LOCUS       NM_144759               1548 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus acetylserotonin O-methyltransferase (Asmt), mRNA.
ACCESSION   NM_144759
VERSION     NM_144759.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1548)
  AUTHORS   Paiva,R.V.N., Mondes,P.H.L., Brandao,B.J., Sant'Anna,J.N., Freire
            Dos Santos,M.E., Fighera,Y.M., Santos,L.C., Markus,R.P.,
            Fernandes,P.A.C.M., Silva,J.F. and Tamura,E.K.
  TITLE     Effects of acute hypothyroidism on plasma melatonin and Aanat and
            Asmt expression in the pineal gland and gonads of rats
  JOURNAL   Front Endocrinol (Lausanne) 15, 1322867 (2024)
   PUBMED   39149125
  REMARK    GeneRIF: Effects of acute hypothyroidism on plasma melatonin and
            Aanat and Asmt expression in the pineal gland and gonads of rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1548)
  AUTHORS   Coelho,L.A., Andrade-Silva,J., Motta-Teixeira,L.C., Amaral,F.G.,
            Reiter,R.J. and Cipolla-Neto,J.
  TITLE     The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1
            (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin
            O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase)
            mRNA Expressions in Rat Testes
  JOURNAL   Mol Neurobiol 56 (11), 7800-7809 (2019)
   PUBMED   31124080
  REMARK    GeneRIF: The testes of control animals express the Tph1, Aanat, and
            Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal
            values during the dark phase.
REFERENCE   3  (bases 1 to 1548)
  AUTHORS   Rath,M.F., Coon,S.L., Amaral,F.G., Weller,J.L., Moller,M. and
            Klein,D.C.
  TITLE     Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is
            Strongly Expressed in a Subpopulation of Pinealocytes in the Male
            Rat Pineal Gland
  JOURNAL   Endocrinology 157 (5), 2028-2040 (2016)
   PUBMED   26950199
REFERENCE   4  (bases 1 to 1548)
  AUTHORS   Botros,H.G., Legrand,P., Pagan,C., Bondet,V., Weber,P.,
            Ben-Abdallah,M., Lemiere,N., Huguet,G., Bellalou,J., Maronde,E.,
            Beguin,P., Haouz,A., Shepard,W. and Bourgeron,T.
  TITLE     Crystal structure and functional mapping of human ASMT, the last
            enzyme of the melatonin synthesis pathway
  JOURNAL   J Pineal Res 54 (1), 46-57 (2013)
   PUBMED   22775292
REFERENCE   5  (bases 1 to 1548)
  AUTHORS   Shimozuma,M., Tokuyama,R., Tatehara,S., Umeki,H., Ide,S.,
            Mishima,K., Saito,I. and Satomura,K.
  TITLE     Expression and cellular localizaion of melatonin-synthesizing
            enzymes in rat and human salivary glands
  JOURNAL   Histochem Cell Biol 135 (4), 389-396 (2011)
   PUBMED   21437622
  REMARK    GeneRIF: The expression of HIOMT in epithelial cells of striated
            ducts in rat submandibular glands.
REFERENCE   6  (bases 1 to 1548)
  AUTHORS   Kasahara,T., Abe,K., Mekada,K., Yoshiki,A. and Kato,T.
  TITLE     Genetic variation of melatonin productivity in laboratory mice
            under domestication
  JOURNAL   Proc Natl Acad Sci U S A 107 (14), 6412-6417 (2010)
   PUBMED   20308563
REFERENCE   7  (bases 1 to 1548)
  AUTHORS   Hosaka,T., Mimuro,T., Hamada,N., Itoh,M.T. and Ishizuka,B.
  TITLE     Stimulatory effects of LH on release of melatonin and activities of
            its synthesizing enzymes NAT and HIOMT in organ-cultured pineal
            glands of female rats
  JOURNAL   Horm Metab Res 34 (8), 441-445 (2002)
   PUBMED   12198599
REFERENCE   8  (bases 1 to 1548)
  AUTHORS   Gauer,F. and Craft,C.M.
  TITLE     Circadian regulation of hydroxyindole-O-methyltransferase mRNA
            levels in rat pineal and retina
  JOURNAL   Brain Res 737 (1-2), 99-109 (1996)
   PUBMED   8930356
REFERENCE   9  (bases 1 to 1548)
  AUTHORS   Ebihara,S., Marks,T., Hudson,D.J. and Menaker,M.
  TITLE     Genetic control of melatonin synthesis in the pineal gland of the
            mouse
  JOURNAL   Science 231 (4737), 491-493 (1986)
   PUBMED   3941912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB765131.1, EU741665.1 and L78306.1.
