LOCUS       NM_001012097            2386 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus autophagy related 7 (Atg7), mRNA.
ACCESSION   NM_001012097 XM_232276
VERSION     NM_001012097.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Sun,Y., Zhao,Y., Lu,Y., Li,H., Xiang,J., Yang,D., Wang,J., Gao,X.
            and Wang,Y.
  TITLE     Urinary stem cell-derived exocrine circRNA ATG7 regulates the
            SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1
            macrophage polarization, and alleviates the progression of diabetes
            nephropathy
  JOURNAL   Int Urol Nephrol 56 (4), 1449-1463 (2024)
   PUBMED   37815664
  REMARK    GeneRIF: Urinary stem cell-derived exocrine circRNA ATG7 regulates
            the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1
            macrophage polarization, and alleviates the progression of diabetes
            nephropathy.
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   Liu,X., Lv,J., Tang,W., Hu,Y., Wen,Y. and Shen,H.
  TITLE     METTL3-mediated maturation of miR-192-5p targets ATG7 to prevent
            Schwann cell autophagy in peripheral nerve injury
  JOURNAL   J Neuropathol Exp Neurol 82 (12), 1010-1019 (2023)
   PUBMED   37964653
  REMARK    GeneRIF: METTL3-mediated maturation of miR-192-5p targets ATG7 to
            prevent Schwann cell autophagy in peripheral nerve injury.
REFERENCE   3  (bases 1 to 2386)
  AUTHORS   Fan,W., Rong,J., Shi,W., Liu,W., Wang,J., Tan,J., Yu,B. and Tong,J.
  TITLE     GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral
            ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent
            Mechanism
  JOURNAL   Neurochem Res 48 (8), 2552-2567 (2023)
   PUBMED   37059928
  REMARK    GeneRIF: GATA6 Inhibits Neuronal Autophagy and Ferroptosis in
            Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7
            axis-dependent Mechanism.
REFERENCE   4  (bases 1 to 2386)
  AUTHORS   Dong,L., Sun,Q., Qiu,H., Yang,K., Xiao,B., Xia,T., Wang,A., Gao,H.
            and Zhang,S.
  TITLE     Melatonin protects against developmental PBDE-47 neurotoxicity by
            targeting the AMPK/mitophagy axis
  JOURNAL   J Pineal Res 75 (1), e12871 (2023)
   PUBMED   37042059
REFERENCE   5  (bases 1 to 2386)
  AUTHORS   Zhang,X.X., Lang,Y.F., Li,X., Li,Z., Xu,Y.Q. and Chu,H.Q.
  TITLE     The protective effect of puerarin-loaded mesoporous silicon
            nanoparticles on alcoholic hepatitis through mTOR-mediated
            autophagy pathway
  JOURNAL   Biomed Microdevices 24 (4), 37 (2022)
   PUBMED   36308627
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2386)
  AUTHORS   Fortun,J., Dunn,W.A. Jr., Joy,S., Li,J. and Notterpek,L.
  TITLE     Emerging role for autophagy in the removal of aggresomes in Schwann
            cells
  JOURNAL   J Neurosci 23 (33), 10672-10680 (2003)
   PUBMED   14627652
REFERENCE   7  (bases 1 to 2386)
  AUTHORS   Nemoto,T., Tanida,I., Tanida-Miyake,E., Minematsu-Ikeguchi,N.,
            Yokota,M., Ohsumi,M., Ueno,T. and Kominami,E.
  TITLE     The mouse APG10 homologue, an E2-like enzyme for Apg12p
            conjugation, facilitates MAP-LC3 modification
  JOURNAL   J Biol Chem 278 (41), 39517-39526 (2003)
   PUBMED   12890687
REFERENCE   8  (bases 1 to 2386)
  AUTHORS   Mizushima,N., Yoshimori,T. and Ohsumi,Y.
  TITLE     Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the
            conjugation-mediated yeast two-hybrid method
  JOURNAL   FEBS Lett 532 (3), 450-454 (2002)
   PUBMED   12482611
REFERENCE   9  (bases 1 to 2386)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   10 (bases 1 to 2386)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Ueno,T. and Kominami,E.
  TITLE     The human homolog of Saccharomyces cerevisiae Apg7p is a
            Protein-activating enzyme for multiple substrates including human
            Apg12p, GATE-16, GABARAP, and MAP-LC3
  JOURNAL   J Biol Chem 276 (3), 1701-1706 (2001)
   PUBMED   11096062
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082059.1.
