LOCUS       NM_001106821            9756 bp    mRNA    linear   ROD 12-MAR-2025
DEFINITION  Rattus norvegicus ATM serine/threonine kinase (Atm), mRNA.
ACCESSION   NM_001106821 XM_001068795 XM_236275
VERSION     NM_001106821.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9756)
  AUTHORS   He,T., You,M., Zhu,H., Chen,P. and Fang,S.
  TITLE     CCCTC-binding factor suppresses alpha-2-macroglobulin transcription
            to improve vascular endothelial cell functions in lower extremity
            arteriosclerosis obliterans
  JOURNAL   Gen Physiol Biophys 43 (3), 231-242 (2024)
   PUBMED   38774923
  REMARK    GeneRIF: CCCTC-binding factor suppresses alpha-2-macroglobulin
            transcription to improve vascular endothelial cell functions in
            lower extremity arteriosclerosis obliterans.
REFERENCE   2  (bases 1 to 9756)
  AUTHORS   Cho,S.O., Lim,J.W. and Kim,H.
  TITLE     Oxidative stress induces apoptosis via calpain- and
            caspase-3-mediated cleavage of ATM in pancreatic acinar cells
  JOURNAL   Free Radic Res 54 (11-12), 799-809 (2020)
   PUBMED   31401888
  REMARK    GeneRIF: Oxidative stress induces apoptosis via calpain- and
            caspase-3-mediated cleavage of ATM in pancreatic acinar cells.
REFERENCE   3  (bases 1 to 9756)
  AUTHORS   Uhlemeyer,C., Muller,N., Griess,K., Wessel,C., Schlegel,C.,
            Kuboth,J. and Belgardt,B.F.
  TITLE     ATM and P53 differentially regulate pancreatic beta cell survival
            in Ins1E cells
  JOURNAL   PLoS One 15 (8), e0237669 (2020)
   PUBMED   32810137
  REMARK    GeneRIF: ATM and P53 differentially regulate pancreatic beta cell
            survival in Ins1E cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9756)
  AUTHORS   Zhao,J., Nguyen,L.N.T., Nguyen,L.N., Dang,X., Cao,D., Khanal,S.,
            Schank,M., Thakuri,B.K.C., Ogbu,S.C., Morrison,Z.D., Wu,X.Y.,
            Li,Z., Zou,Y., El Gazzar,M., Ning,S., Wang,L., Moorman,J.P. and
            Yao,Z.Q.
  TITLE     ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and
            Premature T Cell Aging in HIV-Infected Individuals on
            Antiretroviral Therapy
  JOURNAL   Front Immunol 10, 2531 (2019)
   PUBMED   31781094
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9756)
  AUTHORS   Warren,R., Domm,W., Yee,M., Campbell,A., Malone,J., Wright,T.,
            Mayer-Proschel,M. and O'Reilly,M.A.
  TITLE     Ataxia-telangiectasia mutated is required for the development of
            protective immune memory after influenza A virus infection
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 317 (5), L591-L601 (2019)
   PUBMED   31509427
REFERENCE   6  (bases 1 to 9756)
  AUTHORS   Hirao,A., Kong,Y.Y., Matsuoka,S., Wakeham,A., Ruland,J.,
            Yoshida,H., Liu,D., Elledge,S.J. and Mak,T.W.
  TITLE     DNA damage-induced activation of p53 by the checkpoint kinase Chk2
  JOURNAL   Science 287 (5459), 1824-1827 (2000)
   PUBMED   10710310
REFERENCE   7  (bases 1 to 9756)
  AUTHORS   Chong,M.J., Murray,M.R., Gosink,E.C., Russell,H.R., Srinivasan,A.,
            Kapsetaki,M., Korsmeyer,S.J. and McKinnon,P.J.
  TITLE     Atm and Bax cooperate in ionizing radiation-induced apoptosis in
            the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 889-894 (2000)
   PUBMED   10639175
REFERENCE   8  (bases 1 to 9756)
  AUTHORS   Tibbetts,R.S., Brumbaugh,K.M., Williams,J.M., Sarkaria,J.N.,
            Cliby,W.A., Shieh,S.Y., Taya,Y., Prives,C. and Abraham,R.T.
