LOCUS       NM_001399021            2425 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus autophagy related 5 (Atg5), transcript variant 4,
            mRNA.
ACCESSION   NM_001399021 XM_039098913
VERSION     NM_001399021.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2425)
  AUTHORS   Cai,X., Zhang,P., Yang,Y., Wang,Y., Zhu,H., Li,B., Zeng,H., Hong,L.
            and Shao,L.
  TITLE     MiR-30a-5p Promotes Vein Graft Restenosis by Inhibiting Cell
            Autophagy through Targeting ATG5
  JOURNAL   Curr Med Chem 30 (6), 757-774 (2023)
   PUBMED   35927903
  REMARK    GeneRIF: MiR-30a-5p Promotes Vein Graft Restenosis by Inhibiting
            Cell Autophagy through Targeting ATG5.
REFERENCE   2  (bases 1 to 2425)
  AUTHORS   Tsujimoto,R., Yurube,T., Takeoka,Y., Kanda,Y., Miyazaki,K.,
            Ohnishi,H., Kakiuchi,Y., Miyazaki,S., Zhang,Z., Takada,T.,
            Kuroda,R. and Kakutani,K.
  TITLE     Involvement of autophagy in the maintenance of rat intervertebral
            disc homeostasis: an in-vitro and in-vivo RNA interference study of
            Atg5
  JOURNAL   Osteoarthritis Cartilage 30 (3), 481-493 (2022)
   PUBMED   34958937
  REMARK    GeneRIF: Involvement of autophagy in the maintenance of rat
            intervertebral disc homeostasis: an in-vitro and in-vivo RNA
            interference study of Atg5.
REFERENCE   3  (bases 1 to 2425)
  AUTHORS   Cheng,H., Xu,B., Zhang,L., Wang,Y., Chen,M. and Chen,S.
  TITLE     Bortezomib alleviates antibody-mediated rejection in kidney
            transplantation by facilitating Atg5 expression
  JOURNAL   J Cell Mol Med 25 (23), 10939-10949 (2021)
   PUBMED   34734681
  REMARK    GeneRIF: Bortezomib alleviates antibody-mediated rejection in
            kidney transplantation by facilitating Atg5 expression.
REFERENCE   4  (bases 1 to 2425)
  AUTHORS   Osoro,E.K., Du,X., Liang,D., Lan,X., Farooq,R., Huang,F., Zhu,W.,
            Ren,J., Sadiq,M., Tian,L., Yang,X., Li,D. and Lu,S.
  TITLE     Induction of PDCD4 by albumin in proximal tubule epithelial cells
            potentiates proteinuria-induced dysfunctional autophagy by
            negatively targeting Atg5
  JOURNAL   Biochem Cell Biol 99 (5), 617-628 (2021)
   PUBMED   33831322
  REMARK    GeneRIF: Induction of PDCD4 by albumin in proximal tubule
            epithelial cells potentiates proteinuria-induced dysfunctional
            autophagy by negatively targeting Atg5.
REFERENCE   5  (bases 1 to 2425)
  AUTHORS   El-Derany,M.O. and AbdelHamid,S.G.
  TITLE     Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and
            their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on
            caspase-2 signaling inhibition
  JOURNAL   Biochem Pharmacol 190, 114624 (2021)
   PUBMED   34052187
REFERENCE   6  (bases 1 to 2425)
  AUTHORS   Liu,C.L., Chen,S., Dietrich,D. and Hu,B.R.
  TITLE     Changes in autophagy after traumatic brain injury
  JOURNAL   J Cereb Blood Flow Metab 28 (4), 674-683 (2008)
   PUBMED   18059433
REFERENCE   7  (bases 1 to 2425)
  AUTHORS   Nakai,A., Yamaguchi,O., Takeda,T., Higuchi,Y., Hikoso,S.,
            Taniike,M., Omiya,S., Mizote,I., Matsumura,Y., Asahi,M.,
            Nishida,K., Hori,M., Mizushima,N. and Otsu,K.
