LOCUS       NM_001109545            6340 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus autophagy related 2A (Atg2a), mRNA.
ACCESSION   NM_001109545 XM_219529
VERSION     NM_001109545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6340)
  AUTHORS   Bakula D, Muller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost
            AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B and
            Proikas-Cezanne T.
  TITLE     WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC
            signalling circuits in the control of autophagy
  JOURNAL   Nat Commun 8, 15637 (2017)
   PUBMED   28561066
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On Oct 4, 2007 this sequence version replaced XM_219529.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..6340
                     /gene="Atg2a"
                     /note="autophagy related 2A"
                     /db_xref="GeneID:689688"
                     /db_xref="RGD:1589890"
     exon            1..301
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..5881
                     /gene="Atg2a"
                     /note="ATG2 autophagy related 2 homolog A"
                     /codon_start=1
                     /product="autophagy-related protein 2 homolog A"
                     /protein_id="NP_001103015.1"
                     /db_xref="GeneID:689688"
                     /db_xref="RGD:1589890"
                     /translation="MSRWLWPWSNCVKERVCRYLLQHYLGHFFQEHLSLDQLSLDLYK
                     GSVVLRDIHLETWSVNEVLRSMESPLELVEGFVSSIEVAVPWAALLTDHCTVCVSGLQ
                     LILQPRQGSGPEAADSQTWASCMTTSLQLAQECLREGLPEPSEPPQPLEGLEMFAQTI
                     ETVLRRIKVTFLNTVVRVEHSLGDEERSVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQ
                     PPAFLHKLLQLTGVCLYFEELPSQVDPPKPPLQIGSCTGYMELMVKLKQNEAFPGPKL
                     EVSGQLGSLHLLLTPRQLQQLQKLLSAINLADPGGLADKLNKSRPLGAEDLWLIEQDL
                     NQQLQAGAVAESLSLHPITSPLNLDSADLFFSMAGLTSSVTSGVSELSVYSVDLGSSV
                     HSNMALHRPSTPTHSGGKTAPTPLLDTMRPDSLVKMTLGGLSLTLLQTASPSSGSPDL
                     TTHFFAEFDAAKDGPFGSRDFYHLRPRFQRACPCSHVRLTGTAVQLSWELRTGGHSRR
                     TSSTEVHFGQLEVLECLWPRAASEPEYTEILSFPSYSGSEASARPCAHLRHTQTFRRV
                     LKSRSRRSTACHCHSELSLDLADFQADVELGSLDRLAVLLRQITTPSEPPAGLLTEPP
                     QATEQQTVFRLSAPRATLRLRFPIPDLRPERDPWAGQAVRTEQLRLELSEPQFRSELN
                     SGPGPPAPTRLELTCLDLQGIYEDGEKPPVPCLRVSKALDPRSTEAKYFLPQVVVTLN
                     PQSSGTQWETASEKGRDLELSTESPCELQQPEPSPFSSKRTMYETEEMVIPGDPEEMR
                     AFQNRTLALSRCTLDVIMPSAHIFLPSKEVYESIYNRINNDLLMWEPADLLPTSTTAA
                     RPPGSSGFKMCKSAFKLDSDSDEEDTQFFSMASGAPQTPAPEPSHRQSQSTFSTLVTV
                     LKGRITALCEAKDETGKRLDATHGELVLDVEQGTIFSVAQYRGQPGLGYFCLEAEKAT
                     LYHRAAIEDYLLPTHLEVPSFAPPAQLAPTIYPSEEGVTERGTLGRKSQGPPMLSAAV
                     RIHLDPHKNVKEFLVTIRLHKATLRHYMAPPEQSWHSQLLDFLDVLDDPVLGYLPPTV
                     ITILHTHLFSCAVDYRPLYLPVRVLITAETFTLSSNIVMDTSTFLLRFILDDSALYLS
                     DKCEVENLDLRRDYVCVLDIDLLELVIKTWKGSTEGRLSQPLFELRCSNNVVHVHSCA
                     DSCALLVNLLQYVTSSGDLHPPPQPPSPTEIAGQKLSESPASLPSCLPVETALINQRD
                     LTDALLDTERRSLRELAQSSGGPLPQASPVSVYLFPGERSGAQAPLPPPGGPSHTLGS
                     CSEAKEHDKEEEGDGDTLDSDEFCILDAPGLGIAPRDGEPIVTQLHPGPIVVHDGHFS
                     QPLGSTDLLRAPAHFPVPSSRVVLREVSFIWHLYGGRDFGLHPTYRARVGLAGPRVSP
                     SRSSGPNRPQNSWRTQGGIGRQHQVLMEIQLSKVSFQHEVYPEESAIAGGLDQELDER
                     PLSRQVLIVQELEIRDRLATSKINKFLHLHTSERLPRRTHSNMLTIKALHVAPTGSVG
                     GPECCLRVSMMPLRLNVDQDALFFLKDFFTSLAASINPMVPGDTFEAHRETHSRPSSP
