LOCUS       NM_001106089            2396 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ASH2 like histone lysine methyltransferase
            complex subunit (Ash2l), mRNA.
ACCESSION   NM_001106089 XM_001062523 XM_214369
VERSION     NM_001106089.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Mackowiak M, Bator E, Latusz J, Mordalska P and Wedzony K.
  TITLE     Prenatal MAM administration affects histone H3 methylation in
            postnatal life in the rat medial prefrontal cortex
  JOURNAL   Eur Neuropsychopharmacol 24 (2), 271-289 (2014)
   PUBMED   23932495
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del
            Valle I, Hein K, Vogt R and Kemler R.
  TITLE     Wnt/beta-catenin signaling regulates telomerase in stem cells and
            cancer cells
  JOURNAL   Science 336 (6088), 1549-1554 (2012)
   PUBMED   22723415
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Shilatifard A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Stoller JZ, Huang L, Tan CC, Huang F, Zhou DD, Yang J, Gelb BD and
            Epstein JA.
  TITLE     Ash2l interacts with Tbx1 and is required during early
            embryogenesis
  JOURNAL   Exp Biol Med (Maywood) 235 (5), 569-576 (2010)
   PUBMED   20463296
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Patel A, Dharmarajan V, Vought VE and Cosgrove MS.
  TITLE     On the mechanism of multiple lysine methylation by the human mixed
            lineage leukemia protein-1 (MLL1) core complex
  JOURNAL   J Biol Chem 284 (36), 24242-24256 (2009)
   PUBMED   19556245
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Lee JH, Tate CM, You JS and Skalnik DG.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   7  (bases 1 to 2396)
  AUTHORS   Mo R, Rao SM and Zhu YJ.
  TITLE     Identification of the MLL2 complex as a coactivator for estrogen
            receptor alpha
  JOURNAL   J Biol Chem 281 (23), 15714-15720 (2006)
   PUBMED   16603732
REFERENCE   8  (bases 1 to 2396)
  AUTHORS   Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis
            CD, Chait BT, Hess JL and Roeder RG.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   9  (bases 1 to 2396)
  AUTHORS   Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I,
            Herr W and Cleary ML.
  TITLE     Leukemia proto-oncoprotein MLL forms a SET1-like histone
            methyltransferase complex with menin to regulate Hox gene
            expression
  JOURNAL   Mol Cell Biol 24 (13), 5639-5649 (2004)
   PUBMED   15199122
REFERENCE   10 (bases 1 to 2396)
  AUTHORS   Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS,
            Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF,
            Hayward NK, Hess JL and Meyerson M.
  TITLE     Menin associates with a trithorax family histone methyltransferase
            complex and with the hoxc8 locus
  JOURNAL   Mol Cell 13 (4), 587-597 (2004)
   PUBMED   14992727
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473970.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214369.4, XM_001062523.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2396
                     /gene="Ash2l"
                     /note="ASH2 like histone lysine methyltransferase complex
                     subunit"
                     /db_xref="GeneID:290829"
                     /db_xref="RGD:1305632"
     exon            1..188
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1884
                     /gene="Ash2l"
                     /note="ash2 (absent, small, or homeotic)-like"
                     /codon_start=1
                     /product="set1/Ash2 histone methyltransferase complex
                     subunit ASH2"
                     /protein_id="NP_001099559.1"
                     /db_xref="GeneID:290829"
                     /db_xref="RGD:1305632"
                     /translation="MAATGVGPGPGVGAGSGPGAAASATTTEDRETEPATAGAGEGPS
                     AAPGAEPSSGEAESGDANLVDVSGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENG
                     RQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANL
                     KEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNI
                     VKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSASG
                     NLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKD
                     GYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDD
