LOCUS       NM_145089               1123 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus asparaginase and isoaspartyl peptidase 1
            (Asrgl1), mRNA.
ACCESSION   NM_145089 XM_342016
VERSION     NM_145089.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1123)
  AUTHORS   Biswas,P., Chavali,V.R., Agnello,G., Stone,E., Chakarova,C.,
            Duncan,J.L., Kannabiran,C., Homsher,M., Bhattacharya,S.S.,
            Naeem,M.A., Kimchi,A., Sharon,D., Iwata,T., Riazuddin,S.,
            Reddy,G.B., Hejtmancik,J.F., Georgiou,G., Riazuddin,S.A. and
            Ayyagari,R.
  TITLE     A missense mutation in ASRGL1 is involved in causing autosomal
            recessive retinal degeneration
  JOURNAL   Hum Mol Genet 25 (12), 2483-2497 (2016)
   PUBMED   27106100
REFERENCE   2  (bases 1 to 1123)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1123)
  AUTHORS   Cantor,J.R., Stone,E.M., Chantranupong,L. and Georgiou,G.
  TITLE     The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase
            with beta-aspartyl peptidase activity
  JOURNAL   Biochemistry 48 (46), 11026-11031 (2009)
   PUBMED   19839645
REFERENCE   4  (bases 1 to 1123)
  AUTHORS   Dieterich,D.C., Landwehr,M., Reissner,C., Smalla,K.H., Richter,K.,
            Wolf,G., Bockers,T.M., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Gliap--a novel untypical L-asparaginase localized to rat brain
            astrocytes
  JOURNAL   J Neurochem 85 (5), 1117-1125 (2003)
   PUBMED   12753071
  REMARK    GeneRIF: Gliap is abundant in liver and testis and in brain Gliap
            is exclusively expressed in astrocytes and present in structures
            resembling glial endfeet. This suggests Gliap is involved in
            astroglial production of the neuroactive amino acid L-aspartate
REFERENCE   5  (bases 1 to 1123)
  AUTHORS   Bush,L.A., Herr,J.C., Wolkowicz,M., Sherman,N.E., Shore,A. and
            Flickinger,C.J.
  TITLE     A novel asparaginase-like protein is a sperm autoantigen in rats
  JOURNAL   Mol Reprod Dev 62 (2), 233-247 (2002)
   PUBMED   11984834
  REMARK    GeneRIF: A novel asparaginase-like protein (ALP) of spermatozoa was
            cloned from rat and human testis cDNA libraries on the basis of
            reactivity with antibodies produced after vasectomy
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF329099.1.
            
            On Jun 10, 2007 this sequence version replaced NM_145089.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF329099.1, AJ427914.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1123
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /note="asparaginase and isoaspartyl peptidase 1"
                     /db_xref="GeneID:246307"
                     /db_xref="RGD:708526"
     exon            1..104
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1048
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /EC_number="3.5.1.1"
                     /EC_number="3.4.19.5"
                     /note="ALP; glial asparaginase; L-asparaginase;
                     L-asparagine amidohydrolase; asparaginase-like protein 1;
                     asparaginase-like sperm autoantigen;
                     beta-aspartyl-peptidase; isoaspartyl dipeptidase;
                     asparaginase like 1"
                     /codon_start=1
                     /product="isoaspartyl peptidase/L-asparaginase"
                     /protein_id="NP_659557.1"
                     /db_xref="GeneID:246307"
                     /db_xref="RGD:708526"
                     /translation="MATARPSSCGRDSVPATPRASIDVSLVVVVHGGGASNISPGRKE
                     LVSEGIAKAATEGYNILKAGGSAVDAVEGAVTMLENDPEFNAGYGSVLNADGDIEMDA
                     SIMDGKDLSAGAVSAVRCIANPVKLARLVMEKTPHCFLTGRGAEKFAADMGIPQTPAE
                     KLITERTKKHLEKEKLEKGAQKADCPKNSGTVGAVALDCKGNLAYATSTGGIVNKMVG
                     RVGDSPCIGAGGYADNNLGAVSTTGHGESILKVNLARLALFHVEQGKTVDEAATLALD
                     YMKSKLKGLGGLILINKTGDWVAKWTSASMPWAAVKNGKLQAGIDLCETKTRNLPTC"
     exon            105..305
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..448
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..606
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..725
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..836
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1116
                     /gene="Asrgl1"
                     /gene_synonym="Gliap; Hiob2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcag cggtttgctg cccagtgtct tggccagttt gacatcatgg cgaccgcccg
       61 cccctcttcg tgcggccgcg actcagtccc ggcgacaccc cgagcctcca tcgatgtgag
      121 tctcgtggtg gtagtccatg gtggtggagc aagcaacatc tcacccggcc ggaaagaact
      181 ggtgagcgag ggcattgcca aagctgcaac tgagggctat aacatcctca aggctggagg
      241 gagcgcagta gatgctgtgg aaggagccgt gactatgctg gaaaatgacc cggagttcaa
      301 cgcaggttat gggtctgtcc tgaatgcaga tggtgatatt gagatggatg ctagtatcat
      361 ggatgggaag gacctatctg caggagcagt gtctgccgtg cgctgtatcg caaatcctgt
      421 taaacttgca cggcttgtta tggaaaagac tcctcattgc tttctgacgg gccgtggtgc
      481 agagaaattt gcagcagaca tggggattcc acagactcct gccgaaaaac tgataacgga
      541 gagaaccaag aagcacctgg agaaagagaa gcttgagaag ggggcgcaga aagctgactg
      601 ccctaaaaac tcaggaactg taggtgctgt tgccttggac tgcaaaggga acttggctta
      661 tgcaacctct actgggggga ttgtcaataa aatggttggc cgagttggag actcaccttg
      721 tataggagct ggaggttacg cagataataa ccttggagcc gtttcaacca caggacatgg
      781 ggaaagtatt ctgaaggtga atctggccag actcgccctc ttccatgtag agcaaggaaa
      841 gaccgtagat gaggctgcta cgttggcact ggattatatg aagtcaaagc tcaaaggcct
      901 aggtggcctc atcttgatca acaagacggg agactgggtg gcaaagtgga cctctgcctc
      961 catgccctgg gcagcggtga agaacggcaa gctgcaggcc ggcattgacc tttgcgaaac
     1021 caagacaagg aacctgccca cttgctagcc tggatgtgaa gtcaagctgc ctgcagtgga
     1081 gacctaactt aatcaattag atgtagacat ggaaaaaaaa aaa
//
