LOCUS       NM_001414903            4222 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus acid sensing ion channel subunit 1 (Asic1),
            transcript variant 1, mRNA.
ACCESSION   NM_001414903 XM_039079936
VERSION     NM_001414903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4222)
  AUTHORS   Dong,K., Chen,F., Wang,L., Lin,C., Ying,M., Li,B., Huang,T. and
            Wang,S.
  TITLE     iMSC exosome delivers hsa-mir-125b-5p and strengthens acidosis
            resilience through suppression of ASIC1 protein in cerebral
            ischemia-reperfusion
  JOURNAL   J Biol Chem 300 (8), 107568 (2024)
   PUBMED   39019215
  REMARK    GeneRIF: iMSC exosome delivers hsa-mir-125b-5p and strengthens
            acidosis resilience through suppression of ASIC1 protein in
            cerebral ischemia-reperfusion.
REFERENCE   2  (bases 1 to 4222)
  AUTHORS   Wang,H.J., Zhang,F.C., Xu,T.W., Xu,Y.C., Tian,Y.Q., Wu,Y.Y.,
            Xu,J.T., Hu,S. and Xu,G.Y.
  TITLE     DNMT1 involved in the analgesic effect of folic acid on gastric
            hypersensitivity through downregulating ASIC1 in adult offspring
            rats with prenatal maternal stress
  JOURNAL   CNS Neurosci Ther 29 (6), 1678-1689 (2023)
   PUBMED   36852448
  REMARK    GeneRIF: DNMT1 involved in the analgesic effect of folic acid on
            gastric hypersensitivity through downregulating ASIC1 in adult
            offspring rats with prenatal maternal stress.
REFERENCE   3  (bases 1 to 4222)
  AUTHORS   Zai,Z., Xu,Y., Qian,X., Li,Z., Ou,Z., Zhang,T., Wang,L., Ling,Y.,
            Peng,X., Zhang,Y. and Chen,F.
  TITLE     Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial
            stress in rheumatoid arthritis
  JOURNAL   J Transl Med 20 (1), 561 (2022)
   PUBMED   36463203
  REMARK    GeneRIF: Estrogen antagonizes ASIC1a-induced chondrocyte
            mitochondrial stress in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4222)
  AUTHORS   Xu,Y., Lu,Z., Ling,Y., Hou,R., Tao,J., Deng,G., Xu,X., Chen,X.,
            Ruan,J., Zhang,Y., Peng,X. and Chen,F.
  TITLE     Acid sensor ASIC1a induces synovial fibroblast proliferation via
            Wnt/beta-catenin/c-Myc pathway in rheumatoid arthritis
  JOURNAL   Int Immunopharmacol 113 (Pt A), 109328 (2022)
   PUBMED   36279671
  REMARK    GeneRIF: Acid sensor ASIC1a induces synovial fibroblast
            proliferation via Wnt/beta-catenin/c-Myc pathway in rheumatoid
            arthritis.
REFERENCE   5  (bases 1 to 4222)
  AUTHORS   Li,Y., Zhang,A., Li,K., Zhao,D., Li,F., Liao,S., Zhang,Y. and
            Huang,Y.
  TITLE     ASIC1a induces mitochondrial apoptotic responses in acute lung
            injury
  JOURNAL   Eur J Pharmacol 934, 175296 (2022)
   PUBMED   36162458
  REMARK    GeneRIF: ASIC1a induces mitochondrial apoptotic responses in acute
            lung injury.
REFERENCE   6  (bases 1 to 4222)
  AUTHORS   Chen,C.C., England,S., Akopian,A.N. and Wood,J.N.
  TITLE     A sensory neuron-specific, proton-gated ion channel
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10240-10245 (1998)
   PUBMED   9707631
REFERENCE   7  (bases 1 to 4222)
  AUTHORS   Bassilana,F., Champigny,G., Waldmann,R., de Weille,J.R.,
            Heurteaux,C. and Lazdunski,M.
  TITLE     The acid-sensitive ionic channel subunit ASIC and the mammalian
            degenerin MDEG form a heteromultimeric H+-gated Na+ channel with
            novel properties
  JOURNAL   J Biol Chem 272 (46), 28819-28822 (1997)
   PUBMED   9360943
REFERENCE   8  (bases 1 to 4222)
  AUTHORS   Waldmann,R., Champigny,G., Bassilana,F., Heurteaux,C. and
            Lazdunski,M.
  TITLE     A proton-gated cation channel involved in acid-sensing
  JOURNAL   Nature 386 (6621), 173-177 (1997)
   PUBMED   9062189
REFERENCE   9  (bases 1 to 4222)
  AUTHORS   Popov,O.G., Bashkirova,V.B. and Sidorov,V.S.
  TITLE     [Value and place of a roentgenological method in complex diagnosis
            of colonic cancer]
  JOURNAL   Vestn Rentgenol Radiol (6), 35-40 (1978)
   PUBMED   734886
REFERENCE   10 (bases 1 to 4222)
  AUTHORS   Filipiuk,J., Michalska-Trenkner,E. and Stozkowska,W.
