LOCUS       NM_001038495            2590 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus autophagy related 12 (Atg12), mRNA.
ACCESSION   NM_001038495 XM_341609
VERSION     NM_001038495.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2590)
  AUTHORS   El-Derany,M.O. and AbdelHamid,S.G.
  TITLE     Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and
            their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on
            caspase-2 signaling inhibition
  JOURNAL   Biochem Pharmacol 190, 114624 (2021)
   PUBMED   34052187
REFERENCE   2  (bases 1 to 2590)
  AUTHORS   Cui,P., Hu,W., Ma,T., Hu,M., Tong,X., Zhang,F., Shi,J., Xu,X.,
            Li,X., Shao,L.R., Billig,H. and Feng,Y.
  TITLE     Long-term androgen excess induces insulin resistance and
            non-alcoholic fatty liver disease in PCOS-like rats
  JOURNAL   J Steroid Biochem Mol Biol 208, 105829 (2021)
   PUBMED   33513383
  REMARK    GeneRIF: Long-term androgen excess induces insulin resistance and
            non-alcoholic fatty liver disease in PCOS-like rats.
REFERENCE   3  (bases 1 to 2590)
  AUTHORS   Okada,T. and Ogura,T.
  TITLE     Scanning Electron-Assisted Dielectric Microscopy Reveals
            Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian
            Cells
  JOURNAL   Int J Mol Sci 22 (4), 1834 (2021)
   PUBMED   33673233
  REMARK    GeneRIF: Scanning Electron-Assisted Dielectric Microscopy Reveals
            Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2590)
  AUTHORS   Sun,L., Liu,A., Zhang,J., Ji,W., Li,Y., Yang,X., Wu,Z. and Guo,J.
  TITLE     miR-23b improves cognitive impairments in traumatic brain injury by
            targeting ATG12-mediated neuronal autophagy
  JOURNAL   Behav Brain Res 340, 126-136 (2018)
   PUBMED   27630106
  REMARK    GeneRIF: Study demonstrated that miR-23b expression was
            significantly downregulated following traumatic brain injury (TBI).
            In model TBI, overexpression of miR-23b reduced the lesion volume,
            brain edema and neuronal apoptosis, and improves cognitive
            dysfunction. miR-23b specifically bound with the 3' UTR of ATG12
            mRNA and modulated its translation; suppressed neuronal autophagy
            by directly targeting ATG12 expression.
REFERENCE   5  (bases 1 to 2590)
  AUTHORS   Dooley,H.C., Razi,M., Polson,H.E., Girardin,S.E., Wilson,M.I. and
            Tooze,S.A.
  TITLE     WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and
            pathogen clearance by recruiting Atg12-5-16L1
  JOURNAL   Mol Cell 55 (2), 238-252 (2014)
   PUBMED   24954904
REFERENCE   6  (bases 1 to 2590)
  AUTHORS   Yang,Z. and Klionsky,D.J.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   7  (bases 1 to 2590)
  AUTHORS   Mortensen,M., Ferguson,D.J., Edelmann,M., Kessler,B., Morten,K.J.,
            Komatsu,M. and Simon,A.K.
  TITLE     Loss of autophagy in erythroid cells leads to defective removal of
            mitochondria and severe anemia in vivo
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 832-837 (2010)
   PUBMED   20080761
REFERENCE   8  (bases 1 to 2590)
  AUTHORS   Liu,C.L., Chen,S., Dietrich,D. and Hu,B.R.
  TITLE     Changes in autophagy after traumatic brain injury
  JOURNAL   J Cereb Blood Flow Metab 28 (4), 674-683 (2008)
   PUBMED   18059433
REFERENCE   9  (bases 1 to 2590)
  AUTHORS   Tanida,I., Ueno,T. and Kominami,E.
  TITLE     LC3 conjugation system in mammalian autophagy
  JOURNAL   Int J Biochem Cell Biol 36 (12), 2503-2518 (2004)
   PUBMED   15325588
  REMARK    Review article
REFERENCE   10 (bases 1 to 2590)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC110056.1.
