LOCUS       NM_173135               1977 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus acid sensing ion channel subunit 3 (Asic3), mRNA.
ACCESSION   NM_173135
VERSION     NM_173135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Nasu,T., Hori,A., Hotta,N., Kihara,C., Kubo,A., Katanosaka,K.,
            Suzuki,M. and Mizumura,K.
  TITLE     Vacuolar-ATPase-mediated muscle acidification caused muscular
            mechanical nociceptive hypersensitivity after chronic stress in
            rats, which involved extracellular matrix proteoglycan and ASIC3
  JOURNAL   Sci Rep 13 (1), 13585 (2023)
   PUBMED   37604935
  REMARK    GeneRIF: Vacuolar-ATPase-mediated muscle acidification caused
            muscular mechanical nociceptive hypersensitivity after chronic
            stress in rats, which involved extracellular matrix proteoglycan
            and ASIC3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Han,X., Zhang,Y., Lee,A., Li,Z., Gao,J., Wu,X., Zhao,J., Wang,H.,
            Chen,D., Zou,D. and Owyang,C.
  TITLE     Upregulation of acid sensing ion channels is associated with
            esophageal hypersensitivity in GERD
  JOURNAL   FASEB J 36 (1), e22083 (2022)
   PUBMED   34918385
  REMARK    GeneRIF: Upregulation of acid sensing ion channels is associated
            with esophageal hypersensitivity in GERD.
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Gao,M., Yan,X., Lu,Y., Ren,L., Zhang,S., Zhang,X., Kuang,Q.,
            Liu,L., Zhou,J., Wang,Y., Lai,W. and Long,H.
  TITLE     Retrograde nerve growth factor signaling modulates tooth mechanical
            hyperalgesia induced by orthodontic tooth movement via acid-sensing
            ion channel 3
  JOURNAL   Int J Oral Sci 13 (1), 18 (2021)
   PUBMED   34088898
  REMARK    GeneRIF: Retrograde nerve growth factor signaling modulates tooth
            mechanical hyperalgesia induced by orthodontic tooth movement via
            acid-sensing ion channel 3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Jiang,Q., Peterson,A.M., Chu,Y., Yao,X., Zha,X.M. and Chu,X.P.
  TITLE     Histidine Residues Are Responsible for Bidirectional Effects of
            Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels
  JOURNAL   Biomolecules 10 (9), 1264 (2020)
   PUBMED   32887365
  REMARK    GeneRIF: Histidine Residues Are Responsible for Bidirectional
            Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric
            Channels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Morgan,M., Thai,J., Trinh,P., Habib,M., Effendi,K.N. and
            Ivanusic,J.J.
  TITLE     ASIC3 inhibition modulates inflammation-induced changes in the
            activity and sensitivity of Adelta and C fiber sensory neurons that
            innervate bone
  JOURNAL   Mol Pain 16, 1744806920975950 (2020)
   PUBMED   33280501
  REMARK    GeneRIF: ASIC3 inhibition modulates inflammation-induced changes in
            the activity and sensitivity of Adelta and C fiber sensory neurons
            that innervate bone.
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Babinski,K., Catarsi,S., Biagini,G. and Seguela,P.
  TITLE     Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric
            proton-gated channels sensitive to Gd3+
  JOURNAL   J Biol Chem 275 (37), 28519-28525 (2000)
   PUBMED   10842183
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Coscoy,S., de Weille,J.R., Lingueglia,E. and Lazdunski,M.
  TITLE     The pre-transmembrane 1 domain of acid-sensing ion channels
            participates in the ion pore
  JOURNAL   J Biol Chem 274 (15), 10129-10132 (1999)
   PUBMED   10187795
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Chen,C.C., England,S., Akopian,A.N. and Wood,J.N.
  TITLE     A sensory neuron-specific, proton-gated ion channel
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10240-10245 (1998)
   PUBMED   9707631
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Lingueglia,E., de Weille,J.R., Bassilana,F., Heurteaux,C.,
            Sakai,H., Waldmann,R. and Lazdunski,M.
  TITLE     A modulatory subunit of acid sensing ion channels in brain and
            dorsal root ganglion cells
  JOURNAL   J Biol Chem 272 (47), 29778-29783 (1997)
   PUBMED   9368048
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Waldmann,R., Bassilana,F., de Weille,J., Champigny,G., Heurteaux,C.
            and Lazdunski,M.