                     QEGQSEGTETASSPQEAPGSSHSSSDQQPIYFREFRFTSEVPICLDYHGKHVTVDQVG
                     TFMGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLGYALNEWLQDIRKNQLPGLLGGV
                     GPMHSVVQLFQGFRDLLWLPIEQYRKDGRLIRGLQRGAASFGSSTASAALELSNRLVQ
                     AIQATAETVYDILSPASPISRSLQDKRSSRKLRRGQQPADLREGMAKAYDAVREGILD
                     TAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPIIVATEATSNVLGGMRNQILPD
                     AHKDHALKWRLEETQD"
     exon            302..464
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            465..617
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            618..720
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            721..955
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1052
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1214
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1355
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1593
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1741
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1834
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1990
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2234
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2331
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2491
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2634
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2750
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2908
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3059
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3253
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3334
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3441
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3534
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3605
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3682
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3847
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3977
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..4192
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4193..4401
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4537
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4538..4741
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4742..4843
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..4925
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            4926..5058
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            5059..5131
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            5132..5214
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            5215..5336
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            5337..5491
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            5492..5644
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            5645..6340
                     /gene="Atg2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtccgggg gcgcggcctg gcgctgagag aagcggcggg gcgaaccggg ggctctagtg
       61 aacagcgcag ccggacggag atcgccggct gtcggccagc ggaagcggcc cgggcccggc
      121 ggtccccgag atgtcacgat ggctgtggcc atggtcgaac tgtgtgaaag agcgtgtctg
      181 ccgctacctg ctacagcact acttgggtca cttctttcag gagcacctca gcctggacca
      241 gctcagcctg gatctgtaca agggcagcgt tgtcctgcgg gatattcacc tggaaacctg
      301 gtctgtgaac gaggttttga ggtcaatgga gtcaccactg gaactggtgg aaggcttcgt
      361 gagctccatc gaggtggctg tcccctgggc tgcacttctc actgaccact gcactgtgtg
      421 tgtgtcaggc cttcagctta tcctgcaacc ccgccagggt tcagggccag aggctgcaga
      481 ctctcagact tgggcctcat gcatgaccac aagcctacag ctggctcaag agtgccttcg
