LOCUS       NM_031503               1572 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Rattus norvegicus achaete-scute family bHLH transcription factor 2
            (Ascl2), mRNA.
ACCESSION   NM_031503
VERSION     NM_031503.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Varberg,K.M., Iqbal,K., Muto,M., Simon,M.E., Scott,R.L., Kozai,K.,
            Choudhury,R.H., Aplin,J.D., Biswell,R., Gibson,M., Okae,H.,
            Arima,T., Vivian,J.L., Grundberg,E. and Soares,M.J.
  TITLE     ASCL2 reciprocally controls key trophoblast lineage decisions
            during hemochorial placenta development
  JOURNAL   Proc Natl Acad Sci U S A 118 (10) (2021)
   PUBMED   33649217
  REMARK    GeneRIF: ASCL2 reciprocally controls key trophoblast lineage
            decisions during hemochorial placenta development.
REFERENCE   2  (bases 1 to 1572)
  AUTHORS   Goller,T., Seibold,U.K., Kremmer,E., Voos,W. and Kolanus,W.
  TITLE     Atad3 function is essential for early post-implantation development
            in the mouse
  JOURNAL   PLoS One 8 (1), e54799 (2013)
   PUBMED   23372768
REFERENCE   3  (bases 1 to 1572)
  AUTHORS   Oh-McGinnis,R., Bogutz,A.B. and Lefebvre,L.
  TITLE     Partial loss of Ascl2 function affects all three layers of the
            mature placenta and causes intrauterine growth restriction
  JOURNAL   Dev Biol 351 (2), 277-286 (2011)
   PUBMED   21238448
REFERENCE   4  (bases 1 to 1572)
  AUTHORS   Nishiyama,A., Xin,L., Sharov,A.A., Thomas,M., Mowrer,G., Meyers,E.,
            Piao,Y., Mehta,S., Yee,S., Nakatake,Y., Stagg,C., Sharova,L.,
            Correa-Cerro,L.S., Bassey,U., Hoang,H., Kim,E., Tapnio,R., Qian,Y.,
            Dudekula,D., Zalzman,M., Li,M., Falco,G., Yang,H.T., Lee,S.L.,
            Monti,M., Stanghellini,I., Islam,M.N., Nagaraja,R., Goldberg,I.,
            Wang,W., Longo,D.L., Schlessinger,D. and Ko,M.S.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
REFERENCE   5  (bases 1 to 1572)
  AUTHORS   van der Flier,L.G., van Gijn,M.E., Hatzis,P., Kujala,P.,
            Haegebarth,A., Stange,D.E., Begthel,H., van den Born,M., Guryev,V.,
            Oving,I., van Es,J.H., Barker,N., Peters,P.J., van de Wetering,M.
            and Clevers,H.
  TITLE     Transcription factor achaete scute-like 2 controls intestinal stem
            cell fate
  JOURNAL   Cell 136 (5), 903-912 (2009)
   PUBMED   19269367
REFERENCE   6  (bases 1 to 1572)
  AUTHORS   Westerman,B.A., Poutsma,A., Looijenga,L.H., Wouters,D., van
            Wijk,I.J. and Oudejans,C.B.
  TITLE     The Human Achaete Scute Homolog 2 gene contains two promotors,
            generating overlapping transcripts and encoding two proteins with
            different nuclear localization
  JOURNAL   Placenta 22 (6), 511-518 (2001)
   PUBMED   11440538
REFERENCE   7  (bases 1 to 1572)
  AUTHORS   Nakayama,H., Scott,I.C. and Cross,J.C.
  TITLE     The transition to endoreduplication in trophoblast giant cells is
            regulated by the mSNA zinc finger transcription factor
  JOURNAL   Dev Biol 199 (1), 150-163 (1998)
   PUBMED   9676199
REFERENCE   8  (bases 1 to 1572)
  AUTHORS   Tanaka,M., Gertsenstein,M., Rossant,J. and Nagy,A.
  TITLE     Mash2 acts cell autonomously in mouse spongiotrophoblast
            development
  JOURNAL   Dev Biol 190 (1), 55-65 (1997)
   PUBMED   9331331
REFERENCE   9  (bases 1 to 1572)
  AUTHORS   Guillemot,F., Nagy,A., Auerbach,A., Rossant,J. and Joyner,A.L.
  TITLE     Essential role of Mash-2 in extraembryonic development
  JOURNAL   Nature 371 (6495), 333-336 (1994)
   PUBMED   8090202
REFERENCE   10 (bases 1 to 1572)
  AUTHORS   Johnson,J.E., Birren,S.J. and Anderson,D.J.
