LOCUS       NM_001040190            2722 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ATCAY kinesin light chain interacting caytaxin
            (Atcay), mRNA.
ACCESSION   NM_001040190 XM_001070287 XM_343154
VERSION     NM_001040190.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Sun,J., Pan,C.Q., Chew,T.W., Liang,F., Burmeister,M. and Low,B.C.
  TITLE     BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to
            Promote Acetylcholine Signaling and Neuritogenesis
  JOURNAL   Dev Cell 34 (5), 555-568 (2015)
   PUBMED   26343454
  REMARK    GeneRIF: precise targeting of the cholinergic machinery through
            BNIP-H is essential for the local production of acetylcholine for
            morphogenesis and neurotransmission
REFERENCE   2  (bases 1 to 2722)
  AUTHORS   Aoyama,T., Hata,S., Nakao,T., Tanigawa,Y., Oka,C. and Kawaichi,M.
  TITLE     Cayman ataxia protein caytaxin is transported by kinesin along
            neurites through binding to kinesin light chains
  JOURNAL   J Cell Sci 122 (Pt 22), 4177-4185 (2009)
   PUBMED   19861499
REFERENCE   3  (bases 1 to 2722)
  AUTHORS   Buschdorf,J.P., Chew,L.L., Soh,U.J., Liou,Y.C. and Low,B.C.
  TITLE     Nerve growth factor stimulates interaction of Cayman ataxia protein
            BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in
            differentiating neurons
  JOURNAL   PLoS One 3 (7), e2686 (2008)
   PUBMED   18628984
  REMARK    GeneRIF: nerve growth factor may stimulate the interaction of
            BNIP-H with Pin1 by releasing its intramolecular inhibition
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2722)
  AUTHORS   Hayakawa,Y., Itoh,M., Yamada,A., Mitsuda,T. and Nakagawa,T.
  TITLE     Expression and localization of Cayman ataxia-related protein,
            Caytaxin, is regulated in a developmental- and spatial-dependent
            manner
  JOURNAL   Brain Res 1129 (1), 100-109 (2007)
   PUBMED   17157273
  REMARK    GeneRIF: The above data, disease phenotypes, and mutant animals
            suggest that Caytaxin may be essential for synaptic function.
REFERENCE   5  (bases 1 to 2722)
  AUTHORS   Xiao,J., Gong,S. and Ledoux,M.S.
  TITLE     Caytaxin deficiency disrupts signaling pathways in cerebellar
            cortex
  JOURNAL   Neuroscience 144 (2), 439-461 (2007)
   PUBMED   17092653
  REMARK    GeneRIF: The data of this study indicate that caytaxin plays a
            critical role in the molecular response of Purkinje cells to
            climbing fiber input. Caytaxin may also contribute to maturational
            events in cerebellar cortex.
REFERENCE   6  (bases 1 to 2722)
  AUTHORS   Buschdorf,J.P., Li Chew,L., Zhang,B., Cao,Q., Liang,F.Y.,
            Liou,Y.C., Zhou,Y.T. and Low,B.C.
  TITLE     Brain-specific BNIP-2-homology protein Caytaxin relocalises
            glutaminase to neurite terminals and reduces glutamate levels
  JOURNAL   J Cell Sci 119 (Pt 16), 3337-3350 (2006)
   PUBMED   16899818
REFERENCE   7  (bases 1 to 2722)
  AUTHORS   Xiao,J. and Ledoux,M.S.
  TITLE     Caytaxin deficiency causes generalized dystonia in rats
  JOURNAL   Brain Res Mol Brain Res 141 (2), 181-192 (2005)
   PUBMED   16246457
  REMARK    GeneRIF: Atcay mRNA is found in all brain neuronal populations.In
            cerebellum, it is in the molecular, Purkinje & granular layers. It
            may have a vital role in the development & neurophysiology of
            cerebellar cortex.
REFERENCE   8  (bases 1 to 2722)
  AUTHORS   Bomar,J.M., Benke,P.J., Slattery,E.L., Puttagunta,R., Taylor,L.P.,
            Seong,E., Nystuen,A., Chen,W., Albin,R.L., Patel,P.D.,
            Kittles,R.A., Sheffield,V.C. and Burmeister,M.
