LOCUS       NM_024403               1410 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Rattus norvegicus activating transcription factor 4 (Atf4), mRNA.
ACCESSION   NM_024403 XM_006242127
VERSION     NM_024403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Gu,X., Li,F., Che,X., Wei,X. and Li,P.
  TITLE     HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model
  JOURNAL   BMC Musculoskelet Disord 25 (1), 467 (2024)
   PUBMED   38879481
  REMARK    GeneRIF: HDAC4 represses ER stress induced chondrocyte apoptosis by
            inhibiting ATF4 and attenuates cartilage degeneration in an
            osteoarthritis rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Yu,X., Wang,X., Xie,Y., Peng,T., Lian,Y., Wang,C. and Xie,N.
  TITLE     Activating Transcription Factor 4-mediated Mitochondrial Unfolded
            Protein Response Alleviates Hippocampal Neuronal Damage in an In
            Vitro Model of Epileptiform Discharges
  JOURNAL   Neurochem Res 48 (7), 2253-2264 (2023)
   PUBMED   36928813
  REMARK    GeneRIF: Activating Transcription Factor 4-mediated Mitochondrial
            Unfolded Protein Response Alleviates Hippocampal Neuronal Damage in
            an In Vitro Model of Epileptiform Discharges.
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Wu,G., Zhang,X., Li,S., Wang,L., Bai,J., Wang,H. and Shu,Q.
  TITLE     Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and
            mitigates cerebral ischemic injury
  JOURNAL   J Biochem Mol Toxicol 36 (7), e23070 (2022)
   PUBMED   35403324
  REMARK    GeneRIF: Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and
            mitigates cerebral ischemic injury.
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Wang,X., Zhang,G., Dasgupta,S., Niewold,E.L., Li,C., Li,Q., Luo,X.,
            Tan,L., Ferdous,A., Lorenzi,P.L., Rothermel,B.A., Gillette,T.G.,
            Adams,C.M., Scherer,P.E., Hill,J.A. and Wang,Z.V.
  TITLE     ATF4 Protects the Heart From Failure by Antagonizing Oxidative
            Stress
  JOURNAL   Circ Res 131 (1), 91-105 (2022)
   PUBMED   35574856
  REMARK    GeneRIF: ATF4 Protects the Heart From Failure by Antagonizing
            Oxidative Stress.
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Shi,Y., Zheng,Z., Luo,J., Li,Y., He,S., Shen,X. and Liu,J.
  TITLE     Possible effects of fibroblast growth factor 21 on vascular
            calcification via suppressing activating transcription factor 4
            mediated apoptosis and osteogenic transformation in rats
  JOURNAL   Cell Biochem Funct 40 (4), 349-358 (2022)
   PUBMED   35531910
  REMARK    GeneRIF: Possible effects of fibroblast growth factor 21 on
            vascular calcification via suppressing activating transcription
            factor 4 mediated apoptosis and osteogenic transformation in rats.
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Vattem,K.M. and Wek,R.C.
  TITLE     Reinitiation involving upstream ORFs regulates ATF4 mRNA
            translation in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (31), 11269-11274 (2004)
   PUBMED   15277680
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Tanaka,T., Tsujimura,T., Takeda,K., Sugihara,A., Maekawa,A.,
            Terada,N., Yoshida,N. and Akira,S.
  TITLE     Targeted disruption of ATF4 discloses its essential role in the
            formation of eye lens fibres
  JOURNAL   Genes Cells 3 (12), 801-810 (1998)
   PUBMED   10096021
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Vallejo,M., Ron,D., Miller,C.P. and Habener,J.F.