  TITLE     The role of autophagy in cardiomyocytes in the basal state and in
            response to hemodynamic stress
  JOURNAL   Nat Med 13 (5), 619-624 (2007)
   PUBMED   17450150
REFERENCE   8  (bases 1 to 2425)
  AUTHORS   Kochl,R., Hu,X.W., Chan,E.Y. and Tooze,S.A.
  TITLE     Microtubules facilitate autophagosome formation and fusion of
            autophagosomes with endosomes
  JOURNAL   Traffic 7 (2), 129-145 (2006)
   PUBMED   16420522
REFERENCE   9  (bases 1 to 2425)
  AUTHORS   Simonsen,A., Birkeland,H.C., Gillooly,D.J., Mizushima,N., Kuma,A.,
            Yoshimori,T., Slagsvold,T., Brech,A. and Stenmark,H.
  TITLE     Alfy, a novel FYVE-domain-containing protein associated with
            protein granules and autophagic membranes
  JOURNAL   J Cell Sci 117 (Pt 18), 4239-4251 (2004)
   PUBMED   15292400
REFERENCE   10 (bases 1 to 2425)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 29, 2021 this sequence version replaced XM_039098913.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1718247.1,
                                           SRR26360172.307098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000020.1  49380835-49381077
            244-333             JAXUCZ010000020.1  49383044-49383133
            334-498             JAXUCZ010000020.1  49396408-49396572
            499-626             JAXUCZ010000020.1  49399043-49399170
            627-705             JAXUCZ010000020.1  49404780-49404858
            706-868             JAXUCZ010000020.1  49412017-49412179
            869-963             JAXUCZ010000020.1  49432712-49432806
            964-1081            JAXUCZ010000020.1  49454447-49454564
            1082-2425           JAXUCZ010000020.1  49470483-49471826
FEATURES             Location/Qualifiers
     source          1..2425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..2425
                     /gene="Atg5"
                     /note="autophagy related 5"
                     /db_xref="GeneID:365601"
                     /db_xref="RGD:1359580"
     exon            1..243
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     exon            244..333
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     exon            334..498
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..1218
                     /gene="Atg5"
                     /note="isoform 3 is encoded by transcript variant 4;
                     autophagy protein 5; ATG5 autophagy related 5 homolog"
                     /codon_start=1
                     /product="autophagy protein 5 isoform 3"
                     /protein_id="NP_001385950.1"
                     /db_xref="GeneID:365601"
                     /db_xref="RGD:1359580"
                     /translation="MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSY
                     LTLVTDKVKKHFQKVMRQEDVSEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITV
                     HFKSFPEKDLLHCPCKDAVEAHFMSCVKEADALKHKSQVINEMQRKDHKQLWMGLQND
                     RFDQFWTINRKLMEYPPEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDL
                     LREVCPSAVAPEDGEKKSQVMIHGIEPLLETPLQWLSEHLSYPDNFLHISIVPQPTD"
     exon            499..626
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     exon            627..705
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     exon            706..868