            
            On Jun 10, 2008 this sequence version replaced NM_144759.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU741665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               CB765131.1         1-170
            171-1500            EU741665.1         151-1480
            1501-1548           L78306.1           1660-1707
FEATURES             Location/Qualifiers
     source          1..1548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1548
                     /gene="Asmt"
                     /note="acetylserotonin O-methyltransferase"
                     /db_xref="GeneID:246281"
                     /db_xref="RGD:708472"
     exon            1..101
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1319
                     /gene="Asmt"
                     /EC_number="2.1.1.4"
                     /note="hydroxyindole O-methyltransferase"
                     /codon_start=1
                     /product="acetylserotonin O-methyltransferase"
                     /protein_id="NP_653360.2"
                     /db_xref="GeneID:246281"
                     /db_xref="RGD:708472"
                     /translation="MAPGREGELDRDFRVLMSLAHGFMVSQVLFAALDLGIFDLAAQG
                     PVAAEAVAQTGGWSPRGTQLLMDACTRLGLLRGAGDGSYTNSALSSTFLVSGSPQSQR
                     CMLLYLAGTTYGCWAHLAAGVREGRNQYSRAVGISAEDPFSAIYRSEPERLLFMRGLQ
                     ETWSLCGGRVLTAFDLSRFRVICDLGGGSGALAQEAARLYPGSSVCVFDLPDVIAAAR
                     THFLSPGARPSVRFVAGDFFRSRLPRADLFILARVLHDWADGACVELLGRLHRACRPG
                     GALLLVEAVLAKGGAGPLRSLLLSLNMMLQAEGWERQASDYRNLATRAGFPRLQLRRP
                     GGPYHAMLARRGPRPGIITGVGSNTTGTGSFVTGIRRDVPGARSDAAGTGSGTGNTGS
                     GIMLQGETLESEVSAPQAGSDVGGAGNEPRSGTLKQGDWK"
     exon            102..261
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
     exon            262..391
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
     exon            392..460
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
     exon            461..579
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
     exon            580..723
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
     exon            724..846
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1548
                     /gene="Asmt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaggctag gataggcaag atggcacccg gccgggaggg cgagcttgac cgcgacttcc
       61 gagtccttat gagcctcgcc cacggcttca tggtctccca ggtgctgttt gctgccctgg
      121 atctgggcat cttcgacctt gcggcccagg gcccggtggc agcggaggcg gtggcacaga
      181 ctggggggtg gagtccgcgg ggaacgcagc tgctaatgga cgcctgcacc aggctggggc
      241 tactaagagg ggccggggac ggctcctaca ccaactctgc gctgtcatcc acattcctgg
      301 tgagcggaag cccccagtct caacgctgca tgctgctcta cctggcgggc acaacatacg
      361 gctgctgggc ccacctggct gctggggtca gggaagggcg gaaccagtac tccagggccg
      421 tgggcatctc cgctgaggac cccttttcgg ccatctacag gtcagagcct gagcgcctgc
      481 tgttcatgag gggcctgcag gagacatgga gtctatgcgg gggacgggtc ctcacagcct
      541 ttgacctctc acgcttccgg gtcatctgtg accttggcgg cgggtctggg gcgctggcac
      601 aggaggccgc ccgcctctat cccggtagct ccgtgtgtgt ctttgatctc cctgatgtca
      661 tcgccgctgc ccgcacccac ttcctgtcgc caggggcaag acccagtgtg aggtttgtcg
      721 ctggtgactt cttccgttcc cgcctccccc gcgctgacct cttcattctt gcccgggtcc
      781 tgcacgactg ggctgatggt gcctgcgtgg agttgctggg gcggctgcac agggcctgca
      841 ggccaggtgg tgcactactg ctggtggagg cagtgctggc caagggcggg gctgggccgc
      901 tgcggtcgct cctgctgtca ctcaacatga tgctgcaggc tgaggggtgg gagcgccagg
      961 ccagcgacta ccgcaacctg gccactcgtg caggcttccc ccgcctgcag ctgcggcgtc
     1021 ctggtgggcc ataccatgcc atgctggccc ggcggggacc ccgccctggg atcatcacag
     1081 gagtgggaag taacactacg gggacaggaa gttttgtcac aggtataaga cgtgatgtcc
     1141 ctggggcaag aagtgacgct gcagggacag gaagtggcac tggaaacaca ggaagtggca
     1201 tcatgctaca gggagagacg ttggaatcag aggtcagcgc cccacaagca ggaagtgacg
     1261 ttggcggggc aggaaatgaa cccagaagtg gcaccctcaa gcaaggagac tggaagtgac
     1321 tggggagtga gggcagggaa tcctgggcaa gaaatgatgt cccggatggg aatggaggag
     1381 ttttggccag gaagtgacgc cataaccaaa acctgtgact tgggatagga agtgacatca
     1441 tgggtgggaa tttatgactt ctggacagtt acattacagc tgagagtcag tgagttttag
     1501 gcaggaagtg atgtcacagt aatggtgggg taggggacaa taaacgca
//