  TITLE     C/ATF, a member of the activating transcription factor family of
            DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins
            and directs their binding to cAMP response elements
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4679-4683 (1993)
   PUBMED   8506317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1 and BC158588.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006242127.1, NM_024403.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221881.1, FQ232762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 15277680
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                JAXUCZ010000007.1  113684681-113684707
            28-1401             BC158588.1         1-1374
            1402-1410           JAXUCZ010000007.1  113686731-113686739
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1410
                     /gene="Atf4"
                     /note="activating transcription factor 4"
                     /db_xref="GeneID:79255"
                     /db_xref="RGD:621863"
     exon            1..184
                     /gene="Atf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      81..92
                     /regulatory_class="uORF"
                     /gene="Atf4"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15277680]"
                     /note="this uORF is predicted to encode a 3 aa peptide
                     (PMID:15277680)"
     regulatory      180..359
                     /regulatory_class="uORF"
                     /gene="Atf4"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15277680]"
                     /note="this uORF is predicted to encode a 59 aa peptide
                     (PMID:15277680)"
     exon            185..496
                     /gene="Atf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1320
                     /gene="Atf4"
                     /note="activating transcription factor 4 (tax-responsive
                     enhancer element B67); rATF-4; cAMP-dependent
                     transcription factor ATF-4; activating transcription
                     factor ATF-4"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-4"
                     /protein_id="NP_077379.1"
                     /db_xref="GeneID:79255"
                     /db_xref="RGD:621863"
                     /translation="MTEMSFLNSEVLAGDLMSPFDQSGLGAEESLGLLDDYLEVAKHF
                     KPHGFSSDKAGSSEWLAMDGLVSASDTGKEDAFSGTDWMLEKMDLKEFDFDALFRMDD
                     LETMPDELLATLDDTCDLFAPLVQETNKEPPQTVNPIGHLPESVIKVDQAAPFTFLQP
                     LPCSPGFLSSTPDHSFSLELGSEVDISEGDRKPDSAAYITLTPQCVKEEDTPSDSDSG
                     ICMSPESYLGSPQHSPSTSRAPPDSLPSPGVPRGSRPKPYDPPGVSVTAKVKTEKLDK
                     KLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKEKADSLAKEIQYLKDLI
                     EEVRKARGKKRVP"
     exon            497..1410
                     /gene="Atf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catttctgct tgctctgtgg tagatgtctc tctgtacgct gttcctttcc tcttcccctc
       61 ccgcagggct tgcggccacc atggcgtatt agaggcagca gagcctgcgg cagcgttggc
      121 ctttgcagcg gcggcagcag caccaggctc tgcagcggca acccccaccg gcttaagcca
      181 tggcgctctt cacgaaaccc agcagcagcg ttgctgtaac ggacaaagat accttcgagt
      241 taagcacatt cctcgatacc agcaaatccc tacaacatga ccgagatgag cttcctgaac
      301 agcgaagtgt tggcggggga cttaatgtcc cccttcgacc agtcgggttt gggggctgaa
      361 gaaagcctag gtctcttaga tgactatctg gaggtggcca agcacttcaa acctcatggg
      421 ttctccagcg acaaggcggg ctcctcagaa tggctggcta tggatgggtt ggtcagtgcc
      481 tcagacaccg gcaaggagga tgccttttcc gggacagatt ggatgttgga gaaaatggac
      541 ctgaaagagt ttgacttcga tgctctgttt cgaatggatg acctggaaac catgccagat
      601 gagcttttgg ccacgttgga tgacacatgt gatctttttg cccctctagt ccaagagact
      661 aataaggagc cccctcagac agtgaaccca attggccatc tcccagaaag tgtaataaaa
      721 gtcgaccagg ctgccccctt tacattcttg cagcctcttc cctgttcccc agggtttctg
      781 tcttccactc cagatcattc ctttagttta gagctgggaa gtgaggttga tatctctgaa
      841 ggagatagga agcctgactc tgctgcttat attactctaa cccctcagtg tgtaaaggag
      901 gaagacactc cctctgatag tgacagtggc atctgtatga gccctgagtc ctacctgggc
      961 tctccccaac acagcccttc cacctccagg gccccaccag acagtctgcc ttctccaggt
     1021 gttcctcgtg gttctcgacc caaaccttat gacccacctg gagttagtgt gacagctaaa
     1081 gtgaagactg aaaagttgga taagaagctg aaaaagatgg agcaaaacaa gacagcagct
     1141 actaggtacc gccagaagaa gagggctgag caggaagccc tcactggcga gtgtaaagag
     1201 ctagaaaaga agaacgaggc tctgaaagag aaggcagatt ctctcgccaa agagattcag
     1261 tatctaaaag acctgataga agaggtccgt aaggcaaggg ggaagaagag agttccttaa
     1321 tagggtagtc aggtgctttg tgcttgtaca tagtcttgtg atgctgtgtt tgctgtaata
     1381 aattattttg tagtgaaagt agccatggaa
//
