LOCUS       NM_001126298            2171 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus autophagy related 4A, cysteine peptidase (Atg4a),
            mRNA.
ACCESSION   NM_001126298 XM_001053095
VERSION     NM_001126298.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Li,M., Hou,Y., Wang,J., Chen,X., Shao,Z.M. and Yin,X.M.
  TITLE     Kinetics comparisons of mammalian Atg4 homologues indicate
            selective preferences toward diverse Atg8 substrates
  JOURNAL   J Biol Chem 286 (9), 7327-7338 (2011)
   PUBMED   21177865
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   Tanida,I., Ueno,T. and Kominami,E.
  TITLE     LC3 conjugation system in mammalian autophagy
  JOURNAL   Int J Biochem Cell Biol 36 (12), 2503-2518 (2004)
   PUBMED   15325588
  REMARK    Review article
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Kabeya,Y., Mizushima,N., Yamamoto,A., Oshitani-Okamoto,S.,
            Ohsumi,Y. and Yoshimori,T.
  TITLE     LC3, GABARAP and GATE16 localize to autophagosomal membrane
            depending on form-II formation
  JOURNAL   J Cell Sci 117 (Pt 13), 2805-2812 (2004)
   PUBMED   15169837
REFERENCE   5  (bases 1 to 2171)
  AUTHORS   Scherz-Shouval,R., Sagiv,Y., Shorer,H. and Elazar,Z.
  TITLE     The COOH terminus of GATE-16, an intra-Golgi transport modulator,
            is cleaved by the human cysteine protease HsApg4A
  JOURNAL   J Biol Chem 278 (16), 14053-14058 (2003)
   PUBMED   12473658
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160890.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001126298.2.
            
            On May 7, 2008 this sequence version replaced XM_001053095.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155310, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     gene            1..2171
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /note="autophagy related 4A, cysteine peptidase"
                     /db_xref="GeneID:678769"
                     /db_xref="RGD:1596915"
     exon            1..40
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1251
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /note="autophagy related 4 homolog A; autophagy related
                     4A, cysteine peptidase-like 1; cysteine protease
                     ATG4A-like"
                     /codon_start=1
                     /product="cysteine protease ATG4A"
                     /protein_id="NP_001119770.1"
                     /db_xref="GeneID:678769"
                     /db_xref="RGD:1596915"
                     /translation="MESVMSKYENQIIIFTEYLEEFPDTDELVWILGKPHLLKTEKSK
                     LLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWE
                     RQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLAL
                     FDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADTAGESPPDSLIASSQSKGTSAPC
                     LAWKPLLLIVPLRLGINQINPVYIEAFKECFKMPQSLGALGGKPNNAYYFIGSLGDEL
                     IFLDPHTTQTFVDTEESGLVDDHTFHCLQSPQRMSILNLDPSVALVGQGAFMGFFCKE
                     EKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQL
                     EDFDLEEDFEILSV"
     exon            41..151
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            152..223
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            224..322
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            323..424
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            425..497
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            498..577
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            578..768
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            769..847
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1014
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1071
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1180
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..2146
                     /gene="Atg4a"
                     /gene_synonym="Agt4a; Atg4al1; RGD1588268"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggaattgg cccaggatga cagctggaga atggagtcag ttatgtccaa gtatgaaaac
       61 cagattatta ttttcactga atacctagaa gaattcccag atacagatga gctagtatgg
      121 atcctgggga agccacatct ccttaagaca gaaaaatcta agctgttgtc tgatataagt
      181 gctcgtctat ggtttacata cagaaggaaa ttttcaccga ttgggggaac aggcccttcg
      241 tcggatgctg gctggggatg tatgctgcgc tgtgggcaga tgatgctggc tcaagccctc
      301 atctgtagac acttgggaag ggattggaac tgggagagac aaaaagaaca acccaaagaa
      361 taccaaagga tactgcagtg tttcctagat agaaaagact gttgctattc aatccatcag
      421 atggcacaaa tgggtgtagg agaagggaaa tcaattggcg aatggtttgg accaaataca
      481 gttgcacagg tgataaaaaa acttgcttta tttgatgaat ggaattcctt ggctgtttat
      541 gtttcaatgg ataacacagt ggtcattgaa gatatcaaga aaatgtgctg tgttcttcct
      601 gtgggtgctg ctgacacagc tggtgagagc cctcctgatt ctctgattgc ttccagtcag
      661 agtaagggca cctctgcccc gtgcctagcc tggaaacccc tgctgctcat tgtgcccctt
      721 cgcctgggca taaaccaaat caaccctgtg tatattgaag cattcaaaga gtgttttaag
      781 atgccacagt ctttaggggc tttaggagga aagccaaata acgcctatta tttcatagga
      841 tccttaggtg acgagctcat tttcttggat cctcacacaa cccagacctt cgttgatact
      901 gaagagagtg gactagtaga cgaccacact ttccattgcc tgcagtctcc acagcggatg
      961 agtatcctga acttggatcc ttctgtggcc ttggtgggtc aaggagcttt tatgggattt
     1021 ttctgcaaag aagagaaaga ctttgataat tggtgtagtc ttgttcagaa ggaaattcta
     1081 aaggagaatt tgaggatgtt tgaattagtt cagaaacatc catcacactg gcctcccttt
     1141 gtacctccag ccaagccaga agtgacaacc acaggggcag aattcataga ctctaccgaa
     1201 caactggagg acttcgacct ggaggaagat tttgagattc tgagtgtgta ggatagtgag
     1261 aactcaatga ggtactcttc tgccctcaat ctggcatcac aagaacatga acttgttaca
     1321 taaaactttt ctggtcagca agtgcctgat atgccaatag catacgaact aaacagcaac
     1381 tgtgactgag ccgattgccc tttttctcag aactaaaaca aaaaagagca aaccaatgac
     1441 accaagtcat ccctgaaaga cagaaaaatc gtggagtcta ggagaagatc cagaatccat
     1501 tgcttcccag ctcgtcttgg tgatagcaat tcttcagcaa ctgaaacgag ggcatttgga
     1561 agacagacag catctcccat cttgctgcaa ctctgagcag atgagagaca gttatattat
     1621 ctttcctcac cctttcaggt gtgacctctt tggggctaaa tacgaagaag aaatctgttt
     1681 tcttgctcaa ataataaaat aaatgaatca gggagaaata ctcttgttaa ataatctgaa
     1741 tatgcagttt acataactat aatttttatc aaaatatttg tcaaatgtac acttcttaaa
     1801 tgtcttcctt tttggagaaa cctatttgat aggtcacaat ctccatcctt acttacactt
     1861 tcactagatg tcaccatatc cttaaatcaa accatgatca cttgaagcag aggtcagcaa
     1921 actttttctg taaagatatt attttaggct ttgtagacct ggtggccttt gtcataacta
     1981 ttctactctg taaaaaaagc cccagacaat atgcatgtga ctgagcatgg ctgtaatcta
     2041 ataaaacttg atttacaaaa gcaagtggag ggctggactg gccttgccaa tcactcactt
     2101 aaagcattga tttttgtttg aaggattaaa taaattgttt gaattaaaaa aaaaaaaaaa
     2161 aaaaaaaaaa a
//
