LOCUS       NM_172336               1030 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus activating transcription factor 5 (Atf5), mRNA.
ACCESSION   NM_172336
VERSION     NM_172336.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1030)
  AUTHORS   Madarampalli,B., Yuan,Y., Liu,D., Lengel,K., Xu,Y., Li,G., Yang,J.,
            Liu,X., Lu,Z. and Liu,D.X.
  TITLE     ATF5 Connects the Pericentriolar Materials to the Proximal End of
            the Mother Centriole
  JOURNAL   Cell 162 (3), 580-592 (2015)
   PUBMED   26213385
REFERENCE   2  (bases 1 to 1030)
  AUTHORS   Zhang,Z.Y., Li,S.Z., Zhang,H.H., Wu,Q.R., Gong,J., Liang,T.,
            Gao,L., Xing,N.N., Liu,W.B., Du,R.L. and Zhang,X.D.
  TITLE     Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates
            the interleukin-1beta-stimulated C/EBP signaling pathway
  JOURNAL   Mol Cell Biol 35 (5), 778-788 (2015)
   PUBMED   25512613
REFERENCE   3  (bases 1 to 1030)
  AUTHORS   Zhao,Y., Zhang,Y.D., Zhang,Y.Y., Qian,S.W., Zhang,Z.C., Li,S.F.,
            Guo,L., Liu,Y., Wen,B., Lei,Q.Y., Tang,Q.Q. and Li,X.
  TITLE     p300-dependent acetylation of activating transcription factor 5
            enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1
            differentiation
  JOURNAL   Mol Cell Biol 34 (3), 315-324 (2014)
   PUBMED   24216764
REFERENCE   4  (bases 1 to 1030)
  AUTHORS   Wang,S.Z., Ou,J., Zhu,L.J. and Green,M.R.
  TITLE     Transcription factor ATF5 is required for terminal differentiation
            and survival of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 109 (45), 18589-18594 (2012)
   PUBMED   23090999
REFERENCE   5  (bases 1 to 1030)
  AUTHORS   Liu,X., Liu,D., Qian,D., Dai,J., An,Y., Jiang,S., Stanley,B.,
            Yang,J., Wang,B., Liu,X. and Liu,D.X.
  TITLE     Nucleophosmin (NPM1/B23) interacts with activating transcription
            factor 5 (ATF5) protein and promotes proteasome- and
            caspase-dependent ATF5 degradation in hepatocellular carcinoma
            cells
  JOURNAL   J Biol Chem 287 (23), 19599-19609 (2012)
   PUBMED   22528486
REFERENCE   6  (bases 1 to 1030)
  AUTHORS   Forgacs,E., Gupta,S.K., Kerry,J.A. and Semmes,O.J.
  TITLE     The bZIP transcription factor ATFx binds human T-cell leukemia
            virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal
            repeat-mediated transcription
  JOURNAL   J Virol 79 (11), 6932-6939 (2005)
   PUBMED   15890932
REFERENCE   7  (bases 1 to 1030)
  AUTHORS   Angelastro,J.M., Mason,J.L., Ignatova,T.N., Kukekov,V.G.,
            Stengren,G.B., Goldman,J.E. and Greene,L.A.
  TITLE     Downregulation of activating transcription factor 5 is required for
            differentiation of neural progenitor cells into astrocytes
  JOURNAL   J Neurosci 25 (15), 3889-3899 (2005)
   PUBMED   15829641
REFERENCE   8  (bases 1 to 1030)
  AUTHORS   Angelastro,J.M., Ignatova,T.N., Kukekov,V.G., Steindler,D.A.,
            Stengren,G.B., Mendelsohn,C. and Greene,L.A.
  TITLE     Regulated expression of ATF5 is required for the progression of
            neural progenitor cells to neurons
  JOURNAL   J Neurosci 23 (11), 4590-4600 (2003)
   PUBMED   12805299
  REMARK    GeneRIF: ATF5 blocks the differentiation of neuroprogenitor cells
            into neurons and must be downregulated to permit this process to
            occur.
