctggagg ggtcagcacg tccagcagtg
      421 atggcaaagc cgagaaatcc aggcagacag ccaagaaggc ccgagtagag gagacctcta
      481 ccccaaaagc caacaagcag ggccggagcg aggagatctc agagagtgaa agcgaagaga
      541 ccagtgcgcc caaaaagacc aagaccgagg agcttccgcg cccacagtct ccctcggatc
      601 tggacagctt agatggccgc agcatcaacg atgacggcag cagtgaccct agagatatag
      661 accaggacaa ccgaagcaca tcccccagca tctacagccc tggcagtgtg gaaaatgact
      721 cggattcatc ctctggcctg tcccagggcc cggctcgccc ctaccaccca cctccactct
      781 ttcctccttc ccctccacca ccagacagca ttccccgaca gccagagtct ggctttgaac
      841 cgcacccttc tgtgccgcct actggatatc atgctccaat ggagcccccc acatctcggt
      901 tattccaggg cccacctcct ggagctcctc ccccacaccc acagctctac cctgggagtg
      961 ctggtggagg tgttttatct ggacccccca tgggtcccaa agggggagca gccgcctcct
     1021 cagtgggtcc ccctagtggg ggcaagcagc accccccacc cactacccca attccaatat
     1081 caagctctgg ggccagtggc gctcctccag caaagccccc caatactcca gtgggtgctg
     1141 ggaacttacc ttctgctcca ccaccagcta ctttccccca cgtgacacca aacctgcctc
     1201 ctccacctgc cctgagaccc ctcaacaatg cctcagcctc tcctcctggc atgggggctc
     1261 agccaatccc tgggcatctg ccctctcccc atgccatggg gcagggtatg agtggacttc
     1321 ctcctggccc agagaagggc ccaaccctgg ccccctctcc ccacccttta cccccggctt
     1381 cttcctccgc tcctgggccc ccaatgcggt acccgtattc atcctgctcc agtagctctg
     1441 ttgcagcgtc ttctagttcc tccgccgcca cctcccagta cccagcttcc cagaccctgc
     1501 ccagttaccc tcactccttc cccccaccaa caagtatgtc tgtctctaat cagccaccca
     1561 agtacaccca gccttctctc ccatcccagg ctgtgtggag ccagggccca cctcctcctc
     1621 ctccttatgg ccgcctcttg cccaacaaca acactcatcc gggccctttc cctcctaccg
     1681 ggggtcaatc cacagcccac ccgccagccc ctgcacatca ccatcaccag cagcagcagc
     1741 agccacagcc acagccacag ccacagccgc aacaacatca tcatggaaac tctgggcccc
     1801 ctccacctgg ggcatatcct caccccctag agagcagtaa ctcccaccat gcacaccctt
     1861 acaacatgtc accctccctg gggtctttga ggccctaccc accagggcca gcacacctgc
     1921 ctccgtctca tggccaggtg tcttatagcc aagcaggtcc caatggtccc ccggtttctt
     1981 cttcttccaa ctcttccggg tcttcgtctc aagccgccta ttcatgctca cacccttctt
     2041 catcccaggg cccccaaggg gcatcctacc ccttcccacc agttcctcca atcaccacct
     2101 cctcagctac tctttccact gtcatcgcca ccgtggcttc ctcgccagca ggttataaga
     2161 cagcctcacc acctggcccc cctcagtaca gcaagagagc cccatcccca gggtcctaca
     2221 agacagccac cccgcctgga tacaagccag ggtcaccacc gtccttcaga acagggaccc
     2281 cacctggcta tcgaggcacc tctccgccag caggcccagg gaccttcaag ccaggttcac
     2341 ccaccgtggg gccggggccc ctaccacccg cggggccttc aagtttgtca tctctgcctc
     2401 caccacccgc ggccccgact acagggccgc ccctgactgc cacgcagatc aaacaggaac
     2461 cagctgaaga gtatgaaacc cccgagagtc cggtgcctcc ggctcgcagc ccctcgcccc
     2521 ctcctaaggt ggtggacgtg cctagccatg ccagccagtc agccaggttc aataagcacc
     2581 tggaccgtgg cttcaactcg tgcgcgcgca gcgacctgta ctttgtgccg ctggagggat
     2641 ccaagctggc caagaagcgc gcggacctgg tggagaaagt gcggcgcgag gccgagcagc
     2701 gcgcgcgcga agaaaaagag cgcgagcgcg agcgggaacg tgagaaggag cgcgagcgcg
     2761 agaaagagcg cgagctggag cgcagtgtga aattggccca ggagggccgt gctccagtgg
     2821 agtgcccgtc cctgggtcca gtgccccatc ggcctccctt tgaacctggc agcgctgtgg
     2881 ctaccgtgcc cccttacctg ggtcctgata ctccagccct gcgcactctc agtgaatacg
     2941 cccgacctca tgtcatgtct cctggcaatc gcaaccaccc attctatgtg cccttggggg
     3001 cagtggaccc ggggcttctg ggttacaatg tcccagccct gtacagcagc gacccagctg
     3061 cccgagaacg ggagcgggaa gcccgtgaac gtgacctccg tgaccggctc aagcctggct
     3121 ttgaggtgaa acctagtgag ctggaacccc tacatggggt ccccgggcca ggcctggatc
     3181 ccttcccccg acacgggggc ctggctctac aacctgggcc acctggcctg catcctttcc
     3241 cttttcatcc gagcctgggg cccctggaac gagaacggct agcgctggca gctgggccag
     3301 ccctgcgtcc tgacatgtct tatgctgagc ggttggcagc tgaaaggcag catgcagaaa
     3361 gggtggcagc cctgggcaat gacccactag cccggctgca gatgctcaac gtgactcccc
     3421 atcatcacca gcactcccac atccactctc acctacacct gcaccagcag gatgccatcc
     3481 atgcggcctc cgcctcggtg caccctctca ttgaccccct ggcctcaggg tctcacctta
     3541 cccggatccc ctacccagct gggaccctcc ctaatcccct tcttcctcac cctctgcacg
     3601 agaacgaagt tcttcgtcac cagctctttg ctgcccctta ccgggaccta ccggcctctc
     3661 tatctgcgcc aatgtcagcc gcccatcagc tgcaggccat gcacgcacag tcagccgagc
     3721 tgcagcgctt ggcactggaa cagcaacagt ggctgcacgc tcatcaccca ttgcacagcg
     3781 tgccgctgcc tgcccaggag gactactaca gtcacctgaa gaaggagagt gacaagccgc
     3841 tgtagaacct gccatccaga cagcacccac tgctccttca tccagacctt ggaggaccac
     3901 ccccgacctt ttgaccccat cccaccccca agccgaggac agggtgctgc ccacttgcag
     3961 agcttctgca gccgggcaga gggagggagg gaagaaggga cagacaaggt cagggcccgg
     4021 ggaagtggca agggtgggga cagaaagtgg acagtatctt ggaccaggtc cctcctccca
     4081 tcccctgctt ttcttctgta tgcccaatcc ttggtggcca ctgctcctcc cctaacccgt
     4141 tggtgtgatt tttttcatct gttagatgtg gctgttttgc gtagcattgt gtgctgcccc
     4201 tgccccatcc ctgtgtgtgc accccctcgg cgatatgtgc cccttgcccg tcccacatta
     4261 ataatttata tatataaata tctatatgat gctctttaaa aacatcctga ccaaaacatc
     4321 ccaacaaaaa catcctcacg gtgccccagg aa
//
