LOCUS       NM_001108115            2238 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Rattus norvegicus activating transcription factor 7 (Atf7),
            transcript variant 4, mRNA.
ACCESSION   NM_001108115 XM_001068889 XM_235694
VERSION     NM_001108115.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2238)
  AUTHORS   Guo,H.Q., Ye,S., Huang,G.L., Liu,L., Liu,O.F. and Yang,S.J.
  TITLE     Expression of activating transcription factor 7 is correlated with
            prognosis of colorectal cancer
  JOURNAL   J Cancer Res Ther 11 (2), 319-323 (2015)
   PUBMED   26148593
REFERENCE   2  (bases 1 to 2238)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   3  (bases 1 to 2238)
  AUTHORS   Hamard,P.J., Boyer-Guittaut,M., Camuzeaux,B., Dujardin,D.,
            Hauss,C., Oelgeschlager,T., Vigneron,M., Kedinger,C. and Chatton,B.
  TITLE     Sumoylation delays the ATF7 transcription factor subcellular
            localization and inhibits its transcriptional activity
  JOURNAL   Nucleic Acids Res 35 (4), 1134-1144 (2007)
   PUBMED   17264123
REFERENCE   4  (bases 1 to 2238)
  AUTHORS   De Graeve,F., Bahr,A., Sabapathy,K.T., Hauss,C., Wagner,E.F.,
            Kedinger,C. and Chatton,B.
  TITLE     Role of the ATFa/JNK2 complex in Jun activation
  JOURNAL   Oncogene 18 (23), 3491-3500 (1999)
   PUBMED   10376527
REFERENCE   5  (bases 1 to 2238)
  AUTHORS   Pescini,R., Kaszubska,W., Whelan,J., DeLamarter,J.F. and Hooft van
            Huijsduijnen,R.
  TITLE     ATF-a0, a novel variant of the ATF/CREB transcription factor
            family, forms a dominant transcription inhibitor in ATF-a
            heterodimers
  JOURNAL   J Biol Chem 269 (2), 1159-1165 (1994)
   PUBMED   8288576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474035.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235694.4, XM_001068889.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2238
                     /gene="Atf7"
                     /note="activating transcription factor 7"
                     /db_xref="GeneID:315333"
                     /db_xref="RGD:1304940"
     exon            1..93
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            94..162
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1572
                     /gene="Atf7"
                     /note="isoform 2 is encoded by transcript variant 4;
                     cyclic AMP-dependent transcription factor ATF-7"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-7
                     isoform 2"
                     /protein_id="NP_001101585.1"
                     /db_xref="GeneID:315333"
                     /db_xref="RGD:1304940"
                     /translation="MGDDRPFVCSAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDS
                     VIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKASDDDEKKASSAAGPLDMSLPS
                     TPDIKVKEEEPVEVDSSPPDSPASCPCSPPLKDKEVATKPVVISTPTPTIVRPGSLPL
                     HLGYDPLHPTLPSPTSVITQAPPSNRQIGSPTGSLPLVMHLANGQTMPMLPGPPVQMP
                     SVISLARPVSMVPNIPGIPGPPVNNSGSISPSGHPMPSEAKMRLKATLTHQVSSINGG
                     CGMVVGTASTMVTARPEQNQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPD
                     ERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQ
                     LLLAHKDCPVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPSNGLSVRSAAEA
                     VATSVLTQMASQRTELSMPIQSHVIMTPQSQSAGR"
     exon            163..259
