LOCUS       NM_001398758            7140 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus arginyltransferase 1 (Ate1), transcript variant
            2, mRNA.
ACCESSION   NM_001398758 XM_039107558
VERSION     NM_001398758.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7140)
  AUTHORS   Singh,K., Gupta,A., Sarkar,A., Gupta,I., Rana,S., Sarkar,S. and
            Khan,S.
  TITLE     Arginyltransferase knockdown attenuates cardiac hypertrophy and
            fibrosis through TAK1-JNK1/2 pathway
  JOURNAL   Sci Rep 10 (1), 598 (2020)
   PUBMED   31953451
  REMARK    GeneRIF: Arginyltransferase knockdown attenuates cardiac
            hypertrophy and fibrosis through TAK1-JNK1/2 pathway.
            Erratum:[Sci Rep. 2020 Jun 25;10(1):10662. PMID: 32581244]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7140)
  AUTHORS   Sjogren,B., Swaney,S. and Neubig,R.R.
  TITLE     FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a
            Cullin 4B/DDB1 Complex
  JOURNAL   PLoS One 10 (5), e0123581 (2015)
   PUBMED   25970626
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7140)
  AUTHORS   Rai,R. and Kashina,A.
  TITLE     Identification of mammalian arginyltransferases that modify a
            specific subset of protein substrates
  JOURNAL   Proc Natl Acad Sci U S A 102 (29), 10123-10128 (2005)
   PUBMED   16002466
REFERENCE   4  (bases 1 to 7140)
  AUTHORS   Kwon,Y.T., Kashina,A.S. and Varshavsky,A.
  TITLE     Alternative splicing results in differential expression, activity,
            and localization of the two forms of arginyl-tRNA-protein
            transferase, a component of the N-end rule pathway
  JOURNAL   Mol Cell Biol 19 (1), 182-193 (1999)
   PUBMED   9858543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 22, 2021 this sequence version replaced XM_039107558.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1735317.1,
                                           SRR26643299.4739.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000001.1  194510542-194510741 c
            201-264             JAXUCZ010000001.1  194507211-194507274 c
            265-327             JAXUCZ010000001.1  194504585-194504647 c
            328-431             JAXUCZ010000001.1  194501483-194501586 c
            432-686             JAXUCZ010000001.1  194499747-194500001 c
            687-913             JAXUCZ010000001.1  194498655-194498881 c
            914-1042            JAXUCZ010000001.1  194494906-194495034 c
            1043-1075           JAXUCZ010000001.1  194478468-194478500 c
            1076-1257           JAXUCZ010000001.1  194464815-194464996 c
            1258-1357           JAXUCZ010000001.1  194463233-194463332 c
            1358-1478           JAXUCZ010000001.1  194429288-194429408 c
            1479-7140           JAXUCZ010000001.1  194391843-194397504 c
FEATURES             Location/Qualifiers
     source          1..7140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..7140
                     /gene="Ate1"
                     /note="arginyltransferase 1"
                     /db_xref="GeneID:293526"
                     /db_xref="RGD:1309335"
     exon            1..200
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1657
                     /gene="Ate1"
                     /EC_number="2.3.2.8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     arginyl-tRNA--protein transferase 1; arginine-tRNA-protein
                     transferase 1"
                     /codon_start=1
                     /product="arginyl-tRNA--protein transferase 1 isoform 2"