      541 ggaagggttg ccagaaccct cagaaccacc acagccccta gaggggctgg aaatgtttgc
      601 acagaccatt gagactgtgc tccggaggat caaggtgacc ttcctgaaca ctgttgtgag
      661 ggtggagcat tcactgggtg atgaggaacg gagtgtagct gtggaggtcc gagtgcagag
      721 actggaatac tgtgacgaag cagtgcggga cccaagccag gcaccacctg tggacgtgca
      781 ccagccacct gccttcttgc acaagctgct gcagctgact ggggtctgcc tgtactttga
      841 agagctgccc tcccaggtgg acccgccaaa gccacctttg caaatcggca gctgcacagg
      901 gtacatggag ctcatggtga agctgaaaca gaatgaggcc ttcccggggc ccaagttgga
      961 ggtatcagga cagctgggat ccctgcatct gctcttgacc ccgcgtcagc tccagcagct
     1021 ccaaaaactg ctcagtgcca tcaaccttgc agatccagga ggcctggctg acaagctgaa
     1081 caagagccgc ccactaggtg ctgaagactt gtggctcatt gagcaagatc ttaaccagca
     1141 gctgcaggcg ggtgcagtgg ctgagtccct cagcctgcac cccatcacca gccccctcaa
     1201 tttggacagt gcagacctat tcttctccat ggctggcctc acaagcagtg tgacctccgg
     1261 tgtctctgag ctctcagtgt atagtgtaga cctgggctcc tcggttcaca gcaacatggc
     1321 cctccatcga ccctcaaccc caacccactc aggtggcaag acggctccga ctccccttct
     1381 ggataccatg cgccctgact cactggtgaa gatgaccttg ggaggtttga gcctgacctt
     1441 gcttcagaca gcttccccat cttcaggatc acctgacctc accacccact tttttgctga
     1501 gttcgatgct gccaaagatg ggccgttcgg gtcccgagac ttctaccacc tccggccacg
     1561 cttccagagg gcctgccctt gtagccatgt ccgattaaca ggcacagccg tgcagctgtc
     1621 ctgggagctg cgtactggcg gccacagccg gaggacaagc agcacagaag tgcacttcgg
     1681 acagctggag gtgctggagt gcctgtggcc cagggctgcc tcagagccag agtacacaga
     1741 gatcctgagc ttccccagtt actctggctc cgaagcctca gctcggccct gcgcccatct
     1801 gcgccacaca caaacctttc gccgggtgct caagagccgg tcccggcgct ccactgcctg
     1861 ccattgtcac tcagaactct ccctggacct ggctgatttc caagctgacg tggagctggg
     1921 gtcgctggac cgccttgctg tcttgctccg tcaaatcacc acaccctctg agccacccgc
     1981 tggcctacta acagagcccc cacaggccac tgagcagcag acagtgtttc gtctctcagc
     2041 accccgggcc accctgaggc tacgcttccc catcccagac ttacggcctg aacgggaccc
     2101 ctgggctggc caggctgtac ggactgagca gctgcgactg gagctgagtg agcctcagtt
     2161 ccgctcagag ctcaacagtg ggcctggccc cccagctcct acccgcttgg aacttacttg
     2221 cttagaccta caaggaatct acgaagatgg agagaagcca cctgtcccct gcctgcgggt
     2281 ctctaaggct ctggatccca ggagcactga ggccaagtac ttcctacctc aggtagtggt
     2341 gaccctgaac ccccagtcca gtggcacaca gtgggagaca gcctctgaga aaggccggga
     2401 tctagaactg tctaccgaga gtccatgtga gctccagcag cctgagccct cacctttctc
     2461 ctccaagcgg actatgtatg aaactgagga gatggtgatc cctggagacc ctgaggagat
     2521 gagggcattc cagaaccgga cgctggcgct gtcccgctgt actctggatg tgatcatgcc
     2581 cagtgcccac atcttcctgc ccagcaagga ggtctacgaa agcatctaca acaggatcaa
     2641 caatgacctg ctcatgtggg agcctgcaga cctacttccc acatccacca ctgctgctcg
     2701 gccgcccggc tcttctgggt tcaagatgtg caagtcagcc ttcaagctag actcggattc
     2761 ggatgaagaa gacacccagt tcttctcgat ggcatcaggt gccccccaga ctcctgcccc
     2821 ggaaccttcc catcgtcagt ctcagagtac cttctccaca ctggtgacag tgctgaaggg
     2881 tcggatcact gcgctctgtg aggctaagga tgagacaggg aagcggctgg atgccactca
     2941 cggggagctg gtactagatg tggagcaagg caccatcttc agcgtagccc agtaccgtgg
     3001 ccagccgggg ctcggctact tctgcttgga agctgaaaag gcaacactct accatcgagc
     3061 ggccattgag gactacctgc tgcccactca cttggaagta cccagctttg ctcccccagc
     3121 tcagctggct ccaaccatct acccatcaga ggaaggggtg actgagcggg gaacattggg
     3181 ccgcaagagc cagggtcccc ccatgctgtc tgcagctgtc cgcatccacc tggaccccca
     3241 caagaatgtc aaggaatttt tggtgacaat acggctgcac aaagccactc tacgccacta
     3301 catggcccct cctgagcaga gctggcactc ccagctattg gacttcttgg atgtactgga
     3361 tgaccctgtg ctgggttacc tgcccccaac agtcatcact attctgcaca cacacctctt