            
            On Feb 11, 2005 this sequence version replaced XM_232276.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132272
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2386
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /note="autophagy related 7"
                     /db_xref="GeneID:312647"
                     /db_xref="RGD:1304817"
     exon            1..163
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2112
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /note="autophagy-related protein 7; ubiquitin-activating
                     enzyme E1-like protein; ATG7 autophagy related 7 homolog;
                     ATG12-activating enzyme E1 ATG7; autophagy 7-like"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme ATG7"
                     /protein_id="NP_001012097.1"
                     /db_xref="GeneID:312647"
                     /db_xref="RGD:1304817"
                     /translation="MGDPGLSKLQFAPFNSALDVGFWHELTQKKLNEYRLDEAPKDIK
                     GYYYNGDSAGLPTRLTLEFSAFDMSAPTPARCCPAMGTLHNTNTLEAFKTADKKLLLE
                     QSANEIWEAIKSGAALENPMLLNKFLLLTFADLKKYHFYYWFCCPALCLPESIPLIRG
                     PVGLDQRLSPKQIQALEHAYDDLCRTEGVTALPYFLFKYDDDTVLVSLLKHYSDFFQG
                     QRTKLTVGVYDPCNLTQHPGWPLRNFLVLAAHRWSGSFQSVEVLCFRDRTMQGARDVT
                     HSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSGCMDPKRLAESSVDLNLK
                     LMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHVTFVDNAKISYSNPV
                     RQPLYEFEDCLGGGKPKALAAAERLQKIFPGVNASGFNMSIPMPGHPVNFSDVTMEQA
                     RRDVEQLEELIDSHDVIFLLMDTRESRWLPTVIAASKRKLVINAALGFDTFVVMRHGL
                     KKPKQQGAGDLCPSHLVAPADLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQ
                     CTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGF
                     LSRFDNVLPVSLAFDKCTACSSKVLDQYEQEGFTFLAKVFNSSHSFLEDLTGLTLLHQ
                     ETQAAEIWDMSDEETV"
     exon            164..218
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            219..336
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            337..414
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            415..531
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            532..681
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            682..770
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            771..892
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            893..983
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1128
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1287
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1482
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1683
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1799
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1875
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1956
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2079
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2308
                     /gene="Atg7"
                     /gene_synonym="Apg7l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaagagcag tggccatggg ggaccctgga ctgtccaagc tgcagtttgc cccctttaat
       61 agtgccctgg acgttggctt ctggcacgaa ctgacccaga agaagttgaa cgagtatcgc
      121 ctggacgagg cacccaaaga catcaagggc tattactaca atggtgactc tgccggcctc
      181 cccacccgct tgacattgga gttcagtgct tttgacatga gcgcccccac gcctgcccgc
      241 tgctgcccgg ccatgggaac cctgcacaac accaacacac ttgaggcttt taagactgca
      301 gacaagaagc tccttctgga gcagtcagcc aatgagatct gggaagccat aaagtcaggt
      361 gctgctctcg aaaaccccat gctcctcaac aagtttctgc tcttgacctt cgcggaccta
      421 aagaagtacc acttctacta ctggttttgc tgccctgccc tctgtcttcc tgagagcatc
      481 cctctaatcc ggggacctgt gggcttggat caaaggcttt caccaaaaca gatccaggcc
      541 ctggagcatg cctacgatga cctgtgtcga actgaaggcg tcacagccct gccatacttc
      601 ttattcaagt acgatgacga cactgtgctg gtctccttgc tcaaacacta cagtgatttc
      661 ttccaaggtc aaaggacaaa gttaacagtc ggtgtgtacg atccctgtaa cctaacccag
      721 caccctggat ggcctttgag gaattttttg gtcctggcag cccacagatg gagcggcagt
      781 ttccagtctg ttgaagttct ctgctttcgg gaccgcacca tgcagggagc aagagatgtg
      841 acacacagca tcatctttga agtgaaactt ccagaaatgg cgtttagccc agattgtcct
      901 aaggcagttg gctgggagaa gaaccagaaa ggaggcatgg gtccgaggat ggtgaacctc
      961 agcggatgta tggaccccaa aaggctggct gagtcatccg tggatctgaa tctcaagctg
     1021 atgtgctggc ggttggtccc caccttggac ttggacaagg tcgtgtctgt caagtgcctg
     1081 ctgctgggag ctggtacctt ggggtgtaat gtggctagaa cactgatggg ctggggcgtc
     1141 agacacgtca cgtttgtgga caacgccaag atctcctact ccaatcccgt gaggcagcct
     1201 ctgtatgaat ttgaagattg tctagggggt ggcaagccca aggccctggc tgcagcagag
     1261 cggctccaga aaatatttcc cggagtgaat gccagcgggt tcaacatgag catccccatg
     1321 cccggacacc ctgtgaactt ctctgacgtc acgatggagc aggcccgcag agatgtggag
     1381 cagctggagg aactcatcga tagccacgat gtcatcttcc tgctaatgga caccagggag
     1441 agccgatggc ttcctactgt tattgcagcc agcaagcgaa agctggtcat caatgctgcc
     1501 ttggggtttg acacctttgt tgtcatgaga catggcctga agaaacccaa gcagcaggga
     1561 gccggggacc tgtgcccaag ccatcttgta gcacctgctg acctgggctc ctcacttttt
     1621 gccaacatcc ctggatacaa gcttggctgc tacttctgca atgatgtggt ggctccagga
     1681 gattccacca gagaccggac tctggaccag cagtgcacag tgagccgccc agggctggcc
     1741 gtgattgcag gagccctggc tgtggagctg atggtttctg tcttgcagca tcctgagggg
     1801 ggctacgcca tcgccagcag cagtgatgac cgcatgaatg agcctcccac ctcgctgggg
     1861 cttgtacctc accagatccg gggctttctg tcacggttcg ataatgtcct tcctgtcagc
     1921 ctggcatttg ataaatgtac agcctgttca tccaaagttc ttgatcaata tgagcaagaa
     1981 ggattcacct tcctggccaa ggtgtttaac tcttcacatt ccttcttaga agatttgact
     2041 ggtcttacac tgctccacca agagacccaa gctgctgaga tctgggacat gagtgacgag
     2101 gagaccgtct gagcaaccac agctcaggag tacttggccc tcagcgcaga actgaacccc
     2161 aggactggtg atctgggccc tgccacgtcc ctggtcctga tccccacacc tctgaggact
     2221 agggtgtgcc ctctgctgcc cagttgcacc ctttcctgtg tcatctcacc agctctgaac
     2281 tcaataataa cttcggcatt gccactgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
