LOCUS       NM_001271212            2442 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus autophagy related 13 (Atg13), mRNA.
ACCESSION   NM_001271212 XM_001069036 XM_003753749 XM_342465
VERSION     NM_001271212.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Shi G, Zhang Z, Ma S, Li Y, Du S, Chu Y, Li Y, Tang X, Yang Y, Chen
            Z, Wang Z and Wu H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Zhao P, Zhu Y, Sun L, Zhu W, Lu Y, Zhang J, Mao Y, Chen Q and Zhang
            F.
  TITLE     Circulating Exosomal miR-1-3p from Rats with Myocardial Infarction
            Plays a Protective Effect on Contrast-Induced Nephropathy via
            Targeting ATG13 and activating the AKT Signaling Pathway
  JOURNAL   Int J Biol Sci 17 (4), 972-985 (2021)
   PUBMED   33867822
  REMARK    GeneRIF: Circulating Exosomal miR-1-3p from Rats with Myocardial
            Infarction Plays a Protective Effect on Contrast-Induced
            Nephropathy via Targeting ATG13 and activating the AKT Signaling
            Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang
            C, Heman-Ackah SM, Hessa T, Guha R, Martin SE and Youle RJ.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL,
            McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, Steeves MA,
            Yang CY, Prater SM, Kim DH, Thompson CB, Youle RJ, Ney PA,
            Cleveland JL and Kundu M.
  TITLE     Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated
            mitophagy
  JOURNAL   Mol Cell 43 (4), 572-585 (2011)
   PUBMED   21855797
REFERENCE   5  (bases 1 to 2442)
  AUTHORS   Yang Z and Klionsky DJ.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   6  (bases 1 to 2442)
  AUTHORS   Ganley IG, Lam du H, Wang J, Ding X, Chen S and Jiang X.
  TITLE     ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential
            for autophagy
  JOURNAL   J Biol Chem 284 (18), 12297-12305 (2009)
   PUBMED   19258318
REFERENCE   7  (bases 1 to 2442)
  AUTHORS   Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura
            S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N and Mizushima
            N.
  TITLE     Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200
            complex required for autophagy
  JOURNAL   Mol Biol Cell 20 (7), 1981-1991 (2009)
   PUBMED   19211835
REFERENCE   8  (bases 1 to 2442)
  AUTHORS   Chan EY, Longatti A, McKnight NC and Tooze SA.
  TITLE     Kinase-inactivated ULK proteins inhibit autophagy via their
            conserved C-terminal domains using an Atg13-independent mechanism
  JOURNAL   Mol Cell Biol 29 (1), 157-171 (2009)
   PUBMED   18936157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ217242.1 and CB774831.1.
            
            On or before Sep 8, 2012 this sequence version replaced
            XM_003753749.1, XM_001069036.3, XM_342465.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217242.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1153              FQ217242.1         3-1155
            1154-1154           CB774831.1         173-173
            1155-2442           FQ217242.1         1157-2444
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2442
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /note="autophagy related 13"
                     /db_xref="GeneID:362164"
                     /db_xref="RGD:1310685"
     exon            1..291
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            292..373
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1744
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /note="harbinger transposase derived 1; ATG13 autophagy
                     related 13 homolog"
                     /codon_start=1
                     /product="autophagy-related protein 13"
                     /protein_id="NP_001258141.1"
                     /db_xref="GeneID:362164"
                     /db_xref="RGD:1310685"
                     /translation="METDLSSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSS
                     PTGSDWFNLAIKDIPEVTHEAKKALSGQLPAVGRSMCVEISLKTSEGDSMELEIWCLE
                     MNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQ
                     LNGLGEGFQTVRVGTVGTPVGTLTLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDR
                     PYPSSSPMHPCNYRTAEDAGVAYPSVEDSQEVCTTSFSTSPPSQLMVPGKEGGVPLAP
                     NHPAHGAQADQERLVVHMPSDGTHCAATPSSSEDTETVSNSSEGRASPHDILETIFVR
