LOCUS       NM_001107196            3217 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus activating transcription factor 6 (Atf6), mRNA.
ACCESSION   NM_001107196 XM_001076843 XM_222871
VERSION     NM_001107196.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Liang,T., Xu,S., Liu,R. and Xia,X.
  TITLE     Activating transcription factor 6 alleviates secondary brain injury
            by increasing cystathionine gamma-lyase expression in a rat model
            of intracerebral hemorrhage
  JOURNAL   Aging (Albany NY) 16 (8), 6990-7008 (2024)
   PUBMED   38613810
  REMARK    GeneRIF: Activating transcription factor 6 alleviates secondary
            brain injury by increasing cystathionine gamma-lyase expression in
            a rat model of intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 3217)
  AUTHORS   Ishteyaque,S., Yadav,K.S., Verma,S., Washimkar,K.R. and Mugale,M.N.
  TITLE     CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis
            and promotes progression of hepatocellular carcinoma
  JOURNAL   Arch Biochem Biophys 745, 109701 (2023)
   PUBMED   37499993
  REMARK    GeneRIF: CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit
            apoptosis and promotes progression of hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   Zhang,Q., Liu,G., Liu,R., Liu,J., Zeng,X., Ren,D., Yan,X. and
            Yuan,X.
  TITLE     Dual role of endoplasmic reticulum stress-ATF-6 activation in
            autophagy and apoptosis induced by cyclic stretch in myoblast
  JOURNAL   Apoptosis 28 (5-6), 796-809 (2023)
   PUBMED   36881290
  REMARK    GeneRIF: Dual role of endoplasmic reticulum stress-ATF-6 activation
            in autophagy and apoptosis induced by cyclic stretch in myoblast.
            Erratum:[Apoptosis. 2023 Oct;28(9-10):1501. doi:
            10.1007/s10495-023-01864-y.. PMID: 37439923]
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Wang,S., Duan,J., Liao,J., Wang,Y., Xiao,X., Li,L., Liu,Y., Gu,H.,
            Yang,P., Fu,D., Du,J., Li,X. and Shao,M.
  TITLE     LncRNA H19 inhibits ER stress induced apoptosis and improves
            diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis
  JOURNAL   Aging (Albany NY) 14 (16), 6809-6828 (2022)
   PUBMED   36044268
REFERENCE   5  (bases 1 to 3217)
  AUTHORS   Xia,H., Zhao,H., Yang,W., Luo,X., Wei,J. and Xia,H.
  TITLE     MiR-195-5p represses inflammation, apoptosis, oxidative stress, and
            endoplasmic reticulum stress in sepsis-induced myocardial injury by
            targeting activating transcription factor 6
  JOURNAL   Cell Biol Int 46 (2), 243-254 (2022)
   PUBMED   34816499
  REMARK    GeneRIF: MiR-195-5p represses inflammation, apoptosis, oxidative
            stress, and endoplasmic reticulum stress in sepsis-induced
            myocardial injury by targeting activating transcription factor 6.
REFERENCE   6  (bases 1 to 3217)
  AUTHORS   Yoshida,H., Matsui,T., Yamamoto,A., Okada,T. and Mori,K.
  TITLE     XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER
            stress to produce a highly active transcription factor
  JOURNAL   Cell 107 (7), 881-891 (2001)
   PUBMED   11779464
REFERENCE   7  (bases 1 to 3217)
  AUTHORS   Haze,K., Okada,T., Yoshida,H., Yanagi,H., Yura,T., Negishi,M. and
            Mori,K.
  TITLE     Identification of the G13 (cAMP-response-element-binding
            protein-related protein) gene product related to activating
            transcription factor 6 as a transcriptional activator of the
            mammalian unfolded protein response
  JOURNAL   Biochem J 355 (Pt 1), 19-28 (2001)
   PUBMED   11256944
REFERENCE   8  (bases 1 to 3217)
  AUTHORS   Ye,J., Rawson,R.B., Komuro,R., Chen,X., Dave,U.P., Prywes,R.,
            Brown,M.S. and Goldstein,J.L.
  TITLE     ER stress induces cleavage of membrane-bound ATF6 by the same
            proteases that process SREBPs
  JOURNAL   Mol Cell 6 (6), 1355-1364 (2000)
   PUBMED   11163209
REFERENCE   9  (bases 1 to 3217)
  AUTHORS   Haze,K., Yoshida,H., Yanagi,H., Yura,T. and Mori,K.