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     exon            869..963
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1081
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..2425
                     /gene="Atg5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctccgggc gccgagggtg actggactta cggtgggcta cgggcgctgc ggttcgctct
       61 ggttcggagg gcggaagtgc ccgctgggct gttttctgac ccccggcggc ggcgctctgt
      121 gcggctgcgc gcgcactggg acttctgctc ctgcgcctct gcaggacgct gtgatcccgg
      181 tagacccaac ccgaccgagc gtcttccgcg ctgcgggaag ccggagcaga gccggcacct
      241 cgggtttctc tgtgtaacag ccctggatgt ccgggaactt gctttgtgga tcaggctggc
      301 cttgaactca cagagattgt cgggagcaag aagtttggct tggttgaaga aagcacttag
      361 cctatatgta ctgctctgtc cactggaaga atgacagatg acaaagatgt gcttcgagac
      421 gtgtggtttg gacggattcc aacgtgcttt actctctatc aggatgagat aactgaacga
      481 gaagcagagc catactattt gcttttgcca agagtcagct atttgacgct ggtaactgac
      541 aaagtgaaaa agcactttca gaaggttatg agacaagaag atgttagtga gatttggttt
      601 gaatatgaag gcacacccct gaaatggcat tatccaattg gcctactgtt cgatcttctt
      661 gcatcaagct cagctctgcc ttggaacatc acagtacatt tcaagagttt tccagaaaag
      721 gaccttctgc actgtccgtg caaggatgca gttgaggctc actttatgtc atgtgtgaag
      781 gaagctgacg ctttaaagca caaaagtcag gtgatcaacg aaatgcagag aaaagaccac
      841 aagcagctct ggatgggact gcagaatgac agatttgacc agttttggac catcaaccgg
      901 aaactcatgg aataccctcc agaagaaaat ggatttcgtt atatcccttt tagaatatat
      961 cagaccacaa ctgaacggcc tttcattcag aagctgttcc gtcctgtggc cgcagatgga
     1021 cagctgcata cccttggaga tctcctaaga gaagtctgtc cttccgcagt cgcccctgaa
     1081 gacggagaga agaagagcca ggtgatgatt cacgggatcg agcccttgct ggaaaccccg
     1141 ctgcagtggc tgagcgagca tctgagctat ccagacaact tccttcacat cagcattgtg
     1201 ccccagccaa cagactgaag gccgtgtcct gctcactgga tggaaccacc cgcagtcagg
     1261 acaccgaagc atgacaccct tgcttcccgt caggctcagt ggaggcaaca gaaccccggg
     1321 ctgctgcaag ccaaggcggc agaagattcc atgggagata gggcaccggc agggctgagt
     1381 gtgctccacc gctgcgtcag taaacctcgc tgacaggcag gaccacgcag cctctcttct
     1441 cgggaactgc agtgcgcacg cttttgctca gtgaaaacat tggaaatgtg ccagttcgtg
     1501 tctgattaac aaatcagggg gtgtttccta aggtgacggt ggtcggacct tcggctggag
     1561 agtggaaaca ctggttgaat tttcaataga attagactta agaaagtaaa agagaaattc
     1621 tgttattaat aacttgcagt aatttttttg taaaagatca aattacagta aacccgtctt
     1681 tccttaatga gaatttcctg tttacagtca gtctattggt atgcaaacaa tcttgtaact
     1741 ttgataatga acagtgagag atttttaaat aaagcctcta actacgtttg tcatttaata
     1801 acatacagtc tgtcactttt cagggacctc ctgaatctca cacagtaagc ctctttctac
     1861 tctgtttcca gtgctcactg gtgtagcaag ggtgcagggc ataggggaac tcgtctcagg
     1921 agctctcaca ggattcatta ctgtgacttg aaaatctgtc ttctagatac taaagtatca
     1981 ataatactct gtctctgctg tcctgttggc cgctgtacac ctgtcaaatc atagtatgcc
     2041 aagtatctgt ctacagaaac tcagtatttc gaagctccgg ttccttccca gtgtctgatt
     2101 ttcctttttc ctttttggct cctggattac tgtgtcactg tggcccctgg cagccagtct
     2161 ttaaagcctg aaggtggcct gtctctagac tgcagtagct tttccttatc attaccaaaa
     2221 aaacatccag aagtgactgg aactcctgcc acagtaaggg aagttcgctg cactctcccg
     2281 atggctgctt ggagactcct gccattgact gtgagctagc ttgctgtcca tattgaatgt
     2341 caacccacct gagtatgcta aaagatgata tcataaaata atggttttag atttaaaaat
     2401 aaaggtgaat gttttcttat aaaaa
//