                     /protein_id="NP_001385687.1"
                     /db_xref="GeneID:293526"
                     /db_xref="RGD:1309335"
                     /translation="MASWSAPSPSLVEYFEGQTSFQCGYCKSNFGSRSHGMWAHSMTV
                     QDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCHPLQFQPSKSHKKVLKKMLKFLA
                     KGEISKGNCEDEPMDSTMEDAVDGDFALMNKLDIKCDLKTLSSDLKVSIESEEKEKEK
                     SLKKEGSKDLIHPQAIEEKLGSGEPSHSIKVHVGPKPGKGADLSKPPCRKAKEMRKER
                     KRLKLMQQSSAGAFEGFQAQGQPVSLLPKAKSNQPKSLEDLIFESLPEDASHKLEVRL
                     VPASFEDPEFKSSFNQSLSLYTKYQVAIHQDEPDICDKSEFTRFLCNSPLEAEHPANG
                     PECGYGSFHQQYWLDGKIIAVGVIDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAF
                     TRQLHEKTSQLSYYYMGFYIHSCPKMRYKGQYRPSDLLCPETYVWVPIEQCLPSLDNS
                     KYCRFNQDPQAEDEGRSKELDRLRVFHRRSAMPYGVYKNHQEDPSEEAVVLEYANLVG
                     QKCSETMLLFRH"
     exon            201..264
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..327
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..431
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..686
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..913
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1042
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1075
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1257
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1357
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1478
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..7140
                     /gene="Ate1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgcgctg cattgtgggg tgggaggcaa aggcggaggg agatagcggc agctgcgtag
       61 aactgggtgg cgcagcggcg gcggtgccga ggagatggct tcctggagcg cgccttcgcc
      121 cagccttgta gagtattttg agggccagac ctccttccag tgtggctatt gcaagagcaa
      181 ctttggcagt cgctcccatg gcatgtgggc acattccatg acagtgcagg attatcagga
      241 tcttatagac cgaggatgga gaagaagcgg gaaatatgtg tacaagcctg tcatgaatca
      301 aacatgctgt cctcagtata caataaggtg tcatccttta cagtttcagc cctcaaaatc
      361 tcacaagaaa gttttgaaaa aaatgctgaa atttctggct aaaggagaga tctcgaaagg
      421 caattgtgag gacgagccca tggattctac aatggaggat gctgttgatg gtgattttgc
      481 attaatgaac aagttggata taaagtgtga tcttaaaaca ctcagcagtg acctcaaagt
      541 aagcatagag agtgaagaga aggagaaaga aaagagttta aagaaagaag gatctaaaga
      601 cttgattcat ccacaagcta tagaggagaa gttgggctct ggtgaaccat cacattcaat
      661 caaagttcat gttgggccta agccaggtaa aggggctgat ttgagtaagc ctccatgtcg
      721 aaaagcaaag gaaatgagga aagaaaggaa aaggttaaaa ctgatgcagc agagctcagc
      781 tggagccttt gagggcttcc aggctcaagg tcagccagta tctttgttac caaaggctaa
      841 atccaaccag cccaagtcac tggaagattt gatttttgaa tctttaccag aggatgcatc
      901 gcacaagtta gaggtgaggc tagtacctgc ctcctttgag gacccagagt tcaagtcatc
      961 cttcaaccag tccctttctt tatataccaa gtatcaagtg gctatccacc aggatgaacc
     1021 tgatatatgt gataagtctg agtttacaag attcctttgc aactcaccat tggaggcaga
     1081 gcaccctgct aatggaccag aatgtggtta cggctctttt caccagcagt actggcttga
     1141 cgggaagatc attgctgtgg gggtgataga catcctccca tactgtgtgt cttctgtgta
     1201 tctgtactat gatcctgatt attcattcct gtctttgggt gtctattcag cattaagaga
     1261 aattgctttt actagacaac tgcatgagaa aacatcacag ctcagctatt attacatggg
     1321 tttctacatt cactcctgtc ccaagatgag atacaagggt cagtatagac cttctgattt
     1381 actgtgtcct gagacgtatg tctgggtacc cattgagcaa tgcctgcctt ctctggacaa
     1441 ctccaagtac tgccgtttca accaggaccc acaagcagag gatgaagggc gcagtaagga