                     RLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDK
                     FSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIK
                     FKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKS
                     CTVSINFGPSFKYPPKDVTYHPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP"
     exon            189..252
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            253..398
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            399..487
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            488..582
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            583..678
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            679..774
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            775..850
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            851..944
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1162
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1330
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1524
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1617
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1716
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1776
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2396
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtagcag caatggcggc gactggagtg ggtcctggcc ctggagtggg cgccggctct
       61 ggtccaggag cagctgcaag tgccacaacg acagaagaca gagaaacgga gccggcgacc
      121 gctggggctg gagaggggcc gtctgccgcc ccgggagcgg agcccagctc tggagaggct
      181 gaaagtgggg atgcaaactt ggttgatgta agtggtctgg agacagaatc ttctaatgga
      241 aaagatactt tggaaggcgc tggggatact tcagaagtga tggataccca ggcgggctct
      301 gtggatgagg agaatgggcg gcagttggga gaggtcgagt tgcaatgcgg aatatgtaca
      361 aaatggttca cagcagacac ctttggaata gacacgtcgt catgtctacc ttttatgacc
      421 aactacagct tccattgcaa cgtgtgccat cacagcggga acacttactt tctccggaag
      481 caagcaaatt taaaagaaat gtgccttagt gctctggcga acctgacgtg gcagtctcgg
      541 acacaggatg aacatccgaa aaccatgttt tccaaggata aggatattat accatttatt
      601 gataaatact gggagtgtat gacaaccaga cagagacctg gaaaaatgac ttggcccaat
      661 aacattgtca aaacaatgag taaggaaaga gatgtgttct tggtaaagga acaccctgat
      721 ccagggagca aagacccaga agaagattac cccaaatttg gacttttgga tcaggatctt
      781 agtaatattg gtcctgctta tgacaaccag aaacaaagca gtgctgtgtc tgctagtggg
      841 aacctaaatg gggggatcgc agcaggaagc agtgggaaag gaagaggagc caagcgtaag
      901 cagcaagatg gagggacaac agggaccacc aagaaggcca gaagtgaccc tttattttct
      961 gctcagcgtc tccctcctca tggctaccct ttggaacatc catttaacaa agatggctat
     1021 cggtatattc tagctgagcc cgatcctcat gcccctgacc cagagaagct tgaacttgac
     1081 tgctgggcag gcaaacctat tcctggagac ctctacagag cctgcttata tgaacgagtc
     1141 ttgctagccc tacatgatcg tgctccccag ttaaagatct ctgatgaccg gctgaccgtg
     1201 gttggagaga agggctactc catggtgcgg gcttctcatg gggtgcggaa gggggcctgg
     1261 tactttgaaa tcactgtgga cgagatgccg ccagacactg ctgccaggct gggctggtct
     1321 cagcccttag gtaaccttca ggctccctta ggctatgata aatttagcta ttcttggcgg
     1381 agcaaaaagg gaaccaagtt tcaccagtct attggcaaac actactcgtc tggctatgga
     1441 caaggagatg tcctagggtt ttatatcaat cttcctgaag atacagagac agccaagtca
     1501 ctgccggaca cgtacaaaga taaggctttg ataaagttca agagttattt gtattttgaa
     1561 gaaaaagact ttgtggacaa agcagagaag agcctaaaac agactccaca ttctgagata
     1621 atattttata aaaatggtgt caatcagggt gtggcttaca aggatatttt tgaaggtgtt
     1681 tacttcccag ccatctcact gtacaagagc tgcacggttt ccattaactt tggaccatcc
     1741 ttcaaatacc ctccaaagga cgtcacttac caccctatga gtgacatggg ctggggtgct
     1801 gtggtagaac acactctggc tgatgttttg tatcatgtgg agacagaagt ggacggaagg
     1861 cgcagtccgc cttgggaacc ctagcagatc catgcttctt atgacattgt gaaatgatcc
     1921 tggccttttg cttttgttat ataaagtgtc aaatgttttc ccaaagatgg tgcagtacac
     1981 tttcatcaag gtaaaaggtg gatgggactg cagcaagcat tccctcccct ccccactcct
     2041 gctctcactc tgagtgccgt aaatcagccg ccgactctga agagcccata agctccatgt
     2101 aaaactggtg ctgtgcctct ggcctgccat ggaggacttg ttactttcct gtgtatctaa
     2161 atagtgagta atcatgccca gcttatttaa agatgtttca tcgccctggt ttctggggag
     2221 gcaagcttat ttctgagtgg cagtacattc cagagcagtc tagaagcagt ctttgtggtg
     2281 tggagtttgg ttatctgtga acctagtggg gctgtacaag ctagggttat ggaaggaatc
     2341 tccctggggt taaaagctag atctttcctc cagtaaaact cgtgttcaag tctgtg
//
