LOCUS       NM_031014               2505 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus 5-aminoimidazole-4-carboxamide ribonucleotide
            formyltransferase/IMP cyclohydrolase (Atic), mRNA.
ACCESSION   NM_031014
VERSION     NM_031014.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Wang,H., Zheng,A., Thorley,D., Arias,E.B. and Cartee,G.D.
  TITLE     Independent and combined effects of calorie restriction and AICAR
            on glucose uptake and insulin signaling in skeletal muscles from
            24-month-old female and male rats
  JOURNAL   Appl Physiol Nutr Metab 49 (5), 614-625 (2024)
   PUBMED   38181403
  REMARK    GeneRIF: Independent and combined effects of calorie restriction
            and AICAR on glucose uptake and insulin signaling in skeletal
            muscles from 24-month-old female and male rats.
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   3  (bases 1 to 2505)
  AUTHORS   Boutchueng-Djidjou,M., Collard-Simard,G., Fortier,S., Hebert,S.S.,
            Kelly,I., Landry,C.R. and Faure,R.L.
  TITLE     The last enzyme of the de novo purine synthesis pathway
            5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP
            cyclohydrolase (ATIC) plays a central role in insulin signaling and
            the Golgi/endosomes protein network
  JOURNAL   Mol Cell Proteomics 14 (4), 1079-1092 (2015)
   PUBMED   25687571
  REMARK    GeneRIF: Data identified ATIC as a physical partner of internalized
            insulin receptor (IR) in purified Golgi-endosomes (G/E) fractions
            of rat's liver. They show that ATIC later accumulates in G/E .
            SiRNA-mediated partial knockdown of ATIC decreased tyrosine
            phosphorylation of IR and regulated IR endocytosis in HEK293 cells.
            Treatment with ATIC substrate AICAR, which is an allosteric
            activator of AMPK, increased IR endocytosis.
REFERENCE   4  (bases 1 to 2505)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2505)
  AUTHORS   Stover,P.J. and Field,M.S.
  TITLE     Trafficking of intracellular folates
  JOURNAL   Adv Nutr 2 (4), 325-331 (2011)
   PUBMED   22332074
  REMARK    Review article
REFERENCE   6  (bases 1 to 2505)
  AUTHORS   Baggott,J.E., Johanning,G.L., Branham,K.E., Prince,C.W.,
            Morgan,S.L., Eto,I. and Vaughn,W.H.
  TITLE     Cofactor role for 10-formyldihydrofolic acid
  JOURNAL   Biochem J 308 (Pt 3) (Pt 3), 1031-1036 (1995)
   PUBMED   8948466
REFERENCE   7  (bases 1 to 2505)
  AUTHORS   Deacon,R., Chanarin,I., Lumb,M. and Perry,J.
  TITLE     Role of folate dependent transformylases in synthesis of purine in
            bone marrow of man and in bone marrow and liver of rats
  JOURNAL   J Clin Pathol 38 (12), 1349-1352 (1985)
   PUBMED   4078017
REFERENCE   8  (bases 1 to 2505)
  AUTHORS   Deacon,R., Perry,J., Lumb,M. and Chanarin,I.
  TITLE     Effect of cobalamin inactivation on folate-dependent
            transformylases involved in purine synthesis in rats
  JOURNAL   Biochem J 227 (1), 67-71 (1985)
   PUBMED   3994693
REFERENCE   9  (bases 1 to 2505)
  AUTHORS   Dominguez,J. and Ordonez,L.A.
  TITLE     Developmental changes in the folate-dependent enzymes of de novo
            purine biosynthesis in rat brain
  JOURNAL   J Neurochem 38 (3), 625-630 (1982)
   PUBMED   7057182
REFERENCE   10 (bases 1 to 2505)
  AUTHORS   Worzalla,J.F. and Sweeney,M.J.
  TITLE     Pyrazofurin inhibition of purine biosynthesis via
            5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl
            5'-monophosphate formyltransferase
  JOURNAL   Cancer Res 40 (5), 1482-1485 (1980)
   PUBMED   7370986
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072496.1.
