LOCUS       NM_212498               1424 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus alpha tubulin acetyltransferase 1 (Atat1), mRNA.
ACCESSION   NM_212498 XM_342084
VERSION     NM_212498.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Zhang,Y., Guan,T., Li,Z., Guo,B., Luo,X., Guo,L., Li,M., Xu,M.,
            Liu,M. and Liu,Y.
  TITLE     Eml1 promotes axonal growth by enhancing alphaTAT1-mediated
            microtubule acetylation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119770 (2024)
   PUBMED   38897390
  REMARK    GeneRIF: Eml1 promotes axonal growth by enhancing
            alphaTAT1-mediated microtubule acetylation.
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Zhang,Q., Zhou,L., Xie,H., Zhang,H. and Gao,X.
  TITLE     HAGLR aggravates neuropathic pain and promotes inflammatory
            response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells
            by sequestering miR-182-5p from ATAT1 and activating NLRP3
            inflammasome
  JOURNAL   Neurochem Int 145, 105001 (2021)
   PUBMED   33626373
  REMARK    GeneRIF: HAGLR aggravates neuropathic pain and promotes
            inflammatory response and apoptosis of lipopolysaccharide-treated
            SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating
            NLRP3 inflammasome.
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Lin,S., Sterling,N.A., Junker,I.P., Helm,C.T. and Smith,G.M.
  TITLE     Effects of alphaTAT1 and HDAC5 on axonal regeneration in adult
            neurons
  JOURNAL   PLoS One 12 (5), e0177496 (2017)
   PUBMED   28505206
  REMARK    GeneRIF: while alphaTAT1 may be important for axonal growth in
            vitro, neither alphaTAT1 nor HDAC5 had an effect in vivo on the
            regeneration of sciatic nerves.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Nakakura,T., Nemoto,T., Suzuki,T., Asano-Hoshino,A., Tanaka,H.,
            Arisawa,K., Nishijima,Y., Kiuchi,Y. and Hagiwara,H.
  TITLE     Adrenalectomy facilitates ATAT1 expression and alpha-tubulin
            acetylation in ACTH-producing corticotrophs
  JOURNAL   Cell Tissue Res 366 (2), 363-370 (2016)
   PUBMED   27314403
  REMARK    GeneRIF: These results agree with the hypothesis that the
            acetylation of alpha-tubulin by ATAT1 regulates the intracellular
            transport of secretory granules in corticotrophs.
REFERENCE   5  (bases 1 to 1424)
  AUTHORS   Nakakura,T., Suzuki,T., Nemoto,T., Tanaka,H., Asano-Hoshino,A.,
            Arisawa,K., Nishijima,Y., Kiuchi,Y. and Hagiwara,H.
  TITLE     Intracellular localization of alpha-tubulin acetyltransferase ATAT1
            in rat ciliated cells
  JOURNAL   Med Mol Morphol 49 (3), 133-143 (2016)
   PUBMED   26700226
  REMARK    GeneRIF: These results indicated that alpha-tubulin acetylation by
            ATAT1 at distinct subcellular positions may influence the
            functional regulation of microtubules and cilia in a variety of
            ciliated cells.
REFERENCE   6  (bases 1 to 1424)
  AUTHORS   Yang,W., Guo,X., Thein,S., Xu,F., Sugii,S., Baas,P.W., Radda,G.K.
            and Han,W.
  TITLE     Regulation of adipogenesis by cytoskeleton remodelling is
            facilitated by acetyltransferase MEC-17-dependent acetylation of
            alpha-tubulin
  JOURNAL   Biochem J 449 (3), 605-612 (2013)
   PUBMED   23126280
REFERENCE   7  (bases 1 to 1424)
  AUTHORS   Friedmann,D.R., Aguilar,A., Fan,J., Nachury,M.V. and Marmorstein,R.
  TITLE     Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and
            implications for tubulin-specific acetylation
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19655-19660 (2012)
   PUBMED   23071314
REFERENCE   8  (bases 1 to 1424)
  AUTHORS   Li,L., Wei,D., Wang,Q., Pan,J., Liu,R., Zhang,X. and Bao,L.
  TITLE     MEC-17 deficiency leads to reduced alpha-tubulin acetylation and
            impaired migration of cortical neurons
  JOURNAL   J Neurosci 32 (37), 12673-12683 (2012)
   PUBMED   22972992
  REMARK    GeneRIF: This finding reveals the importance of MEC-17 and
            alpha-tubulin acetylation in cortical development.
