LOCUS       NM_001107258            3409 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus autophagy related 14 (Atg14), mRNA.
ACCESSION   NM_001107258 XM_001073554 XM_223939
VERSION     NM_001107258.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Li,S., Gao,L., Zhang,W., Yu,Y., Zheng,J., Liang,X., Xin,S., Ren,W.
            and Zhi,K.
  TITLE     MiR-152-5p suppresses osteogenic differentiation of mandible
            mesenchymal stem cells by regulating ATG14-mediated autophagy
  JOURNAL   Stem Cell Res Ther 13 (1), 359 (2022)
   PUBMED   35883156
  REMARK    GeneRIF: MiR-152-5p suppresses osteogenic differentiation of
            mandible mesenchymal stem cells by regulating ATG14-mediated
            autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   Chauhan,S., Mandell,M.A. and Deretic,V.
  TITLE     IRGM governs the core autophagy machinery to conduct antimicrobial
            defense
  JOURNAL   Mol Cell 58 (3), 507-521 (2015)
   PUBMED   25891078
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Diao,J., Liu,R., Rong,Y., Zhao,M., Zhang,J., Lai,Y., Zhou,Q.,
            Wilz,L.M., Li,J., Vivona,S., Pfuetzner,R.A., Brunger,A.T. and
            Zhong,Q.
  TITLE     ATG14 promotes membrane tethering and fusion of autophagosomes to
            endolysosomes
  JOURNAL   Nature 520 (7548), 563-566 (2015)
   PUBMED   25686604
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Pampliega,O., Orhon,I., Patel,B., Sridhar,S., Diaz-Carretero,A.,
            Beau,I., Codogno,P., Satir,B.H., Satir,P. and Cuervo,A.M.
  TITLE     Functional interaction between autophagy and ciliogenesis
  JOURNAL   Nature 502 (7470), 194-200 (2013)
   PUBMED   24089209
REFERENCE   5  (bases 1 to 3409)
  AUTHORS   Fogel,A.I., Dlouhy,B.J., Wang,C., Ryu,S.W., Neutzner,A.,
            Hasson,S.A., Sideris,D.P., Abeliovich,H. and Youle,R.J.
  TITLE     Role of membrane association and Atg14-dependent phosphorylation in
            beclin-1-mediated autophagy
  JOURNAL   Mol Cell Biol 33 (18), 3675-3688 (2013)
   PUBMED   23878393
REFERENCE   6  (bases 1 to 3409)
  AUTHORS   Fan,W., Nassiri,A. and Zhong,Q.
  TITLE     Autophagosome targeting and membrane curvature sensing by
            Barkor/Atg14(L)
  JOURNAL   Proc Natl Acad Sci U S A 108 (19), 7769-7774 (2011)
   PUBMED   21518905
REFERENCE   7  (bases 1 to 3409)
  AUTHORS   Sun,Q., Zhang,J., Fan,W., Wong,K.N., Ding,X., Chen,S. and Zhong,Q.
  TITLE     The RUN domain of rubicon is important for hVps34 binding, lipid
            kinase inhibition, and autophagy suppression
  JOURNAL   J Biol Chem 286 (1), 185-191 (2011)
   PUBMED   21062745
REFERENCE   8  (bases 1 to 3409)
  AUTHORS   Yang,Z. and Klionsky,D.J.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   9  (bases 1 to 3409)
  AUTHORS   Matsunaga,K., Saitoh,T., Tabata,K., Omori,H., Satoh,T.,
            Kurotori,N., Maejima,I., Shirahama-Noda,K., Ichimura,T., Isobe,T.,
            Akira,S., Noda,T. and Yoshimori,T.
  TITLE     Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally
            regulate autophagy at different stages
  JOURNAL   Nat Cell Biol 11 (4), 385-396 (2009)
   PUBMED   19270696
REFERENCE   10 (bases 1 to 3409)
  AUTHORS   Zhong,Y., Wang,Q.J., Li,X., Yan,Y., Backer,J.M., Chait,B.T.,
            Heintz,N. and Yue,Z.