  TITLE     [Effectiveness of ointment and cream containing silver salt of
            sulfathiazole in the treatment of leg ulcer]
  JOURNAL   Pol Tyg Lek 33 (29), 1153-1156 (1978)
   PUBMED   704418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 14, 2022 this sequence version replaced XM_039079936.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.42287.1,
                                           SRR22399484.915302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               JAXUCZ010000007.1  132677933-132678489
            558-935             JAXUCZ010000007.1  132679376-132679753
            936-1131            JAXUCZ010000007.1  132680274-132680469
            1132-1282           JAXUCZ010000007.1  132701097-132701247
            1283-1410           JAXUCZ010000007.1  132701836-132701963
            1411-1561           JAXUCZ010000007.1  132702709-132702859
            1562-1618           JAXUCZ010000007.1  132703173-132703229
            1619-1772           JAXUCZ010000007.1  132703655-132703808
            1773-1864           JAXUCZ010000007.1  132704245-132704336
            1865-1944           JAXUCZ010000007.1  132704812-132704891
            1945-2049           JAXUCZ010000007.1  132704969-132705073
            2050-4222           JAXUCZ010000007.1  132705207-132707379
FEATURES             Location/Qualifiers
     source          1..4222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4222
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /note="acid sensing ion channel subunit 1"
                     /db_xref="GeneID:79123"
                     /db_xref="RGD:71062"
     exon            1..557
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..935
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..2154
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /note="BNaC2; brain sodium channel 2; proton gated cation
                     channel ASIC1; amiloride-sensitive cation channel 2,
                     neuronal; acid-sensing (proton-gated) ion channel 1"
                     /codon_start=1
                     /product="acid-sensing ion channel 1"
                     /protein_id="NP_001401832.1"
                     /db_xref="GeneID:79123"
                     /db_xref="RGD:71062"
                     /translation="MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRA
                     LWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQ
                     VSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDR
                     AGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGL
                     EIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQ
                     EQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
                     CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKF
                     NKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLE
                     LFDYAYEVIKHRLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYA
                     ANILPHHPARGTFEDFTC"
     exon            936..1131
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1282
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1410
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1561
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1618
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1772
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1864
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1944
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2049
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..4222
                     /gene="Asic1"
                     /gene_synonym="Accn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacacatac catagtcaca cacacacaca cacacacaca cacacacaca cacacgccac
       61 agggcctcgc aagcggggag cgggctccag gatccgaggc gaggcagctc tgctgagagc
      121 ggcgggagga ggcgagccag cggggggagc cctcggttcc gctcccgggc cgggggcccc
      181 ccgcgcacac cggcccagag acaccctcgc agacactcgt aggcgcgcac gcgcaccctt
      241 tcccctcctc ctcccctccc gccgcctccc ggccggacga tggatccctg cagatcccgg
      301 ggctgagagc accgcgcagc gccagcgcgc cgagcccggg gcggaccgag ccgagagagc
      361 aagcgcgcgc gggcggcaga ccgagctgag ccgagccggc cgggcgggcc gctccctgca
      421 gggctctacg cgggtgccgc ggcggccggc ggctcgggtt ccgggccatg agcccctccg
      481 cggcgcggcg ctgagtccac ggacggcctc gcgccccagg acctgcagcg gcggccggct
      541 ttccccagcc ccctcaggat ccccttggca aggatggaat tgaagaccga ggaggaggag
      601 gtgggtggtg tccagccggt gagcatccag gctttcgcca gcagctccac gctgcatggt
