LOCUS       NM_001393880            3806 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus autophagy related 9A (Atg9a), transcript variant
            2, mRNA.
ACCESSION   NM_001393880
VERSION     NM_001393880.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3806)
  AUTHORS   Mitzel,D.N., Lowry,V., Shirali,A.C., Liu,Y. and Stout-Delgado,H.W.
  TITLE     Age-enhanced endoplasmic reticulum stress contributes to increased
            Atg9A inhibition of STING-mediated IFN-beta production during
            Streptococcus pneumoniae infection
  JOURNAL   J Immunol 192 (9), 4273-4283 (2014)
   PUBMED   24670807
REFERENCE   2  (bases 1 to 3806)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   3  (bases 1 to 3806)
  AUTHORS   Chen,D., Chen,X., Li,M., Zhang,H., Ding,W.X. and Yin,X.M.
  TITLE     CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13
            and Beclin 1/Atg14 are dispensable
  JOURNAL   Biochem Biophys Res Commun 432 (2), 226-230 (2013)
   PUBMED   23402761
REFERENCE   4  (bases 1 to 3806)
  AUTHORS   Orsi,A., Razi,M., Dooley,H.C., Robinson,D., Weston,A.E.,
            Collinson,L.M. and Tooze,S.A.
  TITLE     Dynamic and transient interactions of Atg9 with autophagosomes, but
            not membrane integration, are required for autophagy
  JOURNAL   Mol Biol Cell 23 (10), 1860-1873 (2012)
   PUBMED   22456507
REFERENCE   5  (bases 1 to 3806)
  AUTHORS   Kuang,E., Okumura,C.Y., Sheffy-Levin,S., Varsano,T., Shu,V.C.,
            Qi,J., Niesman,I.R., Yang,H.J., Lopez-Otin,C., Yang,W.Y.,
            Reed,J.C., Broday,L., Nizet,V. and Ronai,Z.A.
  TITLE     Regulation of ATG4B stability by RNF5 limits basal levels of
            autophagy and influences susceptibility to bacterial infection
  JOURNAL   PLoS Genet 8 (10), e1003007 (2012)
   PUBMED   23093945
  REMARK    Erratum:[PLoS Genet. 2020 May 11;16(5):e1008795. doi:
            10.1371/journal.pgen.1008795. PMID: 32392217]
REFERENCE   6  (bases 1 to 3806)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3806)
  AUTHORS   Saitoh,T., Fujita,N., Hayashi,T., Takahara,K., Satoh,T., Lee,H.,
            Matsunaga,K., Kageyama,S., Omori,H., Noda,T., Yamamoto,N.,
            Kawai,T., Ishii,K., Takeuchi,O., Yoshimori,T. and Akira,S.
  TITLE     Atg9a controls dsDNA-driven dynamic translocation of STING and the
            innate immune response
  JOURNAL   Proc Natl Acad Sci U S A 106 (49), 20842-20846 (2009)
   PUBMED   19926846
REFERENCE   8  (bases 1 to 3806)
  AUTHORS   Wohlgemuth,S.E., Julian,D., Akin,D.E., Fried,J., Toscano,K.,
            Leeuwenburgh,C. and Dunn,W.A. Jr.
  TITLE     Autophagy in the heart and liver during normal aging and calorie
            restriction
  JOURNAL   Rejuvenation Res 10 (3), 281-292 (2007)
   PUBMED   17665967
REFERENCE   9  (bases 1 to 3806)
  AUTHORS   Young,A.R., Chan,E.Y., Hu,X.W., Kochl,R., Crawshaw,S.G., High,S.,
            Hailey,D.W., Lippincott-Schwartz,J. and Tooze,S.A.
  TITLE     Starvation and ULK1-dependent cycling of mammalian Atg9 between the
            TGN and endosomes
  JOURNAL   J Cell Sci 119 (Pt 18), 3888-3900 (2006)
   PUBMED   16940348
REFERENCE   10 (bases 1 to 3806)
  AUTHORS   Yamada,T., Carson,A.R., Caniggia,I., Umebayashi,K., Yoshimori,T.,
            Nakabayashi,K. and Scherer,S.W.
