LOCUS       NM_012892               1948 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus acid sensing ion channel subunit 2 (Asic2),
            transcript variant MDEG2, mRNA.
ACCESSION   NM_012892
VERSION     NM_012892.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Shibata,Y., Kumamoto,N., Sakuma,E., Ishida,Y., Ueda,T., Shimada,S.
            and Ugawa,S.
  TITLE     A gain-of-function mutation in the acid-sensing ion channel 2a
            induces marked cerebellar maldevelopment in rats
  JOURNAL   Biochem Biophys Res Commun 610, 77-84 (2022)
   PUBMED   35447498
  REMARK    GeneRIF: A gain-of-function mutation in the acid-sensing ion
            channel 2a induces marked cerebellar maldevelopment in rats.
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Yan,X., Zhang,S., Zhao,H., Liu,P., Huang,H., Niu,W., Wang,W. and
            Zhang,C.
  TITLE     ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction
            of Arterial Baroreceptors
  JOURNAL   Neurosci Bull 37 (10), 1381-1396 (2021)
   PUBMED   34215968
  REMARK    GeneRIF: ASIC2 Synergizes with TRPV1 in the Mechano-Electrical
            Transduction of Arterial Baroreceptors.
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Liu,Y., Hagan,R. and Schoellerman,J.
  TITLE     Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric
            channels (ASIC1a/2a)
  JOURNAL   Sci Rep 8 (1), 7179 (2018)
   PUBMED   29739981
  REMARK    GeneRIF: Our findings identify PcTx1 as a valuable tool for
            studying ASIC1a/2a function and contribute significantly to the
            understanding of the diverse and complex pharmacology of PcTx1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Zhang,H., Gao,G., Zhang,Y., Sun,Y., Li,H., Dong,S., Ma,W., Liu,B.,
            Wang,W., Wu,H. and Zhang,H.
  TITLE     Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression
            and Increases Seizure Susceptibility in Temporal Lobe Epilepsy
  JOURNAL   Sci Rep 7 (1), 5870 (2017)
   PUBMED   28725010
  REMARK    GeneRIF: hippocampal glucose hypometabolism elevates ASIC2a
            expression by suppressing TFCP2 expression, which further enhances
            the intrinsic excitability of CA1 pyramidal neurons and increases
            seizure susceptibility in patients with temporal lobe epilepsy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Wu,H., Wang,C., Liu,B., Li,H., Zhang,Y., Dong,S., Gao,G. and
            Zhang,H.
  TITLE     Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in
            Piriform Cortex After Seizures
  JOURNAL   Mol Neurobiol 53 (3), 1782-1793 (2016)
   PUBMED   25744567
  REMARK    GeneRIF: ASICs may enhance susceptibility to epileptogenesis in the
            piriform cortex.
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Bassilana,F., Champigny,G., Waldmann,R., de Weille,J.R.,
            Heurteaux,C. and Lazdunski,M.
  TITLE     The acid-sensitive ionic channel subunit ASIC and the mammalian
            degenerin MDEG form a heteromultimeric H+-gated Na+ channel with
            novel properties
  JOURNAL   J Biol Chem 272 (46), 28819-28822 (1997)
   PUBMED   9360943
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Waldmann,R., Champigny,G., Voilley,N., Lauritzen,I. and
            Lazdunski,M.
  TITLE     The mammalian degenerin MDEG, an amiloride-sensitive cation channel
            activated by mutations causing neurodegeneration in Caenorhabditis
            elegans
  JOURNAL   J Biol Chem 271 (18), 10433-10436 (1996)
   PUBMED   8631835
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Sokolov,Iu.N., Kaigorodtseva,R.N. and Rudykh,V.F.
  TITLE     [Various roentgenomorphological parallels in ulcers of the
            pyloro-duodenal area]
  JOURNAL   Vestn Rentgenol Radiol (6), 3-11 (1978)
   PUBMED   734884
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Carson,A.
  TITLE     Writing good abstracts: it's a tought job
  JOURNAL   Phys Ther 58 (2), 175-177 (1978)
   PUBMED   625485
REFERENCE   10 (bases 1 to 1948)
  AUTHORS   Tanaka,S., Tamura,K. and Mizuno,Y.
  TITLE     [Clinical consideration with special reference to autopsy cases of
            malignant tumor in the oral cavity, treated with Bleomycin
            (author's transl)]
  JOURNAL   Hiroshima Daigaku Shigaku Zasshi 8 (2), 168-175 (1975)
   PUBMED   69641
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y14635.1.
            
            On Sep 26, 2003 this sequence version replaced NM_012892.1.
