LOCUS       NM_022234               2628 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acid sensing ion channel subunit family member 4
            (Asic4), mRNA.
ACCESSION   NM_022234
VERSION     NM_022234.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2628)
  AUTHORS   Lin,S.H., Chien,Y.C., Chiang,W.W., Liu,Y.Z., Lien,C.C. and
            Chen,C.C.
  TITLE     Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in
            modulating innate fear and anxiety
  JOURNAL   Eur J Neurosci 41 (12), 1553-1568 (2015)
   PUBMED   25828470
REFERENCE   2  (bases 1 to 2628)
  AUTHORS   Andrey,F., Tsintsadze,T., Volkova,T., Lozovaya,N. and Krishtal,O.
  TITLE     Acid sensing ionic channels: modulation by redox reagents
  JOURNAL   Biochim Biophys Acta 1745 (1), 1-6 (2005)
   PUBMED   16085050
  REMARK    GeneRIF: Acid-sensing ion channel currents are susceptible to
            regulation by redox agents. (Acid-sensing ion channels)
REFERENCE   3  (bases 1 to 2628)
  AUTHORS   Akopian,A.N., Chen,C.C., Ding,Y., Cesare,P. and Wood,J.N.
  TITLE     A new member of the acid-sensing ion channel family
  JOURNAL   Neuroreport 11 (10), 2217-2222 (2000)
   PUBMED   10923674
REFERENCE   4  (bases 1 to 2628)
  AUTHORS   Grunder,S., Geissler,H.S., Bassler,E.L. and Ruppersberg,J.P.
  TITLE     A new member of acid-sensing ion channels from pituitary gland
  JOURNAL   Neuroreport 11 (8), 1607-1611 (2000)
   PUBMED   10852210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB703338.1, AJ271642.1 and AJ242554.1.
            
            On Dec 19, 2006 this sequence version replaced NM_022234.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271642.1, AJ242554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                CB703338.1         11-106
            97-1157             AJ271642.1         1-1061
            1158-1386           AJ242554.1         1139-1367
            1387-2628           AJ271642.1         1291-2532
FEATURES             Location/Qualifiers
     source          1..2628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2628
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /note="acid sensing ion channel subunit family member 4"
                     /db_xref="GeneID:63882"
                     /db_xref="RGD:621068"
     exon            1..893
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1931
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /note="spinal chord ASIC; putative acid-sensing ion
                     channel; amiloride-sensitive cation channel 4, pituitary;
                     acid-sensing (proton-gated) ion channel family member 4;
                     acid sensing ion channel 4; spinal cord ASIC"
                     /codon_start=1
                     /product="acid-sensing ion channel 4"
                     /protein_id="NP_071570.2"
                     /db_xref="GeneID:63882"
                     /db_xref="RGD:621068"
                     /translation="MPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAAQGPAAPRDLAT
                     FASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLARGYLTRPHLVAMD
                     PAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEP
                     DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPQSSLPSRAG
                     GMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQ
                     TFVSCQEQRLTYLPQPWGNCRAESKLREPELQGYSAYSVSACRLRCEKEAVLQRCHCR
                     MVHMPGNETICPPNIYIECADHTLDSLGGGSEGPCFCPTPCNLTRYGKEISMVKIPNR
                     GSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLF
                     IGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPNR
                     GRAEGGGASNLLPNHHHPHGPPGSLFEDFAC"
     exon            894..1038
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1166
