LOCUS       NM_012503               1214 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus asialoglycoprotein receptor 1 (Asgr1), transcript
            variant 1, mRNA.
ACCESSION   NM_012503
VERSION     NM_012503.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Li,Y., Yang,C.F., Zuo,H., Li,A., Das,S.K. and Yu,J.H.
  TITLE     Asialoglycoprotein Receptor-Targeted Superparamagnetic
            Perfluorooctylbromide Nanoparticles
  JOURNAL   Contrast Media Mol Imaging 2021, 5510071 (2021)
   PUBMED   34131415
  REMARK    GeneRIF: Asialoglycoprotein Receptor-Targeted Superparamagnetic
            Perfluorooctylbromide Nanoparticles.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Park,E.I., Mi,Y., Unverzagt,C., Gabius,H.J. and Baenziger,J.U.
  TITLE     The asialoglycoprotein receptor clears glycoconjugates terminating
            with sialic acid alpha 2,6GalNAc
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17125-17129 (2005)
   PUBMED   16286643
  REMARK    GeneRIF: Asialoglycoprotein receptor functions to help regulate the
            concentration of glycoproteins bearing sialic acid alpha 2,6GalNAc
            in the blood.
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Casey,C.A., McVicker,B.L., Donohue,T.M. Jr., McFarland,M.A.,
            Wiegert,R.L. and Nanji,A.A.
  TITLE     Liver asialoglycoprotein receptor levels correlate with severity of
            alcoholic liver damage in rats
  JOURNAL   J Appl Physiol (1985) 96 (1), 76-80 (2004)
   PUBMED   12949020
  REMARK    GeneRIF: a correlation exists between the progression of
            alcohol-associated liver injury, as defined by the severity of
            liver pathology, and an ethanol-induced decline in ASGP-R content.
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Deng,A.Y. and Rapp,J.P.
  TITLE     Locus for the inducible, but not a constitutive, nitric oxide
            synthase cosegregates with blood pressure in the Dahl
            salt-sensitive rat
  JOURNAL   J Clin Invest 95 (5), 2170-2177 (1995)
   PUBMED   7537756
REFERENCE   5  (bases 1 to 1214)
  AUTHORS   Ishibashi,S., Hammer,R.E. and Herz,J.
  TITLE     Asialoglycoprotein receptor deficiency in mice lacking the minor
            receptor subunit
  JOURNAL   J Biol Chem 269 (45), 27803-27806 (1994)
   PUBMED   7961705
REFERENCE   6  (bases 1 to 1214)
  AUTHORS   Reddy,N.S., Roth,W.W., Bragg,P.W. and Wahba,A.J.
  TITLE     Isolation and mapping of a gene for protein synthesis initiation
            factor 4A and its expression during differentiation of murine
            erythroleukemia cells
  JOURNAL   Gene 70 (2), 231-243 (1988)
   PUBMED   3215517
REFERENCE   7  (bases 1 to 1214)
  AUTHORS   McPhaul,M. and Berg,P.
  TITLE     Identification and characterization of cDNA clones encoding two
            homologous proteins that are part of the asialoglycoprotein
            receptor
  JOURNAL   Mol Cell Biol 7 (5), 1841-1847 (1987)
   PUBMED   3600647
REFERENCE   8  (bases 1 to 1214)
  AUTHORS   Watts,C.
  TITLE     Isolation and expression of cDNA clones for a rat liver
            asialoglycoprotein receptor
  JOURNAL   Biosci Rep 6 (6), 527-534 (1986)
   PUBMED   2945599
REFERENCE   9  (bases 1 to 1214)
  AUTHORS   Leung,J.O., Holland,E.C. and Drickamer,K.
  TITLE     Characterization of the gene encoding the major rat liver
            asialoglycoprotein receptor
  JOURNAL   J Biol Chem 260 (23), 12523-12527 (1985)
   PUBMED   2995379
REFERENCE   10 (bases 1 to 1214)
  AUTHORS   Holland,E.C., Leung,J.O. and Drickamer,K.