  TITLE     Molecular cloning of a non-inactivating proton-gated Na+ channel
            specific for sensory neurons
  JOURNAL   J Biol Chem 272 (34), 20975-20978 (1997)
   PUBMED   9261094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 6, 2022 this sequence version replaced NM_173135.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680421
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-824               JAXUCZ010000004.1  11656544-11657367   c
            825-975             JAXUCZ010000004.1  11655188-11655338   c
            976-1103            JAXUCZ010000004.1  11654821-11654948   c
            1104-1302           JAXUCZ010000004.1  11654469-11654667   c
            1303-1359           JAXUCZ010000004.1  11654323-11654379   c
            1360-1507           JAXUCZ010000004.1  11654077-11654224   c
            1508-1599           JAXUCZ010000004.1  11653734-11653825   c
            1600-1679           JAXUCZ010000004.1  11653577-11653656   c
            1680-1751           JAXUCZ010000004.1  11653412-11653483   c
            1752-1810           JAXUCZ010000004.1  11653231-11653289   c
            1811-1977           JAXUCZ010000004.1  11652946-11653112   c
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1977
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /note="acid sensing ion channel subunit 3"
                     /db_xref="GeneID:286920"
                     /db_xref="RGD:708578"
     exon            1..824
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1889
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /note="DRASIC; dorsal root ASIC; proton gated cation
                     channel DRASIC; amiloride-sensitive cation channel 3;
                     acid-sensing (proton-gated) ion channel 3"
                     /codon_start=1
                     /product="acid-sensing ion channel 3"
                     /protein_id="NP_775158.1"
                     /db_xref="GeneID:286920"
                     /db_xref="RGD:708578"
                     /translation="MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRG
                     LWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSR
                     LTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLED
                     MLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAHGAELLTTPKGGAGNGLEIMLDVQ
                     QEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFL
                     PPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRM
                     MHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASA
                     RYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGA
                     SLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPR
                     PPTTPCAVTKTLSASHRTCYLVTRL"
     exon            825..975
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1103
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1302
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1359
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1507
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1599
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1679
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1751
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1810
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1977
                     /gene="Asic3"
                     /gene_synonym="Accn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgctgct acatcccgtg ccctactcgg tcttcactgc agagacccag ccccacggag
       61 ccaacgcctg ttctggggaa ggcagaactg gaccgaagtt caactcatcc agtcctagca
      121 ggccagtact ttcacctctg tcttggctcc tcccttctct cccttcttct ccttttcttt
      181 cctccctagt ccttgctact tgagtcccat ctccatcccc accactaccc tgctagccct
      241 acaaaacagc ttccccagtc agcaactccc cggtccctgg tccagccatg aaacctcgct
      301 ccggactgga ggaggcccag cggcgacagg cctcagacat ccgggtgttt gccagcagct
      361 gcacaatgca tggtctgggc cacatctttg gccctggagg cctgaccctg cgccgagggc
      421 tgtgggccac agctgtgctc ctgtcgctgg cggccttcct ctaccaggtg gctgagcggg
      481 ttcgctacta tggggagttc caccataaga ccaccctgga tgagcgtgag agccaccagc
      541 tcaccttccc agctgtgact ctgtgtaata tcaacccact gcgccgctca cgcctcacac
      601 ccaatgactt gcactgggct ggaacagcgc tgctgggcct ggaccctgct gaacatgctg
      661 cctaccttcg tgcactgggc cagccccccg caccacctgg cttcatgccc agtccgacct
      721 ttgacatggc acaactctac gccagagccg gccactccct tgaggacatg ttgttggatt
      781 gccgataccg tggccagccc tgtgggcctg agaacttcac agtgatcttt actcgaatgg
      841 ggcaatgcta caccttcaac tctggtgccc acggtgcaga gctgctcacc actccaaagg
      901 gtggtgctgg caacggactg gagattatgc tagatgtaca gcaagaggag tatctgccca
      961 tctggaagga catggaagag accccgtttg aggtggggat ccgagtgcag attcacagcc
     1021 aggatgagcc ccctgccatt gaccagctgg gcttcggggc agccccaggc catcagactt
     1081 ttgtgtcctg tcagcagcag caactgagtt tcctgccacc accctggggt gactgcaata
     1141 ccgcatcttt ggatcccgac gactttgatc cagagccctc tgatcccttg ggttccccca
     1201 gacccagacc cagccctcct tatagtttaa taggttgtcg cctggcctgt gagtctcgct
     1261 atgtggctcg gaagtgtggc tgtcgaatga tgcatatgcc tggaaactcc ccagtgtgca
     1321 gcccccagca gtacaaggac tgcgccagcc cagctctgga cgctatgctg cgaaaggaca
     1381 cgtgtgtctg ccccaacccg tgcgctacta cacgctatgc caaggagctc tccatggtgc
     1441 ggattcccag ccgcgcgtca gctcgctacc tggcccggaa atacaaccgc agcgagtcct
     1501 acattacgga gaatgtactg gttctggata tcttctttga ggccctcaac tatgaagcgg
     1561 tggaacaaaa ggcggcctat gaagtgtcgg agctgctggg agacattggg ggacagatgg
     1621 gactgtttat tggagcaagc ctgcttacca tccttgagat cctcgactat ctctgtgagg
     1681 ttttccaaga cagagtcctg gggtatttct ggaacagaag gagcgctcaa aagcgctctg
     1741 gcaacactct gctccaggaa gagttgaatg gccatcgaac acatgttccc cacctcagcc
     1801 tagggcccag gcctcctacc actccctgtg ctgtcaccaa gacactctct gcctcccacc
     1861 gtacctgtta cctcgtcaca aggctctaga ccagcttggc tgcactgtga catcttggac
     1921 atgtccagcc tgtatatctt tgctgtctcc accctaataa agctctcgta catgtgc
//
