LOCUS       NM_001109091            2626 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus activating signal cointegrator 1 complex subunit
            2 (Ascc2), mRNA.
ACCESSION   NM_001109091 XM_001067250 XM_573644
VERSION     NM_001109091.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Knierim E, Hirata H, Wolf NI, Morales-Gonzalez S, Schottmann G,
            Tanaka Y, Rudnik-Schoneborn S, Orgeur M, Zerres K, Vogt S, van
            Riesen A, Gill E, Seifert F, Zwirner A, Kirschner J, Goebel HH,
            Hubner C, Stricker S, Meierhofer D, Stenzel W and Schuelke M.
  TITLE     Mutations in Subunits of the Activating Signal Cointegrator 1
            Complex Are Associated with Prenatal Spinal Muscular Atrophy and
            Congenital Bone Fractures
  JOURNAL   Am J Hum Genet 98 (3), 473-489 (2016)
   PUBMED   26924529
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ,
            Lee SK, Kim TS, Lee JW and Lee YC.
  TITLE     Novel transcription coactivator complex containing activating
            signal cointegrator 1
  JOURNAL   Mol Cell Biol 22 (14), 5203-5211 (2002)
   PUBMED   12077347
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_573644.2, XM_001067250.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2626
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /note="activating signal cointegrator 1 complex subunit 2"
                     /db_xref="GeneID:498402"
                     /db_xref="RGD:1561422"
     exon            1..53
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            54..151
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2320
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /codon_start=1
                     /product="activating signal cointegrator 1 complex subunit
                     2"
                     /protein_id="NP_001102561.1"
                     /db_xref="GeneID:498402"
                     /db_xref="RGD:1561422"
                     /translation="MPALPLDQLQITHKDPKTGKLRTSAALHPEQKADRYFVLYKPPP
                     KDNIPALVEEYLERANFVANDLDWLLALPHDKFWCQVIFDESLQKCLDSYLHYVPRKF
                     DEWVAPTPEVADMQKHLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPK
                     ILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYNDLDETIPTILQVFSNILQHCGLQGDG
                     INTIPQKLGERPRLTPSDMPLLELKDIVLYLCDTSTTLWAFLDIFPLACQTFQKHDFC
                     YRLASFYEMAIPEIESAIKKRRLEDSKLLGDMWQRLSHSKKKLMEVFHTILNQICLLP
                     ILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDSFFPVAEDISLLQQASSALDETRT
                     TYILQAVEGAWEGVDRQKIKDIKDPSRAKDSNNGVTMTAEPVSEMPSQLENSEDDEEC
                     MGAAAAVGPAVSGVELDSLISQVKDLLPDLGEGFILACLEHYSYDSERVINNILEDRL
                     APELSQLDRSLERQVKPDPTPLLSSRHNVFQNDEFDVFSRDSVDLSRVHKGRRKEETV
                     RSLVNDKQAVVAQWQRYQKYSVIVEEVPLQPGEYQADDYEDEYDDTYDGNQVGANDAD
                     SDDELISRRPFTIPQVLRTKMPVEGQEEECDEEDEVEEEAPKPDHFIQDPAVLREKAE
                     ARRIAFLARKGYRPENSTAVTGGPRGHGQSRETTQERRKKEANKAARANHSRRTMADR
                     KRNKGMIPS"
     exon            152..310
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            311..481
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            482..611
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            612..679
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            680..790
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            791..903
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            904..978
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1086
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1155
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1230
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1417
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1632