  TITLE     Mammalian transcription factor ATF6 is synthesized as a
            transmembrane protein and activated by proteolysis in response to
            endoplasmic reticulum stress
  JOURNAL   Mol Biol Cell 10 (11), 3787-3799 (1999)
   PUBMED   10564271
REFERENCE   10 (bases 1 to 3217)
  AUTHORS   Yoshida,H., Haze,K., Yanagi,H., Yura,T. and Mori,K.
  TITLE     Identification of the cis-acting endoplasmic reticulum stress
            response element responsible for transcriptional induction of
            mammalian glucose-regulated proteins. Involvement of basic leucine
            zipper transcription factors
  JOURNAL   J Biol Chem 273 (50), 33741-33749 (1998)
   PUBMED   9837962
  REMARK    Erratum:[J Biol Chem 1999 Jan 22;274(4):2592]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222871.4, XM_001076843.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168890.1, SRR8487227.299522.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..3217
                     /gene="Atf6"
                     /note="activating transcription factor 6"
                     /db_xref="GeneID:304962"
                     /db_xref="RGD:1305471"
     exon            1..122
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2041
                     /gene="Atf6"
                     /note="ATF6-alpha; activating transcription factor 6
                     alpha; cAMP-dependent transcription factor ATF-6 alpha"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-6
                     alpha"
                     /protein_id="NP_001100666.1"
                     /db_xref="GeneID:304962"
                     /db_xref="RGD:1305471"
                     /translation="MESPFSPVLPHGPGEDWESTLFAELGYFTDTDDVQFDAAHETYE
                     NNFDHLNFDLDLMPWESDIWSPSSHFCSDIKAEPQPLSPASSSCSVSSPRSTDSCSST
                     QHVPEELDLLSSSQSPLSLYGDSCHSPSSAEPLKEEKPVTGPGNKTEHGLTPKKKIQM
                     SSKPSVQPKPLLLPAAPKTPANASVPAKTIIIQTLPALMPLAKQQSIISIQPAPTKGQ
                     TVLLSQPAVVQLQTPGVLPSAQPVLAVTGGATQLPNHVVNVVPAPVVNSPVNGKLCVT
                     KPVLQSSTRSTGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQ
                     LKKENGSLKRQLDQVVSENQRLKVPSPKRRAVCVMIVLAFIMLNYGPMSMLEQDSRRV
                     KPSVSPANQRRHLLEFSAKEVKDTSDGDNQKNSYRYDHSVSNDKALMVLSEEPLLYIP
                     PPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNSQQKTRILQGALEQGSNSQ
                     LMAVQYTETTSISRNSGSELQVYYASPGSYQGFFDAIRRRGDTFYVVSFRRDHLLLPA
                     TTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLR
                     DHQRNQTSTFFGSPPTATETTHVVSTLPESVQ"
     exon            123..199
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            200..287
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            288..388
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            389..515
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            516..719
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            720..940
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1126
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1218
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1350
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1464
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1564
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1632
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1747
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1832
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..3217
                     /gene="Atf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attactcacc gatccgagtt gcgagggaga ggtgtctgtt tcggggaagc cggcttctgt
       61 tgccggcgcc atggagtcgc cttttagtcc ggttcttcct catggaccag gtgaagactg
      121 ggagtccacg ttgtttgctg agcttggcta tttcacagac acggatgatg tccagtttga