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1329
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1386
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1540
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1632
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1712
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1817
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2628
                     /gene="Asic4"
                     /gene_synonym="Accn4; Spasic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagggaca cacgcagggg ctgacagctg tgcgggtgct gataagggaa gccacaagga
       61 gacgatcgag gagagagaca agcggcagca gaggcagcag cgacagaggc agcgccgggg
      121 ctgcggagct gctgggagtg ggagtgacgc ccccacctcg ggcccccacc ctgtccccat
      181 cctcctcctg gttgccctga gtttagaaga gcagccgctg ccaccaccac cactccggag
      241 ggcaccaggg ctgctgtcca gggaaggaca gtagcagtga ggctctggcc agtcccagca
      301 gccggggaca gatgccgatc gagattgtgt gcaaaatcaa atttgctgag gaggatgcaa
      361 aacccaagga gaaggaggca ggggatgagc agagcctcct gggggctgct caggggccag
      421 cagcccctcg ggacctggct acctttgcca gcaccagtac tctgcatggg ctgggccggg
      481 cctgtggccc aggcccccat ggactgcgca gaaccctgtg ggtactggcc ctactcacct
      541 cactggctgc cttcctgtac caggcagcca gcctggccag gggctacctg acccggcctc
      601 acctggtagc catggaccct gctgccccag ccccagtggc gggctttccg gctgtcaccc
      661 tctgcaacat caaccgcttc cggcattcgg cactcagcga tgctgatatc ttccacctgg
      721 ccaatctgac agggctgccc cccaaagacc gggatgggca ccgtgcagct ggccttcgct
      781 acccagagcc tgacatggta gacatcctca accgcactgg ccaccagctt gctgacatgc
      841 tcaagagctg caacttcagt gggcaccact gctccgccag caacttctct gtggtctata
      901 ctcgctatgg aaagtgttac accttcaatg cagatcctca gagttcactg cccagcaggg
      961 caggcggcat gggtagtggc ctggagatca tgctagacat ccagcaggag gaatacctac
     1021 ccatatggag ggagacaaat gagacatcat tcgaggcagg gatccgggtg cagatccaca
     1081 gccaggagga gcctccctac atccaccagc tggggttcgg tgtgtcccca ggcttccaga
     1141 cttttgtgtc ctgccaggaa cagcggctaa cttatctgcc ccagccttgg ggcaactgcc
     1201 gggcggaaag caagctcagg gagcctgagc ttcagggcta ctcagcctat agtgtgtctg
     1261 cctgccgact gcgctgtgag aaggaggccg tgcttcagcg ctgccactgc cggatggtgc
     1321 acatgccagg caatgagacc atctgcccgc caaatatcta cattgaatgt gccgaccaca
     1381 cactggactc cctgggtggg ggctctgagg gcccatgctt ctgccctaca ccctgcaacc
     1441 tgactcgtta cggcaaagag atctccatgg tcaagatccc caacaggggc tctgccaggt
     1501 acctggcgag gaagtacaac cgcaatgaga cctacataag ggaaaacttc ttggtcctgg
     1561 atgtcttctt tgaggcccta acctctgaag ccatggaaca gcgagctgcc tatggtctgt
     1621 cagccttgct gggggacctt gggggacaga tgggcctgtt cattggggct agcatcctca
     1681 ccttgctgga gatccttgac tacatctatg aggtctcctg ggatcgactc aagagggtgt
     1741 ggcgacggcc caagacccca cttaggacgt ccactggggg catctccact ttggggctgc
     1801 aggaactgaa ggaacagagt ccctgtccaa atcgaggccg tgctgagggt ggtggggcta
     1861 gcaacctgct tcccaaccat caccaccccc acggcccccc aggaagcctc tttgaagact
     1921 ttgcttgcta ggatggtgct gtgtggggaa agtacccatg aaaccccaca catctcctat
     1981 tcctgggaca gaaggtctgg ggcagcccag ggctaaggga aggggtggtg ctcactgaga
     2041 ggccaggact agggtcctgc tctccctgac ctaggctcag ctgccttgca caagagtcct
     2101 tcttgtccat actccctgct cccaggcagg tgtccaggaa gggctagaga ccggactaga
     2161 ggcccctgag gaggggaggg aggaagagag ggaggaaggc ggaaccctgg tagagcccct
     2221 ctgtacattt gtatatattt agggactggg tgggggtggg acacagacat agaagggtgg
     2281 ggctgcaggg gagggtgaca caggatagtc agggtcccaa ccctaatggc agaaggcaac
     2341 tccttgggac ctaggcatgt tgggctggtt ctacttccct ctttccaggc ccagctccct
     2401 cttggcaggg ggagtgggtg gcccagcagg cctggcccag ctcccagttc cccctgtacc
     2461 agccccacca caagttccct tcgtggggag tgggtggaaa gacctttcag accttggcta
     2521 agcttagggg gagagggagt ggccttctca ggccttgctc cctagagact ggttttataa
     2581 agtgctggtg aacttgggaa taaagagaca caaagaattc tgtgtctg
//
