LOCUS       NM_021577               2100 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus argininosuccinate lyase (Asl), mRNA.
ACCESSION   NM_021577
VERSION     NM_021577.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Premkumar,M.H., Sule,G., Nagamani,S.C., Chakkalakal,S., Nordin,A.,
            Jain,M., Ruan,M.Z., Bertin,T., Dawson,B., Zhang,J., Schady,D.,
            Bryan,N.S., Campeau,P.M., Erez,A. and Lee,B.
  TITLE     Argininosuccinate lyase in enterocytes protects from development of
            necrotizing enterocolitis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 307 (3), G347-G354 (2014)
   PUBMED   24904080
  REMARK    GeneRIF: Enterocyte-derived ASL has a protective role in
            necrotizing enterocolitis.
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   Walker,D.C., McCloskey,D.A., Simard,L.R. and McInnes,R.R.
  TITLE     Molecular analysis of human argininosuccinate lyase: mutant
            characterization and alternative splicing of the coding region
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9625-9629 (1990)
   PUBMED   2263616
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   Morris,S.M. Jr., Moncman,C.L., Holub,J.S. and Hod,Y.
  TITLE     Nutritional and hormonal regulation of mRNA abundance for arginine
            biosynthetic enzymes in kidney
  JOURNAL   Arch Biochem Biophys 273 (1), 230-237 (1989)
   PUBMED   2547341
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   Kawamoto,S., Kaneko,T., Mizuki,N., Ohsuga,A., Fukushima,J.,
            Amaya,Y., Mori,M. and Okuda,K.
  TITLE     Molecular cloning and nucleotide sequence of rat brain
            argininosuccinate lyase cDNA with an extremely long 5'-untranslated
            sequence: evidence for the identity of the brain and liver enzymes
  JOURNAL   Brain Res Mol Brain Res 5 (3), 235-241 (1989)
   PUBMED   2725197
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Matsubasa,T., Takiguchi,M., Amaya,Y., Matsuda,I. and Mori,M.
  TITLE     Structure of the rat argininosuccinate lyase gene: close similarity
            to chicken delta-crystallin genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (2), 592-596 (1989)
   PUBMED   2789519
REFERENCE   10 (bases 1 to 2100)
  AUTHORS   Amaya,Y., Matsubasa,T., Takiguchi,M., Kobayashi,K., Saheki,T.,
            Kawamoto,S. and Mori,M.
  TITLE     Amino acid sequence of rat argininosuccinate lyase deduced from
            cDNA
  JOURNAL   J Biochem 103 (1), 177-181 (1988)
   PUBMED   2834354
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097270.1.
            
            On Jun 10, 2007 this sequence version replaced NM_021577.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2100
                     /gene="Asl"
                     /note="argininosuccinate lyase"
                     /db_xref="GeneID:59085"
                     /db_xref="RGD:619974"
     exon            1..261
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            262..319
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            320..631
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..2005
                     /gene="Asl"
                     /EC_number="4.3.2.1"
                     /note="ASAL; arginosuccinase"
                     /codon_start=1
                     /product="argininosuccinate lyase"
                     /protein_id="NP_067588.2"
                     /db_xref="GeneID:59085"
                     /db_xref="RGD:619974"
                     /translation="MASESGKLWGGRFAGSVDPTMDKFNSSIAYDRHLWNVDLQGSKA
                     YSRGLEKAGLLTKAEMQQILQGLDKVAEEWAQGIFKLYPNDEDIHTANERRLKELIGE
                     AAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSTFLKVLIEAMVDRAEAECEVLFPGYTH
                     LQRAQPIRWSHWILSHAVALTRDLERLKEVQKRINVLPLGSGAIAGNPLGVDREFLCA
                     ELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFNFVQLSDA
                     YSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFE
                     VSDTMTAVLQVATGVISTLQIHRENMAQALSPDMLATDLAYYLVRKGMPFRQAHEASG
                     KAVVVAEMKGVALNQLSLQELQTVSPLFSSDVNLVWDYSHSVEQYTALGGTAQSSVEW
                     QISQVRALLQM"
     exon            632..826
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            827..910
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            911..967
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1065
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1143
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1221
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1274
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1337
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1452
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1537
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1597
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1681
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1762
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1869
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2075
                     /gene="Asl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaattcta ggtgttccta ccttggtcta atttcagctt gtcgggtgtt ttcatagtgt
       61 aggttttgtt agggtttgcc ttggccacgt taaaaatccc taaaccaggc atgcagcccc
      121 acacctgtaa tcctagcact agagaggccg agacaggaga attgtcatga gtttctggcc
      181 agcctgacct acctaattac tttcaagcca tccgaagctg tttgagacct tgtgtttaaa
      241 aaaacaaaaa acagaagcca ggtcctgcat tcaaactctc gacatcccca cctcaggctc
      301 ccgactgctg agatcacagg aggcggggac aaggcagggg cagcagacgc catccggacc
      361 agaaaaagcc aggagagacc agaaggtgcc tggtccctga gagtctggtc cactaactcc
      421 agggactgtg ggacagagga acaaacaaga aagaactcga ggcctcgctg agtggcgcgc
      481 ttgctgagtg ctgccacatc ccgcaagctg agcaggtatc ccaactctgt tcctgcccgg
      541 tagaccaccc gaggtggtga gtgtggtctt gtcttccaga ttcgtaggac agaagctcca
      601 ggaggaggac ccgcccaaca tggcatcgga gagcgggaag ctatggggtg gccgatttgc
      661 aggctcggtc gaccccacca tggacaagtt caactcatct atcgcctatg accggcatct
      721 gtggaatgtg gacctgcagg gaagcaaggc ctacagcagg ggcctggaga aggcagggct
      781 tctcaccaaa gctgagatgc agcagatact gcaaggcctg gacaaggtgg ctgaagagtg
      841 ggcccaaggc atcttcaaat tgtaccctaa tgatgaagac atccacacgg ccaacgagcg
      901 gcgcctgaag gaactcattg gtgaagctgc agggaagtta cacacaggca gaagtcgcaa
      961 tgaccaggtg gtcacggacc tcaggctgtg gatgaggcaa acctgctcaa aactctccac
     1021 cttcctcaag gtgctcattg aagccatggt agaccgggca gaggcggagt gtgaagtcct
     1081 cttccctggg tacacacact tgcagagagc tcagcccatc cgctggagcc actggatcct
     1141 gagtcacgcc gttgcgctga cacgagattt agagagactg aaggaggtgc agaagcggat
     1201 caatgtcctg ccactgggca gtggggccat tgcaggcaac cctctgggtg tggaccggga
     1261 gttcctctgt gcagaactga actttggagc cattacgctc aacagtatgg atgccaccag
     1321 cgagagagac ttcgtggctg agttcctgtt ttgggcttct ctgtgcatga cccatctcag
     1381 caggatggca gaagacctga ttctctacgg taccaaggaa ttcaactttg tgcagctctc
     1441 cgatgcctac agcaccggaa gcagcttgat gccccagaag aaaaacccag acagcttgga
     1501 gctgatccgg agcaaggcgg gccgagtgtt tggacggtgc gcaggactcc tgatgaccct
     1561 caagggactt ccaagcacct acaacaagga cttacaggaa gacaaggagg ctgtgtttga
     1621 agtgtctgac accatgacag ctgtcctcca agtagccact ggagtcatct ctacactgca
     1681 gattcatcgt gagaacatgg cacaggcact cagccctgac atgctggcta ccgaccttgc
     1741 ctactacctg gtccgcaaag ggatgccatt ccgccaggcc cacgaggcct cagggaaagc
     1801 tgtggtcgtg gcagagatga aaggggtggc tctcaaccag ctgtcacttc aggagctgca
     1861 gaccgtcagt cccctgttct cgagtgacgt gaatctcgtg tgggactaca gccacagcgt
     1921 ggagcagtac acagccttgg gtggcacagc acagtccagt gttgagtggc agatcagcca
     1981 ggtgcgggcc ctgctgcaga tgtagcagcc ctagattcca cccagtcaaa gctgcgcccc
     2041 aataaagtgg agccctggag aggccgccat aaacaaaaaa aaaaaaaaaa aaaaaaaaaa
//