     3421 ctcctgtgct gtggattaca ggcccctcta cctccctgtg cgtgtcctta tcactgctga
     3481 gaccttcact ctctccagca acattgtcat ggacacgtcg accttcctgc tcaggttcat
     3541 cctcgatgac tccgctctgt acctgtctga caagtgtgag gtggagaacc tggacctgcg
     3601 gcgagattat gtctgcgtcc tggacattga cctcctggag cttgtaatca aaacctggaa
     3661 gggcagcacc gagggcagac tgagccagcc gctgtttgag ctgcgctgct ccaacaatgt
     3721 ggtgcatgta cacagctgtg ctgactcctg cgccctgctg gtcaacctgc tccagtatgt
     3781 aactagctcc ggtgacctgc atcccccgcc ccagcccccc agccctacgg agatcgccgg
     3841 ccagaagctt tcagagagcc cggcctccct gccttcctgc ctaccagtgg agacagccct
     3901 catcaaccag cgagacctga ctgatgccct tctggacact gaacggcgta gcctacggga
     3961 gctggcccag tcatcaggtg gcccacttcc tcaggcctct cccgtctccg tctatctgtt
     4021 cccaggtgaa cggagtgggg cccaggcccc cttgcctcct cctgggggcc cttctcatac
     4081 cttggggtcc tgttctgagg caaaggaaca tgacaaagaa gaggaagggg atggagacac
     4141 cctggacagt gacgagttct gcatccttga cgcccctggc ctaggcattg cgccccgaga
     4201 cggtgagccc atcgtgactc agctgcatcc aggccccatc gttgtgcatg atgggcactt
     4261 ctcccagccc ctgggaagca ctgacctgct gcgggcgcct gcccacttcc cagtgcccag
     4321 cagccgtgtg gtactacggg aggtctcctt catctggcac ctttatgggg gtagagactt
     4381 tggccttcac cccacttaca gagcaagagt aggcctcgca ggccctaggg tctcaccttc
     4441 ccgttcctct ggtcccaacc ggccacagaa ctcctggcgt acccaaggtg gcattggacg
     4501 gcaacaccag gtcctcatgg agatccagct cagcaaagtg agcttccaac atgaagtata
     4561 cccagaagaa tcagccatag ccgggggcct ggaccaggaa ctggatgagc gaccactgtc
     4621 ccgccaggtg ctcattgttc aggagctaga aatccgagac cggctggcca cctccaagat
     4681 caacaagttc cttcatttgc acacgagcga gcggctgcca cggcgcacac actccaacat
     4741 gcttaccatc aaggcactgc acgtggctcc caccggcagt gtaggagggc cggagtgctg
     4801 tcttcgagtc tccatgatgc ctctgaggct caatgtggac caggatgccc ttttcttcct
     4861 caaggacttt ttcaccagcc tagcagccag catcaacccc atggtcccag gggacacttt
     4921 tgaggctcac cgagagaccc acagccggcc cagcagcccc caggaagggc agtctgaggg
     4981 cacagagaca gccagcagcc cccaggaagc tccaggcagt agccacagct cctctgacca
     5041 acagcccatc tacttcaggg agttccgctt cacatctgag gtgcccatct gcctggatta
     5101 ccatggcaaa catgtcactg tggaccaggt gggcactttc atgggactcc taattggcct
     5161 ggcccagctc aactgctccg agctgaagct caagaggctt tgctgccggc atgggctcct
     5221 aggtgtggac aaagtgctcg gctatgccct caatgaatgg ctgcaggaca tccgaaagaa
     5281 ccagctgcct ggcctgctgg gaggcgtggg tcccatgcat tcggttgtac aactcttcca
     5341 ggggttccgg gacctgctgt ggctacccat cgagcagtac aggaaagatg ggcgcctcat
     5401 tcgggggctg cagcgtggcg ctgcctcctt tgggtcatcc acagcctctg ctgctctgga
     5461 actgagcaac aggctggtcc aggccatcca ggctacagct gagacagtat atgacatcct
     5521 gtcccctgca tctcccatct cccgatccct acaagacaaa cgttcttcac ggaaactacg
     5581 cagaggtcaa caacctgctg acctccggga aggcatggct aaggcatatg acgctgttcg
     5641 agagggtatc ctggatacag ctcaaaccat ctgtgatgtg gcatcaaggg gccatgagca
     5701 gaagggactg acaggtgccg tggggggtgt gatccgacag ctccccccaa ctgtggtaaa
     5761 accaataatt gtagcaacag aggcaacatc caacgtgcta gggggcatgc gtaaccagat
     5821 cctgccagat gcacacaagg accatgctct caagtggcga ttggaggaga cccaggactg
     5881 actgcaggca cccaagatcc acccactgtc ccaacatgcc cactgtgtcc agccagccac
     5941 agtggtgcca ccagctccct gttttcctga ttgctgtgac ccacagctag gccaccaggt
     6001 ccttcaaagg atagccactg tgaaggatac ctgcccagcc tgcttgttgc caattgaccg
     6061 ggagagtggg gcctcccggc tctggggcct ctgccctgtc tgtgcacttt cgtctgggga
     6121 gaaaggacgc tgctcctccc tgctacctgg gcccacactg ctgccttgtt ccagaatgag
     6181 gatggaggct tttggaccca tggaccccac tcagccaagt gtctctccgt gtctcatggg
     6241 gaggtggggg atagatgcca tgtgggtcag tgtattttta agctccctga gcgtgtgggt
     6301 cagtgtctgc atgaagtgga ataaacttgc ccaccgccag
//
