LOCUS       NM_022227               1885 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Rattus norvegicus acid sensing ion channel subunit family member 5
            (Asic5), mRNA.
ACCESSION   NM_022227
VERSION     NM_022227.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Wiegreffe,S., Lohrer,D., Wirtz,M. and Wiemuth,D.
  TITLE     The bile acid-sensitive ion channel (BASIC) mediates bile
            acid-dependent currents in bile duct epithelial cells
  JOURNAL   Pflugers Arch 473 (12), 1841-1850 (2021)
   PUBMED   34549327
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Wiemuth,D., Sahin,H., Lefevre,C.M., Wasmuth,H.E. and Grunder,S.
  TITLE     Strong activation of bile acid-sensitive ion channel (BASIC) by
            ursodeoxycholic acid
  JOURNAL   Channels (Austin) 7 (1), 38-42 (2013)
   PUBMED   23064163
  REMARK    GeneRIF: BASIC is strongly activated by ursodeoxycholic acid.
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Wiemuth,D., Sahin,H., Falkenburger,B.H., Lefevre,C.M., Wasmuth,H.E.
            and Grunder,S.
  TITLE     BASIC--a bile acid-sensitive ion channel highly expressed in bile
            ducts
  JOURNAL   FASEB J 26 (10), 4122-4130 (2012)
   PUBMED   22735174
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Wiemuth,D. and Grunder,S.
  TITLE     A single amino acid tunes Ca2+ inhibition of brain liver intestine
            Na+ channel (BLINaC)
  JOURNAL   J Biol Chem 285 (40), 30404-30410 (2010)
   PUBMED   20656685
  REMARK    GeneRIF: rBLINaC is opened by an unknown ligand whereas mBLINaC is
            a constitutively open epithelial Na(+) channel.
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Konstas,A.A., Shearwin-Whyatt,L.M., Fotia,A.B., Degger,B.,
            Riccardi,D., Cook,D.I., Korbmacher,C. and Kumar,S.
  TITLE     Regulation of the epithelial sodium channel by N4WBP5A, a novel
            Nedd4/Nedd4-2-interacting protein
  JOURNAL   J Biol Chem 277 (33), 29406-29416 (2002)
   PUBMED   12050153
  REMARK    GeneRIF: regulation by N4WBP5A
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Sakai,H., Lingueglia,E., Champigny,G., Mattei,M.G. and Lazdunski,M.
  TITLE     Cloning and functional expression of a novel degenerin-like Na+
            channel gene in mammals
  JOURNAL   J Physiol 519 Pt 2 (Pt 2), 323-333 (1999)
   PUBMED   10457052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022227.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y19034.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                JAXUCZ010000002.1  169606059-169606071
            14-125              JAXUCZ010000002.1  169607367-169607478
            126-432             JAXUCZ010000002.1  169609855-169610161
            433-670             JAXUCZ010000002.1  169615861-169616098
            671-796             JAXUCZ010000002.1  169617906-169618031
            797-946             JAXUCZ010000002.1  169619883-169620032
            947-1094            JAXUCZ010000002.1  169620919-169621066
            1095-1151           JAXUCZ010000002.1  169625424-169625480
            1152-1320           JAXUCZ010000002.1  169627746-169627914
            1321-1412           JAXUCZ010000002.1  169633256-169633347
            1413-1885           JAXUCZ010000002.1  169634413-169634885
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1885
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /note="acid sensing ion channel subunit family member 5"
                     /db_xref="GeneID:63866"
                     /db_xref="RGD:69295"
     exon            1..13
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            14..125
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1573
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /note="amiloride-sensitive Na+ channel (BLINaC gene);
                     brain-liver-intestine amiloride-sensitive Na(+) channel;
                     amiloride-sensitive sodium channel; inactivation no
                     afterpotential C; amiloride-sensitive cation channel 5,
                     intestinal; acid-sensing (proton-gated) ion channel family