  TITLE     Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes
            an autophagy-related protein (APG9-like2) highly expressed in
            trophoblast
  JOURNAL   J Biol Chem 280 (18), 18283-18290 (2005)
   PUBMED   15755735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.39968.1,
                                           SRR26643287.22963.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000009.1  84136552-84136718   c
            168-222             JAXUCZ010000009.1  84135553-84135607   c
            223-354             JAXUCZ010000009.1  84135017-84135148   c
            355-398             JAXUCZ010000009.1  84134831-84134874   c
            399-463             JAXUCZ010000009.1  84134303-84134367   c
            464-625             JAXUCZ010000009.1  84132737-84132898   c
            626-767             JAXUCZ010000009.1  84132460-84132601   c
            768-1516            JAXUCZ010000009.1  84131164-84131912   c
            1517-1670           JAXUCZ010000009.1  84130930-84131083   c
            1671-1850           JAXUCZ010000009.1  84130648-84130827   c
            1851-2099           JAXUCZ010000009.1  84130043-84130291   c
            2100-2278           JAXUCZ010000009.1  84129678-84129856   c
            2279-2396           JAXUCZ010000009.1  84129453-84129570   c
            2397-2619           JAXUCZ010000009.1  84127872-84128094   c
            2620-2765           JAXUCZ010000009.1  84127564-84127709   c
            2766-3806           JAXUCZ010000009.1  84126071-84127111   c
FEATURES             Location/Qualifiers
     source          1..3806
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..3806
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /note="autophagy related 9A"
                     /db_xref="GeneID:363254"
                     /db_xref="RGD:1310450"
     exon            1..167
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            168..222
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            223..354
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2771
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /note="APG9-like 1; ATG9 autophagy related 9 homolog A"
                     /codon_start=1
                     /product="autophagy-related protein 9A"
                     /protein_id="NP_001380809.1"
                     /db_xref="GeneID:363254"
                     /db_xref="RGD:1310450"
                     /translation="MAQFDTEYQRLEASYSDSPPGEEDLLVHVAEGSKSPWHHIENLD
                     LFFSRVYNLHQKNGFTCMLIGEIFELMQFLFVVAFTTFLVSCVDYDILFANKMVNHSL
                     HPTEPVKVTLPDAFLPAQVCSARIQENGSLITILVIAGVFWIHRLIKFIYNICCYWEI
                     HSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNY
                     MVALVNKSLLPLRFRLPGLGEVVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRG
                     GQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSL
                     YGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILAVLI
                     ALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPD
                     HWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNF
                     TVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPG
                     WQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANV
                     VAGSSCRGPPLSRDLQGSRHRADVASALRSFSPLQPGQAPQGRVPSTMTGSGVDARTA
                     SSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQTQAEPERHVWHRRESDESGE
                     SAPEEGGEGARAPQPIPRSASYPCATPRPGAPETTALHGGFQRRYGGITDPGTVPRAP
                     SHFSRLPLGGWAEDGQPASRHPEPVPEEGSEDELPPQVHKV"
     exon            355..398
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            399..463
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            464..625
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            626..767
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1516
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1670
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1850
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2099
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2278
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2396
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2619
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2765
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..3806
                     /gene="Atg9a"
                     /gene_synonym="RGD1310450"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaatgacag acggagggcc tagagctcct ggtctagctg agcccagcag aacagaccgg
       61 gcttctggaa tcgcccgggt cgcggttcct gcggtgacac gcgaggctgg taactggaat