  TITLE     Distinct regulation of autophagic activity by Atg14L and Rubicon
            associated with Beclin 1-phosphatidylinositol-3-kinase complex
  JOURNAL   Nat Cell Biol 11 (4), 468-476 (2009)
   PUBMED   19270693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474040.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001073554.1, XM_223939.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223033.1, SRR8487226.173115.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..3409
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /note="autophagy related 14"
                     /db_xref="GeneID:305831"
                     /db_xref="RGD:1304610"
     exon            1..256
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1514
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /note="barkor; autophagy-related protein 14-like protein;
                     beclin 1-associated autophagy-related key regulator-like;
                     ATG14 autophagy related 14 homolog"
                     /codon_start=1
                     /product="beclin 1-associated autophagy-related key
                     regulator"
                     /protein_id="NP_001100728.1"
                     /db_xref="GeneID:305831"
                     /db_xref="RGD:1304610"
                     /translation="MASPSGKGSWTPEAPGFGPRALAPDLVDSVDDAEGLYVAVERCP
                     LCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSQLKNKQEEFQKEVLKAMEG
                     KRLTDQLRWKIMSCKMRIEQLKQTICKGNEEMKKNSEGLLKNKEKNQKLYSRAQRHQE
                     KKEKIQRHNRKLGDLVEKKTSDLREHYDRLACLRRLHILELTSVIFPMDEVKTSGRDP
                     ADVSSETDSAMTSSMVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDY
                     SAYYNWVEEKKTTQGPDMEHNNPAYTISAALGYATQLVNIVSHILDINLPKKLCNSEF
                     CGENLSKQRLTRAVRKLNANILYLCSSQHVNLDQLQPLHTLRNLMHLVSPHSEHLGRS
                     GPFEVRADLEESMEFVDPGVAGESDVSGDERVSDEETDLGTDWENLPSPRFCDIPSQP
                     VEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR"
     exon            257..319
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            320..362
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            363..444
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            445..682
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            683..912
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1030
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1121
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1207
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..3409
                     /gene="Atg14"
                     /gene_synonym="Atg14L; RGD1304610"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatcccacg tgactggccc tgagctcaga tcatcatggc gtctcccagt gggaagggtt
       61 cttggacgcc cgaggctcct ggctttgggc cgcgggctct agcaccggac ctggtggact
      121 cggtggacga cgccgagggc ctttacgtgg ctgttgagcg gtgtcctctg tgcaacacca
      181 ctcgccggcg gttgacttgc gctaagtgcg tccagagcgg tgatttcgtc tatttcgacg
      241 gccgcgaccg ggagaggttt attgacaaga aggaaaggct tagtcaactg aagaacaaac
      301 aagaagaatt tcaaaaagaa gtactaaagg ccatggaagg aaaacggcta acagatcagt
      361 tgcgatggaa aataatgtcc tgcaagatga ggattgaaca gctgaagcaa acgatatgta
      421 aaggaaatga ggaaatgaag aaaaattctg aaggcctcct caagaacaag gaaaagaacc
      481 agaagcttta cagccgagcg cagcgacacc aagagaaaaa ggagaagatt cagcggcaca
      541 accgcaagct tggggacctg gtggagaaga aaaccagtga cctgagggaa cactacgatc
      601 ggttggcgtg tttgcggagg ttacacatcc tagagctcac ctctgtcatc ttcccaatgg
