LOCUS       NM_013157               1496 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus argininosuccinate synthase 1 (Ass1), mRNA.
ACCESSION   NM_013157
VERSION     NM_013157.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Lin,R., Mo,Y., Zha,H., Qu,Z., Xie,P., Zhu,Z.J., Xu,Y., Xiong,Y. and
            Guan,K.L.
  TITLE     CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis
  JOURNAL   Mol Cell 68 (1), 198-209 (2017)
   PUBMED   28985504
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Diez-Fernandez,C., Wellauer,O., Gemperle,C., Rufenacht,V.,
            Fingerhut,R. and Haberle,J.
  TITLE     Kinetic mutations in argininosuccinate synthetase deficiency:
            characterisation and in vitro correction by substrate
            supplementation
  JOURNAL   J Med Genet 53 (10), 710-719 (2016)
   PUBMED   27287393
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Madiraju,A.K., Alves,T., Zhao,X., Cline,G.W., Zhang,D., Bhanot,S.,
            Samuel,V.T., Kibbey,R.G. and Shulman,G.I.
  TITLE     Argininosuccinate synthetase regulates hepatic AMPK linking protein
            catabolism and ureagenesis to hepatic lipid metabolism
  JOURNAL   Proc Natl Acad Sci U S A 113 (24), E3423-E3430 (2016)
   PUBMED   27247419
  REMARK    GeneRIF: these studies demonstrate that increased amino acid flux
            can activate AMPK through increased AMP generated by ASS, thus
            providing a novel link between protein catabolism, ureagenesis, and
            hepatic lipid metabolism.
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Kobayashi,K., Kakinoki,H., Fukushige,T., Shaheen,N., Terazono,H.
            and Saheki,T.
  TITLE     Nature and frequency of mutations in the argininosuccinate
            synthetase gene that cause classical citrullinemia
  JOURNAL   Hum Genet 96 (4), 454-463 (1995)
   PUBMED   7557970
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Kobayashi,K., Shaheen,N., Terazono,H. and Saheki,T.
  TITLE     Mutations in argininosuccinate synthetase mRNA of Japanese
            patients, causing classical citrullinemia
  JOURNAL   Am J Hum Genet 55 (6), 1103-1112 (1994)
   PUBMED   7977368
  REMARK    Erratum:[Am J Hum Genet. 1995 Jan;56(1):356.. PMID: 7825601]
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Shaheen,N., Kobayashi,K., Terazono,H., Fukushige,T., Horiuchi,M.
            and Saheki,T.
  TITLE     Characterization of human wild-type and mutant argininosuccinate
            synthetase proteins expressed in bacterial cells
  JOURNAL   Enzyme Protein 48 (5-6), 251-264 (1994)
   PUBMED   8792870
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Surh,L.C., Morris,S.M., O'Brien,W.E. and Beaudet,A.L.
  TITLE     Nucleotide sequence of the cDNA encoding the rat argininosuccinate
            synthetase
  JOURNAL   Nucleic Acids Res 16 (19), 9352 (1988)
   PUBMED   3174461
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Barber,T., Vina,J.R., Vina,J. and Cabo,J.