     1501 acttgaccgg ctacgcgtgt ttcacagacg gtctgccatg ccttatggtg tttataagaa
     1561 ccaccaagaa gatccaagcg aggaggctgt tgtgctggag tatgcgaacc tcgtagggca
     1621 gaagtgctcg gagacgatgc tgctcttcag acactgaggg cctgccccac agcccagcac
     1681 agcctgggcc tcctgccgca gccctgcctg cgcctcgctc ggctcctgca gccactcgcc
     1741 aagtacattc gtagagcttt ttaaaaatat tttgtggaat tgtatttatg agaaccttgt
     1801 gattaatata aagattttaa aatactctat tatctagtcc tttaattggg actggacttt
     1861 tggagtttgc ttctggagca aagtatgcta aatgtctcca gtaaatattt ggggaaggaa
     1921 agtgaggaag tgaatctaag taatttcctc atagttagtt ttgtcctgga gaaattctga
     1981 cacagagact attcttttag accagtggtt cttgtggatt cacgacatcg taggggccga
     2041 atgttagata acctgtgtat aagattcatt ctaattcata agtgtagcaa aattacactt
     2101 atgaagtagc aatgaaataa atttatggtt ggtgagaggg gtccccacaa tgtgaggaac
     2161 tgaattaaag gatcacagta ttaggaagat agagaaccac tggctaagac ccatgcaaga
     2221 cctgagctta tgctgggaaa tttaggtggg gtcaaaggtg aagtacacat tccctcacta
     2281 ggaaatgtgc ctttcccaca aaccaaaact ctgttactct gtttgatatt aaattcttcc
     2341 agtgctacag tgtattatta atagacaacc tgtaatgaaa tgtaaacatt acaaacatca
     2401 ggtgttcact ttgggtgtct gtccaggatg gtcctgctta tgtccgttgt cttggcataa
     2461 ttgttttccc ctgttgctag tgttcccttg tgccccagag ttatctcagt ttggtgataa
     2521 aatatacagt gatcttagtg atgtttgttc tatttctaca aatcttaaga aacatctttt
     2581 aaagaaatgg taactcttgc ttgatctgag gcttatccaa agaaaatagg ttcctacttt
     2641 ccattctctg gagctcagga agctctctcg tggttgatga tagaagtggt tgttaacgag
     2701 tcctgtagct gtgcacaggc tgtagtgaag ggggccatag cccctgcatc cctcctctgc
     2761 ttgtgggtca gagaataggc acggccattg gtactgcagc acagagacag ctgcttacct
     2821 ttactcctgt gctcttgggc cttctgcttg ctcaccaaat gcctgctgtc agcccgttaa
     2881 agagtcactc agacatggtg aggcaaagct cccctcaagt gtgctagaag ctagatcatg
     2941 ggttagctct ttgtactcgt tctcagctgg actcttctgt gctgcctgcc tggccttgaa
     3001 cctgtcaaga gcaccctatc ctacagtgag ggtagtgtta ctttatttct ctttataaaa
     3061 attactccaa tagtaagaaa ctaaaatgct aagaaattaa gagtcattta aaatcctccc
     3121 aggcctagag aaaggtacat tatagaaatg cagacatcat cagtctgcct cagataaaac
     3181 cgcgcagtcc ttgctgtgta gttgctctca gtggtaactt gtgaatgtat ttgagattgg
     3241 agattgtaga aaatgtgatt ggtaatcttg gaattattaa atagcatgga gtcagcatat
     3301 gtgcccttgg cattgggttg ccgggcacac tgcatccccc ttttccctgt aggtagtgct
     3361 accagagttg gggcagaggg tgttcagtcc attgtcttac cctagctctg agctcctccc
     3421 gcagagtgga ggaagatgct cactgccctg tttctatacc tgggagacta cagagcaact
     3481 tgggcatgaa aactcttcag cttagttgct gtgctctcat tctcttcctc tccctccctc
     3541 cctctgcccc ccccccaata tattttttaa ctagtatgaa atcttagggg tctagatgtt
     3601 gtcaaagatg tgcccttggg taaggctgag gagatagctc agtacagtgc ctggttttct
     3661 ctctagagcc catgtaaaga gggtctggag tgtgtgtttg caatgcaggc gctgggcaat
     3721 cagtagagaa gaacctctgg ggcccaccgg gagcgtggag aattcagaat gctgtctaaa
     3781 aggaggtgga cattacatgt tgtcctctat acgtggatta caaagaggag cttgctaatg
     3841 tcttgagctc tcaagtgagt gtccatcaca gctaggttag gacagtcaag gaaagtatcc
     3901 caacttggca tttttgcaaa gtctagttga ggtacctgat tctgtgtcag tgattttcat
     3961 ctgaataaag atacgtggaa tccttccttt ctgagacagt ttctgtcttc tccttcttta
     4021 gcccctctga gttcaggtaa cgtcacagcc cctccatgcc tgacagcacg ggtttcattt
     4081 tgactctcag tgtaccgtct ttatttaaat tattttcagt tctctgagac ttccgttact
     4141 ctattacagg taatctgagc acttctatat tctaagatag aggctatatt atcagatgaa
     4201 tatattcact cagttaaaat tatttagata caaattattg tttatgtttt ctttcagcaa
     4261 tctcctattt ttatccattt gaaaatgcca gttttgtgtg gtttcttagc atatcaaaat