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            260..384
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            385..522
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            523..680
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            681..780
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            781..894
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1047
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1245
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1354
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..2238
                     /gene="Atf7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtatctgc tccgctgagg ggggaaagga ggagcaggag acagattgtg ggaccgagcg
       61 cgggcgggcg ggaggcgccg gagctaccag cggctctgct ctgctttatg aaatatggga
      121 gacgacagac cgtttgtgtg cagtgcccca ggctgtggac agagatttac aaatgaggac
      181 cacctggcag ttcataaaca taagcatgag atgaccctga agttcggccc ggcccggacg
      241 gactctgtca tcattgcaga tcaaacacct actccaacaa gattcctgaa gaactgtgag
      301 gaggtggggc tcttcaatga attagctagt tcctttgaac atgaatttaa gaaagcttct
      361 gatgatgatg aaaaaaaggc aagtagtgct gctgggcctc tagacatgtc tctgccttct
      421 acaccagaca tcaaagtcaa ggaggaagag ccagtggagg tggactcatc accccccgac
      481 agtcctgctt cctgcccctg ctccccgcca ctgaaagaca aggaagttgc cacaaaacct
      541 gttgtgatct ctacccctac acccaccatc gtacgtcctg gctccctgcc tctgcactta
      601 ggttatgatc cacttcatcc aactcttcct tccccaacct ctgtcatcac acaggctcca
      661 ccatccaaca ggcaaatagg atctcctact ggctccctcc ctctcgtcat gcatcttgct
      721 aatggacaga ccatgccaat gctgccaggg cctccagtac agatgccttc tgttatttcg
      781 ctggccagac ctgtttccat ggtgcccaac attcctggta tacctggccc accagttaac
      841 aatagtggct ctatttctcc ctctggccac cctatgccgt cagaagccaa aatgagacta
      901 aaagccacat tgacccacca agtttcttca atcaatggag gttgtggaat ggtggtaggc
      961 actgcaagca ccatggtgac agcccgtcca gagcagaacc agatcctcat ccagcacccg
     1021 gatgccccat cccctgccca gccacaggtg tctccagctc agcccacccc tagcacaggg
     1081 ggacggcgtc ggcgcacagt ggatgaagat ccagatgagc ggcggcagcg atttttagag
     1141 cggaacagag ctgcagcctc ccgatgccgc caaaagcgaa agctgtgggt ctcctccctg
     1201 gaaaagaagg cagaagaact tacttctcag aacattcagc tgagtaatga agtcacatta
     1261 ctacgcaatg aggtggctca gttgaaacag ctactgttag ctcataaaga ctgcccagtc
     1321 actgcactac agaaaaagac tcaaggctac ctagaaagtc ccaaggaaag ctcagagcca
     1381 acgggttctc cagccccagt gattcagcac agttccgcaa cagcccctag caatggcctt
     1441 agtgttcgat ctgcagctga agctgtggcc acctcggtcc tcactcagat ggccagccaa
     1501 aggacagaac tgagcatgcc catacagtca catgtgatca tgaccccaca gtcacagtct
     1561 gcgggcagat gatgcctccc atgatggaga ggtccccagc cagagctcgc cagcctgagc
     1621 caaaagagag atcaacttat ccctcctgtc tgccttggaa ttggcagtat ggagagggag
     1681 aaattgtgtg ttgtgagtat ggacagatgt ggggcttttc tctttagcca catgatcatg
     1741 tacaattaac acctgtacaa cgggcttttg gccccaaagc cacatagatc atcccccaag
     1801 ggtagggttt cttatgatcc tacaaccaaa ggcctttcca catggtctga gcaatcaccc
     1861 cagccctgat gcatgtgtgc ctctcttaac actaaccctt gcacttgtag gtttggggtt
     1921 tctcagtgtc ctctcctccc cttgagctgt ggctgatacc ttcttatctc ttactagcat
     1981 gccacttcct gccagataga gggagacgag atttgatggc gtgttacttg ctgtcccatc
     2041 cccagccacc ccatgcactc aggactttgt ccccaacagc tgcttatttg tctcttcccc
     2101 ttctaagcga cagtgaaaac actcacttgt tgagaatgta atgcatttaa tgtgtgaggt
     2161 agcagtgctt cccgcctctt ccctgggctc tactcctgtc tgctaccaaa aacaaacaca
     2221 gacagaaaaa gcaaaact
//