  TITLE     Rat liver asialoglycoprotein receptor lacks a cleavable
            NH2-terminal signal sequence
  JOURNAL   Proc Natl Acad Sci U S A 81 (23), 7338-7342 (1984)
   PUBMED   6095287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088154.1.
            
            On Jan 2, 2005 this sequence version replaced NM_012503.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1214
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /note="asialoglycoprotein receptor 1"
                     /db_xref="GeneID:24210"
                     /db_xref="RGD:2160"
     exon            1..46
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            47..132
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..920
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /note="isoform a is encoded by transcript variant 1;
                     RHL-1; ASGPR 1; ASGP-R 1; HL-1; hepatic lectin 1, RHL1;
                     Asialoglycoprotein receptor 1 (hepatic lectin);
                     asialoglycoprotein receptor (RHL1)"
                     /codon_start=1
                     /product="asialoglycoprotein receptor 1 isoform a"
                     /protein_id="NP_036635.1"
                     /db_xref="GeneID:24210"
                     /db_xref="RGD:2160"
                     /translation="MTKDYQDFQHLDNENDHHQLQRGPPPAPRLLQRLCSGFRLFLLS
                     LGLSILLLVVVCVITSQNSQLREDLRVLRQNFSNFTVSTEDQVKALTTQGERVGRKMK
                     LVESQLEKHQEDLREDHSRLLLHVKQLVSDVRSLSCQMAALRGNGSERICCPINWVEY
                     EGSCYWFSSSVKPWTEADKYCQLENAHLVVVTSWEEQRFVQQHMGPLNTWIGLTDQNG
                     PWKWVDGTDYETGFKNWRPGQPDDWYGHGLGGGEDCAHFTTDGHWNDDVCRRPYRWVC
                     ETELGKAN"
     exon            133..249
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..345
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..417
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..504
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..656
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..763
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1183
                     /gene="Asgr1"
                     /gene_synonym="ASGR; RATRHL1; RHL1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaactgaa ccccagcctt tttagacctg tctcacccac aaaaaggtcc tgccccagtg
       61 ctatcatgac aaaggattat caagatttcc agcacttgga caatgagaac gaccaccatc
      121 aactccagag agggccacct cccgctccaa ggctcttgca gcgactctgc tctggattcc
      181 gtctcttcct gctttccctg ggcctcagca tcctgctgct ggtggttgtc tgtgtgatca
      241 catcccaaaa ttcccaactc cgggaagatc tgcgggttct aaggcagaat ttcagcaact
      301 ttaccgtgag cactgaggac caggtcaagg ccctgaccac ccagggagag agagtgggaa
      361 gaaagatgaa gttagtcgag tcacagctgg aaaaacatca ggaggatctg agggaagacc
      421 actctagatt gctactgcat gtaaagcagt tagtgtctga cgtgcgaagc ttgagctgcc
      481 agatggccgc acttcggggc aatggctctg aaaggatctg ctgccccatc aactgggtgg
      541 agtatgaagg cagctgctac tggttctcca gctctgtgaa gccttggacg gaagctgaca
      601 agtactgcca gctggagaac gcccacctgg tggtggtgac ttcctgggag gagcagagat
      661 tcgtccagca acacatgggc cccttaaata cttggattgg cctaactgac cagaacggac
      721 cctggaaatg ggtggatggg acagactatg agacaggctt caagaactgg agaccagggc
      781 agccagatga ctggtacgga catgggcttg gagggggtga agactgtgcc cacttcacca
      841 ccgatggcca ctggaatgat gacgtctgca ggaggcccta ccgctgggtc tgtgagacag
      901 agttgggcaa ggccaattag gagcctccat tcccctgatt tatttcctga gtgccttgag
      961 ctgtgaggct tagagttggg aggtcctact caagggtctc cccatctttg ggaactttca
     1021 tctaggattt taaggggctg gtaaagaatg gtgtttgagg aatgtggtat gatgcctggt
     1081 ggtggtggtg gtggtggtta ttggaaccca tgacactttg tgcagtgtgc agcttactac
     1141 tgccaacttg tttttgagag taaaagaagg aagataaaca ttcaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaa
//
