LOCUS       NM_001009831            2585 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus atlastin GTPase 1 (Atl1), mRNA.
ACCESSION   NM_001009831 XM_343075
VERSION     NM_001009831.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Wang,S., Tukachinsky,H., Romano,F.B. and Rapoport,T.A.
  TITLE     Cooperation of the ER-shaping proteins atlastin, lunapark, and
            reticulons to generate a tubular membrane network
  JOURNAL   Elife 5, e18605 (2016)
   PUBMED   27619977
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   Hashimoto,Y., Shirane,M., Matsuzaki,F., Saita,S., Ohnishi,T. and
            Nakayama,K.I.
  TITLE     Protrudin regulates endoplasmic reticulum morphology and function
            associated with the pathogenesis of hereditary spastic paraplegia
  JOURNAL   J Biol Chem 289 (19), 12946-12961 (2014)
   PUBMED   24668814
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Yamamoto,Y., Yoshida,A., Miyazaki,N., Iwasaki,K. and Sakisaka,T.
  TITLE     Arl6IP1 has the ability to shape the mammalian ER membrane in a
            reticulon-like fashion
  JOURNAL   Biochem J 458 (1), 69-79 (2014)
   PUBMED   24262037
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Byrnes,L.J., Singh,A., Szeto,K., Benvin,N.M., O'Donnell,J.P.,
            Zipfel,W.R. and Sondermann,H.
  TITLE     Structural basis for conformational switching and GTP loading of
            the large G protein atlastin
  JOURNAL   EMBO J 32 (3), 369-384 (2013)
   PUBMED   23334294
REFERENCE   5  (bases 1 to 2585)
  AUTHORS   Zhao,J. and Hedera,P.
  TITLE     Hereditary spastic paraplegia-causing mutations in atlastin-1
            interfere with BMPRII trafficking
  JOURNAL   Mol Cell Neurosci 52, 87-96 (2013)
   PUBMED   23079343
  REMARK    GeneRIF: these results further supports the role of the atlastin-1
            of BMP signaling cascade in axonal maintenance and axonal
            degeneration, which is seen in various types of hereditary spastic
            paraplegia.
REFERENCE   6  (bases 1 to 2585)
  AUTHORS   Byrnes,L.J. and Sondermann,H.
  TITLE     Structural basis for the nucleotide-dependent dimerization of the
            large G protein atlastin-1/SPG3A
  JOURNAL   Proc Natl Acad Sci U S A 108 (6), 2216-2221 (2011)
   PUBMED   21220294
REFERENCE   7  (bases 1 to 2585)
  AUTHORS   Botzolakis,E.J., Zhao,J., Gurba,K.N., Macdonald,R.L. and Hedera,P.
  TITLE     The effect of HSP-causing mutations in SPG3A and NIPA1 on the
            assembly, trafficking, and interaction between atlastin-1 and NIPA1
  JOURNAL   Mol Cell Neurosci 46 (1), 122-135 (2011)
   PUBMED   20816793
  REMARK    GeneRIF: Data suggest that NIPA1 and atlastin-1 are members of a
            common biochemical pathway that supports axonal maintenance, which
            may explain in part the characteristic degeneration of long spinal
            pathways observed in patients with HSP.
REFERENCE   8  (bases 1 to 2585)
  AUTHORS   Hu,J., Shibata,Y., Zhu,P.P., Voss,C., Rismanchi,N., Prinz,W.A.,
            Rapoport,T.A. and Blackstone,C.
  TITLE     A class of dynamin-like GTPases involved in the generation of the
            tubular ER network
  JOURNAL   Cell 138 (3), 549-561 (2009)
   PUBMED   19665976
REFERENCE   9  (bases 1 to 2585)
  AUTHORS   Zhu,P.P., Soderblom,C., Tao-Cheng,J.H., Stadler,J. and
            Blackstone,C.
  TITLE     SPG3A protein atlastin-1 is enriched in growth cones and promotes
            axon elongation during neuronal development
  JOURNAL   Hum Mol Genet 15 (8), 1343-1353 (2006)
   PUBMED   16537571
  REMARK    GeneRIF: SPG3A protein atlastin-1 is enriched in growth cones and
            promotes axon elongation during neuronal development
REFERENCE   10 (bases 1 to 2585)
  AUTHORS   Zhu,P.P., Patterson,A., Lavoie,B., Stadler,J., Shoeb,M., Patel,R.
            and Blackstone,C.
  TITLE     Cellular localization, oligomerization, and membrane association of
            the hereditary spastic paraplegia 3A (SPG3A) protein atlastin
  JOURNAL   J Biol Chem 278 (49), 49063-49071 (2003)
   PUBMED   14506257
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY581896.2.
