LOCUS       NM_022384               2528 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus achaete-scute family bHLH transcription factor 1
            (Ascl1), mRNA.
ACCESSION   NM_022384 XM_346792
VERSION     NM_022384.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Peng,E., Hu,C., Feng,J. and He,R.
  TITLE     MASH1 induces neuron transdifferentiation of adrenal medulla
            chromaffin cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (4), 526-537 (2023)
   PUBMED   37385615
  REMARK    GeneRIF: MASH1 induces neuron transdifferentiation of adrenal
            medulla chromaffin cells.
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Deng,M., Xie,P., Chen,Z., Zhou,Y., Liu,J., Ming,J. and Yang,J.
  TITLE     Mash-1 modified neural stem cells transplantation promotes neural
            stem cells differentiation into neurons to further improve
            locomotor functional recovery in spinal cord injury rats
  JOURNAL   Gene 781, 145528 (2021)
   PUBMED   33631250
  REMARK    GeneRIF: Mash-1 modified neural stem cells transplantation promotes
            neural stem cells differentiation into neurons to further improve
            locomotor functional recovery in spinal cord injury rats.
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Raina,A., Mahajani,S., Bahr,M. and Kugler,S.
  TITLE     Neuronal Trans-differentiation by Transcription Factors Ascl1 and
            Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in
            Cortical GABAergic Neurons
  JOURNAL   Mol Neurobiol 57 (1), 249-260 (2020)
   PUBMED   31317490
  REMARK    GeneRIF: Neuronal Trans-differentiation by Transcription Factors
            Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter
            Phenotype in Cortical GABAergic Neurons.
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Liu,Y.H., Tsai,J.W., Chen,J.L., Yang,W.S., Chang,P.C., Cheng,P.L.,
            Turner,D.L., Yanagawa,Y., Wang,T.W. and Yu,J.Y.
  TITLE     Ascl1 promotes tangential migration and confines migratory routes
            by induction of Ephb2 in the telencephalon
  JOURNAL   Sci Rep 7, 42895 (2017)
   PUBMED   28276447
  REMARK    GeneRIF: Data found that Ascl1 promoted tangential migration along
            the ventricular zone/subventricular zone (VZ/SVZ) and intermediate
            zone (IZ) of the dorsal telencephalon. Also, Ascl1 induces Ephb2
            expression in the telencephalon.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2528)
  AUTHORS   Yan,G., Li,B., Xin,X., Xu,M., Ji,G. and Yu,H.
  TITLE     MicroRNA-34a Promotes Hepatic Stellate Cell Activation via
            Targeting ACSL1
  JOURNAL   Med Sci Monit 21, 3008-3015 (2015)
   PUBMED   26437572
  REMARK    GeneRIF: miR-34a appears to play an important role in the process
            of liver fibrosis by targeting ACSL1 and may show promise as a
            therapeutic molecular target for hepatic fibrosis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2528)
  AUTHORS   Black,B.L., Ligon,K.L., Zhang,Y. and Olson,E.N.
  TITLE     Cooperative transcriptional activation by the neurogenic basic
            helix-loop-helix protein MASH1 and members of the myocyte enhancer
            factor-2 (MEF2) family
  JOURNAL   J Biol Chem 271 (43), 26659-26663 (1996)
   PUBMED   8900141
REFERENCE   7  (bases 1 to 2528)
  AUTHORS   Sommer,L., Shah,N., Rao,M. and Anderson,D.J.
  TITLE     The cellular function of MASH1 in autonomic neurogenesis
  JOURNAL   Neuron 15 (6), 1245-1258 (1995)
   PUBMED   8845150
REFERENCE   8  (bases 1 to 2528)
  AUTHORS   Guillemot,F., Lo,L.C., Johnson,J.E., Auerbach,A., Anderson,D.J. and
            Joyner,A.L.
  TITLE     Mammalian achaete-scute homolog 1 is required for the early
            development of olfactory and autonomic neurons
  JOURNAL   Cell 75 (3), 463-476 (1993)
   PUBMED   8221886
REFERENCE   9  (bases 1 to 2528)
  AUTHORS   Johnson,J.E., Zimmerman,K., Saito,T. and Anderson,D.J.
  TITLE     Induction and repression of mammalian achaete-scute homologue
            (MASH) gene expression during neuronal differentiation of P19
            embryonal carcinoma cells
  JOURNAL   Development 114 (1), 75-87 (1992)
   PUBMED   1576967
REFERENCE   10 (bases 1 to 2528)
  AUTHORS   Johnson,J.E., Birren,S.J. and Anderson,D.J.
