LOCUS       NM_031018               1848 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus activating transcription factor 2 (Atf2), mRNA.
ACCESSION   NM_031018 XM_346658
VERSION     NM_031018.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Salinas-Abarca,A.B., Velazquez-Lagunas,I., Franco-Enzastiga,U.,
            Torres-Lopez,J.E., Rocha-Gonzalez,H.I. and Granados-Soto,V.
  TITLE     ATF2, but not ATF3, participates in the maintenance of nerve
            injury-induced tactile allodynia and thermal hyperalgesia
  JOURNAL   Mol Pain 14, 1744806918787427 (2018)
   PUBMED   29921170
  REMARK    GeneRIF: This study demonstrated that ATF2 participates in nerve
            injury-induced tactile allodynia and thermal hyperalgesia in rats.
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Howe,G.A., Kazda,K. and Addison,C.L.
  TITLE     MicroRNA-30b controls endothelial cell capillary morphogenesis
            through regulation of transforming growth factor beta 2
  JOURNAL   PLoS One 12 (10), e0185619 (2017)
   PUBMED   28977001
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   de Franca,S.A., dos Santos,M.P., Przygodda,F., Garofalo,M.A.,
            Kettelhut,I.C., Magalhaes,D.A., Bezerra,K.S., Colodel,E.M.,
            Flouris,A.D., Andrade,C.M. and Kawashita,N.H.
  TITLE     A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in
            the Brown Adipose Tissue of Rats via ATF-2
  JOURNAL   Lipids 51 (3), 303-310 (2016)
   PUBMED   26781764
  REMARK    GeneRIF: The results suggest that the increase in uncoupling
            protein 1 (UCP1) content may occur via p38 MAPK and ATF2.
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   Rauch,A.K., Rosskothen-Kuhl,N. and Illing,R.B.
  TITLE     Counter-regulation of the AP-1 monomers pATF2 and Fos: Molecular
            readjustment of brainstem neurons in hearing and deaf adult rats
            after electrical intracochlear stimulation
  JOURNAL   Neuroscience 313, 184-198 (2016)
   PUBMED   26601778
  REMARK    GeneRIF: Following unilateral intracochlear stimulation, study
            quantified an increase of Fos expression with a simultaneous and
            locally corresponding decrease of pATF2 expression in major
            auditory brainstem regions of both hearing and deaf rats
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Gahete,M.D., Duran-Prado,M., Delgado-Niebla,E., Garrido,J.J.,
            Rhodes,S.J., Garcia-Navarro,S., Gracia-Navarro,F., Malagon,M.M.,
            Luque,R.M. and Castano,J.P.
  TITLE     Porcine sst1 can physically interact with other somatostatin
            receptors, and its expression is regulated by
            metabolic/inflammatory sensors
  JOURNAL   Am J Physiol Endocrinol Metab 306 (5), E483-E493 (2014)
   PUBMED   24368669
REFERENCE   6  (bases 1 to 1848)
  AUTHORS   Ji,L., Mochon,E., Arcinas,M. and Boxer,L.M.
  TITLE     CREB proteins function as positive regulators of the translocated
            bcl-2 allele in t(14;18) lymphomas
  JOURNAL   J Biol Chem 271 (37), 22687-22691 (1996)
   PUBMED   8798441
REFERENCE   7  (bases 1 to 1848)
  AUTHORS   Alonso,C.R., Pesce,C.G. and Kornblihtt,A.R.
  TITLE     The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the
            transcription of the fibronectin gene
  JOURNAL   J Biol Chem 271 (36), 22271-22279 (1996)
   PUBMED   8703044
REFERENCE   8  (bases 1 to 1848)
  AUTHORS   Kageyama,R., Sasai,Y. and Nakanishi,S.
  TITLE     Molecular characterization of transcription factors that bind to
            the cAMP responsive region of the substance P precursor gene. cDNA
            cloning of a novel C/EBP-related factor
  JOURNAL   J Biol Chem 266 (23), 15525-15531 (1991)
   PUBMED   1714459
REFERENCE   9  (bases 1 to 1848)
  AUTHORS   Yoshimura,T., Fujisawa,J. and Yoshida,M.
  TITLE     Multiple cDNA clones encoding nuclear proteins that bind to the
            tax-dependent enhancer of HTLV-1: all contain a leucine zipper
            structure and basic amino acid domain
  JOURNAL   EMBO J 9 (8), 2537-2542 (1990)
   PUBMED   2196176
REFERENCE   10 (bases 1 to 1848)
  AUTHORS   Hai,T.W., Liu,F., Coukos,W.J. and Green,M.R.
