LOCUS       NP_001386007             254 aa            linear   ROD 31-MAR-2024
DEFINITION  retroviral-like aspartic protease 1 [Rattus norvegicus].
ACCESSION   NP_001386007 XP_008761336
VERSION     NP_001386007.1
DBSOURCE    REFSEQ: accession NM_001399078.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 254)
  AUTHORS   Matsui,T., Kinoshita-Ida,Y., Hayashi-Kisumi,F., Hata,M.,
            Matsubara,K., Chiba,M., Katahira-Tayama,S., Morita,K., Miyachi,Y.
            and Tsukita,S.
  TITLE     Mouse homologue of skin-specific retroviral-like aspartic protease
            involved in wrinkle formation
  JOURNAL   J Biol Chem 281 (37), 27512-27525 (2006)
   PUBMED   16837463
REFERENCE   2  (residues 1 to 254)
  AUTHORS   Bernard,D., Mehul,B., Thomas-Collignon,A., Delattre,C., Donovan,M.
            and Schmidt,R.
  TITLE     Identification and characterization of a novel retroviral-like
            aspartic protease specifically expressed in human epidermis
  JOURNAL   J Invest Dermatol 125 (2), 278-287 (2005)
   PUBMED   16098038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 4, 2022 this sequence version replaced XP_008761336.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582424.1821486.1,
                                        SRR22582424.1699838.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     Protein         1..254
                     /product="retroviral-like aspartic protease 1"
                     /calculated_mol_wt=27785
     Region          113..205
                     /region_name="retropepsin_like"
                     /note="Retropepsins; pepsin-like aspartate proteases;
                     cd00303"
                     /db_xref="CDD:133136"
     Site            order(127,129,131,158..160,198)
                     /site_type="active"
                     /note="inhibitor binding site [active]"
                     /db_xref="CDD:133136"
     Site            127..129
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133136"
     Site            127
                     /site_type="active"
                     /note="Catalytic residue [active]"
                     /db_xref="CDD:133136"
     Site            order(158..161,165..168)
                     /site_type="active"
                     /note="Active site flap [active]"
                     /db_xref="CDD:133136"
     CDS             1..254
                     /gene="Asprv1"
                     /gene_synonym="RGD1560859"
                     /coded_by="NM_001399078.1:201..965"
                     /db_xref="GeneID:500243"
                     /db_xref="RGD:1560859"
ORIGIN      
        1 maasgvrske grrehafvpe pfngtnvaps lwlnrfevid dlnhwdhatk lrflkeslrg
       61 daldvyngld sqaqgdyntv keallksfgg lgaahnkpke ivfansmgkg yylkgkighv
      121 pvrflvdsga qvsvvhpalw eevtdadldt lrpfdnvvkv angaemkilg vwdtevalgk
      181 lkleahflva nasaeeaiig tdvlqdhnav ldfehrtctl kgkkfrllpv ggsledefdl
      241 elieeessap eash
//