      181 tgcagcacat gagacttacg aaaataattt tgatcatctt aattttgatt tggatttgat
      241 gccttgggag tcagacatat ggagccccag cagccacttc tgctcagaca ttaaggcaga
      301 gccccagcct ctttctccgg cttcctccag ttgttctgtc tcttctcctc ggtccacaga
      361 ctcctgttct tcaactcagc acgttcctga ggagttggac ttgttgtcta gttctcagtc
      421 tcccctttcc ttgtatggcg acagctgtca cagcccctcc tcagcagagc cactgaagga
      481 agagaagcct gtcactggtc ctggaaacaa aacggaacat ggactgactc caaagaaaaa
      541 aatccagatg agttcaaaac cttcagttca gcccaagcct ttgttacttc cagcagcacc
      601 caagactcca gcaaacgcca gtgtcccagc aaagaccatc atcattcaga cactgccagc
      661 cctgatgcca ctggcaaagc agcagtcgat tatcagtata cagcctgcgc ccaccaaagg
      721 tcagactgtt ttgctctctc agcctgctgt ggttcaactt cagacccctg gagttctgcc
      781 ctctgctcag ccagtacttg ctgtcactgg cggagccaca cagctaccta accatgtggt
      841 gaatgtggtg ccagccccgg tggtgaacag cccggtgaac ggaaaactgt gtgtgactaa
      901 acctgttcta caaagcagca ccagaagcac gggttcagat attgccgtac tgaggagaca
      961 gcagcgtatg atcaagaacc gagagtctgc ttgtcagtca cgaaagaaga agaaagagta
     1021 tatgctaggc ctggaggcca ggttgaaggc cgccctctcc gagaatgagc agctgaagaa
     1081 ggagaatggg tccctgaagc gacagctgga ccaggtggtg tcagagaacc agaggctcaa
     1141 agtcccaagt ccaaagcgca gagctgtctg tgtgatgata gtattagcat ttatcatgct
     1201 gaactatggg cccatgagca tgctggagca agattccagg agagtgaaac ctagtgtgag
     1261 ccctgccaat caaaggaggc atcttttaga gttttcagca aaagaagtta aagacacgtc
     1321 agatggtgac aaccagaaaa acagttacag atatgatcat tctgtgtcca atgacaaagc
     1381 cttaatggtg ctaagtgaag aaccattact ttatatccct ccacctccat gtcagcccct
     1441 cattaacacg acagagtctc tcaggttgaa ccatgaactt cgaggctggg ttcatagaca
     1501 tgaagtggaa aggaccaaat cgagaagaat gacaaatagc cagcagaaaa cccgcattct
     1561 ccagggtgct ctggaacagg gctcgaattc tcagctgatg gctgtccagt acacagaaac
     1621 cactagcatc agtaggaatt ctgggagtga gctgcaggtg tattacgctt cgcctggaag
     1681 ttaccaaggc ttctttgacg ccatccgcag gaggggagat acattttacg tcgtatcatt
     1741 tcgaagggat cacctgctat taccagctac cacccataac aagaccacaa gaccgaagat
     1801 gtccattgtg ttaccagcaa taaacataaa tgataacgtg atcaatgggc aggattatga
     1861 agtaatgatg cagattgact gtcaggtcat ggacaccagg atcctccaca tcaaaagctc
     1921 ctcggttccc ccgtatctcc gagatcatca gagaaaccaa accagcacct tcttcggttc
     1981 ccctcccaca gccacagaga cgacccatgt ggtcagcacc ctccctgagt cggtacagta
     2041 gtgcctgagc tgcactggga agcagagagt gggcctcgcc aagctgaaga gctgaagagg
     2101 acgctgctct ctgcctctcg gcaagcggag aaccaccttg tactgcaact ccagggaaag
     2161 agagagaaaa caagaggccg ttctgctttt caccgtcttc ccacagcgtg cagctgctgg
     2221 agcacagttc tctgatggcc gtgcatccct gtgggcagtg tctcctggtg ttggttctgt
     2281 gggtcatctt cagaacttct cccgtcgtgt gttttgttct cagtcacctt ccttcaggtc
     2341 agacccactt cctcttctgt ccactgcact tcctggcaca gtcaagagtt tttatttaaa
     2401 gcttagaaca catgctcatg tggttaccac cagttggctt tctctctcct ttgattcaaa
     2461 tccattctga ttattatact tgagaaaaca catttcaaaa aaccgagcag ccaaaaacat
     2521 cccacaaaga gtcaaaacag ttcggagttt gggtaaaggg attatctcca gttggtagag
     2581 tttattttta cttgtgattt gtggttcagc cctggacaaa caactgttgt ggggtcccag
     2641 aatgagccgc acactggaga ccagggaagg gaaggccagt tgtggaatgt aagaggaggg
     2701 gactccgttt acatatgtgt ttaaccatac gtatggcctc agtggagttc agagccacag
     2761 ccacctttca ctcttggaag tctgccaatc agcaaagatc tttaaaggcc tcagggcaaa
     2821 tgctttcctc tcattgggaa tcctcagccc aggacacagt cctgtgaaac caggctcagc
     2881 caaggaactc aaggtgacta gatttaagca agactcagtt tcccttaaag acagacagta
     2941 cacagaacaa gcatggcttc ccagagaggc tgcagcccag tgtggtgaaa gtctcagttt
     3001 ctccagagag aagatgataa ggaactaagc tctctttgtt gttgcttagt ggaatatttt
     3061 taaaaagcta tgactgtgaa catgccttta atcctagctc catttgaaag ggaaggcaga
     3121 ctgtttaata tcagcctggt ctacatatca aattccagga caggacagct aacggtgtct
     3181 agagaaccca cctcaaaaca aacaaacaaa taaataa
//