  TITLE     Two rat homologues of Drosophila achaete-scute specifically
            expressed in neuronal precursors
  JOURNAL   Nature 346 (6287), 858-861 (1990)
   PUBMED   2392153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000044.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_031503.3.
            
            On May 15, 2014 this sequence version replaced NM_031503.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JACYVU010000044.1  25080394-25080663   c
            271-1061            JACYVU010000044.1  25079334-25080124   c
            1062-1572           JACYVU010000044.1  25078256-25078766   c
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1572
                     /gene="Ascl2"
                     /note="achaete-scute family bHLH transcription factor 2"
                     /db_xref="GeneID:24209"
                     /db_xref="RGD:2159"
     exon            1..270
                     /gene="Ascl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1043
                     /gene="Ascl2"
                     /note="mash2; achaete-scute complex homolog-like 2;
                     achaete-scute complex homolog 2"
                     /codon_start=1
                     /product="achaete-scute homolog 2"
                     /protein_id="NP_113691.1"
                     /db_xref="GeneID:24209"
                     /db_xref="RGD:2159"
                     /translation="MESHFNWYGVPRLQKASDACPRESCSSALPEAREGANVHFPPHP
                     VPREHFSCGAPKPVAGAPALNASLMDGGALPRLVPTSSGVAGACTARRRPPSPELLRC
                     SRRRRSGATEASSSSAAVARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETL
                     RSAVEYIRALQRLLAEHDAVRAALSGGLLTPATRPSDVCTQPSASPASASLSCTSTSP
                     DRLGCSEPASPRSAYSSEDSSCEGETYPMGQMFDFSNWLGGY"
     exon            271..1061
                     /gene="Ascl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1572
                     /gene="Ascl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctagggg gtcgcgctct tctacctctt tggccaccgc aaagcctagt ccgttcttca
       61 cccggctgca agcgctaggt gtacggagac ctggcagctc ttggggctta aggactgagc
      121 accagagccg gtggaggttc ctgtggagta cattcggacc ctctcacagc ccccgagagt
      181 gcgggacgtg cggagcgcag ttcgggatct gcactcgagg acttgtcgag gacgcattaa
      241 gctaagcatc tgctcggagc atggaatcgc actttaactg gtacggggtc ccaaggctcc
      301 agaaggctag cgacgcgtgc cctagggaat cctgcagcag tgccctgcct gaggcccgtg
      361 aaggtgcgaa cgtccacttc ccaccgcacc cggttcctcg cgagcacttt tcctgtggcg
      421 caccgaaacc cgtagcgggg gccccggcgc tgaatgcaag cttgatggac ggcggcgcgc
      481 tgcccagact cgtgcccacc tcgtctggag tcgctggagc ctgcactgct cggcggagac
      541 ccccgtcccc ggaactgctt cgctgcagcc gacggcggcg atcgggagca acggaggcca
      601 gcagcagctc ggcggccgtg gcacgccgca atgagcgtga gcgcaaccgc gtaaagctgg
      661 taaacttggg cttccaggcg ctgcggcagc acgtgccgca cggcggcgcc aacaagaagc
      721 tgagtaaggt ggagacgctg cgctccgcgg tagagtacat ccgtgcgctg cagcggctgc
      781 tagcagagca cgacgcggtg cgtgctgcgc tctctggggg tctattaaca cccgctactc
      841 ggccgtccga tgtgtgcacg cagccctccg cctcccctgc cagcgcgtct ctgtcctgca
      901 cctctacatc cccagaccgc ctaggctgct ccgagcctgc ctctccgcgc tccgcctact
      961 cgtcggagga cagcagctgc gagggagaga cttacccgat ggggcagatg tttgactttt
     1021 ccaattggtt agggggctac tgagcacccc acacccctaa gctgcgtccc tgggtgtccc
     1081 ctggtggacc tacctgcgtt tcttgcccag gaaacctggg cccatgcctt acccatgctg
     1141 tctagtgcag cctgaccaaa tgccaagtac tgacctctgc tcggcctcca cgccgcggaa
     1201 tgacatcttc catctcccag tccttgccga accaggactt ggaaatttct caggagaaag
     1261 aattttacaa tgacaatctg ctttttatca attaacttga actgctggag gactctgctg
     1321 aaaatatgaa gaattatttt tatacaaagg atccttaagc ttggagcaca ataaagatga
     1381 cctctgtctc tcacccccac tgtctagaac tttccaacct ggccaaagtg tggacgggtc
     1441 gggccctgag ggcaagatgc ctggctgcac ccttcttcct cttccgaagc ctatcctgac
     1501 gctgatgttt ggccagtgtg ggaaccctgc tattgcaaag tgtactattc tataaaagtt
     1561 gtttttcatt gg
//