  TITLE     Mutations in a novel gene encoding a CRAL-TRIO domain cause human
            Cayman ataxia and ataxia/dystonia in the jittery mouse
  JOURNAL   Nat Genet 35 (3), 264-269 (2003)
   PUBMED   14556008
  REMARK    Erratum:[Nat Genet. 2005 May;37(5):555]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY611623.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_343154.3, XM_001070287.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY611623.1, BC128695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2722
                     /gene="Atcay"
                     /note="ATCAY kinesin light chain interacting caytaxin"
                     /db_xref="GeneID:362826"
                     /db_xref="RGD:1309312"
     exon            1..426
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            427..553
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1595
                     /gene="Atcay"
                     /note="ATCAY, caytaxin; ataxia, cerebellar, Cayman type"
                     /codon_start=1
                     /product="caytaxin"
                     /protein_id="NP_001035280.1"
                     /db_xref="GeneID:362826"
                     /db_xref="RGD:1309312"
                     /translation="MGTTEATLRMENVDVRDEWQDEDLPRPLPEDTGEDHLGGTVEDS
                     SSPPSTLNLSGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPD
                     ETDSLEFLGNGNELEWEDDTPVATAKNMPGDSADLFGDGSGEDGSAANGRLWRTVIIG
                     EQEHRIDLHMIRPYMKVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYV
                     ISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWF
                     IRTVLAISRPFISVKFISKIQYVHSLEELEQLIPMEHVQLPACVLQYEEQRLRAKRES
                     ARPPQPEFLLPRSEEKPETVEEEDRAAEVTEDQETSMS"
     exon            554..612
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            613..834
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1020
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1123
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1255
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1342
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1441
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1477
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1552
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1585
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..2722
                     /gene="Atcay"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggcatgg ctgagagaga tgctttcccc tcagccaatg ggaagaggag gatgcaggta
       61 gggatgctgg agctgtctat caggcctgag cccgccccct gcacacaaaa gcagcttcct
      121 tcactatctg agggcagaca gagcctcagc catcagaaag ggaaaagcca gagccgcagt
      181 aggcctgggc cgcgatggcg ggggacacgg agactaaagg gggacagggg tgctgctact
      241 aacccacggc gccgccttct acagctgggc ctcacaggtg tgcgtggcca cgtcgccctg
      301 ggtgaccttc ttcggatgtg gacttggccc tgagcatcct tccgccaggc ccctcgcctg
      361 ggtaccacca agaaatgccc gcctttgtgt ccgagtgaca gcgcacgggc agccgccgcc
      421 accgagatca tcttctgggt cacccaagcc tccagtcggc tttctttcca gctctcatgg
      481 ggaccacaga agctacatta cgaatggaaa atgtggacgt gagggatgaa tggcaggatg
      541 aggatctgcc cagaccgctc ccagaagaca ccggggagga tcacctgggc ggcacggtgg
      601 aagactcctc ctctcctccc tccaccctaa acctgagtgg agcacatcgg aagagaaaga
      661 cgctggtggc cccagagatc aacatctctc tggaccaaag tgagggctct ctgctgtctg
      721 atgacttcct cgacacccct gatgacctgg acatcaatgt ggatgacatt gagacgccag
      781 atgaaactga ctctctggag ttcttgggaa atggcaatga gcttgagtgg gaagatgaca
      841 ccccagtggc caccgctaaa aacatgcctg gtgacagcgc agacctgttt ggggacggct
      901 ctggggaaga cggcagtgca gccaatggcc gtctgtggcg gactgtcatc atcggggagc
      961 aggagcatcg cattgacctg catatgatcc ggccctacat gaaggtggtg acccacggag
     1021 gatactacgg agaaggtctc aacgccatca tcgtctttgc ggcctgcttc ctgccagata
     1081 gcagctctcc agactaccac tacatcatgg agaatctctt cctgtacgtc atcagcagcc
     1141 tagagctgct agtggctgag gactacatga tcgtgtacct gaatggtgcc acgccccgga
     1201 ggaggatgcc gggcattggc tggctgaaga agtgttacca catgattgac aggagactga
     1261 ggaagaatct aaagtccctg atcatcgtcc acccctcctg gttcattcgc accgtgctgg
     1321 ccatctcccg gcccttcatc agtgtcaagt tcatcagtaa aatccagtat gtgcacagcc
     1381 tcgaggagct ggagcagctc atccccatgg agcacgtgca gctgccagcc tgtgtcctgc
     1441 aatatgaaga acagagactc cgagccaaga gggagagcgc tcggccaccg cagcccgagt
     1501 tcctcctgcc caggtctgaa gaaaaaccag agactgtgga agaagaggac agggcagcag
     1561 aggtgacaga ggaccaggaa acgagcatgt cctgatttac cagaacctag agatggacag
     1621 agatttttcc agacatcatg taaccctcat cagaagccct gggaaccccg acttcatcgt
     1681 gcctctgcgg cctgaggact cctggctcca tcatgtccct ctatgtccct ctgcacccag
     1741 ggtcctctgg ctgcttgaat acatttcact gttttctttt gaagaaagtg gtacaagcac
     1801 atcttggaat ggaccaggtt cttgaccctt tcacattctg agcttgtgga tgtcaaagct
     1861 ggacctgggc agtgacaccc gtggttcctc ctccaggcct cagcattccc aagatgccct
     1921 tctccgtccc agctaggata acacagatgt gtattttggg ctgacccaat gaggacttgg
     1981 ttgccacgtg ttatgtccct agctggagcc tcaggtgcct ggtggccccg gctgaggctg
     2041 catctgcttc tctgtggaat gtgacgacct ctcttcctgt caccccaagc agggctatga
     2101 ccatggactt tacatcttca cctgacatcc cctgttctgc cacttgattg tctttggggg
     2161 tcttcaagcc tgttgcacat gtattgatca gcctggtggc cgccaaactg catcccaaca
     2221 tttccaagct ccttaaagta gatgtgactc cagatgttaa cttacgcctc actccaaggg
     2281 aaggagttgt gtccactttc ctgtcccctg cccagtccag actcagactc ttgtgccacc
     2341 aagcagggga cagtttagtg tctgaaagtg acaagaaagg tgaagaccca aggctgcggg
     2401 tgctagagat ctgggggaga gcctaagaca atgtgtccca gtgggtggga cactgtggcc
     2461 acctgatctc caagctggat caaagcactc tctgcctggg tggctagata gtctgagcta
     2521 atgcgtggga ggagcctcct gtccccaggg acattaggac taggtgacat ttgcagggag
     2581 gactctccct gtggttccct caagactgag cagtggtggc atatgtggca tatgccttta
     2641 atatcagcac tcaggagatg gaggcaggga aagttttgtg agttccaaga cagcaaaaac
     2701 tacatagtga gaccctgtct ag
//