REFERENCE   9  (bases 1 to 1030)
  AUTHORS   Persengiev,S.P., Devireddy,L.R. and Green,M.R.
  TITLE     Inhibition of apoptosis by ATFx: a novel role for a member of the
            ATF/CREB family of mammalian bZIP transcription factors
  JOURNAL   Genes Dev 16 (14), 1806-1814 (2002)
   PUBMED   12130540
REFERENCE   10 (bases 1 to 1030)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172336.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY123225.1, CK366581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840109, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000001.1  104434601-104434795 c
            196-1030            JAXUCZ010000001.1  104432514-104433348 c
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1030
                     /gene="Atf5"
                     /note="activating transcription factor 5"
                     /db_xref="GeneID:282840"
                     /db_xref="RGD:628902"
     exon            1..195
                     /gene="Atf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..863
                     /gene="Atf5"
                     /note="cAMP-dependent transcription factor ATF-5;
                     transcription factor ATFx"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-5"
                     /protein_id="NP_758839.3"
                     /db_xref="GeneID:282840"
                     /db_xref="RGD:628902"
                     /translation="MSLLATLGLELDRALLPASGLGWLVDYGKLPLAPAPLGPYEVLG
                     GALEGGLPGGGEPLAGDGFSDWMTERVDFTALLPLEAPLPPGTLPPPSPAPPDLEAMA
                     SLLKKELEQMEDFFLDAPLLPPPSPPPPPPPAPSLPLPLPLPTFDLPQPPTLDTLDLL
                     AVYCRSEAGPGDSGLTTLPVPQQPPPLAPLPSPSRPAPYPSPASTRGDRKQKKRDQNK
                     SAALRYRQRKRAEGEALEGECQGLEARNRELRERAESVEREIQYVKDLLIEVYKARSQ
                     RTRSA"
     exon            196..1030
                     /gene="Atf5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacctgtgc ctcagccatg tcactcctgg cgaccctggg actggagctg gacagggccc
       61 tgctcccagc tagcgggctg ggctggctcg tagactatgg gaaactcccc ctggcccctg
      121 cccccctggg cccctatgag gtccttgggg gtgccctgga gggcgggctt ccaggggggg
      181 gagagcccct ggcaggtgac ggcttctctg attggatgac cgagcgggtg gacttcacag
      241 ccctccttcc tctggaggcc cctctgcccc caggcactct ccccccaccc tcccctgccc
      301 cccctgacct ggaagccatg gcatccctac tcaagaagga gctagaacag atggaagact
      361 tcttccttga tgccccactc cttccaccgc cctccccacc tccaccccca cccccagcac
      421 cctctctgcc cctgccctta cccttgccca cctttgatct cccgcagcct cctaccctgg
      481 ataccctgga cttgctagct gtttactgcc gcagtgaggc tgggccaggg gattcaggct
      541 tgacaaccct gcctgtcccc cagcagcctc ctcctctggc ccctctgcct tcaccctccc
      601 gaccagcccc ctatcctagt cctgccagca cccgagggga ccgcaagcaa aagaagagag
      661 accagaataa gtcagctgct ctcaggtacc gccagaggaa gcgggcagag ggcgaggccc
      721 tggagggcga gtgccaaggg ctagaggcgc ggaatcggga gctgagggag agggcagagt
      781 cagtggaacg ggagatccag tatgtgaagg atctgctaat tgaggtgtat aaggcacgaa
      841 gccagaggac ccgcagtgcc tagggtacag gaggaggcag ttctggtgta cctgtgcctc
      901 cagcttcacc ctgtccctcc atttcacttc cctgtgcatc cgtgtctagg tctcccctct
      961 gcctatcccc attatgggtt atttggcata gtcagtttct gtaccccttc agtgcaactg
     1021 agaaaccaag
//