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1752
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1846
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1968
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2068
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2148
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2626
                     /gene="Ascc2"
                     /gene_synonym="RGD1561422"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagctgtc gcggtgaatt gcggctgaac atcacgggtg tggagccggg gaggagggtc
       61 acgcagcaca atgccagctc tgcccctgga ccaactccag atcacccaca aagacccgaa
      121 gacaggcaag ctgaggactt cagcagcgct gcaccctgag cagaaggcag accggtattt
      181 tgtgttgtac aaaccacccc ctaaagacaa cattcctgcc ctggtggagg agtacctgga
      241 gcgtgccaac ttcgtagcca atgacctcga ctggctcctg gccttgcctc acgataaatt
      301 ctggtgccag gtcatctttg atgagagcct gcagaagtgc ctggactcct acctgcacta
      361 tgtgccccga aaatttgatg agtgggtggc cccaacccct gaggttgctg acatgcagaa
      421 gcacctgcac cgaagtgttt tcctcacctt ccttcgaatg tccactcaca aggaatccaa
      481 agaccacttc atttctccat ccgcatttgg agaaatcctc tacaataact tcctctttga
      541 catcccaaag atcctggacc tctgtgtgct ctttgggaaa ggcaactcac cactgctcca
      601 gaaaatgata ggaaacatat ttacccagca gccaagttac tataatgacc tggacgaaac
      661 cattcccacc atacttcagg tcttcagcaa tatcctccag cactgtggtt tgcaagggga
      721 tggaataaac accatacccc agaaactcgg ggagaggcct cggttgacgc ccagtgacat
      781 gcctctcttg gaattaaagg acattgttct ctacctgtgt gacacctcca ccacactctg
      841 ggcctttctg gacatcttcc ctttggcctg ccaaaccttc cagaaacatg acttttgtta
      901 cagactagct tccttttatg agatggcgat tccggaaata gagtctgcaa ttaagaagag
      961 gaggcttgaa gacagcaagc tcctgggtga catgtggcag aggctctccc attccaagaa
     1021 gaagctaatg gaggtgtttc acaccatcct gaaccagatc tgcctccttc ccattctaga
     1081 gagcagctgt gacaacattc aaggcttcat tgaagaattc cttcaaatct ttagctcttt
     1141 gctgcaggag aagagattcc tccgagacta tgactcattc ttccctgtag ctgaagacat
     1201 cagcttgctg cagcaggctt catcagcatt ggatgaaacc cggactacct acatcctaca
     1261 ggctgtggaa ggtgcatggg aaggggtgga cagacagaaa atcaaggaca ttaaagaccc
     1321 atcaagagcc aaggattcta ataacggagt cacaatgaca gcagagccag tcagtgaaat
     1381 gccatcacag ctggagaatt cggaagacga tgaggagtgc atgggtgcag cagctgccgt
     1441 gggccccgcc gtgagcggtg tggaactgga ctcactcatc tcccaagtga aggacctgct
     1501 gccagacctc ggggagggct ttattctggc ctgcctggag cactacagct atgattcaga
     1561 gcgggttatc aacaacatcc tggaggatcg gctggcccct gagctcagtc agctggaccg
     1621 aagcctagaa agacaagtaa agccggaccc cacacccctg ttgtcatcgc gtcacaacgt
     1681 cttccagaac gatgagttcg atgtgttcag cagggactca gtagacctga gccgagtgca
     1741 caagggcagg aggaaggagg agaccgtgag gagcctggtg aatgacaagc aggctgtggt
     1801 ggcacagtgg cagcgctacc agaagtacag tgtgatagtg gaggaggtcc cactgcagcc
     1861 aggagaatac caggctgatg actatgagga cgagtatgat gacacatacg atggcaacca
     1921 ggtgggcgcc aatgatgctg actctgatga cgagctcatc agccgcaggc ccttcaccat
     1981 ccctcaggtg ctgagaacca aaatgcctgt ggaagggcag gaggaggagt gtgatgaaga
     2041 ggatgaggtt gaagaggagg cccccaagcc agaccatttc attcaggatc ctgcagtgct
     2101 gagggaaaag gctgaagcta ggcgcatagc cttcctcgcc aggaaagggt atcgacctga
     2161 gaactccact gcagtgacag gtggaccccg gggccatggg caaagccgag aaacaaccca
     2221 ggagcgcagg aagaaagagg ccaacaaggc agccagagcc aaccacagcc gtagaaccat
     2281 ggctgaccga aagagaaaca aaggcatgat cccatcctga ggccacaagc tgcctggacc
     2341 agggaggccc ctcaagacca ccatcacacc tcacctacca gccagccgtg agcgccttct
     2401 tgtcaaacac acagtgcctt atcccttggt gcgggaaccc agtgccatcg agcaggctct
     2461 ctcccagctg tgctggtggg aaggatgggg ctgcagaacc aaagtgtctc tcatctcggg
     2521 cagcaaggca ccacctccag aagtcctgga tggcaggaga cctgtatatt cagaagcaac
     2581 gaaaggccca tgaataaagt ttctgacctt ccaacagtgc tccctg
//