            
            On Dec 30, 2005 this sequence version replaced XM_341609.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110056.1, FQ086418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2590
                     /gene="Atg12"
                     /gene_synonym="Apg12l"
                     /note="autophagy related 12"
                     /db_xref="GeneID:361321"
                     /db_xref="RGD:1306306"
     exon            1..181
                     /gene="Atg12"
                     /gene_synonym="Apg12l"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..441
                     /gene="Atg12"
                     /gene_synonym="Apg12l"
                     /note="autophagy-related protein 12; ATG12 autophagy
                     related 12 homolog; autophagy 12-like"
                     /codon_start=1
                     /product="ubiquitin-like protein ATG12"
                     /protein_id="NP_001033584.1"
                     /db_xref="GeneID:361321"
                     /db_xref="RGD:1306306"
                     /translation="MAEDPEAVLQLPAAPAAAAGESLLELSPETAIPEPPSSVAVSPG
                     TEEPPGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTVQALIDFIRKFLRLLASEQLF
                     IYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG"
     exon            182..318
                     /gene="Atg12"
                     /gene_synonym="Apg12l"
                     /inference="alignment:Splign:2.1.0"
     exon            319..381
                     /gene="Atg12"
                     /gene_synonym="Apg12l"
                     /inference="alignment:Splign:2.1.0"
     exon            382..2567
                     /gene="Atg12"
                     /gene_synonym="Apg12l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcagcaa gcaagatggc agaagaccca gaggctgtgc tgcagctccc cgcggctccg
       61 gctgctgcgg cgggcgagag ccttttggag ctctccccag aaacagccat cccagagccc
      121 ccgtcttcgg ttgcagtttc gcccggtacg gaggaacctc ccggagacac caagaaaaaa
      181 attgacatcc tgctgaaggc tgtaggagac actcccataa tgaaaacgaa gaaatgggct
      241 gtggagcgga cccggactgt ccaagcactc atcgacttca tcagaaaatt cctcagactg
      301 ctggcctcgg agcagttgtt tatttatgtg aatcagtcct ttgccccttc cccagaccaa
      361 gaagttggga ctctatatga gtgttttggc agtgatggta aactggtcct acattactgc
      421 aaatcacagg catggggatg agccacaaat gaacaacttg atgtttcaca gaagaaaaaa
      481 attcagagaa gttttgatgc tgtgggaaga gacttacatg actatcacat attcagcaca
      541 aatctgttat gatgtgttta tgtgtaagaa aacatcgtag ggtaaataga ctattgaatg
      601 agatttgtgt caccataaaa tcatcatgag agattggtat tagagtatgt gtattacccc
      661 cacacttctg tttcctgttt cagatctacc tctagggtta gaaaggagac tggaattcta
      721 tatgtactac agggtctcag gatgactgaa gttattggat tggcactgtg ttgattccat
      781 gataaaaact aatttactga agggcttgtg ttttgaggta atttagtttt ttaacttatt
      841 caggatgtgt ttgggatgta gaatgtttac atttatctgt tgctttgtaa aacaaagtgc
      901 actgattcta aagttgtcca gtagagggca gccagttggc agaaagtctt gacagttttg
      961 acatctttgc caggtgattg gaggaaagac tgttgaacta atttctagtt aatgtgtaat
     1021 ccggaaagca gctgtattga cacactggcg gacttagggg acgtgcatag tttaaaatta
     1081 atcatgcagg gaagcagttt tacaaattgc gagcaaatga attgcaactc ttttcagtcc
     1141 ttgagcctca ccctgagcat tgtgatccac acctataatc tcagcactca ggaaacgtga
     1201 gccaagggga ttggtccccg agttcaaaac tagactgaac tgcaaaagaa cttaccccaa
     1261 aaagcttcta gagccctact cagtgtattc ccactgttac ttctgtgtcc gagaagctga
     1321 cttgggaaac caagcagcac caagtttccc atttcatccc aacactcact ctcatctctg
     1381 tatttttagt ttgtagtttt gcagacctag ggatcattcc ctgtgccttg tgcactcaag
     1441 gcgtgagttc tgctgggctg catcccagca ttcattgagt gttcataatg tgtcgtccac
     1501 attgaaagca ttcagagata atggttgaaa aatagtgtcc aatcacaata aagtgcaact
     1561 gtcactggta atgttaggct agccattgct taagctgaca tttgaccttt ttcttacata
     1621 ttttatgtca aacttgcttt tgagactggg tcccatgatg tagatctgcc tagcctggaa
     1681 ctcagagatt gatgtgcctg tccgtgaagc tcacccagct ccacaggagt cttaaagcag
     1741 agcacacagg gctactgtgc attcttacct ggcgttgagg gagtggagac aaaaggttga
     1801 aagtttaaga ctatatgggc tacagagtaa gactgtcaca aaaaccataa aatcagctct
     1861 tcttcccttc tctgaaaaaa agcattccaa taaatggtgt gtaaagagga ttacagggtt
     1921 tgaagtgtgc aaggattcca agtgtttgct ttcaaaggtg atgatagaaa tgtatttttc
     1981 atcaaaagaa aagaaccttg aagacctgaa atactaccct tttgttatgc ttttaagatt
     2041 ggctgtgttg ctcaggctga cttgcctcag gctcctgggc accagctcta ggcttatagt
     2101 tgtgcaccac tgcacctgcc tcatttttaa ctcttaagcc ctagaatgtg cttcagagta
     2161 gtcctcagcc atgtgtgcca tggaaaatgc tgtggaacaa catggtcact tcttgtcttc
     2221 tgcctgagaa tgtgaatttg ggacatcccc tttccctgcg ccccttgcag tgagttaatg
     2281 cagggaatag ttcacagagt actatgttca gtgagttatg cacagtacag gcttagaaaa
     2341 ccaccttaca tcttgaaagc tgggacgtat tgatttatga acaatgtcac ttggaaaggg
     2401 aaaagatcgt gtctagcttt gcctagtaag aggtgactga aagaacataa tggtagatat
     2461 tttacaggag aaatctgttg aatttattgt tggctggtat tcatttgcga tgatggaatg
     2521 cttcttacct ctatgaaatc gaaaataaac ttgagtttga atttgtaaaa aaaaaaaaaa
     2581 aaaaaaaaaa
//