  TITLE     A role for ATR in the DNA damage-induced phosphorylation of p53
  JOURNAL   Genes Dev 13 (2), 152-157 (1999)
   PUBMED   9925639
REFERENCE   9  (bases 1 to 9756)
  AUTHORS   Canman,C.E., Lim,D.S., Cimprich,K.A., Taya,Y., Tamai,K.,
            Sakaguchi,K., Appella,E., Kastan,M.B. and Siliciano,J.D.
  TITLE     Activation of the ATM kinase by ionizing radiation and
            phosphorylation of p53
  JOURNAL   Science 281 (5383), 1677-1679 (1998)
   PUBMED   9733515
REFERENCE   10 (bases 1 to 9756)
  AUTHORS   Xu,Y., Ashley,T., Brainerd,E.E., Bronson,R.T., Meyn,M.S. and
            Baltimore,D.
  TITLE     Targeted disruption of ATM leads to growth retardation, chromosomal
            fragmentation during meiosis, immune defects, and thymic lymphoma
  JOURNAL   Genes Dev 10 (19), 2411-2422 (1996)
   PUBMED   8843194
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068795.1, XM_236275.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..9756
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..9756
                     /gene="Atm"
                     /note="ATM serine/threonine kinase"
                     /db_xref="GeneID:300711"
                     /db_xref="RGD:1593265"
     exon            1..194
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            195..296
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..9419
                     /gene="Atm"
                     /EC_number="2.7.11.1"
                     /note="Ataxia telangiectasia gene mutated in human beings;
                     ataxia telangiectasia mutated homolog"
                     /codon_start=1
                     /product="serine-protein kinase ATM"
                     /protein_id="NP_001100291.1"
                     /db_xref="GeneID:300711"
                     /db_xref="RGD:1593265"
                     /translation="MSLALNDLLICCRQLEHDRATERRKEVDKFKRLIQDPETVQHLD
                     RHSDSKQGKYLNWDAVFRFLQKYIQKETESLRTAKSNVSASTQTSRQKKMQEISSLVR
                     FFIKCANKRAPRLKCQDLLNYVMDTVKDSSNGATYGADCSNILLKDILSVRKYWCEVS
                     QQQWLELFSLYIRLYLKPSQDINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQ
                     YARQEKSSPGLSHILAALNIFLKTLAVNFRKRVCEIGDEILPTLLYIWTQHRLNDSLK
                     EVIIELIHLQIYIHHPQGAKAPEEGAYESMKWKRILYNLYDLLVNEISHIGSRGKYSS
                     GSRNIAVKENLIDLMADVCYQLFNADTRSVEISQSYATQRESTDYSVPCKRRKIDIGW
                     EVIKDYLQKSQNDFDLVPWLQITTRLISKYPSSLPNCELSPLILILYQLLPQQRRGER
                     IPHVLRCLTEVALCQGKKSNLESSQKSDLLKLWIKIWSITFRGISSEQTQTENFGLLG
                     AIIQGSLVELDREFWKLFTGSACKPSSPSVRCLTLALSMCVVPDAIKMGTEQSVCDAN
                     RSFSVKESIMRWLLFYQLEGDLEDSAEPPPILQSNFPHLILEKILVSLTMKNSKAAMK
                     FFQSAPECEQHCEDTEEPSFSEAEELFLQTTFDKMDFLTPVKEDTVEKFQSRVGFSVH
                     QNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGVITEDEAY
                     KSELFQKAKSLMQCAGESISLFKNKTNEESRVGSLRSVIHLCTSCLCRHTKHTLNKIA
                     SGFFLRLLTSKLMNDIADICKSLASCTKKPFDYGEEHSLRDDDDDGDGGDGGESLMET
                     QGSSSTDLFSDYSASTVSDANDYGENQNAVGAANPLTADWLSRQDHLLLDMLRFLCLS
                     VTACQSRTASFRGADIRRKLLMLLDPSTLDLTKSLHLHMYLVLLKDLPGKEHLLPMED
