LOCUS       NP_653351                564 aa            linear   ROD 06-JUN-2024
DEFINITION  60 kDa lysophospholipase [Rattus norvegicus].
ACCESSION   NP_653351
VERSION     NP_653351.1
DBSOURCE    REFSEQ: accession NM_144750.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Sugimoto,H. and Yamashita,S.
  TITLE     Characterization of the transacylase activity of rat liver 60-kDa
            lysophospholipase-transacylase. Acyl transfer from the sn-2 to the
            sn-1 position
  JOURNAL   Biochim Biophys Acta 1438 (2), 264-272 (1999)
   PUBMED   10320809
REFERENCE   2  (residues 1 to 564)
  AUTHORS   Sugimoto,H., Odani,S. and Yamashita,S.
  TITLE     Cloning and expression of cDNA encoding rat liver 60-kDa
            lysophospholipase containing an asparaginase-like region and
            ankyrin repeat
  JOURNAL   J Biol Chem 273 (20), 12536-12542 (1998)
   PUBMED   9575212
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Sugimoto,H. and Yamashita,S.
  TITLE     Purification, characterization, and inhibition by phosphatidic acid
            of lysophospholipase transacylase from rat liver
  JOURNAL   J Biol Chem 269 (8), 6252-6258 (1994)
   PUBMED   8119970
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB009372.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB009372.1, BC098655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     Protein         1..564
                     /product="60 kDa lysophospholipase"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.47"
                     /EC_number="3.5.1.1"
                     /note="lysophospholipase; asparaginase homolog;
                     lysophospholipase-transacylase"
                     /calculated_mol_wt=60664
     Region          15..361
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(18..19,85..86,115..117,142,188)
                     /site_type="active"
                     /db_xref="CDD:199207"
     Site            order(19,28..30,81,84..90,92..93,117..118,121,143..144,
                     188..193,237..247,249..250,253,256..257,266,268..270,274,
                     298,301..304,308,327,331,335)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          41..350
                     /region_name="Asparaginase"
                     /note="propagated from UniProtKB/Swiss-Prot (O88202.1)"
     Region          396..426
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O88202.1)"
     Region          <412..559
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          430..461
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          430..459
                     /region_name="ANK 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O88202.1)"
     Region          463..493
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          463..492
                     /region_name="ANK 4"
                     /note="propagated from UniProtKB/Swiss-Prot (O88202.1)"
     Site            478
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A0JNU3; propagated from
                     UniProtKB/Swiss-Prot (O88202.1)"
     Region          530..560
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          530..559
                     /region_name="ANK 5"
                     /note="propagated from UniProtKB/Swiss-Prot (O88202.1)"
     CDS             1..564
                     /gene="Aspg"
                     /coded_by="NM_144750.2:79..1773"
                     /db_xref="GeneID:246266"
                     /db_xref="RGD:708388"
ORIGIN      
        1 maratgpeqr llaiytggti gmrseggvlv pgrglaavlr tlhmlhdeey arahslpedt
       61 lvlppassdq riiykvlecq plfdssdmti tewvqiaqti erhytqyqgf vvihgtdtma
      121 faasvlsfml enlqkpvilt gaqvpihelw sdgrenllga llmagqyvip evclffqnql
      181 frgnrttkvd arrfaafcsp nlpplatvga dvtinrelvr kaswkshlvv hsnmepdvgl
      241 lrlypgipas lvrtflqppl kgvvmetfgs gngptkpdli qelraaaerg liivncthcl
      301 qgavtsdyap gmamagagii sgfdmtseaa laklsyvlgq pglslsdrkk llakdlrgem
      361 tlpttddllg ddmlgcratw llsmngsqda damkdvllpg lalaaahagd ldtlqafvel
      421 grdlnlkdys gqtplhvaar rghasvvaml lqkgvdvdac nedgqsplll avrgrhqsvi
      481 rllraagahl spqeledvgt elcrlasrad seglrawwqa gadlgqpdyd ghcalqvaea
      541 agnadvvall qsledrvsaq pqph
//