  TITLE     Transcription factor ATF cDNA clones: an extensive family of
            leucine zipper proteins able to selectively form DNA-binding
            heterodimers
  JOURNAL   Genes Dev 3 (12B), 2083-2090 (1989)
   PUBMED   2516827
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):682]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031018.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U38938.1, SRR26643429.11947.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000003.1  79202606-79202745   c
            141-240             JAXUCZ010000003.1  79190072-79190171   c
            241-316             JAXUCZ010000003.1  79182075-79182150   c
            317-386             JAXUCZ010000003.1  79172362-79172431   c
            387-483             JAXUCZ010000003.1  79162732-79162828   c
            484-602             JAXUCZ010000003.1  79159809-79159927   c
            603-731             JAXUCZ010000003.1  79159537-79159665   c
            732-910             JAXUCZ010000003.1  79155201-79155379   c
            911-1025            JAXUCZ010000003.1  79154417-79154531   c
            1026-1112           JAXUCZ010000003.1  79151533-79151619   c
            1113-1262           JAXUCZ010000003.1  79140089-79140238   c
            1263-1469           JAXUCZ010000003.1  79138916-79139122   c
            1470-1575           JAXUCZ010000003.1  79133506-79133611   c
            1576-1848           JAXUCZ010000003.1  79128095-79128367   c
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..1848
                     /gene="Atf2"
                     /note="activating transcription factor 2"
                     /db_xref="GeneID:81647"
                     /db_xref="RGD:621862"
     exon            1..140
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            141..240
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            241..316
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..386
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1802
                     /gene="Atf2"
                     /EC_number="2.3.1.48"
                     /note="cAMP-dependent transcription factor ATF-2; cAMP
                     response element-binding protein CRE-BP1"
                     /codon_start=1
                     /product="cyclic AMP-dependent transcription factor ATF-2"
                     /protein_id="NP_112280.1"
                     /db_xref="GeneID:81647"
                     /db_xref="RGD:621862"
                     /translation="MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDS
                     VIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIR
                     SKIEEPSVVETTHQDSPLPHPESTTNDEKEIPLAQTAQPTSAIVRPASLQVPNVLLTS
                     SDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASIT
                     SSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDT
                     VKGHGSGLVRAQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTSGRRRRAANEDPD
                     EKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQ
                     LLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSK
                     TEAGATSVLTQMADQSTEPALSQIVMAPSSQAQPSGS"
     exon            387..483
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..602
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..731
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..910
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1025
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1112
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1262
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1469
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1575
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1848
                     /gene="Atf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagagagg acggaagcct gtgggagccc gtggccttta aagtgcgatt cagccctttc
       61 ctccggggct agtttgtaaa cacggcagcg ctccgggctc gctggtggct gaaaggaaca
      121 tgaattagtg acctggaaag acactagatg gcaacttggg aagtattgcc atcccaagta
      181 tagcaagagc ttagggattc ctgttaacag aataaaactc atggcccacc agctacaaag
      241 tgtctttgcc atgaaacaga ggacatgata aactgtttaa cttaatgaaa ttcaagttgc
      301 atgtgaattc tgccagataa aacaaggacc tgtggaatat gagtgatgac aaaccctttc
      361 tatgcactgc ccctgggtgt ggccagcgtt ttaccaacga ggatcatttg gctgtccata
      421 aacataaaca tgagatgaca ctgaaatttg gtccagcacg taatgacagt gtcattgtgg
      481 ctgatcagac tccaacgcca acaaggttcc taaaaaactg tgaagaagtg ggtttgttta
      541 atgagttggc aagtccattc gagaatgaat tcaagaaggc ttcagaagat gacattaaaa
      601 aaatgcctct agatctgtcc cctcttgcaa cacccatcat aagaagcaaa attgaggaac
      661 cttctgttgt agaaacaact caccaggata gcccgttacc tcaccccgag tctactacca
      721 atgatgaaaa ggaaatacca ttggcacaaa ctgcacagcc cacatcagct atcgttcgtc
      781 cagcatcatt acaggttccc aatgtgctgc tcacaagttc tgactcaagt gtaattattc
      841 aacaagcagt accttcacca acctcaagta ctgtaatcac ccaggcacca tcctctaaca
      901 ggccaattgt tcctgtacca ggcccatttc ctcttctatt acatcttcct aatggacaaa
      961 ccatgcccgt tgctattcct gcatcaatta caagttctaa tgtgcatgtt ccagctgcag
     1021 tcccacttgt tcggccagtc accatggtgc ctagtgttcc aggaatccca ggcccttcct
     1081 ctcctcaacc ggtccagtca gaagcaaaaa tgagattaaa agctgctttg acccagcaac
     1141 accctccagt taccaatggt gatactgtaa aaggccacgg cagtggattg gttagggccc
     1201 agtcagaaga gtctcgtcca cagtccttgc agcagccagc cacgtccact acagagactc
     1261 cggcgtctcc agctcacaca actccacaga cccaaaatac aagtggccgt cgaagaagag
     1321 cagctaatga agatcctgat gagaaaagga ggaagtttct agaacgaaat agagcagcag
     1381 cttcaagatg ccgtcaaaaa aggaaagtat gggttcagtc cttagagaag aaagcagaag
     1441 acttgagctc actaaatggc cagctgcaga gcgaagtcac cctgctgaga aatgaagtgg
     1501 cacagctgaa acagcttctt ctggctcata aagattgccc tgtaaccgcc atgcagaaga
     1561 agtctggcta tcatactgct gataaagatg acagctcaga agacctttcc gtgccaagca
     1621 gcccacatac agaagcgatc cagcacagct ctgtcagtac gtccaatgga gtcagttcaa
     1681 catcaaaaac agaagctgga gccacttcag tcctcaccca gatggcggac cagagcaccg
     1741 agcctgcact ttcacagatt gtcatggctc cttcctccca ggcacagccc tcaggaagtt
     1801 gattaaaacc tgcagtgcaa caggtttaga tactgattag tgacttca
//