                     VVELLQPLSLVCSLYRRDQDVCKTILSNVLHIVTNLGQGSVDTESTRNAQGQFLTVMG
                     AFWHLTKEKKCIFSVRMALVKCLQTLLEADPYSKWAILNVKGQDFPVREAFPQFLADG
                     HHHVRMLAAGSISRLFQDMRQGDSSRSLKALPLKFQQTSFNSAYMIAEAGIRELLCDS
                     QNPDLLDEIYNRKSVLLTVIAVVLHCSPICEKQALFALCKSVKENGLEPHLVKKVLEK
                     VSESFGCRCLEDFMASHLDYLVLEWLNLQDAKYSLSSFPFTLLNYMSVEDFYRSCYKI
                     LIPHLVIRKHFDEVKSIANQIQRCWKSLLIDCFPKMLVHILPYFACEGTGDSSSAQKR
                     ETATEVYDTLKGEDFLGKQIDQVFISNLPEIVVELLMTLHETADSDSGQSPDLCDFSG
                     DLDPAPNPPYFPSHVIKATFAYISSCHKTKFKSILEILSKIPDSYQKILLAICEQAAE
                     TNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDV
                     SLRSFSLCCDLLSRVCRTAVTHCKDALENHLHVIVGTLIPLVDYQEVQEQVLDLLKYL
                     VIDNKDNKNLFVTIKLLDPFPDHVVFKDLRLTQQKIKYSGGPFTLLEEINHFLSVSAY
                     NPLPLTRLEGLKDLRRQLEQHKDQMLDLVRASQDNPQDGIVVKLVVSLLQLSKMAVNQ
                     TGEREVLEAVGRCLGEIGPLDFSTIAVQHSKDTPYTKAYGLPEDRELQWTLIMLTALN
                     NTLVEDSVKIRSAAATCLKNILATKTGHIFWENHKTSADPMLTYLQPFRASRKKFLEL
                     PQFVKEDALEGLDDVNLWVPQSESHDIWIKTLTCAFLDSGGIKSEILQLLKPMCEVKT
                     DFCQMVLPYLIHDVLLQDTHESWRTLLSTHVRGFFTNCFKHSSQASRSATPANSDSES
                     ENFLRCCLDKKSQRTMLAVVDYLRRQKRPSSGTAFEDAFWLDLNYLEVAKVAQSCAAH
                     FTALLYAEIYSDKKNMDEQEKRSPTFEEGSQGTTISSLSEKSKEETGISLQDLLLEIY
                     RSIGEPDSLYGCGGGKVLQPLTRIRTYEHEATWEKALVTYDLETTISSSTRQSGIIQA
                     LQNLGLSHILSIYLKGLDHERREWCGELQELHYQAAWRNMQWDLCTSANQELEGTSYH
                     ESLYNALQCLRNREFSTFYDSLRHARVKEVEELSKGSLESVYSLYPTLSRLQAVGELE
                     NSGELFSRSVTDRERSEVYLKWQKHSQLLKDSDFSFQEPLMALRTVILEILVQKEMEN
                     SQGGCSKDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNPAICGISEWHLEEAQVF
                     WAKKEQSLALSILKQMIKKLDSSFREVCNEAGLKGLHAECLRVCGNWLAETCLENPAV
                     IMQTYLEKAVKVAGSYDGDSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQ
                     ALLKRAKEEVGLIREHKIQTNRYTIKVQRELELDECALRALKEDRKRFLCKAVENYIS
                     CLLSGEEHDLWVFRLCSLWLENSGVSEVNGMMKRDGMKISSYKFLPLMYQLAARMGTK
                     MTGGLGFHEVLNNLISRISMDHPHHTLFIILALANANKDEFLSKPETARRGRITKNAP
                     KESSQLDEDRAEAASRIIHTIRSARRTMVKDMEALCDAYIILANLDASQWRNQRKGIS
                     IPANQPITKLKNLEDVVVPTMEIKVDPTGEYEKLVTIKSFKTEFRLAGGLNLPKIIDC
                     VGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNMLLQRNTETRKRKLTICTYKVVPLSQ
                     RSGVLEWCTGTIPIGEYLVNNEEGAHKRYRPNDLSANQCQKKMMEVQKKSFEEKYETF
                     MTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILI
                     NEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTME
                     VMRSSQEALLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETDLQSTPSADDQECKRS
                     LSDTDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFPGW
                     KAWV"
     exon            297..409
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            410..555
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            556..720
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            721..886