     4321 tattatgtag aagaatcttc ctagctttct gaacagcaaa tagtttggtt tataaatatt
     4381 gtattatttc agtatgaata aaagagagag aatacaaaca ttttaccaaa atgattatac
     4441 tgtgactgac ttaaaagaag gaaatgagtg aggacttgat atgtttgaat tacaattatt
     4501 caaataccac tgggtataag gcaaaataag tttgactgca tcagacagtt ttgctcttgt
     4561 aaaaaagccc aaaatgaaaa aaataataaa gctgtttcta tctgcagtgc ttctcttcat
     4621 ccatttctta gtgacatatg gttccagcac catgtatacc tgtaaccatt cagcgttagc
     4681 tacagagaag caggcgcaca cacgcgcgcg cgcgcacaca cagacacaca cacacacacg
     4741 cacatatatc cttgaatacg ttacatctgt aataaacatg tagaaaatat tgactatatg
     4801 aattataaaa tatagttggc aataataagc tgcagaccat ttggttatgt caaagtatgg
     4861 gtgacttcct ctttagagaa taaaataatc tcaatttaag caaaatgtgt agaattcaca
     4921 aaaattagca tgaacatttt tcttttatcc tgaggatttc cagagataat tgtcaaactg
     4981 tgaggccaca gtgtatttaa ttcacagttg tattggtggg atgcatttac cagtgttttg
     5041 cctttccctg tgataaagag gatcgtggtg gattggtgat aagatgaacc ttattttcaa
     5101 gagaattaaa tattactttt actttttctc cagacagaat ggttatagtt ttattatttt
     5161 ctgatttgaa agtgacggtg tttgtttgcc ggctgtgtgt acgtgtctgt aatcctagca
     5221 ctcaggaggc agaagcagat agatctctga ttttgaggcc agcctggtct acaaatcaag
     5281 ttctaaaaca gaaacatttt ggtatatatt ctttcacact tattttctac catatatgta
     5341 tatatgtgta tgtatacata gatgcactta aacatacact ttttttcctt aaagaaaagt
     5401 gaaatcatgg cacaaatatg gtctcatgcc ttttcatcat tttactttga gtgtattaaa
     5461 gtagaatggt cttagactga agagatggct cagaagttaa gagcactggc tcctcttctg
     5521 aggtcctgag ttcagttccc agctaacaca tagtgcttca cagccatctg taatgagatc
     5581 tggcgccctc ttctggtgtg taggtatgca tgcaggcaga attctgtatg cataataaat
     5641 aaataaacaa cagatcttta aaagaaaacg aatggtctta atgctttcat agtattctag
     5701 tgtgcatttg atcctaatgc ttgcatagaa ccccggtatg tacttaattt tggagaagaa
     5761 ggcttgtacc tctgagccct ctttatgagt aacaggaatt ataattaata gcattaccag
     5821 gtttttggtt ttttgctact aattgttatt tgggtttttt tcctttttaa gaaaacccaa
     5881 gctttgtttt tagaaggtaa aataactagc attttatatc cgttatacaa acttgataaa
     5941 caatacagaa ggaatgttat ttatctatct gtgtggtcct agggatcaaa ccctacacat
     6001 gccaggcaaa caatctaccc ttaagttcca caaagaggaa ggccacctcc agccttgtgt
     6061 gcttatcagc atgtaattag tgtgagcgct gtagttgtta ctgcaacaag ttacctgggt
     6121 gaaagaaaag gttttacaat atttattcat tgactgttgc atgcatgtct gtaatgtact
     6181 gtgagtatat tcatcccttt gcccttttgt attgaccctt tgcagtattt ggggcttaga
     6241 ttctccgtgt ccccctggga attctataca gtattgaaag ccataacttc actgtgctca
     6301 gaaggtgagg cccatggcag gtcatcagat cacaagggca aaagtgtttt aagtttatct
     6361 ggttcccctg tagaccctat ctcccatcac aggaagataa agcaagctag catttataac
     6421 tagatcgtgt gtttttgtca gaaacacagt ctcctacacc atgatcttaa acttcccaag
     6481 aagttcctcc agaactcaag aatgaattcc ttttgtccaa cgcccccaat ctgtgccttg
     6541 tcataatagc cccaacagga acctgctagc attatttctg cccccgccag tccccagctg
     6601 tctttgcctc tttatccaaa gcttcagaaa aataagcttt gaaagattat tgtctctctt
     6661 ttcattgttt attttttcta ctgtgtttta agtttgtatg tccaacagaa tgctttaact
     6721 taaggcttaa gtttatttta aagcattaag gttctgaatt ctttcaaaaa tcaaaagtct
     6781 ttaagtgaca cttacagaaa tgaatgagta accgtgctat ttttgttaag ttcaactttg
     6841 gagtttagta cattggctgt attgagatgt aacctgagtg aaattgcacc tttctatcca
     6901 gtcagttgct agaacatctt tgctcccatt tagaactgtt gtctgttagc tattccagtg
     6961 agacccagag ctaaagtcac cagatatact gtctcccaaa ttatgagatt taaaatattg
     7021 ttaaaatttt ttggtgaatt tcacttcatg cacccaagtc tcattcattt cccaggcctt
     7081 ccatgtctgc cctccaccct tgtaaatact tcccccaatt aaatgttgtc ttttctaaga
//