                     member 5"
                     /codon_start=1
                     /product="acid-sensing ion channel 5"
                     /protein_id="NP_071563.1"
                     /db_xref="GeneID:63866"
                     /db_xref="RGD:69295"
                     /translation="MEHTEKSKGPAEKGLLGKIRRYLSKRPLPSPTDRKKFDHDFAIS
                     TSFHGIHNIAQNQNKVRKVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYVE
                     KIEFPAVTFCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVAS
                     HRNFSITEFVKNNGFYLNHDTLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQS
                     KNKVSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVG
                     MHARVTIRQLKTIHQEYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPFL
                     LPGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFP
                     SQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLG
                     LFCGASLITIIEIIEYLFTSFYWVFIFFLLKILEMIQRTSPPQTV"
     exon            126..432
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            433..670
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            671..796
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            797..946
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1094
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1151
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1320
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1412
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1885
                     /gene="Asic5"
                     /gene_synonym="Accn5; Blinac; Inac"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctaagtga aaggcgcaaa atggatattg ttattgaaaa aaaattggat gcacccagag
       61 gacttggcat cactgagagc aaaacatgga acatactgag aaatcaaaag ggcccgccga
      121 gaaaggactc ttaggaaaga taagacgtta cctctcaaag agaccactgc catctccaac
      181 tgaccggaag aagtttgatc atgactttgc catctccact tcctttcatg ggatacataa
      241 tattgcccag aaccagaaca aggttcgaaa ggtgatctgg ctgtctgtgg tgctgggctc
      301 tgtctcgctc ttggtgtggc aaatctacag tcgcttggtc aattatttca tgtggccaac
      361 gacaacatct atagaagttc agtatgtgga gaaaattgag ttcccggctg tgacattctg
      421 taacttgaac agatttcaaa cagaagcagt atccagattt ggcatcattt tcttcttatg
      481 ggacatagtc tccaaagtcc tccgccttca ggaaatcagt ggcaacaaca ctggctctcc
      541 agaggcctta gattttgttg caagtcaccg aaacttcagc attacagagt ttgttaagaa
      601 caatggtttt tatctcaatc atgacacttt ggtgcactgt gagttctttg gaaaaacatg
      661 tgatccaaag gatttcaaac acgtctttac tgaatatggg aattgcttca ctttcaacta
      721 tggcgagaat gtccaaagca agaacaaagt gagtgtgtct ggaagaggct tgaagctgct
      781 gcttgatgtc catcaggagg aattcacgga caacccagtc cctggttttg ctgatgccgg
      841 ggtcatcttt gtcattcact caccgaagaa ggagccccag ttcgatggct tgggtttgtc
      901 ttctcctgtg gggatgcatg cacgggtgac catccgccaa ctgaagacca tccaccagga
      961 gtacccatgg ggagaatgca atcctgacat caagttgagg aactttacca cctacagcac
     1021 gtatggttgt ctgaaggagt gcaaagccaa gcacatccaa aggctgtgtg gatgtttgcc
     1081 ctttctgctt ccaggaaatg gtgtagagtg tgacctacta aaatactaca actgtgtgtc
     1141 tcccatcctt gaccacatcg agcgtaaagg gctgtgcaca atgggaacac acaactccag
     1201 ctgccccgtg ccatgcgaag aaacagaata ccctgctaca attgcttatt cgactttccc
     1261 aagtcaaaga gcaacaaaat ttcttgccaa gaaattgaat caaagccaag aatatatccg
     1321 ggagaatctt gtgaacattg aaataaacta tagcgactta aactataaga taacacagca
     1381 acaaaaggca gtgagtgtgc ctgagttact tgcagatgtt ggaggtcagc tgggactatt
     1441 ttgcggagct agtttgatta caattataga gattattgaa tatctattca ccagtttcta
     1501 ctgggtattc attttctttt tgctgaaaat acttgaaatg atccagcgga cttctccacc
     1561 tcagacagtt tagaagaatg tgaatattct attagaataa aagtgttggt tttcttttca
     1621 tactacatat aattataatg gcttattcat tgttatgaga ctttatgtcc tagtttggaa
     1681 agtctaataa aaaccattga agattcccat ttctgtacac acacttctct ctgtattgtt
     1741 tcatatattc tgtattgtct tttttctatt gtagcctcag cacttaaagt agtaccaatt
     1801 gcatggtatg catattttaa tcttcttata ataagtaatg gaaaatcttt gtgtctaagt
     1861 atgttaatta cacttaatga gctgt
//