                     KVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDADPMVNPPDSPETTSPLHGSLHSE
                     GSSGGSSGNAHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDFGAQSM
                     AEDLDSLPEKLAVHEKNVREFDAFVETLQ"
     exon            374..454
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            455..574
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            575..621
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            622..762
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            763..803
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            804..900
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            901..999
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1090
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1227
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1342
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1420
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1537
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1666
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..2442
                     /gene="Atg13"
                     /gene_synonym="Harbi1; Harbi1l; RGD1310685"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacactaac gatggcggcg ccgggcagcg actggttgct gtcttaggga gggagagatc
       61 gcttgacgcg tgaaggggaa gctgtgaaga aaaccagtcg acaccagtcc gacagctttt
      121 ttagttctgg gatctcagaa cctcgttagc gtgaggtatc tctctgcgac ctgtgctgtc
      181 actgccgccc gggagcgcgg aaccctcagc cgggaggtgc ggttggccgg ccccaggccc
      241 cggcctccgg aatgagagcc cggagtcact ctatgtgccg tagcttcaca ggttccagta
      301 ggcaatggaa actgatctca gttcccagga cagaaaggac ctggacaagt ttattaagtt
      361 ttttgccctc aagactgtcc aagtgattgt ccaggctcga cttggagaaa agatttgcac
      421 ccgttcatca tcttccccga cgggttcaga ttggttcaat ttagcaatca aagatatccc
      481 agaagtcacc catgaagcaa agaaggccct gtctgggcag ctgcctgctg tggggcgatc
      541 tatgtgtgtg gagatctcac tcaagacttc tgagggagat tccatggagt tggaaatttg
      601 gtgtcttgaa atgaatgaaa agtgtgacaa agaaatcaaa gtttcctaca ctgtatacaa
      661 ccgattgtca ctgctgctga agtctctcct tgctattacg agggtgacac cagcctatag
      721 actctccagg aagcaagggc atgaatatgt aattttgtac aggatttatt ttggagaagt
      781 tcaactgaat ggcttaggag aaggcttcca gacagttcgt gttggaacag tgggcacccc
      841 cgtgggtacc ctcactcttt cctgtgctta tagaattaac ttggcgttca tgtccaccag
      901 gcaatttgag aggaccccac ctatcatggg gattatcatt gatcactttg ttgaccgtcc
      961 ctatcccagc tcctctccta tgcacccttg caattacaga actgctgagg atgctggagt
     1021 cgcataccca tcagtggaag actctcagga agtgtgtacc acatcttttt ccacatcccc
     1081 tccctcccag ctgatggttc ctgggaagga aggtggggtg cctcttgctc ccaaccaccc
     1141 tgctcatggt gcccaggctg atcaggagag actggtggtg cacatgcctt ctgatggaac
     1201 ccactgtgca gccacaccct ccagcagtga ggacactgag actgtatcta acagcagtga
     1261 aggacgggcc tcaccccatg acatcctgga aactatcttt gtccgaaaag tgggagcatt
     1321 tgtcaacaaa cccatcaatc aggtgacact gacgagtttg gacataccct ttgccatgtt
     1381 tgctcccaag aatttggagc tggaggatgc tgatcctatg gtgaaccctc cagactcccc
     1441 agagaccacg tctcccctcc atggcagtct gcactcagag ggctccagcg ggggcagcag
     1501 tggcaatgca catgatgact ttgtcatgat tgactttaaa ccagcttttt ctaaagacga
     1561 cattcttcca atggacttgg ggacctttta ccgtgaattt cagaatcccc ctcagctgag
     1621 cagcctctcc atagattttg gagctcagtc tatggcagaa gacttggact ccttaccaga
     1681 gaagctggct gtgcatgaga agaatgtccg agaatttgat gccttcgtcg aaaccctgca
     1741 gtaaaagtgt cccgagtgtc tgcagcatcc cctttctgtg gactcagcag agaacctcgt
     1801 cttcctcagc ctctccccag cctccatgct gtttctagcc aggtgaaaga cagggtggtt
     1861 cccctatggg acttagaagt ctctgctctt ggacttcctg gactcatagc agcagtcagg
     1921 cccaatggca ggcttggggg gagctggctg tgacagcctc agcaaggact gtccgcagca
     1981 cttcaccaag ggcgtcgtct gctcttccct gctgccagcc tcctgcctgg gtctacccga
     2041 ggccagccct acctgcctgt ccttaccatc aatcacctga cattccagct ggtggctggg
     2101 acactgggca aagcaaaaag aggaagaaaa ccaaggagac caagcaagtc gaaggagggc
     2161 cctgtgcacc agtagctcct ggaccacccc actctccctc cctcctttct ccccttcctt
     2221 ccctctatct ttactcactc ccttttcccc accttctttc ttctcttcat ctccccccca
     2281 cccttccatt ccttgccttc ctgggtctgt gattttgatg atatgaaagg cctatctgcc
     2341 taaaatgaca cctattccaa agctagccat catctcccaa aggctgtacc agcctgtttc
     2401 tagaatttgt tattgagagt cacagaaagg ttttttgttt tt
//
