LOCUS       NM_001034922            2416 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Rattus norvegicus ATPase family, AAA domain containing 3A (Atad3a),
            mRNA.
ACCESSION   NM_001034922 XM_216606
VERSION     NM_001034922.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Zhao,Y., Sun,X., Hu,D., Prosdocimo,D.A., Hoppel,C., Jain,M.K.,
            Ramachandran,R. and Qi,X.
  TITLE     ATAD3A oligomerization causes neurodegeneration by coupling
            mitochondrial fragmentation and bioenergetics defects
  JOURNAL   Nat Commun 10 (1), 1371 (2019)
   PUBMED   30914652
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Issop,L., Fan,J., Lee,S., Rone,M.B., Basu,K., Mui,J. and
            Papadopoulos,V.
  TITLE     Mitochondria-associated membrane formation in hormone-stimulated
            Leydig cell steroidogenesis: role of ATAD3
  JOURNAL   Endocrinology 156 (1), 334-345 (2015)
   PUBMED   25375035
  REMARK    GeneRIF: These results demonstrate that ATAD3-mediated
            mitochondrial membrane formation participates in the optimal
            transfer of cholesterol from the endoplasmic reticulum into
            mitochondria.
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Goller,T., Seibold,U.K., Kremmer,E., Voos,W. and Kolanus,W.
  TITLE     Atad3 function is essential for early post-implantation development
            in the mouse
  JOURNAL   PLoS One 8 (1), e54799 (2013)
   PUBMED   23372768
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Fang,H.Y., Chang,C.L., Hsu,S.H., Huang,C.Y., Chiang,S.F.,
            Chiou,S.H., Huang,C.H., Hsiao,Y.T., Lin,T.Y., Chiang,I.P.,
            Hsu,W.H., Sugano,S., Chen,C.Y., Lin,C.Y., Ko,W.J. and Chow,K.C.
  TITLE     ATPase family AAA domain-containing 3A is a novel anti-apoptotic
            factor in lung adenocarcinoma cells
  JOURNAL   J Cell Sci 123 (Pt 7), 1171-1180 (2010)
   PUBMED   20332122
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105762.1.
            
            On Oct 21, 2005 this sequence version replaced XM_216606.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105762.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2416
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /note="ATPase family, AAA domain containing 3A"
                     /db_xref="GeneID:298682"
                     /db_xref="RGD:1305964"
     exon            1..249
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1823
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /note="ATPase family AAA domain-containing protein 3"
                     /codon_start=1
                     /product="ATPase family AAA domain-containing protein 3A"
                     /protein_id="NP_001030094.1"
                     /db_xref="GeneID:298682"
                     /db_xref="RGD:1305964"
                     /translation="MSWLFGIKGPKGEGTGPPLPLPPAQPGAESGGDRGAGDRPSPKD
                     KWSNFDPTGLERAAKAARELEHSRHAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQL
                     KSEQIRVQAEERRKTLNEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEE
                     SVQKQEAIRRATVEREMELRHKNEMLRVEAEARARAKADRENADIIREQIRLKAAEHR
                     QTILESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATSVAGRYIEA
                     RLGKPSLVRETSRISVLEALRHPIQVSRRLVSRPQDALEGVILSPSLEARVRDIAIAT
                     RNTKKNKSLYRNVLMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMH
                     KVFDWASTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLHRTGQHSNKFMLVL
                     ASNQPEQFDWAINDRIDEMVCFALPQREERERLVRMYFDKYVLKPATEGKQRLKVAQF
                     DYGKKCSEVAQLTAGMSGREIAQLAVAWQAMAYSSEDGVLTEAMMDARVQDAVQQHQQ
                     KMQWLKVERPDSEASKPPHPSLLSC"
     exon            250..326
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            327..428
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..488