            
            On Feb 8, 2005 this sequence version replaced NM_001009831.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY581896.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2585
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /note="atlastin GTPase 1"
                     /db_xref="GeneID:362750"
                     /db_xref="RGD:1359232"
     exon            1..64
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            65..252
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1895
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /note="spastic paraplegia 3A homolog"
                     /codon_start=1
                     /product="atlastin-1"
                     /protein_id="NP_001009831.1"
                     /db_xref="GeneID:362750"
                     /db_xref="RGD:1359232"
                     /translation="MAKSRRDRNSWGGFSEKSSDWSSEEEEPVRKAGPVQVLIVKDDH
                     SFELDEAALNRILLSEAVRDKEVVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGD
                     YNEPLTGFSWRGGSERETTGIQIWSEVFLINKLDGKKVAVLLMDTQGTFDSQSTLRDS
                     ATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRD
                     WSFPYEFSYGADGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKV
                     ATNPNFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLLEYFKAYIK
                     IYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHL
                     QLKEDSVKLFRGVKKMGGEEFSRRYLQQLESEIDELYIQYIKHNDSKNIFHAARTPAT
                     LFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTLITLCTWAYIRYSGEYRELGAVID
                     QVAAALWDQGSTNEALYKLYSAAATHRHLYQQAFPAPKSEPTEQPEKKKI"
     exon            253..500
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            501..635
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            636..740
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            741..791
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            792..848
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            849..941
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1080
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1208
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1265
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1337
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1769
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1784
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..2585
                     /gene="Atl1"
                     /gene_synonym="Spg3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actagaggag gagggcctgt gcgcaggcct cggaagcggt gcctcctact tccattcagt
       61 caagtccttc ccaccagcgc cacagcaaca tcctcagaat ctgagcgaac tgcgcccaga
      121 acgggcacag agcctcttaa ctgccagaaa cctgcggggc cctggaggag accgcaagag
      181 cagtgacagc gcctcgccac accagtccac agaccgccat ggctaagagc cgcagggaca
      241 gaaacagttg gggtgggttt tcagagaagt caagtgattg gagctcagaa gaggaggagc
      301 cggtgagaaa ggcaggaccc gtccaagtcc tcatcgtcaa agacgaccat tcctttgagt
      361 tagatgaggc tgcactgaac cggatccttc tgtctgaggc cgtcagagac aaggaagtgg
      421 ttgccgtgtc tgttgctgga gcctttagaa aaggaaaatc cttcctgatg gacttcatgt
      481 tacggtacat gtacaaccag gaatctgttg attgggttgg agattacaat gaaccattga
      541 ctggattttc atggagaggt ggatctgaac gagaaaccac aggaatccag atctggagcg
      601 aagttttcct catcaataag cttgatggta aaaaggttgc agtgttactg atggatactc
      661 agggaacctt tgacagtcag tcaactttga gagattcggc cacagtattt gcccttagca
      721 caatgataag ctcaatacag gtctacaact tatcccaaaa tgtccaggag gacgaccttc
      781 agcatctcca gcttttcact gagtatggca ggttggcaat ggaagaaaca ttcctgaagc
      841 cttttcagag tctgatattt cttgttcgag actggagttt cccatacgaa ttctcatacg
      901 gagctgatgg tggcgccaag tttttggaaa aacgcctcaa ggtctcaggg aaccagcacg
      961 aagaactaca gaatgtcaga aagcacatcc attcctgttt taccaacatt tcctgttttc
     1021 tcctacctca tcctggctta aaagtagcta cgaacccaaa ctttgatgga aaactaaaag
     1081 aaatagatga cgaattcatc aaaaacttga aaatactgat tccgtggctc cttagtcccg
     1141 agagcctaga tattaaagag atcaatggga ataaaatcac ctgccgaggt ctgctggagt
     1201 acttcaaggc gtacataaag atctaccaag gggaagaatt gccacatccc aagtccatgt
     1261 tacaggccac agcagaagcc aacaacctag cagctgttgc aaccgccaag gacacataca
     1321 acaagaagat ggaggagatt tgtggtggtg acaaaccatt cttggccccc aatgacctgc
     1381 aaaccaagca cctgcagcta aaagaagact ctgtgaagct gttccgaggt gtgaagaaga
     1441 tgggtgggga agaattcagc cggcgctacc tacagcagct ggagagtgaa atagacgaac
     1501 tctacatcca gtacatcaag cacaatgaca gcaaaaatat cttccatgcc gctcgcaccc
     1561 cagccacact gtttgttgtc atctttatca cgtatgtcat cgctggtgtg actggattca
     1621 ttggtttgga catcatagct agcctgtgca acatgatcat gggactgaca ctcatcacgc
     1681 tgtgcacctg ggcatacatc cgctactctg gggagtatcg agagctgggc gctgtaatcg
     1741 accaggtagc tgcagctttg tgggaccagg gaagcacaaa tgaggcttta tacaagctgt
     1801 acagtgcagc agcaacccac agacacctgt atcagcaagc ctttcctgca cccaagtcag
     1861 aacctactga gcaaccggaa aagaagaaaa tttaatttaa aaagtgcagg tgcatgacca
     1921 tttgtcagct gtcaaagctt ttgtctccat gcaaacatgc aaagtgcttc cttcagacag
     1981 agtgagaccc caacacccaa ggactcgaac actttactgc tttactccag tgtttaatga
     2041 gcagatgtat gtatgcatgg ttggttgtta acacgcaggt tcttgatttc tgtctttaaa
     2101 catgctatta tcattttagg tatttgtaaa tttgagggca gtagatttgt tctgcttgac
     2161 ttttctaagt tctactactg ggttataatt aaatattgtg tgatattact ctgggtttgg
     2221 atatgctcct ttaatttcta taggaaattt aagttatttt acctagttat ttgttgaagc
     2281 acagcataac tcggcaggct tgattttaat ctatataatc ttatacatac cacaggctct
     2341 tatcttgaga catatttaag agcttaaaag ttgctttacc aaaaactata cattgtttct
     2401 tttatatctt tatgaattaa tatagaatgt aaatctcttg atcaaaaatg cacaaaattg
     2461 ttttgtatat gtttgagttt caccgcactg tatatttttt catttggtat accacaaatg
     2521 tattcctcat aggtttattc ttttaatatg tgaactatta aactttactg tttcctaaca
     2581 ttaaa
//