      661 atgaagtgaa gacttctggg agggaccctg cagacgtgtc ctcagagact gacagtgcca
      721 tgacctccag catggtgagc aaacttgctg aggcccggag gacgacatac ctctccggaa
      781 gatgggtctg tgacgaccac aacggcgaca ccagcattag catcacgggc ccttggatca
      841 gcctgccgaa caatggggac tactctgctt actataactg ggtagaagag aagaaaacaa
      901 cccaaggacc tgacatggag cataacaacc ctgcctacac catcagcgcc gcgctcggct
      961 atgccacgca gctggtcaac attgtgtctc acatccttga catcaacctt cccaaaaagc
     1021 tgtgcaacag tgagttctgt ggagaaaacc tcagcaagca gaggctgacc cgcgcagtga
     1081 ggaaactgaa cgcaaacatc ctttaccttt gttcttctca gcatgttaat ttagatcagt
     1141 tgcaacccct gcacacactg aggaacttga tgcatctggt cagcccgcac tccgagcacc
     1201 tgggcaggtc aggacctttt gaagtgcgag cagacctcga ggagtccatg gaatttgtgg
     1261 accctggagt tgctggggaa tcagatgtga gtggagatga gcgtgtgagc gatgaggaga
     1321 ctgacctggg cacagactgg gagaacctgc caagcccacg attctgtgac atcccttccc
     1381 agccggtgga agtttcccag agccagagca cccaggcgtc ccctcccata gccagcagca
     1441 gcgctggtgg gatgatctcc tctgctgcgg cctcagtgac ctcctggttc aaagcttaca
     1501 ctggacaccg ctaacgagtg gggaccaaaa ctgctcattt tgtgtctggg aatcccccac
     1561 tgcactcatg accttgtctg tgtagttggt agagcttggg agctatcgtc aggacaggag
     1621 gaggagggcc tgagctgggg cttcctggcc ccaggtcctc cgaacgctgg tccctaggtg
     1681 ccgagtcttc ctgacactga gttctaggct ttggtcagag cacacagaaa tttcttggtc
     1741 atgaggactg aaagacaaag gctgagtttg tttttctgtc atcctcttga gagaccggcc
     1801 agcaggccag tggcagtttt ggcctcatca gggagaggtg gttgtctggg gagggaggag
     1861 gtgaaagctt actgctgtcg tcattgtgtg tcacattcct gatttcctac tacacaccaa
     1921 agaaaccgag gtttatttct gtggacccat atctgcgagt gggggaatct gcagggatat
     1981 tggctgtcta aacagttttc tcttgtattc tgaagggaga tgagtcttcg gagttctctg
     2041 tcctgcactc ccgggacctt cttccttgtc attccctgga tgagctgaat gttccctgag
     2101 cattggttga cctcttgatg attaagtggt cccttgcttg ctgtctggtt tcttccttgg
     2161 tggtggtggt ggtggtgggg ttgactagta gcaggtgttt ccagggaaat ctccctgctt
     2221 gtctgcgggg tctccaaggc tctgaagaca gcgcagagtg tggcagccga gtggctgccc
     2281 caggaagtgc tcagctgtca aggggtttcc caagaggccg ttctaatgac aatcttagag
     2341 aaagctagaa caagagaggc attatgttta attcatcgta agtagttttt atttttctta
     2401 acttccaaaa ggaagttcta tgtaacagac tcctgtgaga aaaccccagg ccttgtcacc
     2461 gtatcttcct gttgggactg gtgtggtggt acctcccagc tcctgctgac tcactctctg
     2521 ggtggtactt tgcctgcaga ctgaggcact gtggagcttc tgctgtagta gagctgtaga
     2581 gaggactcca tcctcgccag gaccccacgt cccctagctc tagatactcc ggctgtggag
     2641 gagacggacg gctggagcct gttctgtgct cagctctgca actgctgggc ctgtgtttgc
     2701 cgcttgtaga ctgagagact gagcgtgccg gaacaaacct ctgcaagaga ccgcgagctc
     2761 agaggagctg caggaagcac agaggtcgcc agctcaggcc gacggcaatt ctaactgcag
     2821 atgcaggagc accgggctgg acagggactt tgttttattt agtttcaact agaggcacgt
     2881 ttgtcacttt ccctcacact aagtgatcca gcacggacca cctaggctgc tcacctactt
     2941 gggatttcgt tattttgcac tggaccccct gttgtaaata gtctcgacta cacatttcag
     3001 ccactgtttc atttcccatc ctctttgctg ctcattagaa ccttttgtgt aggtgccaga
     3061 accatacaca aacagctttc tggaaaaaag tgaagctggt attttttttt tttaaaccaa
     3121 aagccataga agttgatcat ggttttcatt ttaaaatgat ttattggaac aaggtaatac
     3181 taatagacac tcagaggcac cacacaggct gctttacatg gtcttacata gaaccaagaa
     3241 atgtaactta ccatggtatg ggggtcagca ttaggcaggg ttcggtgtgc attgggaaag
     3301 aactgtcaca tcagaaccgt cttgctgcaa ccgaaacttg caagtcaggt tgatcataca
     3361 gatgttttct aaacttttgt tgtattactg caataaagcc tttaacagt
//