REFERENCE   9  (bases 1 to 1424)
  AUTHORS   Akella,J.S., Wloga,D., Kim,J., Starostina,N.G., Lyons-Abbott,S.,
            Morrissette,N.S., Dougan,S.T., Kipreos,E.T. and Gaertig,J.
  TITLE     MEC-17 is an alpha-tubulin acetyltransferase
  JOURNAL   Nature 467 (7312), 218-222 (2010)
   PUBMED   20829795
REFERENCE   10 (bases 1 to 1424)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883048.1.
            
            On Aug 30, 2004 this sequence version replaced XM_342084.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132280,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1424
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /note="alpha tubulin acetyltransferase 1"
                     /db_xref="GeneID:361789"
                     /db_xref="RGD:1303066"
     exon            1..119
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1278
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /EC_number="2.3.1.108"
                     /note="alpha-TAT; alpha-TAT1; acetyltransferase mec-17
                     homolog"
                     /codon_start=1
                     /product="alpha-tubulin N-acetyltransferase 1"
                     /protein_id="NP_997663.1"
                     /db_xref="GeneID:361789"
                     /db_xref="RGD:1303066"
                     /translation="MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIM
                     TIVDELGKASAKAQHLPAPITSALRMQSNRHVIYVLKDTSARPAGKGAIIGFLKVGYK
                     KLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPS
                     PKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRSPTPSLRATRHSRAAVVDPIPAA
                     PARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNS
                     PDRGPLRPFVPEQELLRSLRLCPPHPTARLLLATDPGGSPAQRRRTRETPWGLVAQSC
                     HYSRHGGFNTSFLGTGNQERKQGEQEAEDRSASEDQVLLQDGSGEEPTHTVAPRAQAP
                     PAQSWMVGGDILNARVIRNLQERRNTRPW"
     exon            120..180
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            181..272
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            273..333
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            334..447
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            448..549
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            550..595
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            596..664
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            665..736
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            737..980
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1060
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1103
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1424
                     /gene="Atat1"
                     /gene_synonym="3110080J08Rik; Mec17; RGD1303066; TAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacaatggg ccatggagtt cccgttcgat gtggatgcgc tgttcccgga gcggatcacc
       61 gtgctggacc agcacctgcg gcctccggcc cgccgacccg gaaccacaac gccggcccgt
      121 gtggatctgc agcagcaaat catgactatt gtagatgagc tgggcaaggc ttctgccaag
      181 gctcagcacc tccctgcacc catcaccagc gctttgagga tgcagagcaa ccgacacgtt
      241 atttatgtac taaaggacac ctcagcccgc ccggcaggga aaggagccat tattggtttc
      301 ctcaaagttg gatacaagaa gctctttgta ctggatgacc gtgaggctca caatgaggta
      361 gaaccccttt gcattctgga cttttacatc cacgagtcag tgcaacggca cggccatggg
      421 agagaacttt tccagtatat gttacagaaa gagcgagtgg aaccacacca acttgccatt
      481 gaccgaccat caccgaaact gctcaagttc ctgaacaagc actacaacct ggagaccaca
      541 gtcccacagg tgaacaactt cgtgatcttc gaaggcttct ttgcccatca acaccggtcc
      601 cccactccct ctctgagggc aactcgacac tctcgtgctg ctgtggtcga tcctataccc
      661 gctgctccgg caaggaagct gccaccgaaa agagcagagg gagacattaa gccatactcc
      721 tccagtgaca gagaattcct gaaggtggct gtggagcctc cctggcccct gaacagggcc
      781 ccccggcgtg ccacacctcc agcacaccca cctccacgtt ctagcagcct gggcaactcg
      841 ccggatcggg gtccccttcg gcccttcgtg ccagagcagg agctgcttcg atccctgcgt
      901 ctctgtcccc cacaccccac tgcacgcctt ctgctggcca ctgaccctgg aggcagccca
      961 gcccagcgca gacgcaccag ggagactccc tgggggctgg tagcccaaag ctgccactac
     1021 agccgccatg ggggattcaa tacctcattc ctgggtacag gcaaccaaga acggaagcag
     1081 ggggaacagg aagcagagga taggtcggcc agtgaggatc aggtcttgtt acaggatggg
     1141 tctggggagg aacctacgca tacagttgct ccaagggccc aggctccacc ggcccagtcc
     1201 tggatggtgg gtggggacat actgaacgcc agggtcattc gaaacctgca ggaacgccgc
     1261 aacaccaggc cttggtgacc acaaccaaag cttggccctc ataatggatg tactcattca
     1321 ttcattcatt caacaggcct gtcagcttca gatcctttgt atcttatttt taaccagagc
     1381 aataaaaata tttatttgtt atcactatag ctactgaaaa aaaa
//