  TITLE     Decreased urea synthesis in cafeteria-diet-induced obesity in the
            rat
  JOURNAL   Biochem J 230 (3), 675-681 (1985)
   PUBMED   4062872
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013157.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M36708.1, X12459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 JAXUCZ010000003.1  35149730-35149738
            10-119              JAXUCZ010000003.1  35151796-35151905
            120-188             JAXUCZ010000003.1  35153540-35153608
            189-377             JAXUCZ010000003.1  35154669-35154857
            378-434             JAXUCZ010000003.1  35159959-35160015
            435-509             JAXUCZ010000003.1  35163234-35163308
            510-580             JAXUCZ010000003.1  35167103-35167173
            581-611             JAXUCZ010000003.1  35167670-35167700
            612-702             JAXUCZ010000003.1  35172581-35172671
            703-787             JAXUCZ010000003.1  35175283-35175367
            788-852             JAXUCZ010000003.1  35175951-35176015
            853-984             JAXUCZ010000003.1  35184152-35184283
            985-1141            JAXUCZ010000003.1  35188713-35188869
            1142-1207           JAXUCZ010000003.1  35192963-35193028
            1208-1496           JAXUCZ010000003.1  35194322-35194610
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1496
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /note="argininosuccinate synthase 1"
                     /db_xref="GeneID:25698"
                     /db_xref="RGD:2163"
     exon            1..9
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            10..119
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1253
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /EC_number="6.3.4.5"
                     /note="citrulline--aspartate ligase; arginosuccinate
                     synthetase 1; argininosuccinate synthetase 1"
                     /codon_start=1
                     /product="argininosuccinate synthase"
                     /protein_id="NP_037289.1"
                     /db_xref="GeneID:25698"
                     /db_xref="RGD:2163"
                     /translation="MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDF
                     EEARKKALKLGAKKVFIEDVSKEFVEEFIWPAVQSSALYEDRYLLGTSLARPCIARKQ
                     VEIAQREGAKYVSHGATGKGNDQVRFELTCYSLAPQIKVIAPWRMPEFYNRFKGRNDL
                     MEYAKQHGIPIPVTPKSPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPN
                     TPDVLEIEFKKGVPVKVTNVKDGTTHSTSLDLFMYLNEVAGKHGVGRIDIVENRFIGM
                     KSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFV
                     RHCIDKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPIDATGFI
                     NINSLRLKEYHRLQSKVTAK"
     exon            120..188
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            189..377
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            378..434
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            435..509
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            510..580
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            581..611
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            612..702
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            703..787
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            788..852
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            853..984
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1141
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1207
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1496
                     /gene="Ass1"
                     /gene_synonym="Ass; ASSA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatccaaga caagatgtcc agcaagggct ctgtggttct ggcctacagt ggtggtctgg
       61 acacctcctg catcctcgtg tggctgaagg aacaaggcta tgatgtcatc gcctacctgg
      121 ccaacattgg ccagaaggaa gactttgagg aagccaggaa gaaggcactg aagcttgggg
      181 ccaaaaaggt gttcattgag gatgtaagca aggagtttgt ggaagagttc atctggcctg
      241 ctgtccagtc cagtgcactc tatgaggacc gctatctcct aggcacctct ctcgccaggc
      301 cttgcatagc tcgcaaacaa gtggaaattg cccagcgcga aggggccaag tatgtgtctc
      361 acggcgccac ggggaagggc aatgaccagg tccgctttga gctcacctgc tactcgttag
      421 caccccagat taaggtcatc gccccctgga ggatgcccga gttttacaac cggttcaagg
      481 gccgaaatga tttgatggaa tacgcaaagc aacatggaat ccccatccct gtcaccccca
      541 agagcccctg gagcatggat gagaacctta tgcacatcag ctacgaggct ggaatcctgg
      601 aaaaccccaa gaaccaagca cctccaggtc tctacacaaa aactcaggac cctgccaaag
      661 cacccaacac cccagatgtc cttgagatag aattcaaaaa aggggtccct gtgaaggtga
      721 ccaacgtcaa agatggcact acccacagca catccttgga cctcttcatg tacctgaatg
      781 aagttgcggg caagcatgga gtagggcgca ttgacatcgt ggagaaccgc ttcattggaa
      841 tgaagtcccg gggtatctac gagaccccag cagggaccat cctttaccac gctcatttag
      901 acatagaggc cttcaccatg gatcgggaag tacgcaaaat caagcagggc ctgggcctca
      961 aattcgcaga gctcgtatac accggtttct ggcacagccc tgaatgtgaa tttgttcgcc
     1021 actgcatcga caagtcccag gaacgggtgg aaggaaaggt gcaggtatct gtcttcaagg
     1081 gccaggtgta catccttggc cgggagtctc cactttcact atacaatgaa gagctggtga
     1141 gcatgaacgt acagggtgac tatgaaccca ttgatgccac cggcttcatc aatatcaact
     1201 cgctcaggct gaaggagtac catcgccttc agagcaaggt caccgccaaa tagaccgtga
     1261 caaagaggcg cgggcctccc cgctctgcag ctctcccagg ctccagcatt aattgttgtg
     1321 ataaatttgt aattgtagct tgttctccta ccacctgact ggggctgctg tgccccccct
     1381 cacctccccc ccacccacag gctttgttcc ctggtcccct atagcctaca aaagtggtca
     1441 tcgaagggaa gggggggtgg caggcagctg cagaaagcgc gtaaaatgac aattaa
//