      121 ctccagaccc aggcccaagc tggccagggg tgcccacaga gccccaactg tccaaccagg
      181 gcacccagga ctgacgtgga gcagaaactg tccatggagc tggttaacaa ggtggacagg
      241 gggctgccgt gatggcacag tttgacactg aataccagcg cctagaggcc tcttatagcg
      301 attcaccccc aggggaagag gacctgttgg tgcatgtggc tgaggggagc aaatcacctt
      361 ggcaccacat tgaaaacctt gacctcttct tctctcgagt ttataatcta catcagaaga
      421 atgggttcac atgtatgctc attggagaga tttttgaact catgcagttc ctctttgtgg
      481 ttgccttcac caccttcctg gttagctgtg tggactatga catcctattt gccaacaaga
      541 tggtgaacca cagtctgcat cctaccgagc ctgtcaaggt cactctgcca gatgcctttt
      601 tgcctgccca agtttgcagt gccaggattc aggaaaacgg ctccctcatc accatcctgg
      661 tcatcgctgg tgtcttctgg atccaccggc ttatcaagtt tatctataac atttgctgct
      721 attgggagat ccactccttc tacctacatg ctctgcggat cccaatgtct gcccttccgt
      781 attgcacgtg gcaggaagtg caggcccgga ttgtgcagac ccagaaagag catcagatct
      841 gcatccacaa gcgtgagctg acagagttgg acatctacca tcgcatcctc cgtttccaga
      901 actacatggt ggcactggtg aacaaatccc tcttgcctct gcgcttccgt ctgcccggcc
      961 tcggagaggt tgtcttcttc acccgtggcc tcaagtacaa ctttgagctc atcctcttct
     1021 ggggacccgg ctctctgttt ctcaatgaat ggagcctcaa ggccgagtac aaacgtggag
     1081 ggcaacggct agagctggcc cagcgtctca gcaaccgcat cctgtggatt ggcatcgcca
     1141 acttcctgct ctgtcccctc atcctcatct ggcagatcct ctatgccttc ttcagctatg
     1201 ccgaggtgct gaagagagag ccgggagccc tgggagcgcg ttgctggtca ctctatggcc
     1261 gttgctacct ccgccacttc aatgagctag aacacgagct gcagtcccgc ctcaaccgag
     1321 gatacaagcc cgcctccaag tacatgaatt gcttcttgtc accgctactg actctgctgg
     1381 ccaagaatgg tgccttcttc gcgggctcta tcctggccgt gcttattgct ctcacgatct
     1441 acgatgaaga tgtgttggct gtggagcatg tcctcaccac tgtcacccta ctgggagtca
     1501 cggtgactgt gtgcaggtct ttcatcccag accagcacat ggtgttctgc cctgagcagc
     1561 tgctccgagt gatccttgcc cacatccact acatgcctga ccactggcag ggtaatgccc
     1621 accgctcgca gacccgggac gagtttgccc agctcttcca gtacaaggca gtgttcatct
     1681 tggaggagtt gctgagtccc attgttacac ccctcattct catcttctgc ctacgcccac
     1741 gggccctgga gatcatagac ttcttccgaa actttactgt ggaggtcgtc ggtgtggggg
     1801 acacctgctc ctttgcgcag atggacgttc gccagcacgg tcatcctcag tggctgtctg
     1861 gagggcagac tgaggcctca gtgtaccagc aagccgagga tgggaagacc gagttgtcac
     1921 tcatgcactt tgccatcacc aatcctggct ggcagccccc tcgtgagagc acagccttcc
     1981 tgggcttcct caaggagcag gtgcagcgag atggagcggc tgctggcctt gcccagggtg
     2041 gtctgctccc agagaatgcc cttttcacat ccatccagtc cttacagtct gagtctgagc
     2101 cactgagcct cattgcaaat gtggtagcag gctcgtcctg ccgaggaccc ccactgtcca
     2161 gagacctgca gggttccagg cacagggctg atgttgcttc tgcccttaga tccttctccc
     2221 ctctacagcc tggacaggcc cctcaaggcc gtgttcccag taccatgaca ggctctggag
     2281 tggacgccag gacagccagc tccgggagca gcgtgtggga aggacagctg caaagcctgg
     2341 tgctgtctga atatgcgtcc actgagatga gccttcatgc cctctatatg caccagctcc
     2401 acaagcagca gacccaggct gagcccgagc ggcatgtgtg gcaccgccgg gagagtgatg
     2461 agagtggaga gagtgcccct gaagaggggg gagagggtgc ccgggccccc caacccatcc
     2521 cacgctctgc cagctatccc tgtgctactc cccggcctgg agcacctgag accaccgccc
     2581 tgcatggggg cttccagagg cgctacgggg gcatcacaga tcctggcaca gtgccccgtg
     2641 ctccctctca cttctccagg ctgcccttgg gaggatgggc agaagatggg cagccagcat
     2701 caagacaccc agagccggtg ccagaggagg gctcagagga tgaactgccc cctcaagtgc
     2761 acaaggtata gacaaggcag aagctggttc ccctgctccg ggatggaggc aacagctgtc
     2821 ctgccatctc ttctgcctgc catgagaggg attctctgag tgccgtctgg ccccacgtgt
     2881 gtggtgtttt gtgtgttcct gcctggccaa gggaggtgcc aacgttgggc ttgccatagc
     2941 ccaagaattt gaggcctagg gactaggggc atacacgagt ctagcctcga ccccaggact
     3001 cccttggctc agagtggtgc tagaaactgg tccccagccc agtcccagta ctgccatctt
     3061 tgcatccacc ccacagaagc tgccaagcag aagaacctgt gccaactgtg gagtgggaag
     3121 gcagggcctg aaccctcaat ccctgcaacc tagcccccca tctggaatag ctgagcagct
     3181 caggctgcag cccttacctc cagtcctcac ccagtgctgc agccatctgg ccaccccgac
     3241 ccccgcacat cactggcatg tgtgcgctgc ctgctcccct cagttcactt gccccccttc
     3301 tgtttggctt ttgctttttg ttggggtgag agccctagct cccagctccc ctcacactac
     3361 cttttgacac taagacggaa ggtttctaag ttgcaggaac aggatgaaaa ttctttacta
     3421 ccctcttcaa cttttaggat gggcacttgg gagtgtgagg ccttcctagc tgcttataat
     3481 atactcctat cacccacaca gggactgaca gggcaggaat gtgacctcag ttatatatac
     3541 atatatatcc cagcaagaca gctctgccct gtatccctca ccaaaaggag gatggaggga
     3601 taatggactc accctagcct agggcttcga cattgcatgc tgggattcag ctcctaccct
     3661 tcccccacac tcccccagtt ctgctcggct gtggaaggta aacttatgcc gaaggtggcg
     3721 gactctgctg tcgcagccca cagcagacag ggtgggaacc ctgtacagct tgataaccct
     3781 taataaagaa gggaatttga acgggc
//