  TITLE     Two rat homologues of Drosophila achaete-scute specifically
            expressed in neuronal precursors
  JOURNAL   Nature 346 (6287), 858-861 (1990)
   PUBMED   2392153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 26, 2021 this sequence version replaced NM_022384.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53725.1, SRR22399481.2456961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129, SAMN12840132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1332              JAXUCZ010000007.1  23792178-23793509   c
            1333-2528           JAXUCZ010000007.1  23790642-23791837   c
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2528
                     /gene="Ascl1"
                     /gene_synonym="Mash1"
                     /note="achaete-scute family bHLH transcription factor 1"
                     /db_xref="GeneID:64186"
                     /db_xref="RGD:71010"
     exon            1..1332
                     /gene="Ascl1"
                     /gene_synonym="Mash1"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..1292
                     /gene="Ascl1"
                     /gene_synonym="Mash1"
                     /note="achaete-scute complex homolog-like 1; achaete-scute
                     complex homolog 1"
                     /codon_start=1
                     /product="achaete-scute homolog 1"
                     /protein_id="NP_071779.1"
                     /db_xref="GeneID:64186"
                     /db_xref="RGD:71010"
                     /translation="MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAA
                     QSAQQQQQQQAPQQQAPQLSPVADGQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNF
                     SGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSA
                     VEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDP
                     LSPEEQELLDFTNWF"
     exon            1333..2528
                     /gene="Ascl1"
                     /gene_synonym="Mash1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcctcgc cgcaaccgcc cagcactctc tcacttctgg ccagggaacg tggaaggcgt
       61 accggctagg agccggttag ggagggcgaa ttgggggacg aaagaggaat tagaaagaaa
      121 gggggttcag ccaaataatc ccagaagtag gctcaagccc agactggagc aggggagagc
      181 gagcgcaaga gagcgcagtc cgggagcggc tcgacctggc agagcacgct cggcgctgac
      241 ttttgcggct gctttccttt tccctttcct cttttaaaac cgagaaggcg ccggcggcgg
      301 ccgcacacgc gagcgccacg cgaggctccc gaagccaacc gcggcgggag gaggggaggg
      361 aggaggcggc gcagagggaa gacgatcacc caggcacctt cctccgttgc tgctagacaa
      421 ctctgcctcc ttctgcgcgt ttcttccctt ttaactttct tccggggctg gtttctcccc
      481 tcttcttttt cttcgccccc tttgatcgtg cttcgcagtc ccgcttcctt ctagctctct
      541 gcgtcccctg agtccccaac tcgttctccc ccgcgacagt ttgggccagc atggagagct
      601 ctggcaagat ggagagcgga gccggccagc agccgcagcc tccgcagccc ttcctgccgc
      661 ctgcagcctg cttctttgcg accgcggcgg ccgcggcggc ggcggcagcg gcagcggcag
      721 ctcagagcgc gcagcagcaa cagcagcagc aggcgccgca gcagcaggcg ccgcagctga
      781 gcccggtggc ggacggccag ccctcagggg gcggtcacaa gtcagcggcc aagcaggtca
      841 agcgccagcg ctcgtcctct cccgaactga tgcgctgcaa acgccggctc aacttcagtg
      901 gcttcggcta cagccttcca cagcagcagc cggcagccgt ggcgcgccgc aacgagcgcg
      961 agcgcaaccg ggtcaagttg gttaacctgg gctttgccac cctccgggag catgtcccca
     1021 acggcgctgc caacaagaag atgagcaagg tggagacgct gcgttcggcg gtcgaataca
     1081 tccgcgcgct gcagcagctg ctggacgagc acgatgcggt gagcgctgcc ttccaggcgg
     1141 gcgtcctgtc gcccaccatc tcccccaact actccaacga cttgaactct atggcgggtt
     1201 ctccggtttc gtcctactcc tccgacgagg gatcctacga cccccttagt ccagaggaac
     1261 aagagctgct ggactttacc aactggttct gaggggctga caggccctac tgggaatgga
     1321 ctttggaagc aggatggcag gagatcctgt gtcttcagtg tttcttgaca acgacgtcaa
     1381 aagggggagg cagaaaaaaa aaaaaaaaca agggaagagg aaaagaaaca aacaaaccag
     1441 acacccagcc tcccacgggc accaggactt agattcaatg ttctcagcaa acaggggtgg
     1501 gctccaacag cgtctctaca ctccgtgtca tttccagaca cgagaagagt gactggtgtc
     1561 tgcaacctag cccgagtccc agacggtgtg caaaagtaat cggattcctt tcctggagca
     1621 agagagccac acgtacacac accctatatt cattctcaga caaccgctag caggcagggc
     1681 tgaaagcgcg tgcaagtgcc ttcacctccc acactctgtc agagccgtct tagcccccct
     1741 gaaactgggt tgacgttttt tcctcagtca cccccattcc agcgagctgt ggacatttgc
     1801 ctccagtgaa gctacaccat actgtactcg gttcttggac accctttccc tgtgctggtg
     1861 gcctcctccc caacccccac gttcacgcgc ccatggtctt tgcttctgtt ttcttcatag
     1921 aatgcttcca atctttgtga attttttatt ataagaaaaa aatctatttg tgtctatcct
     1981 aaccagtttg gggatatatt aagatatttt tgtacataag aaaagagaga gagagaaatt
     2041 tatagaagtt ttgtacaaat ggtttaaaat gtgtatatct tgatacttta acatgtaatg
     2101 cgattacctc tgcatacttt agatgtatag ttcatcttac aactgccatc ccccccctcc
     2161 accccagtgt ggttttgtaa agaactctcc tcacaggtga gagctaaatg ccaccagaat
     2221 gacttcagca ccaatgtgtc ttacttcaca gaaacgtggt taatgtatta atgatgttat
     2281 taaaaaaaac tgttcaagga gaacaaagtt tatgcagcta ctgtccaaac gcaaagtggc
     2341 agccagttgg tttccatggg ttgccttttg gaaatttcta ccactgcctt ctccccccct
     2401 cccccacccc cagcccttca ctgttttatt acaaacttac aaaaaaaaaa aacatgtata
     2461 accctgtttc atacaaacta gttttgtaat aaaacttttt ccttttttta tataaagaag
     2521 agagagag
//