      661 cttgcccaca tcttctccta tgagcggctg tctctgaagc gggcactgtg ggccctgtgc
      721 ttcctgggtt cgctggccgt cctgctgtgt gtgtgcactg agcgtgtgca gtactacttc
      781 tgctatcacc acgtcaccaa gcttgacgaa gtggctgcct cccagctcac cttccctgct
      841 gtcacactgt gcaatctcaa tgagttccgc tttagccaag tctccaagaa tgacctgtac
      901 catgctgggg agctgctggc cctgctcaac aacaggtatg agatcccgga cacacagatg
      961 gctgatgaaa agcagctaga gatattgcag gacaaggcca acttccggag cttcaagccc
     1021 aagcccttca acatgcgtga attctacgac agagcggggc acgatattcg agacatgctg
     1081 ctctcgtgcc acttccgtgg ggaggcctgc agcgctgaag atttcaaagt ggtcttcact
     1141 cggtatggga agtgttacac attcaactcg ggccaagatg ggcggccacg gctgaagacc
     1201 atgaaaggtg ggactggcaa tggcctggag atcatgctgg acattcagca agatgaatat
     1261 ttgcctgtgt ggggagagac cgacgagaca tccttcgaag caggcatcaa agtgcagatc
     1321 cacagtcagg atgaaccccc tttcatcgac cagctgggct ttggtgtggc tccaggtttc
     1381 cagacgtttg tgtcttgcca ggagcagagg ctcatctacc tgccctcacc ctggggcacc
     1441 tgcaatgctg ttaccatgga ctcggatttc ttcgactcct acagcatcac tgcctgccgg
     1501 attgattgcg agacgcgtta cctggtggag aactgcaact gccgtatggt gcacatgcca
     1561 ggggacgccc catactgcac tccagagcag tacaaggagt gtgcagatcc tgccctggac
     1621 ttcctagtgg agaaagacca ggaatactgc gtgtgtgaga tgccttgcaa cctgacccgc
     1681 tacggcaagg agctgtccat ggtcaagatc ccaagcaaag cctccgccaa gtacctggcc
     1741 aagaagttca acaaatcgga gcagtacata ggggagaaca ttctggtgct ggacattttc
     1801 tttgaagtcc tcaactatga gaccatcgag cagaaaaagg cctatgagat cgcagggctg
     1861 ttgggtgaca tcgggggcca gatggggttg ttcatcggtg ccagcatcct caccgtgctg
     1921 gaactctttg actatgccta cgaggtcatt aagcacaggc tgtgcagacg tggaaagtgc
     1981 cagaaggagg ctaagaggag cagcgcagac aagggcgtgg cgctcagcct ggatgacgtc
     2041 aaaagacaca atccctgcga gagcctccga ggacatcctg ccgggatgac gtacgctgcc
     2101 aacatcctac ctcaccatcc cgctcgaggc acgtttgagg actttacctg ctaagccctc
     2161 gcaggccgct gtaccaaagg cctaggtggg gagggctggg ggagcaaggg gcccccaact
     2221 gcccccagct accctgtgga cttaactgca ttcctggtca gtggttccct cttgtctgtg
     2281 gtgagaaagg agtcttgacc atagagtcct ctcccagcct ctatcccatc tttttatttt
     2341 aacgaaatta aactaatata aaaagagaga gatcggtcag gacctcaggc tgcccctctg
     2401 ctccatgctg cctcccctag ctccaagcct gaattctgtc tgtctggctg tctgtcatct
     2461 gagtgtccac ctacattctg ctgccaccag tcaccaaagc cccctcttag tgaggggtgg
     2521 aggggatctc caggatctga agtttggccc caaaccagag aatgtacctt aagggagagg
     2581 gctggtgagg ggacttccct agccttaaga gatgctctca gccgggtgac tccccaggag
     2641 cccaagtctc caggtaagga ctccatgccc agttctgctc cctcaagcat atagaacctt
     2701 taggggggcg gaggatctcc tgaagaagta gagacgggga ctccgtgtgg ccctggtgct
     2761 gtaggccaca tcccaatatc cgtaagtcac ctccaaccca aagctgctgg agagagatcc
     2821 caagaggcag ccctctgtga catcccctag aagacctgac tggttagctt ccagctcagg
     2881 gagagcggca cggccgcctg acctcactgg cttctctctc agaggccttt gcagagggcc
     2941 gcatccataa attttcttat ggaacagttc caagtcctct tccctgactt catttgcttc
     3001 tcttggcaac ctcatctgca ttttctattt ctatatgata cagactctat attactatag
     3061 ccttgtatat actcccctcc ggccctgttt gtctcagtcc cattccctct tgtctctgag
     3121 aatcatcccc cagccccaag ttctcccttc tgtctccccc caccccccct gcctcccatt
     3181 ctcctgtctc tgaatgcctt tgcctgtata aagagttgga ttctcccctg gtgtctgtac
     3241 tgtgtacaca catccctttg agaagcacaa ggagatgaca cgcgcattgt aaccttcaca
     3301 ctgtctcggt ggcgacataa aggaagctgt gaattacaag ctctgcctct ttctggcctc
     3361 tccctcggcc cccatgaccg gggcactctc tgccctcccc acggccttaa catgttcctg
     3421 ctccacctat cctggtgccc tttgtctggc tgactgtagc ctccctgagg gaagggattg
     3481 ctggagaggt agctcctatc caggaatgaa ggacactggc tggaaactaa gccaagaatg
     3541 ttacagacag ggggagctgg ggattggtga ctgacccttg cagttgggca gtgagtaccc
     3601 aaggccagaa gctgaagccc tcattcattc agtggccttt ctttcctcag ggtgcccagt
     3661 gccctgtcct cactttgatg cctaggccca ctgcttgcat tttctggtga gccagggctt
     3721 ggtcatgtga ggaaagaggt aggcctagag caggagttga aagccctgct gttgtgtgtc
     3781 cctaccatac agggctggct aaaagtcgag gtagacgctt acctaggaag cgcaaggccc
     3841 tgggttcggt ccccagctcg gaaaaaaaag aaccaaaaaa aaaaaaaaaa aaagtcgagg
     3901 tagagggcct ccccaccccc accaggtacc cttcccaggc cagagcccca atatctttcc
     3961 aggccttctc tgtccccact gtctcttggt ctctaattcc aaaacaggac ttatgggcag
     4021 atcacctgtg tgggttggcc tggagccaga gagtgaggct atagaatctt tgaaaccttt
     4081 tggttcccaa gagttgttta gagaacagaa ctcccccaga aggaagcagg gcaaagcagg
     4141 gaaatggaca ctgactgggg ggcagcagaa ggggctctgg gtgacgcatg cctctggtct
     4201 aataaactgg gtttcaacca tc
//