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1125
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1289
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1456
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1828
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2023
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2119
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2345
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2471
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2597
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2687
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2883
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3083
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3166
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3322
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3398
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3529
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3650
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3824
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3994
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            3995..4241
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4242..4357
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4358..4484
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4684
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..4856
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..5021
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5154
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5250
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5251..5422
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5423..5564
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..5741
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5742..5919
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            5920..6007
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6008..6163
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6164..6251
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6252..6340
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6341..6443
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6444..6592
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6593..6697
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6698..6817
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            6818..7052
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7053..7226
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7227..7340
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7341..7555
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7556..7763
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7764..7877
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            7878..8036
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8037..8175
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8176..8258
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8259..8399
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8400..8516
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8517..8666
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8667..8832
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8833..8919
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            8920..9034
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            9035..9098
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            9099..9235
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
     exon            9236..9756
                     /gene="Atm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgtcacc ttaagggttc tcgtcgacct aggagatttt ttttttatct cacactttag
       61 tctcagaccg tttatttcta tttaagctac aggtttgcat ttgttcgtag ttaagagcac
      121 tggctaggaa atcacagcct cgagagttcg aattcttatt gccagttgta ttacctgtgc
      181 tgtcttttag tgaggtgagg atgcacgttc tgaaatccta aaccatgagt ctagcgctga
      241 atgacctgct catctgctgc cggcagttag aacatgacag ggctacagaa cgaaggaaag
      301 aagtggataa atttaagcgc ctgattcagg atcctgaaac agttcaacat ttggataggc
      361 attctgactc caaacaaggg aaatatctga attgggatgc tgttttcagg tttttgcaga
      421 agtacattca aaaggaaaca gaaagtctta gaacagcaaa atcaaatgtc tcagcctcta
      481 cacaaacctc cagacagaag aagatgcaag agattagcag tctggtcaga ttcttcatca
      541 aatgtgcaaa taaaagagca cccaggctaa aatgtcagga cctcttgaat tacgtcatgg
      601 atacagtgaa agactcatct aatggcgcaa cttacggagc tgactgcagc aacattcttc
      661 tcaaagacat cctgtctgtg aggaaatact ggtgtgaagt gtctcagcag cagtggctag
      721 aattgttttc cctgtacatc aggctgtatc tcaaaccatc acaggacatt aatagagttt
      781 tagtggctag aataattcat gctgtcacca gaggatgctg ctcacagact gatggattac
      841 cttcaaagtt cttagatctt ttttccaagg ctattcagta tgccagacag gaaaagagct
      901 ctcctggctt aagtcacatc ttagcagccc ttaacatttt cctcaagact ttggctgtca
      961 acttccgaaa gcgggtgtgt gaaataggag atgaaattct tcctacctta ctgtatattt
     1021 ggactcaaca tcgacttaat gactccttaa aagaagtaat tattgaacta attcacctgc
     1081 agatttacat ccatcatcca cagggagcca aagcgcctga ggaaggtgct tatgaatcca
     1141 tgaaatggaa aaggatcttg tacaacttat acgacctgct ggtgaatgag ataagtcaca
     1201 taggaagcag agggaaatac tcctcaggat ctcgtaatat tgctgtcaag gaaaatttga
     1261 ttgacttgat ggcagatgtc tgttaccagc tttttaatgc agataccaga tccgtggaga
     1321 tttctcagtc ttatgcgaca caaagggaat ccactgacta cagtgtacct tgcaaaagaa
     1381 ggaaaataga cataggctgg gaagtgataa aagattatct tcagaagtca cagaatgatt
     1441 ttgatcttgt gccatggcta cagattacaa cccgattaat atcaaaatat ccttccagtt
     1501 tgcctaactg tgagctgtct ccattaatac tgatcctgta ccagcttctg cctcaacagc
     1561 ggcgtggaga acgcatccca catgtgttac gatgccttac cgaagttgcc ttatgtcaag
     1621 gcaagaaatc aaacctagaa agctctcaaa agtcagattt attgaaacta tggattaaaa
     1681 tttggtctat tacctttcgt ggtataagtt ctgaacaaac acaaactgaa aactttggtt
     1741 tacttggggc cattattcaa ggtagtttag ttgaacttga cagagaattc tggaagttat
     1801 ttactggctc agcctgtaaa ccttcaagtc cttcagttcg ctgcttgact ttggcgctta
     1861 gcatgtgtgt agttccagat gcaataaaaa tgggaacaga acaaagtgtg tgtgacgcaa
     1921 atagaagttt ttctgtgaag gagtcgataa tgaggtggct cttattctac cagttagagg
     1981 gcgacttgga agacagcgca gagccgcctc ccattctcca gagtaatttc cctcatctca
     2041 tactggaaaa aattcttgta agtctcacta tgaaaaactc aaaagctgca atgaagtttt
     2101 ttcaaagtgc cccagaatgt gagcagcact gtgaagatac agaagagcct tcgttctcag