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..558
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..724
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            725..794
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            795..950
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1007
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1133
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1258
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1310
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1381
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1549
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1658
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..2358
                     /gene="Atad3a"
                     /gene_synonym="Atad3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacgctcg agtacggtcc accgagggcg cgcggagctt gcagatcatg tcgtggctct
       61 tcggcatcaa gggccccaag ggagaaggca cagggcctcc gctgcccttg ccgcccgccc
      121 aacctggggc ggaaagtggc ggcgaccgtg gtgcgggaga tcggccatcg cccaaggaca
      181 aatggagcaa cttcgacccg acgggcctgg agcgtgcggc caaagcggcg cgcgagttgg
      241 agcactcgcg ccatgccaag gaggcactga atcttgcaca gatgcaggag cagacactgc
      301 agctggaaca acagtctaag ctcaaggaat atgaagctgc cgtagagcag ctgaagagcg
      361 agcagatccg cgtgcaagcc gaggaaagaa ggaaaaccct gaacgaagag acgcggcagc
      421 accaggctag ggcccagtac caggataagc tagcccgaca acgctatgag gaccagctga
      481 aacaacagca acttctgaat gaagagaatt taaggaaaca agaggaatct gtgcagaagc
      541 aggaggccat acggcgagcc actgtggagc gagagatgga gctgcggcat aagaatgaga
      601 tgttgcgggt ggaagctgag gctcgagcac gggccaaggc cgatcgagag aatgcagaca
      661 tcatccggga acagattcga ctcaaggctg ctgagcaccg ccagaccatc ttggagtcta
      721 tcaggacagc cggcaccttg tttggtgaag gattccgtgc ctttgtgaca gactgggaca
      781 aagtgacagc cacggtggct ggattgacac tattagctgt tggagtctat tctgccaaga
      841 acgctacttc tgttgctgga cggtatattg aggcccgatt gggaaagccg tccctggtga
      901 gagagacctc ccgtatctca gtgctggagg cattgaggca tcccatccag gtcagcaggc
      961 ggctggtcag cagaccccag gatgcgttgg agggcgtcat cctcagtcct agcctggagg
     1021 cacgggtccg agatattgcc atcgcaacaa gaaataccaa gaagaacaaa agcctgtaca
     1081 gaaacgttct gatgtatggg ccaccaggga ctggcaagac actatttgct aagaaactcg
     1141 cactgcattc aggcatggac tacgccatca tgacaggcgg ggacgtggcc cccatggggc
     1201 gggagggtgt gactgccatg cacaaggtct tcgactgggc aagcaccagc agacgaggcc
     1261 tcctgctctt tgtggatgaa gcagatgcct tcctcaggaa gcgagcaact gaaaagataa
     1321 gtgaagacct cagggctact ctgaatgcat tcctacacag gacaggacaa cacagtaata
     1381 agttcatgct ggtcctggcc agtaaccagc ctgagcagtt cgattgggcc atcaatgacc
     1441 gcattgacga gatggtctgc tttgccctgc cacagcggga ggagcgggag cgcctggtga
     1501 gaatgtattt tgacaagtat gtccttaagc cggccacaga aggaaagcaa cgcttgaagg
     1561 tggcccagtt tgactacgga aagaagtgct cagaggtcgc ccagctgacg gcgggaatgt
     1621 caggccggga gatagctcag cttgccgtgg catggcaggc catggcatat tcgtctgagg
     1681 atggggtcct cacggaggct atgatggatg cccgtgtgca ggatgctgtc cagcagcacc
     1741 agcagaagat gcagtggctt aaagtagaga gacctgactc tgaggccagc aagccaccac
     1801 atccgtcact cctcagctgc tgagctggac ctggacacct cgtacaccta acgggacagc
     1861 cagtctctat gaccacactt actgctcctc cctttcctgt cttctttgac ctctgtaaga
     1921 ggccatcatt gccccaaatg cctctgccga gctgtggggt gctggaggtg tcagcttctc
     1981 tgcctcccac acctcctagt ctgtctctct gcgtgctggc agagggaagc atctgccttt
     2041 ctgtacctca gactggcgag acgcgtctac aagcccagag cagagagcac gcagagcgcc
     2101 gtaccacaag ccagtggcta tgccagcagg actggggcct tcagggacca ggctaaagga
     2161 acagagggcc ctctgcgtcc tggacattac tcctaccgta cacacatctg tgccaagaat
     2221 tggcccagtc cttacttggt agagtggatc tggtgctaga cagccttggc tggtggcatc
     2281 cgagaatcag agctaccgcc atccccttga ctggatctgg gccttttaaa tccagaatct
     2341 aataaaactg tgactgataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaa
//
