LOCUS       NP_001258292            1354 aa            linear   ROD 31-MAR-2024
DEFINITION  astrotactin-2 [Rattus norvegicus].
ACCESSION   NP_001258292 XP_002729534
VERSION     NP_001258292.1
DBSOURCE    REFSEQ: accession NM_001271363.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1354)
  AUTHORS   Chang,H., Cahill,H., Smallwood,P.M., Wang,Y. and Nathans,J.
  TITLE     Identification of Astrotactin2 as a Genetic Modifier That Regulates
            the Global Orientation of Mammalian Hair Follicles
  JOURNAL   PLoS Genet 11 (9), e1005532 (2015)
   PUBMED   26418459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1354)
  AUTHORS   Wilson,P.M., Fryer,R.H., Fang,Y. and Hatten,M.E.
  TITLE     Astn2, a novel member of the astrotactin gene family, regulates the
            trafficking of ASTN1 during glial-guided neuronal migration
  JOURNAL   J Neurosci 30 (25), 8529-8540 (2010)
   PUBMED   20573900
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000005.1.
            
            On Sep 18, 2012 this sequence version replaced XP_002729534.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1354
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     Protein         1..1354
                     /product="astrotactin-2"
                     /calculated_mol_wt=149444
     Region          162..707
                     /region_name="ASTN_1_2_N"
                     /note="Astrotactin 1/2 N-terminal; pfam19441"
                     /db_xref="CDD:437273"
     Region          718..765
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          867..1050
                     /region_name="MACPF"
                     /note="membrane-attack complex / perforin; smart00457"
                     /db_xref="CDD:214671"
     Region          979..1194
                     /region_name="ASTN1_2_EGF_Fn"
                     /note="ASTN1/2 EGF-like and Fn(III) domains; pfam19743"
                     /db_xref="CDD:437575"
     Region          1205..1297
                     /region_name="Annexin_like"
                     /note="Annexin-like domain; pfam18411"
                     /db_xref="CDD:465756"
     Region          1301..1347
                     /region_name="ASTN_2_hairpin"
                     /note="Astrotactin-2 C-terminal beta-hairpin domain;
                     pfam18577"
                     /db_xref="CDD:436591"
     CDS             1..1354
                     /gene="Astn2"
                     /coded_by="NM_001271363.1:1..4065"
                     /db_xref="GeneID:100361323"
                     /db_xref="RGD:2320342"
ORIGIN      
        1 maaagarrsp gpglglrgrp rlrfhpgppp ppplpllllf llllppppll agataaaasr
       61 epdspcrlkt vtvstlpalr esdigwsgar agaaagagag tgagagasaa aaaaaaaspg
      121 sagsagtaae srlllfvrne lpgriavqdd ldntelpfft lemsgtaadi slvhwrqqwl
      181 engtlyfhvs msssgqlaqa taptlqepse iveeqlhilh isvmgglial lllllvftva
      241 lyaqrrwqkr rripqksast eatheihyip svllgpqare sfrstrlqah nsvigvpire
      301 tpilddydye eeedpprran hvsredefds qmthaldslg rpgeekvefe kkaaaeatqe
      361 tveslmqkfk esfrantpve igqlqpasrs stsagkrkrr nksrggisfg rtkgtsgsea
      421 ddetqltfyt eqyrsrrrsk gllkspvnkt altliavssc ilamvcgnqm scpltvkvtl
      481 hvpehfiadg ssfvvsegsy ldisdwlnpa klslyyqina tspwvrdlcg qrttdaceql
      541 cdpetgecsc hegyapdpvh rhlcirsdwg qsegpwpytt lergydlvtg eqapekilrs
      601 tfslgqglwl pvsksfvvpp velsinplas cktdvlvted padvreeaml styfetindl
      661 lssfgpvrdc srnnggctrn fkcvsdrqvd ssgcvcpeel kpmkdgsgcy dhskgidcsd
      721 gfnggceqlc lqqtmplpyd atsstifmfc gcveeyklap dgksclmlsd vcdgpkclks
      781 dskfndtlfg emlhgynnrt qhvnqgqvfq mtfrennfik dfpqladgll viplpveeqc
      841 rgvlseplpd lqlltgdiry deamgypmvq qwrvrsnlyr vklstitlsa gftnvlkilt
      901 kessrdells fiqhygshyi aealygselt ciihfpskkv qqqlwlqyqk ettelgskke
      961 lksmpfityl sglltaqmls ddqlisgvei rceekgrcps tchlcrrpgk eqlsptpvll
     1021 einrvvplyt liqdngtkea fknalmssyw csgkgdvidd wcrcdlsafd asglpncspl
     1081 pqpvlrlspt vepsstvvsl ewidvqpaig tkvsdyilqh kkvdeytdtd lytgeflsfa
     1141 ddllsglgts cvaagrshge vpevsiysvi fkclepdgly kftlyavdtr grhselstvt
     1201 lrtacplvdd nkaeeiadki ynlyngytsg keqqtayntl mevsasmlfr vqhhynshye
     1261 kfgdfvwrse delgprkahl ilrrlervss hcssllrsay iqsrvdtipy lfcrseevrp
     1321 agmvwysilk dtkitceekm vsmarntyge tkgr
//