     2161 aagcggaaga actgtttctc cagacaactt ttgacaagat ggatttttta actcctgtca
     2221 aagaagatac tgtagaaaaa tttcaatctc gtgttggctt ctctgtccac caaaatctca
     2281 aggaatcact ggatcattat cttctgggat tatcagaaca gcttttaagt aattactctt
     2341 ctgagattac aagttcagaa acccttgtcc ggtgttcgag tcttctggtg ggtgttcttg
     2401 gctgctattg ttacatgggt gtaataactg aagacgaagc atataaatca gaattattcc
     2461 agaaagccaa gtctctgatg cagtgtgcag gggaaagtat ctctttgttt aaaaataaga
     2521 caaatgagga gtccagagtt ggttcactga gaagtgtgat acatctgtgt acaagttgct
     2581 tgtgtagaca taccaagcac actctaaaca agatagcctc tggctttttc ctgcgattat
     2641 taacgtccaa gctcatgaat gacattgcag atatttgtaa aagcttggca tcctgtacga
     2701 aaaagccatt tgactatgga gaggagcatt cgttgagaga tgatgatgat gatggtgatg
     2761 gtggtgatgg tggtgaaagt ctgatggaga cacagggttc atcatccaca gatctattta
     2821 gcgattactc tgctagtact gtgagcgatg caaacgatta tggagagaac cagaatgctg
     2881 ttggtgccgc gaatcctcta actgctgact ggctgtccag acaagatcat cttcttttag
     2941 acatgctcag gttcttgtgc ctctctgtaa ctgcatgtca gagccggact gcgtctttca
     3001 gaggagctga tattagaaga aagttgttaa tgttactcga tcctagcaca ctcgatctca
     3061 ctaaatccct acacctacac atgtacttgg tgcttttgaa ggatctccct ggaaaagagc
     3121 atttgttgcc aatggaagat gttgttgaac ttctgcagcc attatccctt gtatgttctc
     3181 tgtatcggcg tgaccaagat gtctgcaaga cgattttaag caatgtcctc catatagtga
     3241 caaacctagg tcagggcagc gtggacacag agagcacaag gaatgctcaa ggacagttcc
     3301 tgacagtgat gggagcattt tggcatttaa caaaggaaaa gaaatgtata ttctctgtca
     3361 gaatggcgtt agtaaagtgt cttcaaacac tgcttgaggc tgatccatat tccaagtggg
     3421 cgattcttaa tgtaaaggga caggactttc ctgtacgtga agcatttcca cagtttcttg
     3481 ctgacggtca ccatcacgtt cggatgttgg ctgcggggtc gatcagcaga ttattccagg
     3541 atatgagaca aggtgattcc tccagaagct tgaaagcact tcctctgaag tttcagcaga
     3601 catctttcaa cagtgcatac atgatagcag aggcaggaat cagagaactg ttatgtgatt
     3661 ctcagaaccc tgatcttctg gatgagattt ataatagaaa atccgtattg ctgacggtga
     3721 tagctgtggt cttgcactgt agcccaatct gtgaaaagca ggctttgttt gccttatgca
     3781 aatctgtgaa ggaaaatgga ctagaacccc atcttgtgaa aaaggttttg gagaaagtct
     3841 ccgagtcgtt tggatgtagg tgcttagagg acttcatggc ttctcatcta gattacttgg
     3901 ttttggaatg gctgaacctt caagatgcta aatacagctt atcttccttt ccttttacgt
     3961 tattaaacta catgagcgtg gaggatttct atagatcttg ttacaagatt ctgattccac
     4021 acttggtaat tagaaagcac tttgatgagg tgaagtccat tgctaatcag attcagaggt
     4081 gctggaaaag cctgctgatc gactgctttc caaagatgct tgtgcacatc cttccgtact
     4141 ttgcctgtga gggcacgggg gacagcagct cggcacagaa gagggagact gctaccgagg
     4201 tctacgatac tcttaaaggt gaagacttcc taggaaaaca gattgatcaa gtattcatta
     4261 gtaatttgcc agagatcgtg gtggagctgc ttatgacgtt gcatgaaacg gctgactcgg
     4321 attccggtca aagccccgac ctctgcgatt tttcagggga tttggatccc gctcccaatc
     4381 caccatattt cccgtcacat gtcattaagg caacatttgc ctacatcagc agctgtcata
     4441 aaaccaagtt taaaagcatt ctagaaatcc tttctaaaat ccctgattcc tatcagaaaa
     4501 tactcctggc catttgtgaa caagcagctg agacaaataa tgtctttaaa aagcacagaa
     4561 ttcttaaaat ataccacctg tttgttagtt tattactgaa agacatacag agtggcttgg
     4621 gaggagcttg ggcctttgtt ctccgagatg ttatttatac tttgattcac tatatcaaca