            
            Transcript Variant: The variant (MDEG2) encodes the longer protein
            (isoform MDEG2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y14635.1, KP294334.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1948
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /note="acid sensing ion channel subunit 2"
                     /db_xref="GeneID:25364"
                     /db_xref="RGD:2017"
     exon            1..723
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1707
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /note="isoform MDEG2 is encoded by transcript variant
                     MDEG2; degenerin; brain sodium channel 1; acid-sensing ion
                     channel 2; amiloride-sensitive brain sodium channel 2;
                     BNC1; acid-sensing proton-gated ion channel 2 short
                     variant MDEG2; acid-sensing (proton-gated) ion channel 2;
                     amiloride-sensitive cation channel 1, neuronal"
                     /codon_start=1
                     /product="acid-sensing ion channel 2 isoform MDEG2"
                     /protein_id="NP_037024.2"
                     /db_xref="GeneID:25364"
                     /db_xref="RGD:2017"
                     /translation="MSRSGGARLPATALSGPGRFRMAREQPAPVAVAAARQPGGDRSG
                     DPALQGPGVARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGLLLS
                     WSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGL
                     LLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDM
                     LLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQ
                     DEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLP
                     PPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKE
                     CAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS
                     ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYEL
                     IKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC"
     exon            724..874
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1002
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1153
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1210
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1364
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1456
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1536
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1605
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1948
                     /gene="Asic2"
                     /gene_synonym="Accn1; BNaC1; BNC1k; MDEG; MDEG1; MDEG2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcgggctg aatgaatgag ccggagcggc ggagcccggc tgcccgcgac cgcgctcagc
       61 ggcccgggac gcttccgtat ggcccgcgag cagccggcgc ccgtggcggt ggcggcagct
      121 aggcagcccg gaggagaccg gagcggcgat ccggcgctgc aggggccagg ggtcgcccgc
      181 agggggcggc cgtccctgag tcgcactaaa ttgcacgggc tgcggcacat gtgcgcgggg
      241 cgcacggcgg cgggaggctc tttccagcga cgggcgctgt gggtgctggc cttctgcacg
      301 tccctcggct tgctgctgtc ctggtcctcg aaccgcctgc tctactggct cagcttcccg
      361 tcacacacac gagtgcaccg tgagtggagc cgccagctgc cgttccccgc cgtcaccgtg
      421 tgcaacaaca accccctgcg cttcccgcgc ctctccaagg gggacctcta ctacgcgggc
      481 cactggctag ggctgctgct tcccaaccgc accgcgcgcc cgctggtcag cgagctgctg
      541 cggggcgacg agccgcgccg ccagtggttc cgcaaactgg ccgacttccg cctcttcctg
      601 ccgccgcgcc acttcgaggg catcagcgct gccttcatgg accgtttggg ccaccagctg
      661 gaggatatgc tgctctcctg caagtaccgg ggcgagctct gtggcccgca caacttctcc
      721 tcagtgttta caaaatacgg gaagtgttac atgtttaact caggcgagga tggcaagccg
      781 ctgctcacca cggtcaaggg ggggacgggc aacgggctgg agatcatgct ggacattcag
      841 caagatgagt acctgcccat ctggggagag acagaggaaa caacgtttga agcaggagtg
      901 aaggttcaga tccacagtca gtctgagccg cctttcatcc aagagctggg ctttggggtg
      961 gctccggggt tccagacctt cgtggccaca caagagcaga ggctcacata tctgccccca
     1021 ccatgggggg agtgccggtc ctcagagatg ggactcgact tctttcctgt ttacagcatc
     1081 acagcctgtc ggattgactg tgagacccgc tacatcgtgg agaactgtaa ctgccgcatg
     1141 gtccacatgc caggggacgc ccctttctgc acccctgagc agcacaagga gtgtgcagag
     1201 cctgccctcg gtctactggc agaaaaggac agcaattact gtctctgcag gacaccctgc
     1261 aacctgacac gctacaacaa agagctctcc atggtgaaga tccccagcaa gacgtcagcc
     1321 aagtacttag agaagaaatt taacaaatcg gaaaaatata tctcagagaa cattcttgtt
     1381 ctggacatat tttttgaggc gctcaattac gaaacaattg aacagaagaa ggcgtatgaa
     1441 gttgctgcct tacttggtga catcggtggt cagatgggac tgttcattgg tgctagtctc
     1501 ctcacaatac tagagctctt tgattatatt tatgagctga tcaaagagaa gctattagac
     1561 ctgcttggca aagaagaaga ggaagggagc cacgatgaga acatgagcac ctgtgacaca
     1621 atgccaaacc actctgaaac catcagccac actgtgaacg tgcccctgca gacagctttg
     1681 ggcaccctgg aggagattgc ctgctgacac ctctcaggca acgcagcacc tccaaacaga
     1741 ccttaaaggc ccaagaccta ggacaggaga cagcaagcgc aggtgggatc gcccctgacg
     1801 actgaaagaa gcagagcccc ccatatgcac acattgcgaa cttctgccaa acctcacctg
     1861 gccacatctg acatgaaccg tcccgggccc tgcgtcatgt ccctcgcagg accgatgagt
     1921 cgcactccgg aactgtccaa gaactaac
//