            
            On Jun 13, 2004 this sequence version replaced NM_031014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072496.1, D89514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2505
                     /gene="Atic"
                     /note="5-aminoimidazole-4-carboxamide ribonucleotide
                     formyltransferase/IMP cyclohydrolase"
                     /db_xref="GeneID:81643"
                     /db_xref="RGD:70879"
     exon            1..81
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1841
                     /gene="Atic"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /note="bifunctional purine biosynthesis protein PURH;
                     AICAR transformylase/inosine monophosphate cyclohydrolase;
                     bifunctional purine biosynthesis protein PURH-like"
                     /codon_start=1
                     /product="bifunctional purine biosynthesis protein ATIC"
                     /protein_id="NP_112276.2"
                     /db_xref="GeneID:81643"
                     /db_xref="RGD:70879"
                     /translation="MASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDA
                     GLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCN
                     LYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQG
                     SGNKDTSLETRRHLALKAFTHTAQYDEAISDYFRRQYSKGISQMPLRYGMNPHQTPAQ
                     LYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVG
                     VPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVALSDVCDVPTAKIIS
                     REVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGLRLSQKRNN
                     GVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQQS
                     RIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKW
                     KALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGST
                     ADKVVIEACDELGIVLAHTDLRLFHH"
     exon            82..208
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            209..285
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            286..352
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            353..441
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            442..593
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            594..750
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            751..876
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            877..984
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1070
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1160
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1289
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1382
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1565
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1721
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..2485
                     /gene="Atic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctgccag cctaggcacg tgtcctgtct gtctccagac tccgcgaccc ggcgcagcag
       61 ccatggcttc ctcccagctt gccctgttca gtgtgtctga caaaactggc ctcgtggaat
      121 ttgccagaaa cctcgcgtct cttggtttga gtttggtcgc ttctggaggc acggcaaaag
      181 cgatcaggga tgctggcctg gcagtgagag atgtgtctga gctaactggg ttccctgaaa
      241 tgttaggggg gcgtgtgaaa accttgcatc ctgcagtcca tgctggaatc ttagcacgca
      301 atattccaga agatgctgct gacatggcca ggcttgattt caacctcata agagttgttg
      361 tctgtaacct gtacccgttc gtgaagactg tggcttctcc agatgtaacc gttgaggcag
      421 ctgttgagca aattgacatt ggtggcgtga ccttactgag agctgcagcc aaaaaccatg
      481 ctcgagtgac agttgtgtgt gagccagagg actatggtgc ggtggctgca gagatgcagg
      541 gctctggtaa taaggacacc tccctggaga ccaggcgcca cttggcattg aaggcattca
      601 cgcataccgc tcaatatgat gaagcgattt cggattactt caggagacag tacagtaaag
      661 gaatttctca gatgcccttg aggtatggga tgaaccccca tcagactcct gcccagctgt
      721 atacactgaa gcccaagctt cccatcacag ttctcaacgg agccccagga ttcataaacc
      781 tctgcgatgc tttgaatgcc tggcagctgg tgacagagct gagaggagca gtagacattc
      841 cagctgcggc gtctttcaag cacgtcagcc cagcaggtgc tgctgttggg gttccactca
      901 gtgaggacga agccagagtc tgcatggtct atgacctcta tccgaccctc acgcccctgg
      961 ccattgcata tgcaagagca agaggagctg ataggatgtc ttcatttggt gattttgttg
     1021 cattatctga tgtttgtgat gtcccaactg caaaaattat ctccagagaa gtgtcagatg
     1081 gtattgttgc cccaggatat gaggaagagg ccttgaaaat actttctaaa aagaaaaatg
     1141 gaagctactg tgttcttcag atggaccagt cctacaaacc ggatgaaaat gaagttcgaa
     1201 cgctctttgg tcttcgttta agccagaaga gaaataatgg tgttgttgac aagtcgttgt
     1261 ttagcaatat tgtcaccaag aataaagatc tgccggaatc tgctctccga gacctcattg
     1321 tcgccaccat cgctgtcaag tatactcagt ctaattcggt gtgctatgcc aaggacgggc
     1381 aggttattgg catcggagca ggacagcagt ctcggataca ctgtacacgc cttgcaggtg
     1441 ataaggcaaa ctcttggtgg cttcggcacc atccacgagt gctttccatg aagtttaaag
     1501 ctggggtgaa gagagcagaa gtctccaatg ccatcgatca gtatgtgacc ggcaccattg
     1561 gtgagggtga agacctggtg aaatggaaag cactgtttga agaggttcct gagttactca
     1621 ctgaggcgga gaagaaggaa tgggtggaca agctgagtgg cgtgtctgtc agttccgatg
     1681 ctttctttcc tttcagggat aatgtagacc gagcgaaaag gagtggtgtg gcctacattg
     1741 ttgctccatc cggatctact gctgacaagg ttgtgatcga ggcgtgtgac gagctgggga
     1801 tcgtgttggc tcatacagat ctgcgtctct tccaccactg accttggctg acattgttac
     1861 attgtttcct agtgggagat actcatgtgt gggaccctga aagtatctct ttttaaacag
     1921 agtcattctt atcttaatat ttgggtctgt ggttttagat agttaggtct tactcacttg
     1981 aaaggtatag cctgagacac cacgtgggga ggcttgtttc tgcaaaacct gaaaggatcc
     2041 ctccccatgg gagccagctt tcacaaaaag tccctgcaag acacctaagt gcaggtaacc
     2101 aaggagaagc caagctgcct tatgatgaca tcccactgag gactgctctc cccagggctc
     2161 ctttctctgt gcctctcaga actggatcct tagcaggatc tagataatgg tgatactgct
     2221 cttcctttct ccagaactgc ttaaaaaccg tgagctcctt agtgacctgt ttggtacaaa
     2281 cctacaaact gacccataga gcttttcacc catagtgagc agacttggac tgtgtgttgg
     2341 gggcggggga ggtgacagga ctgaatctgt gtccccgtgt tagtcctgac tgttcacaca
     2401 ggcgatgcct ggggtcaacg gtaacctttg gttagttttg ccttctttcc actcctctaa
     2461 ataaatttca aaaagttttt gttgaaaaaa aaaaaaaaaa aaaaa
//