     4681 aaaggtcttc ccatttcact gacgtgtcat tacgtagctt ctccctgtgc tgtgacctat
     4741 taagtcgagt ttgccgtaca gcggtaactc actgtaagga cgccctagaa aaccatcttc
     4801 atgttattgt gggcacactt ataccccttg tggattatca ggaggttcaa gaacaggtat
     4861 tggacctgtt gaagtacttg gtgatagata acaaagacaa taaaaacctc tttgtcacaa
     4921 ttaagcttct ggatccgttt cctgaccatg ttgtttttaa ggatttgcgt cttactcaac
     4981 agaagataaa atatagtgga ggacccttta cactcttaga ggaaataaac cattttctct
     5041 cagtaagtgc ttataatcca cttccactga ccagactcga aggactgaag gatcttcgga
     5101 gacaactgga acagcataaa gatcagatgc tagatcttgt gagagcatct caggataacc
     5161 cacaagatgg cattgtggtg aagctggttg tcagcttgtt gcagctatcc aagatggcag
     5221 tgaaccagac tggtgaaaga gaagttttag aggctgtcgg caggtgtttg ggagaaatcg
     5281 gtcctctgga tttctctact atagctgtac agcatagcaa agatacgccg tacaccaaag
     5341 cctacgggtt acctgaagac agagaacttc agtggacctt gataatgctg actgccctga
     5401 acaacaccct ggtggaggac agtgtcaaaa ttcgatcagc tgctgctacc tgtttgaaaa
     5461 acattttggc taccaagacc ggacatattt tctgggagaa tcataagaca tcagcggatc
     5521 caatgctgac ctatctgcag cctttcagag cgtcgaggaa aaagttttta gaattacccc
     5581 agtttgttaa agaagatgct ttagaaggcc tggatgatgt aaatctgtgg gttcctcaaa
     5641 gtgaaagcca tgacatttgg ataaagactc tgacttgtgc ctttttggac agtggaggca
     5701 taaaaagcga aattcttcag ttactaaagc caatgtgtga agtgaaaact gacttttgtc
     5761 agatggtgct gccatacttg atccatgatg ttttactcca agatacacat gagtcgtgga
     5821 gaactctgct atctacacac gtccgaggat ttttcactaa ctgttttaaa cattcctccc
     5881 aagcaagccg ctcagcgact cccgcaaatt cggattcaga gtcagagaac tttctccgat
     5941 gctgtttgga taaaaaatca caaagaacca tgctcgctgt tgtcgactac ctgagaaggc
     6001 aaaagaggcc ttcctcagga acagctttcg aggatgcctt ctggctagat ttgaattatc
     6061 ttgaggttgc aaaggtggct caatcctgtg cagctcactt cacagcactg ctctatgcag
     6121 agatctattc agataagaaa aacatggatg agcaagagaa aagaagtcca acatttgaag
     6181 aaggaagtca aggtacaact atttctagtt tgagtgaaaa aagtaaagaa gaaactggaa
     6241 taagcttaca ggatcttctc ttggagatct acagaagtat aggagagcca gacagcctgt
     6301 atggctgcgg gggagggaaa gtgttacaac cccttacccg aataaggacg tacgagcatg
     6361 aagcaacgtg ggagaaagcc ttagtgacat acgaccttga gaccaccatc tcctcctcca
     6421 cccgccagtc gggaatcatc caggccttgc agaacttggg gctctcccat attctttcta
     6481 tctacttgaa aggattggac catgaaagga gagagtggtg tggggaactg caggagcttc
     6541 attaccaggc ggcgtggagg aacatgcagt gggacctctg cacttctgcc aaccaagaac
     6601 tagaaggaac cagttaccac gaatcgttgt ataatgctct gcagtgccta agaaacagag
     6661 aattctccac attttatgac agtctccgac atgccagggt gaaggaagtt gaagagttga
     6721 gcaaaggcag ccttgaatcg gtatattcgc tgtaccccac acttagcaga ttgcaggcag
     6781 tcggagaact ggaaaacagt ggagagctct tctcaaggtc agtcacagac agagagcgct
     6841 ctgaggtata cctgaagtgg cagaagcact cccagcttct gaaggacagt gacttcagct
     6901 ttcaggagcc tctcatggct ctccgcacag tcattctgga gatcctggta caaaaggaaa
     6961 tggagaactc tcaaggagga tgctctaagg acattctcac caaacacctt gttgaattct
     7021 ctgttctggc ccgaaccttc aagaatacac agctccctga aagagcaata tttaaaatta
     7081 agcaatataa tccagctatt tgcggaatct ctgaatggca tttggaagaa gcacaagtat
     7141 tttgggcaaa gaaggagcag agtcttgccc tgagtatcct caagcaaatg atcaagaagt
