LOCUS       NM_001106504            2250 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus astacin like metalloendopeptidase (Astl), mRNA.
ACCESSION   NM_001106504 XM_001081097 XM_230576
VERSION     NM_001106504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2250)
  AUTHORS   Burkart,A.D., Xiong,B., Baibakov,B., Jimenez-Movilla,M. and Dean,J.
  TITLE     Ovastacin, a cortical granule protease, cleaves ZP2 in the zona
            pellucida to prevent polyspermy
  JOURNAL   J Cell Biol 197 (1), 37-44 (2012)
   PUBMED   22472438
REFERENCE   2  (bases 1 to 2250)
  AUTHORS   Sachdev,M., Mandal,A., Mulders,S., Digilio,L.C., Panneerdoss,S.,
            Suryavathi,V., Pires,E., Klotz,K.L., Hermens,L., Herrero,M.B.,
            Flickinger,C.J., van Duin,M. and Herr,J.C.
  TITLE     Oocyte specific oolemmal SAS1B involved in sperm binding through
            intra-acrosomal SLLP1 during fertilization
  JOURNAL   Dev Biol 363 (1), 40-51 (2012)
   PUBMED   22206759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_001106504.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081097.1, XM_230576.4.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2250
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /note="astacin like metalloendopeptidase"
                     /db_xref="GeneID:296129"
                     /db_xref="RGD:1562279"
     exon            1..106
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1362
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /EC_number="3.4.24.21"
                     /note="astacin-like metalloendopeptidase (M12 family)"
                     /codon_start=1
                     /product="astacin-like metalloendopeptidase precursor"
                     /protein_id="NP_001099974.1"
                     /db_xref="GeneID:296129"
                     /db_xref="RGD:1562279"
                     /translation="MGGVGSLWPWMLTLLSLTGLILGAPSASRCSGVCSTSVPEGFTP
                     EGSRVSQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVDGIV
                     EIPFLLSSKYDEPSRQVIMEAFAEFERFTCIRFVAYRGQRDFVSILPMAGCFSGVGRS
                     GGMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHSRADRDRYIRVNWNEILPGFEINF
                     IKSRNSNMLAPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVC
                     RLYSCSPSVPDSHGRGFEAPSDGRSPTPASISHLQRLLEALSEESRSSAPSGSGTGGQ
                     GIIAGFVDSQQGWEHPAQSTFSVGALARSPQMLAAASKSRPGAGADSISLEQFQPAQA
                     PAVPPVSFPDARDKPTPIQDAFARLALLPGGCAPGSHIREVPRD"
     exon            107..232
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     exon            233..294
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     exon            295..388
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     exon            389..506
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     exon            507..688
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     exon            689..770
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     exon            771..925
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
     exon            926..2250
                     /gene="Astl"
                     /gene_synonym="RGD1562279"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtgccgca attctgtaca ttgcttgctg agaaggcagt gaggacccac catgggtggc
       61 gtgggaagcc tgtggccttg gatgttaact ttgctctcct tgacaggttt gatcctagga
      121 gcaccctcag catccagatg ttcaggagtc tgcagtacca gtgtcccaga aggcttcact
      181 cctgagggaa gccgagtatc tcaggacaag gacatccccg caattaacca agggctcatc
      241 tcagaggaga ctccagaaag cagcttcctg gtagaagggg acatcattcg gccaagcccc
      301 ttccgattgt tgtcagtgac caataataaa tggcccaagg gtgttgatgg cattgtggag
      361 atccccttcc tgctctccag caagtacgat gaacccagcc gccaggtcat tatggaggcc
      421 tttgccgagt ttgaacgttt cacgtgcatc cggtttgttg cctaccgtgg tcagagagat
      481 tttgtttcta tccttcctat ggcagggtgc ttctctggtg tgggacgcag tggagggatg
      541 caggtggtat ccctggcacc cacttgtctc cagaagggcc ggggcattgt cctacatgaa
      601 ctcatgcacg tgctcggctt ctggcatgag cattctcggg cagatcggga ccgctacatc
      661 cgagtgaact ggaacgagat cctcccaggc tttgagatca acttcatcaa gtctcgaaat
      721 agcaatatgt tagctcccta tgactactcg tcagtgatgc attatgggag gtttgccttc
      781 agctggcgtg ggcagcccac catcatacca ctctggactt ccagtgttca cattggccag
      841 cgatggaacc tgagcacctc agatatcacc cgggtctgcc ggttgtacag ctgcagccca
      901 agtgtccctg actcccacgg gagagggttc gaggccccca gtgatgggag aagccccact
      961 cctgcctcta tatcacatct acaaagactt ctggaggcac tgtcagaaga atctagaagc
     1021 tctgccccca gtggctctgg gactggaggc cagggtatta ttgctgggtt tgtagacagc
     1081 cagcaaggat gggaacaccc tgctcagagc acattcagtg tgggagcctt ggcaagatca
     1141 cctcaaatgc tggccgctgc ttcaaaatcg aggcctggag caggtgcaga cagcatttct
     1201 ctagagcagt tccagccagc ccaggcaccc gctgtacccc ctgtttcatt tccagatgcc
     1261 agagacaagc caacacctat ccaagatgcc tttgcgaggc tagctctgct tccaggaggc
     1321 tgtgcacctg gaagtcacat cagagaggtg cccagagact gagcctgtaa acttctgtcc
     1381 ccaagtggag aggtattctg cccaaagcag ctaggtcttc tagtccttgg cccctctcgg
     1441 tatcacccct gtcttctgtc ccctgcactg gctactcttg gaggtccagg tcactccatt
     1501 ggtctcttct gcacaatatc cccttctctg cagagttcct aggtatagaa aggccctagg
     1561 ggctttacct gacttgagtc tcctagcctt ggaggatgga agatggttgg catggagaca
     1621 ggatcctgag ggtggccatc aagaccaagg attcagcctt gaagacttct ggaagttcta
     1681 caattgagga ctagttcccg gcatggactt gagtgctggt ttgggcctgg acctcagtgg
     1741 gaagctctgt ggctgggacc ctgaatatcc tgctgtccat gatgcctggc tctaaagatg
     1801 gcctaaagcc ctgggattaa gctctgttct ccaggatgca gagagcccac cttgttctcc
     1861 tactaagctg gactagcaag aggtggctcc tgaccagctt tgcatggtgg aggccttggc
     1921 aagaccaagg ccttggacag cagccttgaa ccttagtccc acatcagatc accgtttgtt
     1981 ttgcccactt gaagtcatcg aggggcagat gtcacactta cttgttgtcc ttcagccatg
     2041 ccacattctt tcttgatctt ccatgaggtt cttctaagaa caaagcacgt aggtgctagg
     2101 gtcaggccag gagcccttca ttctccagga gcctgttggg aggccagggg agccctgctt
     2161 gggctgggag gggaacaaga accttgacct agtgaggaag gggcttcatt catacgggaa
     2221 agggcagaaa taaagttggg tttgtttcat
//