     7201 tggactccag ctttagagag gtgtgtaatg aagcaggtct aaaaggccta cacgcagagt
     7261 gtctgagggt ttgtggcaac tggctggcag agacttgcct agaaaatcct gcagtcatca
     7321 tgcagaccta tctagaaaag gcagtgaagg ttgctggcag ttatgatggc gacagccgag
     7381 agctcagaaa tggacagatg aaggccttcc tctcattagc gcggttctct gatacgcagt
     7441 accagaggat tgagaactac atgaagtcgt ccgaattcga aaacaagcaa gctctcttaa
     7501 aaagagccaa ggaagaagtg ggtcttataa gggagcataa aattcagacg aacagataca
     7561 caataaaggt tcagagagaa ctggagctag atgaatgtgc tctccgtgca ctgaaagagg
     7621 accgtaaacg cttcctgtgt aaagcagttg agaactacat cagctgctta ctaagcggag
     7681 aagaacatga tctgtgggtg ttccgactct gctccctctg gctggaaaat tctggagtct
     7741 ctgaagtcaa tggcatgatg aagagagatg gaatgaagat ttcctcctat aagtttttgc
     7801 ctctcatgta ccaattggct gctagaatgg ggaccaaaat gacaggaggc ctaggatttc
     7861 atgaagtcct caataatctc atctctagga tttcaatgga tcacccccat cacaccttgt
     7921 tcatcatcct ggccttagca aatgcaaaca aagatgagtt tttgagcaaa ccagagacag
     7981 caagaagggg cagaataacc aagaatgcac ccaaagaaag ctctcagctt gatgaggatc
     8041 gagcagaggc tgcaagcaga ataatccata caatcagaag tgcgaggcgt acaatggtga
     8101 aggacatgga ggcgctctgc gatgcctaca tcatcctggc gaacctggat gcctctcagt
     8161 ggaggaacca gagaaaaggc atcagcattc cagccaacca gccaatcact aaactgaaga
     8221 atttagaaga cgttgttgtt cccactatgg aaattaaggt tgaccccaca ggagagtatg
     8281 aaaagctggt gactataaag tcatttaaaa cagaatttcg cttagccgga ggcttaaatt
     8341 taccaaaaat aatagactgt gtgggttctg atggcaagga aaggagacag cttgtgaagg
     8401 gccgcgatga cctgaggcaa gatgctgtca tgcagcaggt tttccagatg tgcaatatgc
     8461 tactgcagag gaacaccgag actagaaaga ggaaactgac catctgcaca tacaaggtgg
     8521 ttcccctctc ccagcgaagc ggtgttcttg agtggtgcac aggaaccatc cctattggtg
     8581 aatatcttgt taacaacgaa gaaggtgctc ataaaagata caggccaaat gatctcagcg
     8641 ccaatcagtg ccaaaagaaa atgatggaag tgcagaagaa gtcttttgaa gagaagtatg
     8701 agaccttcat gactatttgc caaaactttg agccagtttt ccgttacttc tgcatggaaa
     8761 aattcttgga tccagctgtt tggtttgaga aacggttggc gtatacgcgt agtgtggcca
     8821 cgtcgtctat cgttggttac atccttggac ttggtgatag gcatgtccag aatatcctga
     8881 taaacgagca gtcagcagaa cttgtgcaca tagatttggg agtggctttt gaacagggga
     8941 agatccttcc cactccagag acagttcctt ttagactcag cagagatatc gtggacggga
     9001 tgggtatcac tggtgtggaa ggtgtcttca gaaggtgctg tgaaaaaaca atggaagtta
     9061 tgcgtagttc ccaggaagct ctgctcacca ttgtagaggt tcttttgtac gacccgctct
     9121 ttgattggac tatgaaccct ttaaaagctt tgtacttaca gcagaggcca gaagacgaga
     9181 ctgacctcca gtccaccccc agtgcagacg atcaggagtg caaacgaagt cttagtgata
     9241 ctgaccagag tttcaacaaa gtagctgagc gcgtcctgat gagattgcaa gagaagctga
     9301 aaggcgtgga ggagggcacc gtgctcagtg tgggcggaca ggtgaacctg cttatccagc
     9361 aggccatgga ccccaaaaac ctcagccgac tcttcccagg gtggaaagcg tgggtgtgac
     9421 cttcagtaga ggagttgctg gacttcagaa aggacctgcc acccaccata tttggatagg
     9481 aattactgaa gtgaacaact gcttttaaac caattgtcta cttgattgat caccacccaa
     9541 atattagtat tcattcctgc tgtcttctgt tagaggcgat ggttactcaa gatccctgtg
     9601 ctgactctta gatcatgctt gtgttaccac agtggtcacc cacacgcaca ccgaactgca
     9661 aacagtggga gtggcagagt gagcttaact ttggtgtact ttaagacaag atcgtaacaa
     9721 tcttagttaa agcatgtttt ccagacagtg tgtgtg
//
